CN104147152A - Pomegranate essential oil hydrogel plaster and preparation method thereof - Google Patents
Pomegranate essential oil hydrogel plaster and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a pomegranate essential oil hydrogel plaster. The plaster comprises a carrier and a traditional Chinese medicine ointment, wherein the traditional Chinese medicine ointment is prepared from puer tea, semen cassiae, folium nelumbinis, fructus crataegi, white kidney bean, evening primrose, scutellaria baicalensis, licorice root, fourstamen stephania root and puer tea essential oil; the carrier is hydrogel. The traditional Chinese medicinal ointment is prepared by virtue of the following steps: decocting, filtering and concentrating the raw materials to obtain the traditional Chinese medicinal ointment; and mixing the traditional Chinese medicinal ointment and the hydrogel to finally prepare the pomegranate essential oil hydrogel plaster with high transdermal absorption rate, low anaphylactic reaction rate and remarkable effect of enhancing breast and nourishing blood.
Description
Technical field
The present invention relates to medical health care products field, be specifically related to Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof.
Background technology
Along with improving constantly of living standard, people also more and more pay attention to for the form of self.Have the hope that tall and straight, plentiful breast is each women, but truth is that a lot of women are because various reasons cause the breast of self modest, flat, lax or sagging.
Modest, flat, lax, the sagging much women that perplexing of breast, reason can be summarized as three aspects:: one, girlhood breast development is incomplete; Two, after suckling, maintain not in place; Three, before and after climacteric, estrogen secretion is inadequate.Now, the method for breast enlargement roughly has three kinds:
One, operation breast enlargement: the goods such as chest filling gel are reached to breast enlargement object, breast-enlarging operation need to cut out wound to put into wadding.Although Augmentation Mammaplasty is very ripe now, is to employ operation on the person all the time, as the saying goes that any operation all has certain risk, it is perfectly safe to be difficult to ensure; Meanwhile, postoperative, also need regularly to carry out corrective surgery, both increased Operation Fee, the misery of being performed the operation again.
Two, dietetic therapy breast enlargement: by adjusting dietary, the nutrient substance of using vegetable the inside reaches breast enlargement object.This kind of breast enlarging method health, has no side effect, but DeGrain.
Three, medicine breast enlargement: this kind of method is divided into again for oral administration and external application, for oral administrationly take the medicines such as breast enlargement and carry out breast enlargement; External application is about to the drug external breast of relevant breast enlargement to reach breast enlargement object.
, on market, there is the product of many strong newborn breast enlargements, but mostly be synthetic hormone now, its curative effect is not good enough, and life-time service can cause endocrine regulation, infringement hepatic and renal function, cause the U.S. dermatoses of damage such as chloasma, acne, even bring out carcinoma of endometrium and breast carcinoma; Also have some Chinese herbal medicine products, but effect is there are no outstanding especially.Therefore, suddenly wait to develop and aly match with female pathology, effect stability, do not harm the breast enlargement product of health.
Number of patent application is the patent of invention of CN201410124138.2, discloses a kind of Chinese medicine composition, comprises Flos Rosae Rugosae, Radix Puerariae, Fructus Chaenomelis, Folium Mori, the Radix Astragali and dry Folium Nelumbinis; Although this Chinese medicine composition has certain breast enlargement effect, take effect slow, medicinal component absorbs low, and breast enlargement effect neither be very good.
Summary of the invention
For above the deficiencies in the prior art, the invention provides that breast enlargement successful, transdermal absorption factor are high, medicinal component long action time and the minimum Punica granatum L. quintessence oil hydrogel plaster of side effect and preparation method thereof.
The technical solution used in the present invention is Punica granatum L. quintessence oil hydrogel plaster, by carrier and Chinese medicine ointment, formed, described Chinese medicine ointment is made by following raw material and parts by weight thereof: Punica granatum L. 10～100 weight portions, Fructus Foeniculi XIANGZI 10～100 weight portions, Radix Puerariae 10～100 weight portions, Folium Kaki 10～100 weight portions, Fructus Caricae 10～100 weight portions, Radix Notoginseng 10～100 weight portions, the Radix Paeoniae Alba 10～100 weight portions, Fructus Ligustri Lucidi 10～100 weight portions, Radix Angelicae Sinensis 10～100 weight portions, the Radix Astragali 10～100 weight portions, Radix Scutellariae 2～20 weight portions, Radix Glycyrrhizae 2～20 weight portions, Radix Stephaniae Tetrandrae 2～20 weight portions and Punica granatum L. quintessence oil 4～24 weight portions.
Preferably, described Chinese medicine ointment is made by following raw material and parts by weight thereof: Punica granatum L. 40～60 weight portions, Fructus Foeniculi XIANGZI 40～60 weight portions, Radix Puerariae 40～60 weight portions, Folium Kaki 40～60 weight portions, Fructus Caricae 40～60 weight portions, Radix Notoginseng 50～70 weight portions, the Radix Paeoniae Alba 50～70 weight portions, Fructus Ligustri Lucidi 50～70 weight portions, Radix Angelicae Sinensis 50～70 weight portions, the Radix Astragali 50～70 weight portions, Radix Scutellariae 8～12 weight portions, Radix Glycyrrhizae 8～12 weight portions, Radix Stephaniae Tetrandrae 8～12 weight portions and Punica granatum L. quintessence oil 10～14 weight portions.
Preferably, in order to improve the transdermal absorption factor of this lowering blood-fat and reducing weight traditional Chinese medicine plaster, described carrier is hydrogel.
Preferably, described hydrogel is made by following raw material and parts by weight thereof: glycerol 60～600 weight portions, sodium polyacrylate 15～150 weight portions, ethylene glycol 5～50 weight portions, polyvinylpyrrolidone 5～50 weight portions, crospolyvinylpyrrolidone 1～10 weight portion, xanthan gum 1～10 weight portion, aluminum glycinate 0.1～1 weight portion, oxalic acid triethylammonium tetrakis disodium 0.1～1 weight portion, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion, imidazoles hydroxyurea 0.05～0.5 weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight portion and purified water 120～1200 weight portions.
Preferably, described hydrogel is made by following raw material and parts by weight thereof: described hydrogel is made by following raw material and parts by weight thereof: glycerol 200～400 weight portions, sodium polyacrylate 60～80 weight portions, ethylene glycol 20～40 weight portions, polyvinylpyrrolidone 20～40 weight portions, crospolyvinylpyrrolidone 4～6 weight portions, xanthan gum 4～6 weight portions, aluminum glycinate 0.4～0.6 weight portion, oxalic acid triethylammonium tetrakis disodium 0.4～0.6 weight portion, tartaric acid 0.4～0.6 weight portion, aluminum sulfate 0.2～0.4 weight portion, imidazoles hydroxyurea 0.2～0.4 weight portion, methyl hydroxybenzoate 0.2～0.4 weight portion, malic acid 0.2～0.4 weight portion and purified water 600～800 weight portions.
A preparation method for above-mentioned Punica granatum L. quintessence oil hydrogel plaster, comprises the steps:
A, Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by;
B, by weight, takes Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Radix Puerariae, Folium Kaki, Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described Punica granatum L. quintessence oil; Then described Chinese medicine ointment raw material is decocted with water, filters, is condensed into cream, obtain Chinese medicine ointment, stand-by;
C, by weight, takes hydrogel raw material glycerol, sodium polyacrylate, ethylene glycol, polyvinylpyrrolidone, crospolyvinylpyrrolidone, xanthan gum, aluminum glycinate, oxalic acid triethylammonium tetrakis disodium, tartaric acid, aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water; Then described hydrogel raw material is mixed and mixed thoroughly, obtain hydrogel, stand-by;
D, described Chinese medicine ointment is mixed with described hydrogel, through coating, section, solidify, obtain Punica granatum L. quintessence oil hydrogel plaster.
Preferably, for described Chinese medicine ointment can better be mixed with described hydrogel, in described step b, the relative proportion of Chinese medicine ointment is 1.15～1.45.
Preferably, in order to get rid of the gas in hydrogel, in described step c, when mixing is mixed thoroughly, the equipment of employing is hydrogel de-airing mixer; During mix and blend, pressure is 0.06～0.08Mpa, and temperature is 35～55 ℃, and the time is 54～74min.
Preferably, in order to be beneficial to the absorption of human body to medicinal active ingredient, in described steps d, mass ratio when Chinese medicine ointment is mixed with hydrogel is 2.5～3.5:18～22.
Punica granatum L., the effect of tool heat clearing away, hemostasis, dampness, is used for the treatment of hemorrhage, damp-heat syndrome; The polyphenol extract of Punica granatum L. is a class powerful antioxidant, contributes to improve joint elastic force and skin elasticity, and strengthening tremulous pulse, vein and blood capillary, have good curative effect to the inflammation of arthritis and sport injury; In Punica granatum L. fruit oil, contain a large amount of (about 68%) unique highly unsaturated fatty acid, it is conjugated fatty acid that this fatty acid is otherwise known as, because he ought to not exist in the world of plant, this is a kind of hypo-linolenic acid of distortion, with three conjugated double bonds (punicic acid), also have in addition important composition-phytohormone 17 alpha-estradiols.This is a kind of very strong antioxidant, and hormone is had to powerful regulating action; But 17 alpha-estradiols that Punica granatum L. fruit oil is heavy and 17 beta estradiols (estrogen of autologous generation) difference that can be carcinogenic, so on available and the unbalance malignancy disease causing of estrogen; See through phytosterol, flavonoid material and cupreol (β-sistosterol, a kind of antiinflammatory agents equally also can affect the material of hormone) and all there is adjusting functions of hormones; Meanwhile, native female hormone 17 alpha-estradiols that contain in Punica granatum L., are one of hormone having breast enlargement effect.
Fructus Foeniculi XIANGZI, has warming kidney for dispelling cold, the effect of regulating the stomach to normalize QI; The diseases such as primary treatment cold syndrome of the stomach stomachache, colic of cold type are had a pain, cold syndrome of the stomach poor appetite; The loose temperature of Fructus Foeniculi XIANGZI is logical, and in kind warming up, lower two Jiao, are good at soothing the liver dispersing cold for relieving pain, especially for controlling colic of cold type key medicine; The secretory function that fennel essential oil contributes to stimulate development of breast, strengthens prolactin antagonist, and there is certain effect for women's breast enlargement, U.S. breast, can increase the size of female chest, in women, can improve well women's in puerperal the more milk of secretion simultaneously puerperal.
Radix Puerariae, having induces sweat brings down a fever, promote the production of body fluid, the effect of rash, yang invigorating antidiarrheal, for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels, it contains " phytoestrogen " and derivant thereof.Radix Puerariae increases, impels fat to reach the effect of the U.S. breast of breast enlargement at the aspects such as elasticity of chest accumulation, recovery breast portion skin by impelling mammary gland and acinus to grow; Radix Puerariae also has the effects such as the body of taste is healthy and strong, defying age, blood pressure lowering, blood sugar lowering, blood fat reducing, increase skin elasticity, skin moistening; The effect that in Radix Puerariae, institute's isoflavone-containing has skin care, recovers skin elasticity, can also slow down the aging of skeletal tissue's cell, contributes to calcareous absorption, reduces bone calcium and loses, increase bone density and stop the hollow of skeleton to disappear molten, thereby away from osteoporosis; Active component in Radix Puerariae can prevent cardio-cerebrovascular diseases and effectively alleviate climacteric syndrome, again can life lengthening, improve health, and be female middle-aged daily health caring, the ideal chose of improving the quality of living.The most recommendable, women often eats Radix Puerariae, can impel breast development to increase, and this is exactly mainly the contribution of isoflavone.
Fructus Caricae, has suppressing the hyperactive liver and easing the stomach, relaxing muscles and tendons network, an effect of live muscles and bones, blood pressure lowering, anticancer for strengthening the spleen to promote digestion, anti-epidemic disease parasite killing, lactogenesis, supplement the nutrients, and improves resistance against diseases, spasmolytic.Chymosin in Fructus Chaenomelis has lactogenesis effect, and carpaine has the merit of antiangiogenic property leukemia, therefore can be used for lactogenesis and treatment lymphoid leukemia (leukemia).
Folium Kaki, except containing appreciable protein, aminoacid and multivitamin, also contain higher than several times of the ordinary tea leaves natural Vc of tens times even, and the content of 17 seed amino acids of rutin, choline, flavonoid glycoside and needed by human is also high tens times than fruit, vegetable, common beverages.Natural Vc promotes human body metabolism, and vitamin C deficiency, cardiovascular diseases and cancer etc. are had to certain curative effect; Rutin, choline have vessel softening, prevent arteriosclerotic effect; Flavonoid glycoside can reduce blood pressure, increase blood flow volume, and golden yellow staphylococcus is had to obvious inhibitory action.
Radix Notoginseng, has the effect of hemostasis, dissipating blood stasis, detumescence, analgesic therapy, cures mainly haematemesis, hemoptysis, epistaxis, has blood in stool, dysentery, metrorrhagia, mass in the abdomen, puerperal blood faints, retention of lochia, falls and flutter blood stasis, traumatic hemorrhage, carbuncle pain.Modern pharmacology: (1) has good hemostasia effect, significant hemopoietic function; (2) can tighten and improve Coronary microcirculation, the effect of blood vessel dilating; (3) there is stronger analgesic activity, the effect that there is resisting fatigue, improves learning and memory ability; (4) anti-inflammatory effect; (5) there is the effect of immunomodulator, can make too high or too low immunoreation return to normally, but the not normal immunoreation of interference body; (6) antitumor action; (7) defying age, antioxidation; (8) reduce blood fat and cholesterol effect; (9) the liver protecting.
The Radix Paeoniae Alba, the effect of have nourishing blood to suppress the hyperactive liver, delay middle pain relieving, yin fluid astringing being received antiperspirant, controls the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia; Paeoniflorin has significant antiinflammatory action.
Fructus Ligustri Lucidi, has nourishing YIN and benefiting blood, and the effect of easing the affected liver improving eyesight cures mainly the diseases such as the dizziness of deficiency of the liver and kindey, tinnitus, order are stuck with paste, weak, early whitening of hair; Fructus Ligustri Lucidi all has obvious inhibitory action to work type, III type, type Ⅳ allergy.This product has obvious inhibitory action to Experimental Inflammation, and its anti-inflammatory mechanisms is: 1. activate pituitary-adrenocortical system, promote the release of 17-hydroxy-11-dehydrocorticosterone; 2. reduce generation and the release of prostaglandin, the increase of the vascular permeability that the inflammatory mediators such as inhibition histamine cause.
Radix Angelicae Sinensis, have enrich blood, invigorate blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation; Cure mainly that blood deficiency, all diseases of blood stasis, dizziness and headache, cardiopalmus limb fiber crops, menoxenia, amenorrhea, dysmenorrhea, metrorrhagia, knot are poly-, weight, dryness of the intestine dyschezia, treating swelling and pain by traumatic injury, ulcer sores after asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, bloody dysentery.
The Radix Astragali, the effect with invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle be difficult bursts, burst for a long time do not hold back, blood deficiency dull yellowish colored skin, interior-heat are quenched one's thirst, chronic nephritis proteinuria, diabetes.
Radix Scutellariae, have that heat clearing and damp drying, removing heat from blood are antiabortive, the effect of removing toxic substances, cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle, baicalin has (1) antiinflammatory, antiallergic, antiallergic action, protection sclerotin; (2) antipyretic, removing toxic substances and antipathogen; (3) function of gallbladder promoting, protect the liver and blood fat reducing; (4) calmness, blood pressure lowering, spasmolytic, diuresis, anticoagulant; (5) antioxidation, anti-cataract, anticancer.
Radix Glycyrrhizae, has the effect of invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine, coordinating the actions of various ingredients in a prescription, and Radix Glycyrrhizae agent has the function of antiinflammatory and antiallergic action; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
Radix Stephaniae Tetrandrae, tetrandrine has the effects such as antiallergic (tetrandrine is an Anaphylactic mediator antagonist, is again an Anaphylactic mediator blocker, and anaphylaxis is had to reliable antagonism and therapeutical effect), resisting hypertension.
Punica granatum L. quintessence oil, has different physiological roles, has the Transdermal absorption that promotes active component simultaneously, has very strong penetration power.
Beneficial effect of the present invention is: the Chinese medicine ointment that adopts above Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Radix Puerariae, Folium Kaki, Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and Punica granatum L. quintessence oil and production technology to produce, because what utilize is the anti-inflammatory component of pure plant, so thering is breast enlargement, in the effect of enriching blood, side effect is minimum, and irritated rate is extremely low; Meanwhile, after described Chinese medicine ointment is mixed with the hydrogel that adopts above specific components and production technology to produce, the Punica granatum L. hydrogel note making, has efficient transdermal absorption factor, makes medical active composition can enter in a large number human body; Meanwhile, not only reduced the oral side effect causing, can also make the not deactivation by the first pass effect of liver of part medical active composition, thereby make active ingredient reach higher bioavailability.
The specific embodiment
For making those skilled in the art understand in detail technique effect of the present invention and production technology thereof, with concrete production instance, further introduce application of the present invention and technique effect below.
Embodiment 1
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 40g that takes Punica granatum L. 100g, Fructus Foeniculi XIANGZI 100g, Radix Puerariae 100g, Folium Kaki 100g, Fructus Caricae 100g, Radix Notoginseng 100g, Radix Paeoniae Alba 100g, Fructus Ligustri Lucidi 100g, Radix Angelicae Sinensis 100g, Radix Astragali 100g, Radix Scutellariae 20g, Radix Glycyrrhizae 20g, Radix Stephaniae Tetrandrae 20g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 5300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 5300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 5300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.2, obtain Chinese medicine ointment finished product 520g; Be cooled to room temperature, then add 5.2g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 600g, sodium polyacrylate 150g, ethylene glycol 50g, polyvinylpyrrolidone 50g, crospolyvinylpyrrolidone 10g, xanthan gum 10g, aluminum glycinate 1g, oxalic acid triethylammonium tetrakis disodium 1g, tartaric acid 1g, aluminum sulfate 0.5g, imidazoles hydroxyurea 0.5g, methyl hydroxybenzoate 0.5g, malic acid 0.5g and purified water 1200g., then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.05Mpa, and temperature is 30 ℃, after 50min, obtains hydrogel 1930g, stand-by.
4, the preparation of finished product:
Take described hydrogel 1930g and Chinese medicine ointment 270g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 66 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 2
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 70g that takes Punica granatum L. 250g, Fructus Foeniculi XIANGZI 250g, Radix Puerariae 250g, Folium Kaki 250g, Fructus Caricae 250g, Radix Notoginseng 200g, Radix Paeoniae Alba 200g, Fructus Ligustri Lucidi 200g, Radix Angelicae Sinensis 200g, Radix Astragali 200g, Radix Scutellariae 50g, Radix Glycyrrhizae 50g, Radix Stephaniae Tetrandrae 50g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 11300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 11300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 11300g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 1200g; Be cooled to room temperature, then add 12g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 1000g, sodium polyacrylate 400g, ethylene glycol 150g, polyvinylpyrrolidone 150g, crospolyvinylpyrrolidone 30g, xanthan gum 30g, aluminum glycinate 3g, oxalic acid triethylammonium tetrakis disodium 3g, tartaric acid 3g, aluminum sulfate 1g, imidazoles hydroxyurea 1g, methyl hydroxybenzoate 1g, malic acid 1g and purified water 5000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.06Mpa, and temperature is 35 ℃, after 50min, obtains hydrogel 6400g, stand-by.
4, the preparation of finished product:
Take described hydrogel 6400g and Chinese medicine ointment 1000g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 68 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 3
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 100g that takes Punica granatum L. 400g, Fructus Foeniculi XIANGZI 400g, Radix Puerariae 400g, Folium Kaki 400g, Fructus Caricae 400g, Radix Notoginseng 500g, Radix Paeoniae Alba 500g, Fructus Ligustri Lucidi 500g, Radix Angelicae Sinensis 500g, Radix Astragali 500g, Radix Scutellariae 80g, Radix Glycyrrhizae 80g, Radix Stephaniae Tetrandrae 80g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 23000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4.5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 23000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 23000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 2200g; Be cooled to room temperature, then add 22g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 2000g, sodium polyacrylate 600g, ethylene glycol 200g, polyvinylpyrrolidone 200g, crospolyvinylpyrrolidone 40g, xanthan gum 40g, aluminum glycinate 4g, oxalic acid triethylammonium tetrakis disodium 4g, tartaric acid 4g, aluminum sulfate 2g, imidazoles hydroxyurea 2g, methyl hydroxybenzoate 2g, malic acid 2g and purified water 6000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.06Mpa, and temperature is 38 ℃, after 58min, obtains hydrogel 8500g, stand-by.
4, the preparation of finished product:
Take described hydrogel 8500g and Chinese medicine ointment 1100g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 69 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 4
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 120g that takes Punica granatum L. 500g, Fructus Foeniculi XIANGZI 500g, Radix Puerariae 500g, Folium Kaki 500g, Fructus Caricae 500g, Radix Notoginseng 600g, Radix Paeoniae Alba 600g, Fructus Ligustri Lucidi 600g, Radix Angelicae Sinensis 600g, Radix Astragali 600g, Radix Scutellariae 100g, Radix Glycyrrhizae 100g, Radix Stephaniae Tetrandrae 100g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 29600g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 29600g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4.5h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 29600g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 2700g; Be cooled to room temperature, reenter 27g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 3000g, sodium polyacrylate 700g, ethylene glycol 300g, PVPK30 0g, crospolyvinylpyrrolidone 50g, xanthan gum 50g, aluminum glycinate 5g, oxalic acid triethylammonium tetrakis disodium 5g, tartaric acid 5g, aluminum sulfate 3g, imidazoles hydroxyurea 3g, methyl hydroxybenzoate 3g, malic acid 3g and purified water 7000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.07Mpa, and temperature is 40 ℃, after 55min, obtains hydrogel 10000g, stand-by.
4, the preparation of finished product:
Take described hydrogel 10000g and Chinese medicine ointment 1500g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 70 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 5
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 140g that takes Punica granatum L. 600g, Fructus Foeniculi XIANGZI 600g, Radix Puerariae 600g, Folium Kaki 600g, Fructus Caricae 600g, Radix Notoginseng 700g, Radix Paeoniae Alba 700g, Fructus Ligustri Lucidi 700g, Radix Angelicae Sinensis 700g, Radix Astragali 700g, Radix Scutellariae 120g, Radix Glycyrrhizae 120g, Radix Stephaniae Tetrandrae 120g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 37000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 37000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 37000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 3300g; Be cooled to room temperature, then add 33g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 4000g, sodium polyacrylate 800g, ethylene glycol 400g, PVP 0g, crospolyvinylpyrrolidone 60g, xanthan gum 60g, aluminum glycinate 6g, oxalic acid triethylammonium tetrakis disodium 6g, tartaric acid 6g, aluminum sulfate 6g, imidazoles hydroxyurea 4g, methyl hydroxybenzoate 4g, malic acid 4g and purified water 8000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.07Mpa, and temperature is 40 ℃, after 60min, obtains hydrogel 12300g, stand-by.
4, the preparation of finished product:
Take described hydrogel 12300g and Chinese medicine ointment 1800g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 70 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 6
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 180g that takes Punica granatum L. 800g, Fructus Foeniculi XIANGZI 800g, Radix Puerariae 800g, Folium Kaki 800g, Fructus Caricae 800g, Radix Notoginseng 800g, Radix Paeoniae Alba 800g, Fructus Ligustri Lucidi 800g, Radix Angelicae Sinensis 800g, Radix Astragali 800g, Radix Scutellariae 150g, Radix Glycyrrhizae 150g, Radix Stephaniae Tetrandrae 150g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 43000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4.5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 43000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 43000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.25, obtain Chinese medicine ointment finished product 4000g; Be cooled to room temperature, then add 40g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 5000g, sodium polyacrylate 1200g, ethylene glycol 450g, polyvinylpyrrolidone 450g, crospolyvinylpyrrolidone 90g, xanthan gum 90g, aluminum glycinate 9g, oxalic acid triethylammonium tetrakis disodium 9g, tartaric acid 9g, aluminum sulfate 9g, imidazoles hydroxyurea 4.5g, methyl hydroxybenzoate 4.5g, malic acid 4.5g and purified water 11000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.07Mpa, and temperature is 45 ℃, after 65min, obtains hydrogel 17000g, stand-by.
4, the preparation of finished product:
Take described hydrogel 17000g and Chinese medicine ointment 3000g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 72 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
Embodiment 7
1, the preparation of Punica granatum L. quintessence oil:
Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
The Punica granatum L. quintessence oil 240g that takes Punica granatum L. 1000g, Fructus Foeniculi XIANGZI 1000g, Radix Puerariae 1000g, Folium Kaki 1000g, Fructus Caricae 1000g, Radix Notoginseng 1000g, Radix Paeoniae Alba 1000g, Fructus Ligustri Lucidi 1000g, Radix Angelicae Sinensis 1000g, Radix Astragali 1000g, Radix Scutellariae 200g, Radix Glycyrrhizae 200g, Radix Stephaniae Tetrandrae 200g and produce, then, in inserting and boiling and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 55000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 5h, filter at once; During gained filtering residue 1 is again inserted and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 55000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 4h, filter at once; During gained filtering residue 2 is inserted again and boiled and irrigate by lifting water to a higher level with a water pump, etc., then toward described in, boil in irrigating by lifting water to a higher level with a water pump, etc. and add water 55000g; Described in heating, boil and irrigate by lifting water to a higher level with a water pump, etc. to solution boiling in filling with, after keeping boiling 3.5h, filter at once; Three gained filtrates are merged, pack in concentration tank and concentrate, until its relative proportion is 1.4, obtain Chinese medicine ointment finished product 5200g; Be cooled to room temperature, then add 52g ethanol, seal preservation, stand-by.
3, the preparation of hydrogel:
Take glycerol 6000g, sodium polyacrylate 1500g, ethylene glycol 500g, polyvinylpyrrolidone 500g, crospolyvinylpyrrolidone 100g, xanthan gum 100g, aluminum glycinate 10g, oxalic acid triethylammonium tetrakis disodium 10g, tartaric acid 10g, aluminum sulfate 10g, imidazoles hydroxyurea 5g, methyl hydroxybenzoate 5g, malic acid 5g and purified water 12000g, then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs; During stirring, pressure is 0.08Mpa, and temperature is 50 ℃, after 70min, obtains hydrogel 19000g, stand-by.
4, the preparation of finished product:
Take described hydrogel 19000g and Chinese medicine ointment 3000g, first evenly mix, then insert hydrogel on foot in microtome, coating, section, place under room temperature 72 hours, solidify, and the Punica granatum L. quintessence oil hydrogel plaster that gets product, then encapsulation is preserved.
From embodiment 1～7, select at random respectively a slice Punica granatum L. quintessence oil hydrogel plaster, be labeled as sticker 1,2,3,4,5,6,7.
Sticker 1,2,3,4,5,6,7 is carried out to microbiology detection, refer to table 1.
Table 1
Sticker 1,2,3,4,5,6,7 is carried out to hygienic chemistry detection, refer to table 2.
Table 2
Sticker 1,2,3,4,5,6,7 is carried out to acute skin irritation test.
Choose without 14 of abnormal regular grade new zealand white rabbits, be divided at random 7 groups, be labeled as group 1,2,3,4,5,6,7,2 every group.Sticker 1,2,3,4,5,6,7 is tested by group 1,2,3,4,5,6,7 respectively.
During test, temperature is: 20～25 ℃; Relative humidity: 40%～70%.
According to Ministry of Public Health < < cosmetics health standard > > (2007) acute skin irritation, test.24h before test, cuts experimental animal back spinal column diamond wool, injured skin not, each 3cm * 3cm of unhairing scope.Get tested material 0.5g and directly spread upon on the side unhairing intact skin that area is 2cm * 2cm, with clean gauze, cover, use nonirritant immobilization with adhesive tape.Opposite side skin in contrast.After 4h, dismantle, with warm water, remove residual tested material.Remove after tested material 1,24,48,72h observes and smears position dermoreaction, with the meansigma methods of animal subject integration, carries out overall merit, according to 24,48 and 72h respectively observe time point top average and judge skin irriate intensity, obtain table 3.
Table 3
By table 1, table 2 and table 3, can be found out, the Punica granatum L. quintessence oil hydrogel plaster that adopts technology provided by the present invention to produce, its Matter Composition content meets the < < of People's Republic of China (PRC) cosmetics health standard > > (2007) completely, very safe; Meanwhile, its zest to skin does not almost have, and people can this product of relieved use.
Clinical trial
Select women's volunteer that 280 ages have slight of stature, flat, lax or sagging situation to occur at 20～60 years old breast, and age bracket is in 20～30 years old, 30～40 years old, 40～50 years old and 50～60 years old, respectively there are 70.During percent test object, following crowd is got rid of: (1) gestation or women breast-feeding their children.(2) suffer from serious disease and affect this programme implementer.(3) using other breast enlargement products person.(4) not by scheme medication, can not adhere to or the imperfect person of data.
280 volunteers are divided into 7 test group, are labeled as respectively test group 1,2,3,4,5,6,7, and every group is in 20～30 years old, 30～40 years old, 40～50 years old and 50～60 years old, to have 10 volunteers at age bracket.According to the age, these 280 volunteers are divided into 4 groups again, are labeled as 20～30 years old group, 30～40 years old group, 40～50 years old group and 50～60 years old group.
From embodiment 1～7, select at random respectively enough Punica granatum L. quintessence oil hydrogel plasters, be labeled as sticker 1., 2., 3., 4., 5., 6., 7., then be affixed on respectively on the volunteer breast in test group 1,2,3,4,5,6,7, every 3 days once, each a slice (specification is 8cm*8cm), each 36h.
After two months, 280 volunteers are checked, check breast enlargement effect, and add up, refer to table 4.In inspection, take the size of breast, tall and straight and consolidation is observation index.And the effect standard of breast enlargement is:
Effective: before test, more than breast increases 3cm; It is strong that breast obviously becomes; The breast consolidation that obviously becomes.
Effective:, before test, breast increases 1～3cm; It is strong that breast becomes slightly; The breast consolidation that slightly becomes.
Invalid:, before test, breast does not almost increase; The firmness of breast is almost constant; The degree of packing of breast is almost constant.
Table 4
As can be seen from Table 4, product provided by the invention, applicable crowd is very wide, above, to the old man of 60 years old, down to the youth maiden of 20 years old, all can use this Punica granatum L. quintessence oil hydrogel note; And its breast enlargement effect is also fairly obvious.
Claims (9)
1. Punica granatum L. quintessence oil hydrogel plaster, by carrier and Chinese medicine ointment, formed, it is characterized in that: described Chinese medicine ointment is made by following raw material and parts by weight thereof: Punica granatum L. 10～100 weight portions, Fructus Foeniculi XIANGZI 10～100 weight portions, Radix Puerariae 10～100 weight portions, Folium Kaki 10～100 weight portions, Fructus Caricae 10～100 weight portions, Radix Notoginseng 10～100 weight portions, the Radix Paeoniae Alba 10～100 weight portions, Fructus Ligustri Lucidi 10～100 weight portions, Radix Angelicae Sinensis 10～100 weight portions, the Radix Astragali 10～100 weight portions, Radix Scutellariae 2～20 weight portions, Radix Glycyrrhizae 2～20 weight portions, Radix Stephaniae Tetrandrae 2～20 weight portions and Punica granatum L. quintessence oil 4～24 weight portions.
2. Punica granatum L. quintessence oil hydrogel plaster according to claim 1, it is characterized in that: described Chinese medicine ointment is made by following raw material and parts by weight thereof: Punica granatum L. 40～60 weight portions, Fructus Foeniculi XIANGZI 40～60 weight portions, Radix Puerariae 40～60 weight portions, Folium Kaki 40～60 weight portions, Fructus Caricae 40～60 weight portions, Radix Notoginseng 50～70 weight portions, the Radix Paeoniae Alba 50～70 weight portions, Fructus Ligustri Lucidi 50～70 weight portions, Radix Angelicae Sinensis 50～70 weight portions, the Radix Astragali 50～70 weight portions, Radix Scutellariae 8～12 weight portions, Radix Glycyrrhizae 8～12 weight portions, Radix Stephaniae Tetrandrae 8～12 weight portions and Punica granatum L. quintessence oil 10～14 weight portions.
3. Punica granatum L. quintessence oil hydrogel plaster according to claim 1 and 2, is characterized in that: described carrier is hydrogel.
4. Punica granatum L. quintessence oil hydrogel plaster according to claim 3, it is characterized in that: described hydrogel is made by following raw material and parts by weight thereof: glycerol 60～600 weight portions, sodium polyacrylate 15～150 weight portions, ethylene glycol 5～50 weight portions, polyvinylpyrrolidone 5～50 weight portions, crospolyvinylpyrrolidone 1～10 weight portion, xanthan gum 1～10 weight portion, aluminum glycinate 0.1～1 weight portion, oxalic acid triethylammonium tetrakis disodium 0.1～1 weight portion, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion, imidazoles hydroxyurea 0.05～0.5 weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight portion and purified water 120～1200 weight portions.
5. Punica granatum L. quintessence oil hydrogel plaster according to claim 3, it is characterized in that: described hydrogel is made by following raw material and parts by weight thereof: glycerol 200～400 weight portions, sodium polyacrylate 60～80 weight portions, ethylene glycol 20～40 weight portions, polyvinylpyrrolidone 20～40 weight portions, crospolyvinylpyrrolidone 4～6 weight portions, xanthan gum 4～6 weight portions, aluminum glycinate 0.4～0.6 weight portion, oxalic acid triethylammonium tetrakis disodium 0.4～0.6 weight portion, tartaric acid 0.4～0.6 weight portion, aluminum sulfate 0.2～0.4 weight portion, imidazoles hydroxyurea 0.2～0.4 weight portion, methyl hydroxybenzoate 0.2～0.4 weight portion, malic acid 0.2～0.4 weight portion and purified water 600～800 weight portions.
6. a preparation method for Punica granatum L. quintessence oil hydrogel plaster as claimed in claim 4, comprises the steps:
A, Punica granatum L. is pulverized and puts into extractor, utilize carbon dioxide to carry out supercritical extraction, collect extract and obtain Punica granatum L. quintessence oil, stand-by;
B, by weight, takes Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Radix Puerariae, Folium Kaki, Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described Punica granatum L. quintessence oil; Then described Chinese medicine ointment raw material is decocted with water, filters, is condensed into cream, obtain Chinese medicine ointment, stand-by;
C, by weight, takes hydrogel raw material glycerol, sodium polyacrylate, ethylene glycol, polyvinylpyrrolidone, crospolyvinylpyrrolidone, xanthan gum, aluminum glycinate, oxalic acid triethylammonium tetrakis disodium, tartaric acid, aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water; Then described hydrogel raw material is mixed and mixed thoroughly, obtain hydrogel, stand-by;
D, described Chinese medicine ointment is mixed with described hydrogel, through coating, section, solidify, obtain Punica granatum L. quintessence oil hydrogel plaster.
7. the preparation method of Punica granatum L. quintessence oil hydrogel plaster according to claim 6, is characterized in that: in described step b, the relative proportion of Chinese medicine ointment is 1.15～1.45.
8. the preparation method of Punica granatum L. quintessence oil hydrogel plaster according to claim 6, is characterized in that: in described step c, when mixing is mixed thoroughly, the equipment of employing is hydrogel de-airing mixer; During mix and blend, pressure is 0.06～0.08Mpa, and temperature is 35～55 ℃, and the time is 54～74min.
9. the preparation method of Punica granatum L. quintessence oil hydrogel plaster according to claim 6, is characterized in that: in described steps d, mass ratio when Chinese medicine ointment is mixed with hydrogel is 2.5～3.5:18～22.
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