CN104162063B - A kind of compound Chinese medicinal preparation and its preparation method treating hyperuricemia - Google Patents
A kind of compound Chinese medicinal preparation and its preparation method treating hyperuricemia Download PDFInfo
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Abstract
Disclosing a kind of compound Chinese medicinal preparation and its preparation method for the treatment of hyperuricemia, being characterised in that this compound Chinese medicinal preparation is is main medicine by Scabrous Elephantfoot Herb, is equipped with Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn be prepared from by certain part by weight proportioning. This compound Chinese medicinal preparation has effect of the wet logical numbness of profit, dissipating stasis and purging turbidity, is particularly useful for wet turbid penting up caused hyperuricemia. The compound Chinese medicinal preparation of the present invention has and significantly reduces blood uric acid, accelerates the pharmacological action of uric acid metabolism.
Description
Technical field
The present invention relates to medical art, specifically, relate to a kind of compound Chinese medicinal preparation and its preparation method for the treatment of hyperuricemia, the pure compound Chinese medicinal preparation of a kind for the treatment of hyperuricemia made taking natural Chinese medicinal herb Scabrous Elephantfoot Herb and its preparation method as main medicine raw material.
Background technology
From the viewpoint of the traditional Chinese medical science, hyperuricemia, belonging to " bi Zheng ", the category of " going through joint " is common clinical, frequently-occurring disease. Think weakness of the spleen and the stomach, eating and drinking without temperance, outer heresy invasion and attack be main diseases because of. Weakness of the spleen and the stomach causing transporting mistake department, endogenous damp formation, with the passing of time heat-transmission, streamer passages through which vital energy circulates is disease. It is turbid, wet turbid that the uric acid that modern Chinese medicine thinks too much belongs to phlegm, strengthens the control to hyperuricemia, can effectively prevent developing of gout, embody the importance that the traditional Chinese medical science is preventiveed treatment of disease. From the viewpoint of doctor trained in Western medicine, uric acid height can cause gout, and the acute attack of gout is that urate organizes the acute inflammatory reaction depositing in crystalline form and causing in joint and periarticular. If gout untreated, urate increases in intraarticular deposition, and inflammation recurrent exerbation enters chronic phase.
In treatment, current doctor trained in Western medicine commonly uses allopurinol tablet, adds probenecid sheet and suppresses the medicine of uricogenesis to reduce uric acid, and curative effect is pretty good substantially, but the side effect of allergic constitution and gastrointestinal upset is rather common. And the traditional Chinese medical science also has many side's medicines can treat hyperuricemia, white tiger can be selected to add cassia twig soup, SIMIAO WAN, clear numbness Medicine wine for activating the channels, Fufangshenjin capsules etc. according to the state of an illness, dialectical application can obtain certain curative effect, but raw material numerous and complicated, price is high and curative effect is still not ideal enough.
Summary of the invention
It is an object of the invention to provide the compound Chinese medicinal preparation of a kind for the treatment of hyperuricemia taking Scabrous Elephantfoot Herb as main medicine. It is a further object of the present invention to provide the preparation method that antihyperuricemic compound Chinese medicinal preparation is controlled in a kind for the treatment of. Compound Chinese medicinal preparation of the present invention take Scabrous Elephantfoot Herb as main raw material, is made up of Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn. Compound Chinese medicinal preparation of the present invention has effect of the wet logical network of profit, dissipating stasis and purging turbidity, is mainly used in treatment hyperuricemia, and the traditional Chinese medical science is distinguished as damp and hot numbness type. Compound Chinese medicinal preparation of the present invention has and significantly reduces blood uric acid, accelerates the pharmacological action of uric acid excretion. The preparation method of compound Chinese medicinal preparation of the present invention, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn:
Scabrous Elephantfoot Herb 15-50
Semen Coicis 9-35
Spica Prunellae 9-20
Rhizome of Glabrous Greenbrier 10-60
Hawthorn 5-15
The preparation method of preferred Chinese medicine composition of the present invention, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn: Scabrous Elephantfoot Herb 15-50
Semen Coicis 9-35
Spica Prunellae 9-20
Rhizome of Glabrous Greenbrier 10-60
The preparation method of hawthorn 5-15 preferred compound Chinese medicinal preparation of the present invention further, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn: Scabrous Elephantfoot Herb 20-40
Semen Coicis 12-30
Spica Prunellae 12-18
Rhizome of Glabrous Greenbrier 15-45
The preparation method of the compound Chinese medicinal preparation of the present invention of hawthorn 8-12 the best, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn: Scabrous Elephantfoot Herb 30
Semen Coicis 15
Spica Prunellae 15
Rhizome of Glabrous Greenbrier 10
A kind of compound Chinese medicinal preparation controlling hyperuricemia of hawthorn 9 the present invention, it can make various formulation according to a conventional method, comprises the oral solid formulations such as granule, oral liquid, tablet, capsule, pill, decoction, powder. In various formulation, it is preferable that a kind of granule being made up of following method, this preparation method is: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice by A, 2-3 hour first time, second time 1-2 hour; B filters, merging filtrate;
C is centrifugal, removal of impurities, is condensed into relative density 1.2-1.3; D adds cane sugar powder, softwood processed, granulates, and dry, whole grain, is distributed into granule finished product. Concrete instructions of taking and consumption: oral, every day 3 times, each 10ml. 7 days acute phases were a course for the treatment of, the chronic phase, within one month, were a course for the treatment of. In various formulation, it is also preferred that a kind of capsule being made up of following method, this preparation method is: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice by A, 2-3 hour first time, second time 1-2 hour; B filters, merging filtrate, and concentrates;
C concentrated solution is centrifugal, removal of impurities, and filtrate concentrates, and is spray dried to fine powder; D fine powder adds appropriate amount of starch, Microcrystalline Cellulose, mixes, and is distributed in capsule, capsule finished product. Each taste Chinese medicine in compound Chinese medicinal preparation of the present invention is crude drug. Scabrous Elephantfoot Herb in side is the rhizome of dicotyledons medicine feverfew Scabrous Elephantfoot Herb HerbaElephantopi. Nature and flavor toil, cold in nature. There is cool blood, heat-clearing, dehumidifying, Li Shui, detoxicating functions. Modern pharmacological research finds that Scabrous Elephantfoot Herb is except having anti inflammation and heat resolution effect, also there is obvious antitumor action and white corpuscle is had obvious restraining effect. its main component is Lupeol, Stigmasterol and sesquiterpenoids-Scabrous Elephantfoot Herb lactone, and its effective constituent is Scabrous Elephantfoot Herb lactone. Scabrous Elephantfoot Herb (ElephantopusscaberL.), another name Scabrous Elephantfoot Herb, turnsole, chicken disease are sticky, native radix bupleuri, horse drive hundred emerging, Scabrous Elephantfoot Herb, mill ground courages. Perennial vertical herbage is high 30��60 centimetres. Sometimes all coarse wool being close to by white. Stem two discrimination branch, branch is hard less, coarse. Single leaf big portion base is raw, and cochlear or oval shape fall lanceolar, and long 5��15 centimetres, wide 2��4.5 centimetres, base portion is gradually narrow, and tip is blunt or short point, edge somewhat crenation: stem leaf is few and thin, petiole length 5��15 millimeters, and base portion expands embraces a stem, or closely without handle. Head inflorescence about has little Hua 4, is born in Zhi Ding; Usually having 3 lobate buds, bract is avette or oval shape is avette, long 1��1.5 centimetre; Head inflorescence has multiple in each bouquet, intensive; Involucre length of a film 8��10 millimeters; Holder is without hair; little Hua is tubulose entirely, both sexes, lavender, and long 7��9 millimeters, tip 4 splits, cracking, the slightly wealthy exhibition of sliver; Stamen 4��5, slightly outside protruded tube; Ovary is the next, Room 1. Achene has rib, the hard seta 4��6 of top tool length.
A kind of compound Chinese medicinal preparation treating hyperuricemia of the present invention is taking Scabrous Elephantfoot Herb as main medicine, it is prepared from by five kinds of herbal medicine, its scientific formula, rationally, belong to the special efficacy side for the treatment of hyperuricemia, curative effect is very remarkable, overcome existing prescription flavour of a drug many, the shortcomings such as complex process, curative effect are remarkable, side effect is many. Illustrate that the present invention treats the drug action of hyperuricemia further below by way of clinical trial:
Method: adopt Chinese medicine compound prescription Scabrous Elephantfoot Herb granule (Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn) to treat high lithemia 43 example, and establish control group (allopurinol tablet adds probenecid sheet) 38 examples to contrast. Result: treatment group always has efficiency 98.2%; Control group always has efficiency 84.0%, and through statistical procedures, difference is very significant (P < 0.01).
Prompting: present method is to this disease favorably wet effect leading to network, dissipating stasis and purging turbidity.
Specific as follows:
Clinical data observation case is Wengyuan County institute of traditional Chinese medicine tcm internal medicine and within 2011, is in hospital and outpatient service patient totally 81 example, adopts digits table to be divided into two groups at random. Treatment group 43 example, the male sex 36 example, women 7 example, the age 34-69 year, average 45.6 years old, course of disease 2d��18 year, average 3.11 years. Obese person 15 example. Heating person 2 example before treatment, fast 11 examples of erythrocyte sedimentation rate, blood uric acid increases 43 examples, and white corpuscle raises 13 examples, hyperlipidaemia 18 example, B ultrasonic: urinary stone disease 5 example, fatty liver 11 example; Control group 38 example, man 31 example, female 7 example, 29��70 years old age, average 46.2 years old, course of disease 1d��16 year, average 2.9 years. Obese person 13 example. Heating person's example before treatment, fast 3 examples of 5 erythrocyte sedimentation rates, blood uric acid increases 38 examples, and white corpuscle raises 9 examples, hyperlipidaemia 12 example, B ultrasonic: urinary stone disease 3 example, fatty liver 7 example. 2 groups of clinical datas, substantially identical, there is stronger comparability. Case definition according to rheumatosis association of the U.S. in 1997 about acute gouty arthritis criteria for classification. The hot numbness of differentiation of symptoms and signs for classification of syndrome: redness and swelling of joints heat pain, generates heat thirsty, red tongue with yellow fur, slippery and rapid pulse. Arthritis: arthralgia is miserable, or enlargement distortion, meet cold increasing the weight of, or tophus, or broken stream white paste of bursting, and tongue is greasy in vain, stringy and tense pulse. Methods for the treatment of treatment group: compound Scabrous Elephantfoot Herb particle (composition: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn. Usage: every day 1 dose, water is decocted 2 times, sooner or later warmly takes; Control group: allopurinol tablet, 100mg, every day 3 times, probenecid sheet (first 0.25g, every day 2 times), can according to circumstances add and select sodium bicarbonate sheet alkalized urine. 2 groups, all to treat 7d as 1 course for the treatment of, are terminated 4 courses for the treatment of statistics treatment result. Criterion of therapeutical effect clinical cure: in blood and urine, uric acid content is normal, follows up a case by regular visits to normal person in January. Effective: in blood and urine, uric acid content obviously reduces. Invalid: blood and urine treatment front and back are unchanged. Treatment result 2 groups of clinical cure rates compare (P < 0.01), and difference has very significantly meaning, and treatment group is obviously better than control group. Hyperuricemia is discussed causes the reason of gout to be cause uric acid metabolism not normal due to purine metabolic disturbance. In treatment, Western medicine adds uricosuric allopurinol tablet mainly with suppression uricogenesis, adds probenecid sheet, if desired, use alkaline drug alkalized urine, reduce uric acid, still lack radical cure measure, once stop the medicine state of an illness easily repeatedly, and said medicine side effect is all relatively big, adds the difficulty of prolonged application. Using tcm syndrome differentiation and treatment, the phlegm turbid heresy that wets is got rid of external, hot and suffocating clearly, environment must be tended to balance, and hyperuricemia is released and disease is fully recovered. This research treatment by Chinese herbs high lithemia disease is different from tradition rheumatism Coryza Treated by Syndrome Differentiation, and tradition is thought that this disease is many and fallen ill because of the outer heresy of the damp and hot grade of chill or the damp and hot heresy numbness resistance joint stasis blocking gas blood of interior life. The rules for the treatment of are in order to effect of wet logical network, dissipating stasis and purging turbidity, and the traditional Chinese medical science is distinguished as damp and hot numbness type. Compound Chinese medicinal preparation of the present invention has and significantly reduces blood uric acid, accelerates the pharmacological action of uric acid excretion.
Embodiment
Form by the following examples illustrates a kind of compound Chinese medicinal preparation and preparation method treating hyperuricemia of the present invention further, but this should not be interpreted as the restriction of the present invention. The technology that all genus foregoing of the present invention realizes all belongs to the category of the present invention.
Embodiment 1
Treating a Chinese native medicine compound prescription pellet agent for hyperuricemia, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn:
Scabrous Elephantfoot Herb 30
Semen Coicis 15
Spica Prunellae 15
Rhizome of Glabrous Greenbrier 10
Hawthorn 9
The preparation method of above-mentioned granule is:
Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice by A, 2-3 hour first time, second time 1-2 hour; B filters, merging filtrate;
C is centrifugal, removal of impurities, is condensed into relative density 1.2-1.3; D adds cane sugar powder, softwood processed, granulates, and dry, whole grain, is distributed into granule, 10 grams every bag.
Embodiment 2
Treating a Herbal compound capsule agent for hyperuricemia, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn:
Scabrous Elephantfoot Herb 30
Semen Coicis 15
Spica Prunellae 15
Rhizome of Glabrous Greenbrier 10
Hawthorn 9
The preparation method of above-mentioned capsule is:
Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice by A, 2-3 hour first time, second time 1-2 hour; B filters, merging filtrate;
C is centrifugal, removal of impurities, is condensed into relative density 1.10-1.15, is spray dried to fine powder; D fine powder adds appropriate amount of starch, Microcrystalline Cellulose, mixes, and is distributed in capsule, 0.4 gram every.
Embodiment 3
Treating a Chinese medicine compound prescription oral liquid for hyperuricemia, it is prepared from by following weight by Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn:
Scabrous Elephantfoot Herb 30
Semen Coicis 15
Spica Prunellae 15
Rhizome of Glabrous Greenbrier 10
Hawthorn 9
The preparation method of above-mentioned oral liquid is:
Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice by A, 2-3 hour first time, second time 1-2 hour; B filters, merging filtrate;
C is centrifugal, removal of impurities, adds purified water to 100ml.
D is distributed into and often props up 10ml, 105 �� of C pressure sterilizing sterilizings 30 minutes.
Claims (2)
1. treat the Chinese native medicine compound prescription pellet agent of hyperuricemia for one kind, it is characterised in that be prepared from by following weight by Scabrous Elephantfoot Herb, Semen Coicis, Spica Prunellae, Rhizome of Glabrous Greenbrier, hawthorn: Scabrous Elephantfoot Herb 30 parts, Semen Coicis 15 parts, Spica Prunellae 15 parts, Rhizome of Glabrous Greenbrier 10 parts, hawthorn 9 parts; The preparation method of described granule is: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice, 2-3 hour first time, second time 1-2 hour; Filter, merging filtrate; Centrifugal, removal of impurities, is condensed into relative density 1.2-1.3; Adding cane sugar powder, softwood processed, granulate, dry, whole grain, is distributed into granule, 10 grams every bag.
2. treat the Herbal compound capsule agent of hyperuricemia for one kind, it is characterised in that be prepared from by following weight by Scabrous Elephantfoot Herb, Semen Coicis, Spica Prunellae, Rhizome of Glabrous Greenbrier, hawthorn: Scabrous Elephantfoot Herb 30 parts, Semen Coicis 15 parts, Spica Prunellae 15 parts, Rhizome of Glabrous Greenbrier 10 parts, hawthorn 9 parts; The preparation method of described capsule is: Scabrous Elephantfoot Herb, Spica Prunellae, Rhizome of Glabrous Greenbrier, Semen Coicis, hawthorn are added 4-8 times amount soak by water twice, 2-3 hour first time, second time 1-2 hour; Filter, merging filtrate; Centrifugal, removal of impurities, is condensed into relative density 1.10-1.15, is spray dried to fine powder; Fine powder adds appropriate amount of starch, Microcrystalline Cellulose, mixes, and is distributed in capsule, 0.4 gram every.
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| CN110327434A (en) * | 2019-08-14 | 2019-10-15 | 吉林省特医食品生物科技有限公司 | A kind of Chinese medicine composition that treating gout, compound Chinese medicinal preparation and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386043A (en) * | 2013-07-16 | 2013-11-13 | 郭强 | Chinese medicine preparation for treating hyperuricemia |
| CN103721125A (en) * | 2014-01-21 | 2014-04-16 | 李朝成 | Medicament for treating gout and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103386043A (en) * | 2013-07-16 | 2013-11-13 | 郭强 | Chinese medicine preparation for treating hyperuricemia |
| CN103721125A (en) * | 2014-01-21 | 2014-04-16 | 李朝成 | Medicament for treating gout and preparation method thereof |
Non-Patent Citations (3)
| Title |
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| 中医药治疗痛风的临床研究进展;李明等;《世界中西医结合杂志》;20140531;第9卷(第5期);547-550 * |
| 中药痛风宁对大鼠急性痛风性关节炎的疗效及作用机制研究;陈明岭;《中国优秀博硕士学位论文全文数据库（博士）医药卫生科技辑》;20040315(第1期);E056-29 * |
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