CN105327182A

CN105327182A - Medicine for treating child pertussis and preparation method thereof

Info

Publication number: CN105327182A
Application number: CN201510878096.6A
Authority: CN
Inventors: 彭连志
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-04
Filing date: 2015-12-04
Publication date: 2016-02-17

Abstract

The invention discloses medicine for treating child pertussis and a preparation method thereof. The medicine is mainly prepared from semen lepidii, concretio silicea bambusae, apricot kernel, perilla leaves, pinellia ternate, mint, bulbus fritillariae cirrhosae, platycodon grandiflorum, houttuynia cordata, rhizoma phragmitis, scutellaria baicalensis, folium mori and fructus aurantii according to a certain weight ratio. The medicine has the effects of purging the sthenic lung-qi and relieving asthma, clearing away heat and dry dampness, expelling phlegm to arrest coughing and dispelling cold and regulating vital energy and is high in curative speed and good in curative effect when being used for treating child pertussis.

Description

A kind of medicine for the treatment of children whooping cough and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of children whooping cough and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Children whooping cough is the common a kind of respiratory infectious disease of children's, and being infected by bordetella pertussis, with paroxysmal spasmodic cough, is principal character with crow sample air-suction-noise.If malpractice, often can Complicating Pneumonia In Patients, encephalopathy etc.And the course of disease is longer, very large to the health effect of child.Because current Western medicine effectively cannot treat children whooping cough, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment children whooping cough, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment children whooping cough, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment children whooping cough.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Semen Lepidii (Semen Descurainiae), Concretio Silicea Bambusae, Semen Armeniacae Amarum, Folium Perillae, the Rhizoma Pinelliae, Herba Menthae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Herba Houttuyniae, Rhizoma Phragmitis, Radix Scutellariae, Folium Mori, Fructus Aurantii medicine to combine, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat children whooping cough.Wherein select Semen Lepidii (Semen Descurainiae) to be because its nature and flavor are pungent, bitter, in Great Cold, return lung, urinary bladder channel, have eliminating pathogen from the lung for relieving asthma, the function of inducing diuresis to remove edema, control sputum and stop up lung, cough with asthma abundant expectoration, fullness and distention in the chest and hypochondrium, ascites pleural fluid swells, dysuria and pulmonary heart disease edema.Select Concretio Silicea Bambusae to be that GUIXIN, Liver Channel, have clear heat and eliminate phlegm because its nature and flavor are sweet, the function of cool heart arresting convulsion, controls calentura coma, middle wind-phlegm fan, the hot infantile convulsion of children's's expectorant, twitches, night cry.Semen Armeniacae Amarum is selected to be that temperature, poisonous, enter lung, large intestine channel, have expelling phlegm for arresting cough, relieving asthma, the function of intestine moistening, controls exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation because its nature and flavor are bitter.Folium Perillae is selected to be that temperature, enters lung, spleen channel, deliver, cold expelling, regulate the flow of vital energy because its nature and flavor are pungent, and the function of battalion, cure cold wind and cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen, frequent fetal movement, and can solving toxin of fish and crab.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Select Herba Menthae to be because its nature and flavor are pungent, cool, enter lung, Liver Channel, have dispelling wind, heat radiation, ward off dirty, the function of removing toxic substances, controls affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Radix Platycodonis to be because its nature and flavor toil, flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, and dysentery is suffered from abdominal pain.Herba Houttuyniae is selected to be that cold, enter meridian of Hand-TAI YIN, have heat-clearing and toxic substances removing, the function of inducing diuresis to remove edema, controls pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies because its nature and flavor are pungent.Rhizoma Phragmitis is selected to be because its nature and flavor are sweet, cold, enter lung, stomach warp, have heat clearing away, promote the production of body fluid, relieving restlessness, the function of preventing or arresting vomiting, control calentura excessive thirst, gastropyretic vomiting, dysphagic, regurgitation, consumptive lung disease, lung abscess, and separate Fugu ocellatus ichthyotoxin.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Folium Mori to be because its property bitter but sweet flavor, cold, enter lung, Liver Channel, have expelling wind and clearing away heat, the function of cooling blood for improving eyesight, dispelling the wind and dampness pathogens generates heat, headache, and conjunctival congestion is thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.Fructus Aurantii is selected to be because its nature and flavor toil, cool.Enter lung, spleen, large intestine channel.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.。

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each grouping all has good therapeutic effect within the scope of following weight:

Semen Lepidii (Semen Descurainiae) 4-12g, Concretio Silicea Bambusae 5-10g, Semen Armeniacae Amarum 4-9g, Folium Perillae 5-12g,

Rhizoma Pinelliae 5-10g, Herba Menthae 6-12g, Bulbus Fritillariae Cirrhosae 4-9g, Radix Platycodonis 5-10g,

Herba Houttuyniae 4-9g, Rhizoma Phragmitis 5-12g, Radix Scutellariae 4-10g, Folium Mori 4-10g, Fructus Aurantii 5-12g

Be preferably:

Semen Lepidii (Semen Descurainiae) 8g, Concretio Silicea Bambusae 7g, Semen Armeniacae Amarum 6g, Folium Perillae 8g,

Rhizoma Pinelliae 8g, Herba Menthae 9g, Bulbus Fritillariae Cirrhosae 5g, Radix Platycodonis 8g,

Herba Houttuyniae 5g, Rhizoma Phragmitis 7g, Radix Scutellariae 6g, Folium Mori 6g, Fructus Aurantii 7g

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Semen Lepidii (Semen Descurainiae): get crude drug, removing impurity

2, Concretio Silicea Bambusae: get crude drug, removing impurity, ash bits;

3, Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, pulls out when crust micro-wrinkle, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

4, Folium Perillae: pick clean impurity, dry;

5, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

6, Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

7, Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;

8, Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

9, Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;

10, Rhizoma Phragmitis: pick decontamination and root, cutting, dry;

11, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

12, Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;

13, Fructus Aurantii: removing flesh, core, cleans, slightly soaks, pull out, soften, and can pinch doubling for degree with hands, section, dries.

Two, prepare

1, described Semen Lepidii (Semen Descurainiae), Concretio Silicea Bambusae, Semen Armeniacae Amarum, Folium Perillae, the Rhizoma Pinelliae, Herba Menthae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Herba Houttuyniae, Rhizoma Phragmitis, Radix Scutellariae, Folium Mori, Fructus Aurantii are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor.

2, add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor.

3, merge twice decoction liquor, intense fire boils, then decocts medicinal liquid to 100 milliliters with slow fire, is divided into three doses.

The function that medicine of the present invention has eliminating pathogen from the lung for relieving asthma, heat clearing and damp drying, expelling phlegm for arresting cough, cold expelling are regulated the flow of vital energy, is used for the treatment of children whooping cough instant effect, good effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept outpatient service infant totally 36 examples for medical treatment.

2, diagnostic criteria

Children whooping cough their early stage, as influenza, there will be watery nasal discharge, sneeze, low grade fever, symptom of tussiculaing, and coughs in two weeks thereafter aggravate gradually, have violent apasm of coughing, and fierce cough is constant and cause dyspnea.Occur that the breathing of patient during this situation is typical crow sound.The baby of less than 6 months is normally not present typical crow.Detailed clinical performance can be divided into for three phases: be first catarrhal period, only show as the upper respiratory tract infection symptoms such as low grade fever, cough, watery nasal discharge, sneeze.Proceed to stage of spasmodic cough after 7 ~ 10 days, show as the cough of paroxysmal pain contraction, outbreak increasingly sharpens, and each apasm of coughing can for several minutes.Cough rear companion crow sample apneusis.If treatment is not good at, this phase is 2 ~ 6 weeks.Be finally convalescent period, apasm of coughing decrescence even stops, 2 weeks or longer this phase.If have respiratory tract infection can cause pain again to cough.

3, Therapeutic Method

Select above-mentioned medicament to take to infant, take 5 to 7 days continuously.Less than 3 years old infant daily potions, divide and take for early, middle and late three times; 3 to 6 years old infants daily 2 doses, respectively take potion sooner or later; More than 6 years old infants daily 3 doses, early, middle and lately respectively take potion.

4, efficacy assessment standard

Effective: children whooping cough symptom is controlled, infant cough reduces, and the state of an illness starts to recover.

Take a turn for the better: children whooping cough symptom improves, and infant discomfort alleviates, cough no longer aggravates, and the state of an illness progressively takes a turn for the better.

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy children whooping cough patient 36 example of the present invention, effective 33 examples of result, obvious effective rate is 91.67%, and take a turn for the better 1 example, and improvement rate is 2.78%, and invalid 2 examples, total effective rate is 94.45%.

Claims

1. treat a medicine for children whooping cough, it is characterized in that: it is made up of the crude drug in following weight range:

Herba Houttuyniae 4-9g, Rhizoma Phragmitis 5-12g, Radix Scutellariae 4-10g, Folium Mori 4-10g, Fructus Aurantii 5-12g.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Herba Houttuyniae 5g, Rhizoma Phragmitis 7g, Radix Scutellariae 6g, Folium Mori 6g, Fructus Aurantii 7g.

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Semen Lepidii (Semen Descurainiae): get crude drug, removing impurity;

(2) Concretio Silicea Bambusae: get crude drug, removing impurity, ash bits;

(3) Semen Armeniacae Amarum: pick clean impurity, put in boiling water and slightly boil, pulls out when crust micro-wrinkle, in leaching cold water, sloughs seed coat, dries, and winnows with a dustpan clean;

(4) Folium Perillae: pick clean impurity, dry;

(5) Rhizoma Pinelliae: pick decontamination, sieve dedust bits;

(6) Herba Menthae: pick clean impurity, removing undesirable root, first trembles leaf and separately to put down, then stem is sprayed clear water, run through rear cutting, dry, then with leaf and even;

(7) Bulbus Fritillariae Cirrhosae: pick decontamination, is soaked in water, and pulls out, and moistening peels off the heart, dries;

(8) Radix Platycodonis: pick clean impurity, except removing LU, cleans and pulls out, run through rear section, dry;

(9) Herba Houttuyniae: remove impurity, removing undesirable root, cleans cutting, dries;

(10) Rhizoma Phragmitis: pick decontamination and root, cutting, dry;

(11) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and section, dries;

(12) Folium Mori: pick decontamination, rub with the hands broken, winnow with a dustpan destemming, and sieve removes spare;

(13) Fructus Aurantii: removing flesh, core, cleans, slightly soaks, pull out, soften, and can pinch doubling for degree with hands, section, dries;

(2) prepare

(1) described Semen Lepidii (Semen Descurainiae), Concretio Silicea Bambusae, Semen Armeniacae Amarum, Folium Perillae, the Rhizoma Pinelliae, Herba Menthae, Bulbus Fritillariae Cirrhosae, Radix Platycodonis, Herba Houttuyniae, Rhizoma Phragmitis, Radix Scutellariae, Folium Mori, Fructus Aurantii are decocted with water twice, add water 6 times amount for the first time, intense fire decocts boiling 10 minutes, use slow fire boiling again 25 minutes, filter first time decoction liquor;

(2) add water the medicinal residues after first time filtration 4 times amount, and intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters and to obtain second time decoction liquor;

(3) merge twice decoction liquor, intense fire boils, then decocts medicinal liquid to 100 milliliters with slow fire, is divided into three doses.