CN103181970A - Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same - Google Patents
Traditional Chinese medicine composition for treating infectious coryza of chicken and preparation method for same Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition capable of relieving exterior syndrome and dissipating cold, dredging nasal orifices, and expelling the wind and relieving pain. The traditional Chinese medicine composition comprises the ten medicinal materials of flos magnoliae liliflorae, cocklebur fruit, schizonepeta, divaricate saposhnikovia root, houttuynia cordata, radix angelicae, ligusticum wallichii, scutellaria baicalensis, fructus forsythiae and honeysuckle, and is used for treatment in the high-incidence season of the infectious coryza of chicken. The traditional Chinese medicine composition disclosed by the invention is reasonable in prescription, without toxic and side effects, easily-available in raw materials, low in cost, and convenient to use, as well as has the advantages of being wide in application range, high in bioavailability, good in treatment effect, and without recurrence.
Description
Technical field
The invention belongs to the herbal medicine technical field, particularly a kind of Chinese medicine composition for the treatment of the infectious coryza of chicken high-incidence season and preparation method thereof.
Background technology
Infectious coryza of chicken is the acute respiratory disease that is caused chicken by haemophilus paragallinarum.Cardinal symptom is nasal cavity and Dou Fayan, rhinorrhea, facial swelling, sneeze, and the conjunctivitis that occurs together.Because this disease has infectiousness and mainly infects nasal cavity, therefore be called as the infective rhinitis.Primary disease is common in laying hen, also can infect broiler.Generally speaking, the broiler in the laying hen of 18-23 age in days and 3-4 age in week is to the susceptible of this disease.The incubation period of primary disease is shorter, infects the back and can fall ill in 24-48 hour.The most significant clinical symptoms occurs in upper respiratory tract, and the initial stage is only flowed out thin clear water, no General Symptoms in the apparent nose.If the state of an illness further develops, nasal cavity flows out serosity or mucus shape secretions, thicken gradually, and frowziness, sneeze, dyspnea, sick chicken often shakes the head, and scratches nose beak portion with pawl frequently.Condense into flaxen incrustation around the dry choana of mucus.The facial inflammation of sick chicken, one or both sides are swollen tissue near the eyes, and serious causing is blind.Cheesy thing is arranged on later stage oral cavity, the cleft palate.The severe patient inflammation spreads to trachea and bronchus and pulmonary, causes dyspnea and rale, and sick chicken spirit is depressed, poor appetite, and body weight descends gradually, and hen egg production descends, the enlargement of cock wattle.Secondary haemophilus meningitis takes place in the minority cases with severe, shows acute nervous symptoms and death.All can take place the whole year, but lacking of taking place summer, and multiple with late fall, the early spring and rainy season, generation and the feeding environment of primary disease have close relationship, generally generation easily in the bad hen house of the chicken farm of improper ventilation and ventilation.The young bird incubation rate is reduced, and the egg-laying season postpones, and laying hen stops to lay eggs or laying rate reduces, if control badly, easily causes the chronic type respiratory tract disease.In intensive poultry, it is one of important eqpidemic disease.
Because the infectious coryza of chicken initial stage is only flowed out thin clear water in the apparent nose, often ignored by the culturist, often develop into nasal cavity and flow out serosity or the dense thick secretions of mucus shape, sneeze, hole, eyelid swelled under face, the socket of the eye, the swelling of cock wattle, hen lower jaw part edematous swelling just can draw attention.The main medicine that is used for the treatment of this disease at present is antibiotic, anti-microbial type medicine, because the complexity of the state of an illness, single use antibiotic therapy can not reach desirable therapeutic effect, and because user's a large amount of medications of blindness, make a lot of antibacterials become multidrug resistant from single drug resistance, drug residue strengthens greatly.In recent years aspect treatment chicken rhinitis except using antimicrobial drug, antibiotic, also compatibility is used a lot of Chinese medicine, can effectively avoid the generation of Resistant strain, reduces in animal body residual of medicine, effectively reach the inhibition rhinitis and enlarged infection, and fundamentally treated the infective rhinitis.
Summary of the invention
The object of the invention is to provide a kind of instant effect for these reasons, the Chinese medicine composition for the treatment of infectious coryza of chicken easy to use.
A kind of Chinese medicine composition that is used for the treatment of infectious coryza of chicken, meter comprises 1～4 part of Flos Magnoliae, 1～4 part of Fructus Xanthii, 0.5～2 part of Herba Schizonepetae, 0.5～2 part of Radix Saposhnikoviae, 2～5 parts of Herba Houttuyniae, 1～3 part of the Radix Angelicae Dahuricae, 0.5～2 part of Rhizoma Chuanxiong, 1～4 part of Radix Scutellariae, 1～4 part of Fructus Forsythiae, 2～5 parts of Flos Loniceraes by weight.
Described Chinese medicine composition is counted by weight, comprises 2 parts of Flos Magnoliae, 2 parts of Fructus Xanthii, 1 part of Herba Schizonepetae, 1 part of Radix Saposhnikoviae, 3.5 parts of Herba Houttuyniae, 2 parts of the Radixs Angelicae Dahuricae, 1.7 parts of Rhizoma Chuanxiongs, 2 parts of Radix Scutellariaes, 2 parts of Fructus Forsythiaes, 3.5 parts of Flos Loniceraes.
The described Chinese medicine composition that is used for the treatment of infectious coryza of chicken, Flos Lonicerae can substitute the same Flos Lonicerae of parts by weight in the side with Caulis Lonicerae.
Described Chinese medicine composition can be prepared as the various dosage forms that make things convenient for chicken to use: comprise oral liquid, powder, spray, granule, injection.
Flos Magnoliae, Fructus Xanthii, Flos Lonicerae are principal agent in the side, and the hot temperature of loosing of Flos Magnoliae is logical, and fragrance is walked to scurry, up women's head-ornaments, and kind clearing the nasal passage is because controlling the nasosinusitis headache key medicine.Modern pharmacological research shows that Flos Magnoliae has the effect of shrinking the nasal membrane blood vessel, can protect nasal membrane, and promotes the absorption of mucosa secretions, reduce inflammation, and even the nose key is unobstructed.Record in " book on Chinese herbal medicine justice ": Fructus Xanthii, gentle dredging reaches, fluent joint, a surname's network of promoting blood circulation spreads all over hole key skin and dry partially strong, is the strongest and tractable person who cures mainly the wet three blockage of QI due to upset of emotion works of wind and cold, again solely can on reach mountain peak top, the wind and cold of mediation Naohu is the key medicine of head wind disease.Do not walk to scurry and there is hot perfume (or spice), rise and let out excessively the worry of dissipation healthy energy.Flos Lonicerae is sweet cold, both clearing heat in QI system, the branch heat that can purify the blood again, and the diffusing merit of slight a surname is arranged again among heat clearing away, thus can control affection due to external wind and heat or epidemic febrile disease from the beginning of the disease that table disease is not separated, interior-heat is contained again.The Caulis Lonicerae heat-clearing and toxic substances removing, dispelling wind collateral dredging, the same Flos Lonicerae of effect in the side.Using cooperates Fructus Forsythiae, Fructus Arctii, Herba Menthae to be equal to usefulness often.Experiment in vitro studies show that the antimicrobial spectrum of Flos Lonicerae and Fructus Forsythiae is complementary, and the two share and can enlarge antibacterial range greatly.Three's combined effect forms monarch drug, fully plays expelling wind and cold, and clearing the nasal passage is fundamentally treated rhinitis.Fructus Forsythiae, Herba Schizonepetae, Radix Saposhnikoviae are ministerial drug altogether, and Fructus Forsythiae has heat-clearing and toxic substances removing, and the function of dispersing swelling and dissipating binds has the title of " persons particularly liable to develop skin infection's panacea ".The in-vitro antibacterial test shows, the compound recipe that Fructus Forsythiae and Rhizoma Coptidis, Radix Scutellariae are formed, and external bacteriostasis is strong when using Fructus Forsythiae than list.The hot gas perfume (or spice) that looses of Herba Schizonepetae is longer than and delivers diffusing wind, and tepor is not strong, and the property of medicine relaxes, for the property of medicine in the wind-cold-dispersing medicinal the most gentle.For the diseases caused by exogenous pathogenic factor exterior syndrome, no matter wind and cold, wind heat or the not obvious person of cold and heat all can be extensive use of.Radix Saposhnikoviae, names in ancient times " screen ", the imperial wind of analogy such as barrier are also.Its acrid-sweet flavor, slightly warm in nature and moistening is " the profit agent in the wind medicine ".Clinical have different two-way functions with the card compatibility, can diaphoresis, again can hidroschesis " so with the Radix Saposhnikoviae Herba Schizonepetae person that must hold concurrently, can go into skin a surname with it and loose ear ", " if belong to the diseases caused by exogenous pathogenic factor card, dislike heat, dislike suddenly with numb osmanthus; When disliking cold with YINQIAO, anti-use the most suitable of chaste tree ", visible Herba Schizonepetae and Radix Saposhnikoviae are furnished with the effect of the space between skin and muscles of reaching, Pulvis Diaphoreticus heresy mutually, and the two complements each other.Herba Schizonepetae is joined Radix Saposhnikoviae, expelling pathogenic wind from the body surface, the diffusing ailment said due to cold or exposure of a surname.The Herba Schizonepetae aroma is strong, and the dispelling wind heresy can be declared the wind in the blood again, and Radix Saposhnikoviae rises and floats away the table dispersing wind and cold, is the key medicine of damp eliminating, Herba Schizonepetae diaphoresis power is strong, and its property of Radix Saposhnikoviae is temperature, and Herba Schizonepetae goes into blood system partially, and edema caused by disorder of QI is gone in anti-windage yaw, so two medicines match, mutual reinforcement between is usefulness, strengthens dispeling the wind curative effect, is good at expelling pathogenic wind from the body surface.Herba Houttuyniae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Scutellariae are adjuvant drug altogether, and Herba Houttuyniae has heat-clearing and toxic substances removing, removing pus and relieving carbuncle, and functions such as inducing diuresis for treating stranguria syndrome cure mainly the lung abscess vomiting pus; The expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Radix Angelicae Dahuricae fragrance rises and looses, and has expelling pathogenic wind from the body surface, dispersing cold for relieving pain, and it is sensible to dehumidify, the effect of detumescence and apocenosis.Hot fragrant kind liter of Rhizoma Chuanxiong, top, the up head of energy mountain peak has the wind-expelling pain-stopping effect, for controlling wind syndrome of head headache key medicine.Radix Scutellariae has the title of " Chinese medicine antibiotic ", strengthens the effectiveness of the anti-bacteria and anti-virus of Chinese medicine composition, and Radix Scutellariae has good heat clearing and damp drying, eliminating fire and detoxication effect, for cough due to lung-heat, carbuncle sore tumefacting virus etc. better curative effect is arranged.Heat and toxic materials clearing away medicine in the side has been strengthened the treatment of " heat symptom-complex " that increase the weight of to occur for the infective rhinitis, reaches therapeutic effect rapidly, reduces mortality rate.All medicines complement each other, the mediation compatibility, and combined effect makes prescription have heat-clearing and toxic substances removing, clearing the nasal passage, the effect of inducing diaphoresis to dispel wind pain relieving.
The invention has the beneficial effects as follows:
1, reasonable recipe is controlled anti-combination, all medicine use in conjunction in the side, and no drug residue does not produce drug resistance, treating both the principal and secondary aspects of a disease;
2, described Chinese medicine composition according to broiler, the different custom of feeding of laying hen, can be made into oral liquid soluble in water, granule for the broiler use, makes powder and uses for the laying hen spice, can be made into injection for cases with severe and uses.
With concrete clinical trial effect of the present invention is described below:
1. materials and methods
1.1 trial drug
For reagent product, the oral liquid that the embodiment of the invention one is made, contrasting medicine is compound sulfadiazine suspension (sulfadiazine 10%, trimethoprim 2%).
1.2 experimental animal
Cut open 300 of the sick chickens that inspection and bacteriology checking are diagnosed as avian infectious infective rhinitis by clinical symptoms, pathology in the Tianjin suburban district chicken house.
1.3 test method:
Sick chicken is divided into 5 groups at random, 60 every group, test group I compound sulfadiazine suspension, convert water yield 1ml and convert water 1L, freely drink, be used in conjunction 5 days, test group II, the embodiment of the invention one medicine is converted water yield 0.5ml and is converted water 1L, freely drinks, be used in conjunction 5 days, the test group III embodiment of the invention one medicine is converted water yield 1ml and is converted water 1L, freely drinks, be used in conjunction 5 days, test group IV inventive embodiments one medicine is converted water yield 2ml and is converted water 1L, freely drinks, be used in conjunction 5 days, any medicine of test group V, positive matched group.Experimental period is 14 days.
Curative effect determinate standard
Cure rate: the state of an illness, appetite, clinical symptoms are recovered normal sick chicken fully and are accounted for the ratio that this organizes total sick chicken number after the off-test;
Effective percentage: the state of an illness, appetite, clinical symptoms take a turn for the better to some extent and recover normal sick chicken and account for the ratio that this organizes total sick chicken number after the off-test;
Mortality rate: respectively organize dead chicken number after the off-test and account for the ratio that this organizes total sick chicken number;
2. experimental result:
After the medication of test I, II, III, IV group, sick chicken spirit state is significantly better than test V group, wherein test group I, III, IV group medication after second day sick chicken spirit state be clearly better, clinical symptoms obviously alleviates, appetite obviously improves.Medication is clinical symptom disappearance after five days, and it is normal that sick chicken recovers.The medication of test II group after the 3rd day sick chicken spirit state be clearly better, clinical symptoms obviously alleviates, appetite obviously improves.Medication after five days clinical symptoms disappear substantially, it is normal that sick chicken recovers.Test V group, sick chicken spirit state is general, and feed intake obviously descends, and dead chicken occurs.Part chicken recurrence appears in test group I, uses the embodiment of the invention one medicine, converts water yield 1ml and converts water 1L, recovers normal after being used in conjunction three days.The test details see Table 1.
Table 1 clinical test results table
| Group | Test chicken number (only) | Cure number (only) | Cure rate (%) | Effective percentage (%) | Mortality rate (%) |
| I | 60 | 50 | 83.3 | 96.7 | 3.3 |
| II | 60 | 45 | 75.0 | 95.0 | 5.0 |
| III | 60 | 52 | 86.7 | 96.7 | 3.3 |
| IV | 60 | 55 | 91.7 | 98.3 | 1.7 |
| V | 60 | - | - | - | 16.7 |
The specific embodiment
Following examples are in order to embodiment preferred of the present invention to be described, to it will be appreciated by those skilled in the art that following description shall not be applied to restriction protection scope of the present invention.
Embodiment one
1. prescription is formed: 2 parts of Flos Magnoliae (2000g), Fructus Xanthii 2 parts of (2000g), Herba Schizonepetae 1 part of (1000g), Radix Saposhnikoviae 1 part of (1000g), Herba Houttuyniae 3.5 parts of (3500g), the Radix Angelicae Dahuricae 2 parts of (2000g), Rhizoma Chuanxiong 1.7 parts of (1700g), Radix Scutellariae 2 parts of (2000g), Fructus Forsythiae 2 parts of (2000g), 3.5 parts of Flos Loniceraes (3500g).
2. be prepared into oral liquid: earlier Chinese medicine composition is taken by weighing by prescription, added 300L water logging bubble 12 hours, decoct twice, 2 hours for the first time, decocted 1.5 hours for the second time, keep slight boiling condition after boiling, after twice medicinal liquid mixing merged filtration, it was 1g/ml (every ml solution contains the 1g raw medicinal herbs) that concentrating under reduced pressure is recycled to solution concentration at every turn, cold preservation 24 hours, pulp board is supplied loss amount after filtering, and cold preservation 24 hours, adds the methyl parahydroxybenzoate of 3 ‰ amounts behind the medical filtration, mixing, flowing steam sterilization 30 minutes, fill, namely.
Embodiment two
1. prescription is formed: 4 parts of Flos Magnoliae (4000g), Fructus Xanthii 3 parts of (3000g), Herba Schizonepetae 2 parts of (2000g), Radix Saposhnikoviae 1.5 parts of (1500g), Herba Houttuyniae 4 parts of (4000g), the Radix Angelicae Dahuricae 3 parts of (3000g), Rhizoma Chuanxiong 2 parts of (2000g), Radix Scutellariae 3 parts of (3000g), Fructus Forsythiae 3 parts of (3000g), 5 parts of Flos Loniceraes (5000g).
2. be prepared into granule: earlier Chinese medicine composition is taken by weighing by prescription, added 300L water logging bubble 12 hours, decoct twice; 2 hours for the first time, decocted 1.5 hours for the second time, the back of at every turn boiling keeps slight boiling condition; after twice medicinal liquid mixing merged filtration, concentrating under reduced pressure was recycled to solution relative density 1.10～1.15 (60 ℃), after auxiliary materials and mixing such as anhydrous glucose, soluble starch; prepare soft material after adding Chinese medicine extract; last granulator is granulated, and 60 ℃ of dryings of boiling drier are sieved; packing, namely.1～4 part of embodiment two Flos Magnoliae, 1～4 part of Fructus Xanthii, 0.5～2 part of Herba Schizonepetae, 0.5～2 part of Radix Saposhnikoviae, 2～5 parts of Herba Houttuyniae, 1～3 part of the Radix Angelicae Dahuricae, 0.5～2 part of Rhizoma Chuanxiong, 1～4 part of Radix Scutellariae, 1～4 part of Fructus Forsythiae, 2～5 parts of Flos Loniceraes.
1. prescription is formed: 1 part of Flos Magnoliae (1000g), Fructus Xanthii 4 parts of (4000g), Herba Schizonepetae 1 part of (1000g), Radix Saposhnikoviae 0.5 part of (500g), Herba Houttuyniae 2 parts of (2000g), the Radix Angelicae Dahuricae 1 part of (1000g), Rhizoma Chuanxiong 0.5 part of (500g), Radix Scutellariae 1 part of (1000g), Fructus Forsythiae 1 part of (1000g), 5 parts of Caulis Loniceraes (5000g).
2. be prepared into powder: earlier Chinese medicine composition is taken by weighing by prescription, pulverize respectively, cross 40 mesh sieves, pulverize the back mix homogeneously, cross 40 mesh sieves namely.
Claims (4)
1. Chinese medicine composition that is used for the treatment of infectious coryza of chicken is characterized in that each constituent of described compositions counts by weight: 1～4 part of Flos Magnoliae, 1～4 part of Fructus Xanthii, 0.5～2 part of Herba Schizonepetae, 0.5～2 part of Radix Saposhnikoviae, 2～5 parts of Herba Houttuyniae, 1～3 part of the Radix Angelicae Dahuricae, 0.5～2 part of Rhizoma Chuanxiong, 1～4 part of Radix Scutellariae, 1～4 part of Fructus Forsythiae, 2～5 parts of Flos Loniceraes.
2. a kind of Chinese medicine composition that is used for the treatment of infectious coryza of chicken according to claim 1 is characterized in that each constituent of described compositions counts by weight: 2 parts of Flos Magnoliae, 2 parts of Fructus Xanthii, 1 part of Herba Schizonepetae, 1 part of Radix Saposhnikoviae, 3.5 parts of Herba Houttuyniae, 2 parts of the Radixs Angelicae Dahuricae, 1.7 parts of Rhizoma Chuanxiongs, 2 parts of Radix Scutellariaes, 2 parts of Fructus Forsythiaes, 3.5 parts of Flos Loniceraes.
3. a kind of Chinese medicine composition that is used for the treatment of infectious coryza of chicken according to claim 1 is characterized in that Flos Lonicerae can substitute with the Caulis Lonicerae of equivalent weight in the component.
4. according to claim 1 or 2 or 3 described a kind of Chinese medicine compositions that are used for the treatment of infectious coryza of chicken, it is characterized in that described Chinese medicine composition can be prepared as the various dosage forms that make things convenient for chicken to use, and comprises oral liquid, powder, spray, granule, injection.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104248724A (en) * | 2014-09-07 | 2014-12-31 | 扬中牧乐药业有限公司 | Oral liquid treating chicken infective rhinitis |
| CN104644742A (en) * | 2013-11-21 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof |
| CN105362639A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating rhinitis |
| CN106177107A (en) * | 2016-06-30 | 2016-12-07 | 张学领 | A kind of medicine treating rhinitis |
| CN106266164A (en) * | 2016-08-30 | 2017-01-04 | 河南省惠民禽业有限公司 | The medicine for the treatment of infectious coryza of chicken and preparation method |
| CN104547351B (en) * | 2015-01-15 | 2018-08-28 | 河北科技师范学院 | Treat the Chinese herbal medicament oral liquid of infectious coryza of chicken |
| CN109331126A (en) * | 2018-12-11 | 2019-02-15 | 郑州赛科药业科技有限公司 | Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken |
-
2011
- 2011-12-27 CN CN 201110444546 patent/CN103181970A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644742A (en) * | 2013-11-21 | 2015-05-27 | 天津瑞贝特科技发展有限公司 | Traditional Chinese medicine composition for treating infectious rhinitis of chicken and preparation method thereof |
| CN104248724A (en) * | 2014-09-07 | 2014-12-31 | 扬中牧乐药业有限公司 | Oral liquid treating chicken infective rhinitis |
| CN104547351B (en) * | 2015-01-15 | 2018-08-28 | 河北科技师范学院 | Treat the Chinese herbal medicament oral liquid of infectious coryza of chicken |
| CN105362639A (en) * | 2015-10-29 | 2016-03-02 | 陈光辉 | Drug for treating rhinitis |
| CN106177107A (en) * | 2016-06-30 | 2016-12-07 | 张学领 | A kind of medicine treating rhinitis |
| CN106266164A (en) * | 2016-08-30 | 2017-01-04 | 河南省惠民禽业有限公司 | The medicine for the treatment of infectious coryza of chicken and preparation method |
| CN109331126A (en) * | 2018-12-11 | 2019-02-15 | 郑州赛科药业科技有限公司 | Chinese medicine composition and preparation method thereof for treating infectious coryza of chicken |
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Application publication date: 20130703 |