CN104622457A - Multichannel synchronous cochlea auditory nerve action potential measuring system and multichannel synchronous cochlea auditory nerve action potential measuring method - Google Patents
Multichannel synchronous cochlea auditory nerve action potential measuring system and multichannel synchronous cochlea auditory nerve action potential measuring method Download PDFInfo
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Abstract
The invention discloses a multichannel synchronous cochlea auditory nerve action potential measuring system and a multichannel synchronous cochlea auditory nerve action potential measuring method. The multichannel synchronous cochlea auditory nerve action potential measuring system comprises a flexible multichannel electrode array, a pre-amplification unit, a multichannel A/D (analog/digital) conversion unit, a signal processing controller, a data caching and transmitting unit, an upper machine and a display unit, wherein the flexible multichannel electrode array is used for acquiring local auditory nerve action potential signals; the pre-amplification unit is connected with outgoing lines of the multichannel electrode array and amplifies weak auditory nerve potential signals acquired by electrodes respectively and independently; the multichannel A/D conversion unit is used for converting multichannel electric signals outputted from the pre-amplification unit into corresponding digital signals; the signal processing controller is respectively connected with the various units and is used for transmitting corresponding control signals to the various units and reading configuration commands, which are downloaded from the upper computer, in a memory; the data caching and transmitting unit is used for locally storing various acquired channels of parallel data or directly transmitting the parallel data to the upper computer which is used for processing the parallel data; and by the upper computer and the display unit, various measurement parameters are set, the acquired data are processed, and auditory nerve synchronous potential waveforms of a selected observation channel are displayed correspondingly.
Description
Technical field
The present invention relates to biological audition and electricity physiological signal fields of measurement, be specifically related to a kind of can the measuring system of multi-channel synchronous record cochlea acoustic nerve current potential.
Background technology
The electrophysiologicalmeasurements measurements of auditory system is significant to hearing mechanism research and analysis.At present, electrophysiologicalmeasurements measurements means for auditory system mainly contain auditory brainstem response ABR (Auditory Brainstem Response) and Compound action potential CAP (Compound Action Potential), wherein, what ABR recorded is a series of bio-electro-physiologic waveforms being transmitted to pons, thalamus after auditory system stimulates arrival acoustic nerve to external world, by the judgement to waveform parameters, determine that whether auditory pathway is normal.CAP action potential is the one reaction that cochlea produces Sound stimulat, it is the composite nerve signal of telecommunication produced after auditory cell transducing in cochlea, its effect transmits acoustic information to maincenter, it is generally acknowledged that it is the complex potential synchronously being superposed generation by the potentiometric response of different acoustic fiberses.It has been generally acknowledged that, CAP than ABR can more clearly, directly react auditory system be excited after acoustic nerve conduction front end signal provide situation, its record can be inserted single electrode and be measured near cochlea oeil de boeuf, the also i-coch multipoint electrode of useful implantation, measures the CAP of multi-point partial.At present, although existing similar measuring method, but be all single electrode or the asynchronous time-sharing recording collection of multi-electrode, although this measurement can record the reaction of multi-point partial neuropotential, the situation of each point potential change that neuropotential cannot be observed at a time synchronously to produce.
Above-mentioned two kinds of Auditory eletrophysiology measurement means are the neural response measurement index of compound, and what reflect is that auditory system is for a kind of entirety of outside stimulus or electrophysiologic response locally.But, the internal ear phonosensitive of auditory system has the topological structure of cochlea and the mutual corresponding feature of sound frequency composition, and the auditory cell that its inside distributes a large amount of by correspondence position (also known as hair cell), it acts on " sensor " of similar induction audio frequency component, the acoustic nerve of these hair cells and rear end is interconnected just, jointly completes the transmission of acoustic intelligence to brain function district.The transmission of auditory cell array neural response signal should be parallel and independently.Auditory nerve electrophysiologicalmeasurements measurements means (as: ABR, CAP) used at present cannot realize multi-channel synchronous, real-time accurate measurement for the local nerve response corresponding to cochlea internal topology.
Summary of the invention
In order to solve prior art Problems existing, the present invention specifically disclose a kind of can the measuring system of multi-channel synchronous record cochlea acoustic nerve potentiometric response.
The technical solution used in the present invention is as follows:
A kind of multi-channel synchronous cochlea action potential measuring system, comprises
Flexible multi-channel electrod-array, for gathering the local action potential signal of cochlea interior substrate film diverse location;
Multichannel Electrophysiology signal pre-amplifier unit, it is connected with the lead-out wire of flexible multi-channel electrod-array, the faint acoustic nerve electric potential signal that magnifying electrode independently collects, and by signal processing controller unit controls;
Multi-channel A/D AD conversion unit, under the control of signal processing controller, is responsible for the multi-channel electric signal that described pre-amplifier unit exports to be converted to corresponding digital signal;
Signal processing controller, is connected with transmission unit with described pre-amplifier unit, multi-channel A/D AD conversion unit and data buffer storage respectively, sends corresponding control signal to each module, reads the configuration order data passed from host computer in memorizer;
Data buffer storage and transmission unit, for carrying out local storage or be directly transferred to host computer by general data-interface processing with certain form to each channel parallel data gathered, and display analysis;
Host computer and display unit, for arranging each parameter of measurement, and process the data gathered, the acoustic nerve potential waveform of passage selected by simultaneous display.
Described flexible multi-channel electrod-array comprises some electrical leads, every bar lead-in wire is the filament of tape insulation layer, leaded again by have biocompatibility flexible material wrap up, plastotype becomes the rectangular of a branch of thin head and thick end of implantable cochlea inside, wherein, each root electrode front end is provided with a metal electrode contact corresponding with cochlea interior substrate film diverse location, and each contact is exposed to outside integument, contacts with cochlea interior tissue.
The number of described electrode contacts needs to select according to certainty of measurement, and the precision of measurement is higher, and electrode contacts is more, and precision is lower, and electrode contacts is fewer.
Described pre-amplifier unit, is divided into the signal amplification unit of several autonomous channels, and its number of active lanes is equal with the number of multi-channel electrode.
Described signal processing controller unit passes through the gain amplifier of each channel signal of adjustment, to adapt to the intensity of input signal.
Described signal processing controller, will control each road signal and amplify, gather, and be stored, or directly be transferred to host computer.And signal processing controller arranges an input port, can be synchronous with external input signal, as required, can be used as the enabling signal of this measuring system image data.
The measuring method of multi-channel synchronous cochlea action potential measuring system,
Flexible measuring electrode is implanted in cochlea interior substrate film by step 1., and fixing;
Step 2. starts Survey Software in host computer, according to measurement requirement, selected Measurement channel position and number on control inerface, arrange mode of operation (as, synchronously, order timesharing, random timesharing etc.), set the relevant parameter of each passage, as: amount of gain, sample rate, sampling precision etc.;
Step 3 sends external cochlear stimulation signal;
Step 4, at host computer, reads or directly shows the corresponding waveform of each passage action potential;
Step 5 converts the selected setting of passage, repeats 2,3,4 steps, carries out the multiple measurement of single channel, multichannel and overall picture, analysis
And comparative study.
The method that described measurement electrode implants cochlea comprises oeil de boeuf implantation or implantation of windowing of holing from the somewhere of cochlea bone wall.
Described cochlea external irritant signal comprises sound, optical, electrical, the various stimulation such as thermal and magnetic, machinery.
The form of described cochlear stimulation signal comprises the short sound of wide range pulse, the short sound of pure tone, the short sound of multifrequency compound tone, various natural sound; Cochlear stimulation Measurement channel number comprises single channel single-point or multichannel multiple spot, when for multichannel multiple spot, interval, each road can close, can dredge.
Beneficial effect of the present invention:
Utilize apparatus of the present invention can realize local, multiple spot, synchronous accurately measurement to the measurement of cochlea action potential, be convenient to the sync response situation grasping the inner acoustic nerve array of cochlea local potential under outside signal stimulus.
The present invention designs in order to the accuracy and precision improving the potential measurement of cochlea acoustic nerve array, because before the conduction of auditory system acoustic intelligence, terminal nerve array distribution is inner at cochlea, these arrays have corresponding relation with the biological audio component that can respond to, the present invention just, time relationship precision inadequate for existing acoustic nerve measurement scheme positional precision is forbidden to propose, compared with existing measurement scheme, this device has following beneficial effect:
1. by be placed on i-coch multi-channel electrode and independently multi-channel signal acquiring link can realize multiple spot, synchronously, accurately action potential measure, can high density distribution electrode quantity, by the method such as reconnaissance, repeated measure, obtain the overall picture of each local nerve action potential sync response in cochlea.
2. the relative analysis signal stimulus acoustic nerve of different stimulated mode, the similarities and differences of the reaction effect that action potential produces, are convenient to comparative study.
3. can realize multichannel synchronousing collection, by software design patterns, also can realize acquisition time, by the wave recording of more different acquisition modes, can the intrinsic relation of accurate assurance acoustic nerve array response, as the foundation improving artificial cochlea's coding.
Accompanying drawing explanation
Fig. 1 multi-channel synchronous cochlea action potential measuring system structured flowchart (wherein: dotted arrow represents the link arranging instruction to signal processing controller passed down by data transmission interface by PC host computer)
Fig. 2 flexible multi-channel cochlea array of measure electrodes structure chart;
Fig. 3 (a), (b) multichannel cochlea measurement electrode implantation schematic diagram; Fig. 3 (a) oeil de boeuf is implanted, and the perforate of Fig. 3 (b) basal turn is implanted.
In figure: 1-1 flexible multi-channel electrod-array, 1-2 multichannel advance signal amplifying unit, 1-3 multi-channel A/D AD conversion unit, 1-4 data store and transmission unit, 1-5 signal processing controller, 1-6PC host computer and display, and 1-7 synchronizing signal inputs; The tinsel 2-3 flexible covering 2-4 contact conductor interface of 2-1 annular electrode contact 2-2 tape insulation layer; 3-1 cochlea 3-2 electrode contacts 3-3 oeil de boeuf, 3-4 flexible multi-channel electrode bundle, turns on window 3-6 flexible multi-channel electrode bundle, 3-7 electrode contacts, 3-8 cochlea, 3-9 acoustic nerve at the bottom of 3-5.
Detailed description of the invention
Below in conjunction with accompanying drawing, the present invention is described in detail:
As shown in Figure 1, multi-channel synchronous cochlea action potential measuring system, comprises flexible multi-channel electrod-array 1-1, multichannel Electrophysiology signal pre-amplifier unit 1-2, multi-channel A/D AD conversion unit 1-3, signal processing controller 1-5, data buffer storage and transmission unit 1-4, PC host computer and display unit 1-6;
Described flexible multi-channel electrod-array 1-1, is distributed with multi-electrode contact (concrete number can need to select according to certainty of measurement), for gathering the local action potential signal of cochlea interior substrate film diverse location.
Described Electrophysiology multi channel signals pre-amplifier unit 1-2, be divided into the signal amplification unit of several autonomous channels, its number of active lanes is equal with the number of multi-channel electrode.It is connected with the lead-out wire of flexible multi-channel electrode, the faint acoustic nerve electric potential signal that magnifying electrode independently collects, and by signal processing controller unit controls, the gain amplifier of each channel signal can be adjusted, to adapt to the intensity of input signal.
Described multi-channel A/D AD conversion unit 1-3, under the control of signal processing controller unit, is responsible for the multi-channel electric signal that pre-amplifier unit exports to be converted to corresponding digital signal.
Described signal processing controller 1-5, be connected with transmission unit with multi channel signals pre-amplifier unit, multi-channel A/D AD conversion unit and data buffer storage, corresponding control signal can be sent to each module, also can read the configuration order data passed from host computer in memorizer.At the control, each road signal is amplified, gathers, and stored, or be directly transferred to host computer; In addition, this unit arranges input port, synchronous with external input signal, can be used as the enabling signal of this measuring system image data.
Described data buffer storage and transmission unit 1-4, built-in memory module, this locality can be carried out to each channel parallel data gathered with certain form to store, also directly can be transferred to host computer by certain general data-interface (USB/LAN etc.) and process, and display analysis.In addition, the measuring command that issues of host computer or configuration parameter can download this place.
Described PC host computer and display unit 1-6, under the operation of host computer Survey Software, can be arranged each parameter of measurement, and suitable process is done to the data gathered, as filtering, noise reduction etc., and with certain display interface, the acoustic nerve potential waveform of simultaneous display selected observation passage.
As shown in Figure 2, flexible multi-channel electrod-array 1-1 comprises some electrical leads, every bar lead-in wire is the tinsel 2-2 of tape insulation layer, leaded again by the flexible covering 2-3 with biocompatible materials, plastotype becomes rectangular (about several centimetres) of a branch of thin head and thick end of implantable cochlea inside, wherein, each root electrode front end is provided with a metal electrode contact 2-1 corresponding with cochlea interior substrate film diverse location, each contact is exposed to outside integument, contacts with cochlea interior tissue.
Described biocompatible materials can be various macromolecular material in the implantable animal bodies such as silicone rubber, epoxy resin, polyethylene, polymerization fat.
Hard contact, can be made into annular electrode contact 2-1 or other shape, is convenient to gather local potential change, adopts the various metal materials with satisfactory electrical conductivity and biocompatibility such as platinum, gold, titanium.
Specific implementation method:
Animal cochlea 3-1, by medical specialty modus operandi, organizes corresponding site to cut and exposes, implanted in cochlea by flexible measuring electrode by step 1, and fixing.
Position of windowing is optional, and one is that oeil de boeuf is implanted, concrete as shown in Fig. 3 (a), puts into flexible multi-channel electrode bundle 3-4, flexible multi-channel electrode bundle 3-4 arranges electrode contacts 3-2 in the oeil de boeuf 3-3 position of cochlea 3-1.
Another kind of implantation of windowing from cochlea bone wall position, concrete as shown in Fig. 3 (b), at the bottom of the cochlea 3-8 bone wall of a large amount of acoustic nerve 3-9 of distribution, turn on window 3-5, place flexible multi-channel electrode bundle 3-6 in position of windowing, flexible multi-channel electrode bundle 3-6 arranges electrode contacts 3-7.
Step 2, according to measurement needs, can be connected external synchronization signal with measuring system;
Step 3 starts Survey Software in host computer, and according to measurement requirement, on control inerface, selected Measurement channel position and number, arrange mode of operation, set the parameters such as each passage amplification, sample rate, sampling precision;
Step 4 sends external cochlear stimulation signal.Acoustic nerve 3-9 stimulation mode is not limited only to sonic stimulation, also may have: light (single channel or multi-channel optical fibre), electricity, thermal and magnetic, mechanical stimulus etc.; Stimulus signal form also can be various, as: the short sound of pulse wide range, the short sound of pure tone, the short sound of multifrequency compound tone, various natural sound etc.); Stimulation channels number also can be various, as single channel single-point, multichannel multiple spot, each road interval can close, can dredge;
Step 5, at host computer, reads or directly shows the corresponding waveform of each passage action potential, can store printed waveform;
Step 6 converts passage and selectes, and repeat 2,3,4,5 steps, to carry out the multiple analysis of single channel, multichannel or overall picture and comparative study;
By reference to the accompanying drawings the specific embodiment of the present invention is described although above-mentioned; but not limiting the scope of the invention; one of ordinary skill in the art should be understood that; on the basis of technical scheme of the present invention, those skilled in the art do not need to pay various amendment or distortion that creative work can make still within protection scope of the present invention.
Claims (10)
1. a multi-channel synchronous cochlea action potential measuring system, is characterized in that, comprise
Flexible multi-channel electrod-array, for gathering the local action potential signal of cochlea interior substrate film diverse location;
Multichannel Electrophysiology signal pre-amplifier unit, it is connected with the lead-out wire of flexible multi-channel electrod-array, the faint acoustic nerve electric potential signal that magnifying electrode independently collects, and by signal processing controller unit controls;
Multi-channel A/D AD conversion unit, under the control of signal processing controller, is responsible for the multi-channel electric signal that described pre-amplifier unit exports to be converted to corresponding digital signal;
Signal processing controller, is connected with transmission unit with described pre-amplifier unit, multi-channel A/D AD conversion unit and data buffer storage respectively, sends corresponding control signal to each module, reads the configuration order data passed from host computer in memorizer;
Data buffer storage and transmission unit, for carrying out local storage or be directly transferred to host computer by general data-interface processing with certain form to each channel parallel data gathered, and display analysis;
Host computer and display unit, for arranging each parameter of measurement, and process to the data gathered the acoustic nerve potential waveform observing passage selected by simultaneous display.
2. multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, it is characterized in that, described flexible multi-channel electrod-array comprises some electrical leads, every bar lead-in wire is the filament of tape insulation layer, leaded again by have biocompatibility flexible material wrap up, plastotype becomes the rectangular of a branch of thin head and thick end of implantable cochlea inside, wherein, each root electrode front end is provided with a metal electrode contact corresponding with cochlea interior substrate film diverse location, each contact is exposed to outside integument, contacts with cochlea interior tissue.
3. multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, it is characterized in that, the number of described electrode contacts needs to select according to certainty of measurement, the precision measured is higher, electrode contacts is more, and precision is lower, and electrode contacts is fewer, when high-acruracy survey, electrode contacts operating position and quantity are carried out selection and are arranged.
4. multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, it is characterized in that described pre-amplifier unit is divided into the signal amplification unit of several autonomous channels, its number of active lanes is equal with the number of multi-channel electrode.
5. multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, it is characterized in that, described signal processing controller unit is arranged by host computer, and the gain amplifier of each channel signal of unified adjustment, to adapt to the intensity of input signal.
6. multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, it is characterized in that, described signal processing controller, each road signal will be controlled amplify, gather, and stored, or be directly transferred to host computer, and signal processing controller arranges input port, synchronous with external input signal, as the enabling signal of this measuring system image data.
7. the measuring method of multi-channel synchronous cochlea action potential measuring system as claimed in claim 1, is characterized in that,
Flexible measuring electrode is implanted in cochlea interior substrate film by step 1., and fixing;
Step 2. starts Survey Software in host computer, and according to measurement requirement, on control inerface, selected Measurement channel position and number, arrange mode of operation, set the relevant parameter of each passage;
Step 3 sends external cochlear stimulation signal;
Step 4, at host computer, reads or directly shows the corresponding waveform of each passage action potential;
Step 5 converts passage and selectes, and repeats 2,3,4 steps, carries out the multiple analysis of single channel, multichannel or overall picture and comparative study.
8. the measuring method of multi-channel synchronous cochlea action potential measuring system as claimed in claim 7, is characterized in that, the method that described measurement electrode implants cochlea comprises oeil de boeuf implantation or at the bottom of cochlea bone wall, turns on window implantation.
9. the measuring method of multi-channel synchronous cochlea action potential measuring system as claimed in claim 7, is characterized in that, described external cochlear stimulation signal comprises sound, optical, electrical, thermal and magnetic or mechanical system.
10. the measuring method of multi-channel synchronous cochlea action potential measuring system as claimed in claim 7, it is characterized in that, the form of described cochlear stimulation signal comprises the short sound of wide range pulse, the short sound of pure tone, the short sound of multifrequency compound tone, various natural sound; Cochlear stimulation Measurement channel number comprises single channel single-point or multichannel multiple spot, when for multichannel multiple spot, interval, each road can close, can dredge.
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