CN105288597A - Skin pigmentation treatment medicine - Google Patents

Abstract

The invention discloses a skin pigmentation treatment medicine. The medicine comprises 20-50 parts of Centella asiatica, 8-30 parts of L-vitamin C, 1-10 parts of white peony root, 1-10 parts of coix seed, 1-10 parts of pearl powder, 1-10 parts of Chinese yam, 1-5 parts of Phymatopsis hastata, 0.5-0.8 parts of Indian Mockstrawberry Herb, 1-5 parts of Herb of Siberian Cocklebur, 1-2.5 parts of Piper betle L., 2-5 parts of Herba Scutellariae Indicae, 10-30 parts of oligopeptides, 5-15 parts of hyaluronic acid, 1-10 parts of nanometer collagens, 5-20 parts of Malaytea Scurfpea Fruit, 0.1-0.3 parts of Fructus Toosendan, 3-5 parts of Radix Morindae officinalis, 3-6 parts of Fructus Rosae Laevigatae, 1-5 parts of Cynara scolymus, 5-10 parts of Radix Codonopsis, 2-5 parts of Chinese wolfberry, 2-5 parts of licorice root, 2-5 parts of Chinese angelica, 5-12 parts of Dendrobium officinale, 5-12 parts of Radix Pseudostellariae, 1-3 parts of Curculigo orchioides, 2-5 parts of Hedyotis diffusa, 10-20 parts of safflower, 3-6 parts of ginger, 2-4 parts of Rhizoma Alpiniae Officinarum, 2-5 parts of rhizome of Whiteback Greenbrier, 1-3 parts of Divaricate Saposhnikovia Root, 5-10 parts of olive oil and 8-12 parts of rose flower.

Description

A kind of medicine for the treatment of cutaneous pigmentation

Technical field

The present invention relates to a kind of medicine.More specifically, content of the present invention relate to a kind of treat cutaneous pigmentation medicine and the oral liquid for oral administration prepared by it and external application ointment.

Background technology

Cutaneous pigmentation is caused by the many factors such as endogenous cause of ill and exopathogenic factor, such as hormonal disorder is with chafing reaction, genetic diseases and ultraviolet radiation, it is mainly derived from melanic comprehensive imbalance and distributivity imbalance, and can cause skin darkening, purpura senile etc. after dyschromasia, freckle, chafing.And cutaneous pigmentation is with old and feeble and increase and become and be difficult to removing, and the worry of Yan Shi great to middle age or old people especially.

Melanic major function is scavenging activated oxygen, injured to protect skin to avoid.Therefore, a large amount of melanin can be understood and represent that powerful reaction occurs integumentary system, avoid the injury being subject to physics or chemotoxic substances to protect skin.Melanin formed by succession of steps, that is: by tryrosinase and further enzymic catalytic reaction and spontaneous oxidation reaction etc., tyrosine is converted into DOPA quinone.In order to the biosynthesis of check melanin, the material of various whiteness of skin, such as hydroquinone, Arbutin, vitamin C, kojic acid and natural herbs extract etc., it is until still used today.But existing commercially available skin-whitening materials has several problem, such as: because skin is responsive and have not good dyeability or abnormal smells from the patient etc. for hydroquinone, cause the restriction of hydroquinone on using; Easily be oxidized under the aerial oxygen effect of vitamin C, cause cosmetics to be adjusted and there is not good dyeability or abnormal smells from the patient; Kojic acid lacks storage stability (being easy to generation painted); Although herbal extract has powerful whiteness of skin effect, be difficult to maintain homogeneity and effectiveness because originating various.

Except the material of above-mentioned whiteness of skin, also develop other skin-whitening materials following recently, such as: by the isolated Kai Er lactone derivatives of Peucedanum praeruptorum DUNN as an active component; And glucose acylated derivatives is as active component etc.But these materials have several problem, such as too low adjustment output capacity etc.

Therefore, be starved of the improvement by formula and production technology, to obtain a kind of medicine for the treatment of cutaneous pigmentation of internal and external application.

Summary of the invention

In order to solve the problems of the technologies described above, this law is bright aims to provide a kind of medicine for the treatment of cutaneous pigmentation, it is short that described medicine has treatment cycle, can effectively dispel skin pigment and prevent Skin pigmentation, and can human five internal organs be nourished, have no side effect, and each constituent content of compositions can be regulated for the patient of different body constitution, improve therapeutic effect.

First aspect of the present invention relates to a kind of medicine for the treatment of cutaneous pigmentation, and it is characterized in that, it comprises compositions A, compositions B, compositions C, compositions D, compositions E and composition F;

In described compositions A, the parts by weight of each material are: Herba Centellae 20 ~ 50, L-vitamin C8 ~ 30, the Radix Paeoniae Alba 1 ~ 10, Semen Coicis 1 ~ 10, Margarita powder 1 ~ 10, Rhizoma Dioscoreae 1 ~ 10, Phymatopsis hastata (Thunb.) Kitag. 1 ~ 5, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 5, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 10 ~ 30, hyaluronic acid 5 ~ 15, nano-collagen 1 ~ 10, Fructus Psoraleae 5 ~ 20;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

In one embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions A, the weight ratio of Herba Centellae and Phymatopsis hastata (Thunb.) Kitag. is 40:3.

In one embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions C, the weight ratio of Fructus Toosendan, Radix Morindae Officinalis is 0.2:3.

In one embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions A, the parts by weight of each material are: Herba Centellae 30 ~ 45, L-vitamin C15 ~ 25, the Radix Paeoniae Alba 5 ~ 10, Semen Coicis 5 ~ 10, Margarita powder 3 ~ 8, Rhizoma Dioscoreae 3 ~ 8, Phymatopsis hastata (Thunb.) Kitag. 2 ~ 4, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 3, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 15 ~ 25, hyaluronic acid 5 ~ 10, nano-collagen 3 ~ 8, Fructus Psoraleae 5 ~ 12;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

In a preferred embodiment, in the compositions of described treatment cutaneous pigmentation, in described compositions A, the parts by weight of the extract of each material in this prescription are: Herba Centellae 30 ~ 45, L-vitamin C15 ~ 25, the Radix Paeoniae Alba 5 ~ 10, Semen Coicis 5 ~ 10, Margarita powder 3 ~ 8, Rhizoma Dioscoreae 3 ~ 8, Phymatopsis hastata (Thunb.) Kitag. 2 ~ 4, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 3, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of the extract of each material in this prescription are: oligopeptide 15 ~ 25, hyaluronic acid 5 ~ 10, nano-collagen 3 ~ 8, Fructus Psoraleae 5 ~ 12;

In described compositions C, the parts by weight of the extract of each material in this prescription are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of the extract of each material in this prescription are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of the extract of each material in this prescription are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of the extract of each material in this prescription are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

In a preferred embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions A, the parts by weight of each material are: Herba Centellae 40, L-vitamin C20, the Radix Paeoniae Alba 8, Semen Coicis 9, Margarita powder 8, Rhizoma Dioscoreae 7, Phymatopsis hastata (Thunb.) Kitag. 3, Herba Duchesneae Indicae 0.7, Herba Xanthii grass 3, Folium piperis betlis 2, India skullcap 3;

In described compositions B, the parts by weight of each material are: oligopeptide 20, hyaluronic acid 8, nano-collagen 7, Fructus Psoraleae 8;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.2, Radix Morindae Officinalis 3, Fructus Rosae Laevigatae 5;

In described compositions D, the parts by weight of each material are: arithoke 3, Radix Codonopsis 6, Fructus Lycii 5, Radix Glycyrrhizae 5, Radix Angelicae Sinensis 4, Herba Dendrobii 10, Radix Pseudostellariae 9, Rhizoma Curculiginis 3, Herba Hedyotidis Diffusae 4, Folium piperis betlis 2;

In described compositions E, the parts by weight of each material are: Flos Carthami 12, Rhizoma Zingiberis Recens 5, Rhizoma Alpiniae Officinarum 3, DASHENJINCAO 4, Radix Saposhnikoviae 2;

In described composition F, the parts by weight of each material are: olive oil 8, Flos Rosae Rugosae 10.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described compositions A also comprises the Radix Oryzae Glutinosae of 1 ~ 10 weight portion.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described compositions A also comprises the Herba Ophioglossi of 1 ~ 3 weight portion.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described oligopeptide is selected from: the combination of one or more in oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6, oligopeptide-10, Matrixyl-3, palmityl tripeptides-1, palmityl tripeptides-5, Semen Myristicae pentapeptide-11.

Another aspect of the present invention relates to a kind of oral liquid for oral administration, with 200 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 3 ~ 20 weight portions, the compositions B of 1 ~ 10 weight portion, 1 ~ 5 weight portion, the compositions D of 30 ~ 100 weight portions, the compositions E of 1 ~ 5 weight portion, the composition F of 1 ~ 10 weight portion, the brown sugar of 5 ~ 10 weight portions, excess water.

In a preferred embodiment, oral liquid for oral administration, with 200 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 10 ~ 16 weight portions, the compositions B of 3 ~ 7 weight portions, 3 ~ 5 weight portions, the compositions D of 50 ~ 80 weight portions, the compositions E of 3 ~ 5 weight portions, the composition F of 5 ~ 8 weight portions, the brown sugar of 5 ~ 10 weight portions, excess water.

Another aspect again of the present invention relates to a kind of external application ointment, with 100 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 15 ~ 45 weight portions, the compositions B of 5 ~ 25 weight portions, 1 ~ 5 weight portion, the compositions D of 3 ~ 15 weight portions, the compositions E of 0.5 ~ 3 weight portion, the composition F of 1 ~ 5 weight portion.

In a preferred embodiment, described external application ointment, with 100 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 30 ~ 40 weight portions, the compositions B of 10 ~ 20 weight portions, 2 ~ 4 weight portions, the compositions D of 5 ~ 12 weight portions, the compositions E of 1 ~ 2 weight portion, the composition F of 2 ~ 4 weight portions.

Be more conducive to understand foregoing of the present invention, advantage and feature with reference to following detailed description.

Detailed description of the invention

Unless otherwise defined, all technology used herein and scientific terminology have the identical implication usually understood with one skilled in the art of the present invention.When there is contradiction, be as the criterion with the definition in this description.

During the Range Representation that equivalent, concentration or other value or parameter limit with scope, preferable range or a series of upper limit preferred value and lower preferable values, this is appreciated that all scopes specifically disclosing and formed by arbitrary pairing of any range limit or preferred value and any range lower limit or preferred value, no matter and whether this scope separately discloses.Such as, when disclosing scope " 1 to 5 ", described scope should be interpreted as comprising scope " 1 to 4 ", " 1 to 3 ", " 1-2 ", " 1-2 and 4-5 ", " 1-3 and 5 " etc.When numerical range is described in this article, unless otherwise indicated, otherwise this scope intention comprises its end value and all integers within the scope of this and mark.

First aspect of the present invention relates to a kind of medicine for the treatment of cutaneous pigmentation, and it is characterized in that, it comprises compositions A, compositions B, compositions C, compositions D, compositions E and composition F;

In described compositions A, the parts by weight of each material are: Herba Centellae 20 ~ 50, L-vitamin C8 ~ 30, the Radix Paeoniae Alba 1 ~ 10, Semen Coicis 1 ~ 10, Margarita powder 1 ~ 10, Rhizoma Dioscoreae 1 ~ 10, Phymatopsis hastata (Thunb.) Kitag. 1 ~ 5, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 5, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 10 ~ 30, hyaluronic acid 5 ~ 15, nano-collagen 1 ~ 10, Fructus Psoraleae 5 ~ 20;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

compositions A:

In the present invention, compositions A comprises: Herba Centellae, L-vitamin C, the Radix Paeoniae Alba, Semen Coicis, Margarita powder, Rhizoma Dioscoreae, Phymatopsis hastata (Thunb.) Kitag., Herba Duchesneae Indicae, Herba Xanthii grass, Folium piperis betlis, India skullcap;

Herba Centellae, Herba Centellae is cold in nature, has heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect.Deep skin cell can be stimulated to substitute.Herba Centellae can be compacted epidermis and corium coupling part, and skin can be made to limber up, and contributes to solving cutis laxa phenomenon, makes skin smooth flexible; Promote that collagen protein is formed in skin corium, makes fibrin regenerate, reconnects, skin is reached compact smooth effect.Herba Centellae has the regeneration of promotion skin collagen, strengthens cell based bottom cell viability, keeps elasticity of skin and consolidation; Antioxidation, suppresses free radical activity, regulates skin immunity; Desalination melanin pigmentation, upgrades skin cell regeneration; Increase skin water conservation degree, activation upgrades skin cell; Antiallergic protective action, protection skin is from external injury.Also can help impaired organization healing and consolidation skin.Can to promote between epidermis with corium close is connected, the increase of adipose cell can be suppressed again, prevent hydroderma, occur fat.Containing the Triterpenoid containing multiple α-balsam alcohol type in Herba Centellae, wherein there are Asiaticoside, thankuniside, isothankuniside, madecassoside, brahmoside, broken hot rice glycoside and Brahmic acid etc., and madasiatic acid.In addition, still containing meso inositol, centellose, wax, Radix Dauci Sativae hydro carbons, chlorophyll, and nimbecetin, Quercetin and glucose, rhamnose flavonoid glycoside.Herb is mainly containing triterpenic acid and triterpenoid saponin.Triterpene has asiatic acid, Madecassic acid, different Madecassic acid and the acid of birch skin etc.Triterpenoid saponin has Asiaticoside, madecassoside, Herba sambuci chinensis three glucoside and Herba sambuci chinensis four glucoside, and meaning is containing the withered glycoside of ginseng and the withered glycoside of different ginseng again.Another containing kaempferol and Quercetin and glycoside, accumulated snow potash), meso inositol, Herba Centellae oligosaccharide, sitosterol, vitamin C, carotene, green volatile oil and resinoid.

L-vitamin C, vitamin C is a kind of strong reductant, has antioxidation.Because vitamin C is the molecule with optically active, according to its optical rotation, left-handed and dextrorotation can be divided into.L-vitamin C (" left-handed C ") be uniquely can directly the vitamin C form that absorbs by human skin.It has promotion collagen hyperplasia, repairs ultraviolet to the injury of skin, the functions such as desalination melanin.Meanwhile, competitive inhibition tryrosinase, the intermediate product dopamine of vat black chromogenesis and DOPA quinone, have the effect of desalination mottle.

The Radix Paeoniae Alba, ranunculaceae plant, the dry root of Radix Paeoniae is used as medicine.The property of medicine is bitter, and acid, is slightly cold.Its chemical composition is containing paeoniflorin, paeonol, paeoniflorin, Radix Paeoniae lactone glycoside, oxypaeoniflorin, benzoylpaeoniflorin, Radix Paeoniae lucky ketone, hydroxypaeoniflorin, benzoic acid, cupreol, times tannin, gallic acid, unconcerned gallate-based ethyl ester, catechin, volatile oil, fatty oil, resin, sugar, starch, phlegmatic temperament, protein and triterpene substance etc.Can be used for treating blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, the effects such as suppressing liver-YANG.

Semen Coicis, returns spleen, stomach, lung meridian; The property of medicine is sweet, light, cool.Have spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.Chemical composition free fatty also has Palmic acid, stearic acid, cis-8-octadecenoic acid and oleic acid etc.There is tool to do the α-glyceryl monooleate of function of tumor in monoacylglycerol, in sterol ester, have cis-, the trans-Resina Ferulae acyl stigmasterol and cis-, trans-Resina Ferulae acyl campesterol etc. of tool ovulation effect.Kernel is also containing Semen Coicis Polysaccharide A, B, C of the glucosan of anticomplementary action and acidic polysaccharose CA-1, CA-2 and hypoglycemic activity.Volatile Oil from Seed is containing 69 kinds of compositions, and wherein main have aldehyde, acid, 2-ethyl 3 hydroxy butyrate ester, nonyl lactone, n-nonanoic acid, sad, ethyl palmitate, methyl linoleate, vanillin and Ethyl linoleate etc.

Margarita powder is sweet in the mouth, salty, cold in nature; GUIXIN, Liver Channel.To calm the nerves arresting convulsion; Liver heat removing and eyesight improving; Removing toxic substances and promoting granulation.Main palpitation with fear severe palpitation; Vexed insomnia; Infantile convulsion epilepsy; Cataract; Aphtha of the mouth and tongue; Throat is burst rotten; Skin infection does not close up for a long time.Margarita powder contains 18 seed amino acids such as leucine, methionine, alanine, and aminoacid is lymphoid tissue organ growth, the institute that reaches maturity is required, and has a significant effect to intracellular protein synthesis rate and synthetic protein type.Adhere to that Margarita powder for oral administration effectively can improve the activity of T in human immune system, bone-marrow-derived lymphocyte for a long time, thus strengthen immune disease-resistance ability.Three kinds of trace element such as the manganese that Margarita powder itself contains, copper, zinc are the compositions of composition SOD, are coated with face, can promote the activity of human skin superoxide dismutase (SOD), the synthesis of check melanin with Margarita powder, keep whitening skin.In addition, because SOD has the effect of scavenging free radicals, therefore be coated with face with Margarita powder and can prevent skin aging, wrinkling.Can play " pacifying with calm " to brain centres containing several amino acids and trace element in Margarita powder to act on, just can make after absorption of human body to be overexcited and cause tired cell to be nourished, make it to quiet down, the frightened epilepsy for children's is applicable equally.Margarita powder has the effect of heat-clearing and toxic substances removing, can clearing away liver-fire.The liver being in charge of the eyes, the raw nebula of hot-tempered then order, blurred vision.Find through research, the selenium in Margarita powder can strengthen the conduction of optic nerve, improves eyesight status simultaneously; Zinc in trace element can promote the axonal transport of optic nerve, improves metabolism and the function of retina and retinal pigment epithelium.

Rhizoma Dioscoreae: sweet, flat, nontoxic.Return spleen, lung, kidney channel.Rhizoma Dioscoreae contains mucoprotein, the material such as amylase, saponin, free amino acid, polyphenol oxidase, and content comparatively horn of plenty, having tonic effect, is the good merchantable brand of the rehabilitation tonic after being ill, has the effect of strong body, kidney nourishing and replenishing vital essence; Rhizoma Dioscoreae contains saponin, lymphatic temperament, has lubrication, moist effect, thus can lung benefiting gas, support lung yin, the disease for the treatment of deficiency of the lung phlegmatic cough chronic cough; Rhizoma Dioscoreae is fatty hardly, and the contained mucoprotein lipidosis that can prevent cardiovascular system, prevents tremulous pulse from hardening prematurely.Rhizoma Dioscoreae contains saponin can reduce cholesterol and triglyceride, is improved effect to the disease such as hypertension and hyperlipidemia; Rhizoma Dioscoreae can increase T lymphocytes in human body, strengthens immunologic function, delaying cell aging; Choline contained by Rhizoma Dioscoreae is the transmitter substance relevant with learning and memory---the material base of acetylcholine, and research finds that Rhizoma Dioscoreae has sedation, can resist hepatic coma; Rhizoma Dioscoreae fine and tender taste, containing profuse nutraceutical agents.Shennong's Herbal is called it " master is good for middle tonify deficiency, except cold and heat pathogen, invigorating the spleen and replenishing QI power, longue meat, takes normal hearing and eyesight for a long time "; ((Japan hanako materia medica " say its " help the five internal organs, muscles and bones, the long will of living is calmed the nerves, cure mainly let out essence forgetful "; Compendium of Material Medica think Rhizoma Dioscoreae can " kidney tonifying gas, strengthening the spleen and stomach, antidiarrheal dysentery, change paralysed saliva, profit fur ".Research in the last few years shows, Rhizoma Dioscoreae has induction and produces interferon, strengthens the effect of immune function of human body.Choline contained by it and lecithin contribute to improving man memory power, normal food can body-building, slow down aging, be the health-care good product that people like.Be the main and auxiliary bionic foods made with Rhizoma amorphophalli with Rhizoma Dioscoreae, having effect of nutritious, healthcare, skin maintenance, is rare health-nutrition cuisines.

Phymatopsis hastata (Thunb.) Kitag., property is put down, bitter in the mouth, and gas is fragrant, nontoxic.Removing heat from blood, diuresis, removing toxic substances.Cure the wound cold and heat disease, excessive thirst, infantile convulsion, tonsillitis, bacillary dysentery, chronic hepatitis, and stranguria with blood, has blood in stool, carbuncle furuncle.Cure the wound algid malaria dysentery, pathogenic wind toxic swelling, seasonal epidemic pathogens bad odor, loose pathogenic wind, acute mastitis, herpes simplex, children's's pox eye infantile malnutrition; The raw moth of inflammation of the throat, with JINSUOSHI juice, vinegar is gargled.Cure the wound wind.Removing toxic substances, controls the plague.Control traumatic injury wound.Dehumidifying diuresis, controls the anxious chronic infantile convulsion of children's, cough, milk regurgitation, carbuncle multiple abscess, knife injury, cold GUFENG bones and muscles pain.Heat clearing away, removing toxic substances, removing heat from blood, treating stranguria.

Herba Duchesneae Indicae, Herba Duchesneae Indicae, sweet, bitter; Cold, return through lung; Liver; Large intestine channel.Function cures mainly: heat clearing away, removing heat from blood, detumescence, removing toxic substances.Control calentura, infantile convulsion, cough, spit blood, laryngopharynx swelling and pain, dysentery, carbuncle, furuncle, snake bite and insect sting, burn.Sweet, sour, cold, slightly poisonous.Heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For cold, fever, cough, infantile hyperpyrexia infantile convulsion, laryngopharynx swelling and pain, diphtheria, icterohepatitis, bacillary dysentery, amebic dysentery, menorrhagia; Parotitis is controlled in external, venom, eye conjunctivitis, furuncle swelling toxin, herpes zoster, eczema.Also curing cancers can be tried.And can be used for killing wriggler, fly larvae.

Herba Xanthii grass, belongs to Compositae, annual herb plant, and its aerial parts can be used as medicine.Property of medicine bitter in the mouth, sweet, pungent, warm in nature, mild toxicity.Its main component is volatile oil, sesquiterpene lactones, glycoside and unsaturated fatty acids wet goods.The effects such as it has dispersing wind and cold, clearing the nasal passage, wind-damp dispelling, antipruritic.Can be used to treat nasal sinusitis, headche due to wind-cold, rheumatic arthralgia, rubella, eczema, scabies.In Drug therapy skin pigment depigmentation of the present invention and leukodermic process, scalable skin metabolism, and complement each other with other components, play antiinflammatory, antioxidative effect.

Folium piperis betlis, has another name called betel leaf, Spica piperis betlis, betel, is Piperaceae Piper plant, is the famous cultivated plant of Ancient Times in China, has both had unique national dietetic therapy culture, and has had again good medical value.Chemical composition, leaf, containing volatile oil, includes chavicol 7.2 ~ 16.7%, chavicol 2.7 ~ 6.2%, allylpyrocatechol 0 ~ 9.6%, carvacrol 2.2 ~ 5.6%, eugenol 26.8 ~ 42.5%, cymol 1.2 ~ 2.5%, 1, 8-Cineole 2.4 ~ 4.8%, methyleugenol 4.2 ~ 15.8%, caryophyllene 3.0 ~ 9.8%, Cadinene 2.4 ~ 8.8%, and uncertain sesquiterpene 4.5 ~ 6,8% etc.Ye Zhongshang is containing multiple free amino acid, ascorbic acid, malic acid, oxalic acid, glucose, fructose, maltose, glucuronic acid etc.Every hectogram iron content 25 milligrams.There is certain antibacterial action.

India skullcap, pungent, micro-hardship, flat.Dispersing liver and promoting blood circulation dissipating blood stasis, heat-clearing and toxic substances removing.For the vexed pain of costa sternales, lung pus is die young, dysentery, enteritis, leucorrhea, carbuncle skin ulcer, venom.

Radix Oryzae Glutinosae, Radix Oryzae Glutinosae is grass family oryza plant Oryza sativa L. var. glutinosa Matsum., and Radix Oryzae Glutinosae is called: Radix Oryzae Glutinosae, rice root hair, glutinous paddy root, Oryza sativa L. var. glutinosa Matsum. grass roots.Sweet, flat, Liver Channel.Be used as medicine with root stock and fibrous root.Yin nourishing heat extraction; Hidroschesis.For fever due to yin deficiency, spontaneous sweating, thirsty and dry pharynx.Radix Oryzae Glutinosae has certain nourishing stomach-YIN, except deficiency-heat and anti-hidropoiesis.To fever due to yin deficiency after being ill and pulmonary tuberculosis steaming night sweat person, particularly suitable.Alone power is thin, and often with card compatibility, as fever due to yin deficiency, thirsty and dry pharynx person, joins the Radix Rehmanniae, Radix Ophiopogonis, Cortex Lycii cure mainly application.Oryza sativa L. var. glutinosa Matsum. radical cure fever due to yin deficiency; Spontaneous sweating; Thirsty and dry pharynx; Hepatitis; Filaricide.

Herba Ophioglossi, micro-sweet, bitter, cold.Removing heat from blood, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Analgesia; Removing toxic substances.Main cough due to lung-heat; Over-strained hemoptysis; Lung abscess; Stomachache; Stranguria with turbid discharge; Carbuncle sore tumefacting virus; Snake bite and insect sting; Traumatic injury; Infantile hyperpyrexia infantile convulsion; Conjunctival congestion and swelling pain.

compositions B:

Oligopeptide: oligopeptide, also referred to as little peptide, oligopeptide or be called small active peptides, molecular weight section is generally below 1000 dalton, and be generally made up of 2 ~ 10 aminoacid, small-molecular peptides has following characteristics: (1) does not need digestion, directly absorbs.(2) do not need when absorbing to consume body energy.(3) human intestines and stomach's function burden is not increased.(4) tool preferential absorption feature.(5) absorb fast, 129600 seconds faster than absorption of human body macro-molecular protein, comparatively human amino acid fast 64800 seconds.(6) promote to absorb with self-energy.(7) 100% are absorbed.(8) when absorption of human body function reduces, human body can Passive intake.(9) there is carrier function, can other nutrition of human body is loaded on matrix, be transported to human cell tissue.(10) there is extremely strong activity and physiological function multiformity.

The restriction that " oligopeptide " described in the present invention does not have, can be commercially available, also can those skilled in the art be obtained by the blanking method synthesis known.

In the present invention, described oligopeptide is selected from: the combination of one or more in oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6, oligopeptide-10, Matrixyl-3, palmityl tripeptides-1, palmityl tripeptides-5, Semen Myristicae pentapeptide-11.

Hyaluronic acid; hyaluronic acid (hyaluronic acid) HA is one of main matrix composition of application on human skin epidermis and corium, and its physiological function to make moisture enter intercellular substance, and forms protein gel with protein bound; cell is sticked together; the cellular metabolism effect of bringing into normal play, plays and keeps cell moisture, and Cell protection is not by the infringement of pathogen; accelerate to recover skin histology; improve wound healing regeneration capacity, reduce cicatrix, the effects such as enhancing immunity.Meanwhile, hyaluronic acid is the main component of proliferative cell and migrating cell extracellular matrix, is especially like this in embryonal tissue.Because self characteristic hyaluronic, cell can be made to keep separated from one another, make cell be easy to motion migration and breed and stop cell differentiation.In growth course, hyaluronic effect seemingly prevent cell propagation enough or migration put in place before break up too early.In medical, hyaluronic acid (hyaluronic acid) HA is used for non-steroid antiinflammatory drug, arthritis treatment, ophthalmology, the paramedicines of cardiac surgery operation, in treatment scald, burn, cold injury, artificial skin etc., has original effect.

Nano-collagen, is abbreviated as OCO, i.e. nano active oligopeptide collagen, or is called for short nanometre collagen.It forms the micromolecule segment of collagen protein, by dipeptides (being called dipeptides by the peptide of two amino acid condensations), tripeptides until seven peptides form there is bioactive nano micromolecule mixing oligopeptide.The basic feature of OCO, one is that molecular weight is little, and mean molecule quantity only has 300 dalton; Two is nano biological molecules, and molecular length only has several nanometer, molecular diameter only less than the short-term state chain-like nanometer structure of 1 nanometer; Three is Collage Activitv, has the biological activity of collagen.OCO has the characteristic amino acid composition of collagen protein: glycine 25-30%, proline 12%, hydroxyproline 10%, alanine has 11%, and hydroxyl is from propylhomoserin 0.5%.It is safe life constitute.Active and the efficient percutaneous permeability of the nano active of OCO, collagenous biological is that it is superior to collagen protein, hydrolytic collagen, collagen peptide and amino acid whose basic feature.

Fructus Psoraleae, belongs to Rosales, the annual upright draft of pulse family, and its fruit can be used as medicine, and the property of medicine is bitter, pungent, temperature.Fruit is containing volatile oil, organic acid, a kind of methyl glucoside, alkali soluble resins, fixedness terpenoid oil, Saponin etc.Seed, containing Coumarins psoralen and isopsorapen, flavonoid bavachin, bavachinin, isobavachin and chalcone Bavachalcone, corylifolinin, monoterpene amphyl Bakuchiol, also contains volatile oil, resin, fatty oil, spends fatty oil, volatile oil, sterol, alkaloid etc.Can be used for reinforcing the kidney and supporting YANG, control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.Fructus Psoraleae has good effect in clinical practice in conjunction with other component for treating skin pigment depigmentations in this medicine and vitiligo.Fructus Psoraleae, can reinforcing the kidney and supporting YANG because returning kidney channel, helping inspiration to relieve asthma, main insufficiency of kidney-YANG, below element deficiency and cold, failure of the kidney in receiving QI, asthenia of both the spleen and kidney, is treatment skin pigment depigmentation and leukodermic common drug.

compositions C:

Fructus Toosendan is bitter, cold.Return liver, small intestinal, urinary bladder channel.Soothing the liverly to expel the heat-evil, promoting the circulation of QI to relieve pain, parasite killing.For pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.Fructus Toosendan nature and flavor bitter cold, slightly poisonous.There is effect of soothing liver-QI circulation of qi promoting, pain relieving anthelmintic.Be used for breast side of body abdominal distention, colic, the treatments such as abdominal pain due to worm stagnation.To the effect of skin.

Radix Morindae Officinalis, sweet, pungent, tepor; Return kidney, Liver Channel.Kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft." conventional Chinese herbal medicine handbook ": " kidney invigorating and YANG supporting, bone and muscle strengthening, wind-damp dispelling.Control waist foot of suffering from a deficiency of the kidney unable, flaccidity syndrome and arthralgia syndrome is paralysed, rheumatic ostalgia, neurasthenia, impotence and seminal emission, premature ejaculation, insomnia; Women is sterile ".

Fructus Rosae Laevigatae, another name, Cortex Hemipteleae Davidii, sub, golden small-mouthed jar of Fructus Rosae Normalis, Catunaregam spinosa (Thunb.) Tirveng., Gallus jabouillei chieftain, sugared Oriolus chinensis diffusus, sugar bowl, confection, Mel tank, Semen Arecae, golden tall bottle with spout, sugared Fructus Citri tangerinae, yellow tea bottle, rattan hook, Mantidis fruit, sugared bur, Radix Ribis manschurici, thorn Fructus Canarii albi, Radix Ribis manschurici, the blue stalk of thorn.Root bark obtains through refining tannic extract; Fruit medicine, has diuresis, kidney tonifying functions; Leaf has removing toxic substances and promoting subsidence of swelling effect; Root is medicinal, can promoting blood circulation to remove blood stasis, convergence of drawing out pus by applying a plaster to the affected part, dispel the wind that it is wet to drive.Cuttage or with seminal propagation; Soil is required not tight, should tailo be born in.Fruit is containing vitamin, malic acid, citric acid, tannin, Saponin etc.Relieving cough and asthma, spasmolytic, blood fat reducing, anti-inflammation.

compositions D:

Arithoke, having another name called French Bulbus Lilii, food holder Cynara scolymus L (Cyhara cardunculus.), Cynara scolymus L (Cyhara cardunculus.), Carlina acaulis, is a kind of Compositae Cynara scolymus L (Cyhara cardunculus.) platymiscium in Mediterranean growth, arithoke is nutritious, in every 100 grams of edible parts, and moisture 80.5 grams, 0.2 gram, fat, 2.8 grams, protein, saccharide 9.9 grams, retinol1 60mg, vitamin C 8mg, calcium 51 milligrams, 69 milligrams, phosphorus, ferrum 1.5 milligrams, also have the cinarine useful to the mankind, asparagine and flavone compound etc.In the curative effect adult contained by arithoke, make us most knowing with foreign Portugal acid (Cynarin), it is a kind of derivant by cinnamic acid.Cynarin can: the vigor improving liver promote to get rid of toxin in liver (as digesting protein the ammonia that produces) promote that the secretion of gallbladder method and the digestion (cholesterol in control agent) of fat are promoted in the regeneration of liver cell.Other curative effect compositions contained by arithoke have: flavonoid bitter principle 50% is wherein that these curative effect materials have auxiliary cynarin the liver protecting and promote the function of liver toxin expelling.And flavone compound has useful physiological effect.Suitable effect is had to malignant cell.Mitigation is had to blood vessel purpura.Normal food arithoke has treatment chronic hepatitis, reduces gallbladder alcohol and treatment dyspepsia, improves gastrointestinal function, increases effect of the secretion of gallbladder method and constipation, diarrhoea, Nausea and vomiting etc., stimulate the secretion of gallbladder method, have the function preventing arteriosclerosis, protection painstaking effort.

Radix Codonopsis, campanulaceae Codonopsis plant, root can be used as medicine.Mild in medicine property, sweet in the mouth.Chemical composition is containing sterols, and alkaloid, still contains triterpenes, multiple inorganic elements and aminoacid etc.There is the easy gas of invigorating middle warmer, spleen invigorating lung benefiting, defying age, the effects such as antioxidation.Have a delicate constitution, shallow complexion, deficiency of spleen-QI and stomach-QI, tired, anorexia and loose stool, chronic diarrhea, insufficiency of lung-QI, cough tachypnea, is easy to flu; Qi and blood deficiency person should eat.This medicine can enhancing body resistance, has the function strengthening antibody produced cell.The function of invigorating the spleen and benefiting QI and immunity moderation system is played in Drug therapy skin pigment depigmentation of the present invention and leukodermic process.

Fructus Lycii, bitter in the mouth; Sweet; Cool in nature; Return liver; Spleen; Kidney channel.Chemical analysis: the mature fruit of lycium barbarum contains betanin, atropine, hyoscyamine.Again containing Semen Maydis xanthin, physalin, kryptoxanthin, scopoletin, carotene, thiamine, riboflavin, nicotinic acid, vitamin C.Seed is containing aminoacid: aspartic acid, proline, alanine, leucine, phenylalanine, serine, glycine, glutamic acid, cysteine, lysine, arginine, isoleucine, threonine, histidine, cruel propylhomoserin, tryptophan, methionine.Also containing elements such as potassium, calcium, sodium, zinc, ferrum, copper, chromium, strontium, lead, nickel, cadmium, cobalt, magnesium.The another polysaccharide containing the effect of tool Promote immunity, content is 7.09%.Again containing taurine, γ-aminobutyric acid.Fructus Lycii, profit and nourishing, doublely can bring down a fever, and specially in the kidney invigorating, lung moistening, promote the production of body fluid, QI invigorating, be the key medicine of Liver and kidney kidney-YIN being deficient, tired interior-heat tonification.Old man deficiency of YIN person ten seven or eight, therefore that to take house be benefit astute day is top grade.Its energy spermatogenesis QI invigorating of the many meanings of former times people, except yin asthenia generating intrinsic heat improving eyesight person.Lid heat is moved back then cloudy raw, and cloudy raw then essence and blood is from long, and liver opening at eye, Heisui River God Light belongs to kidney, and two dirty cloudy gas gains, then order is self-evident.

Radix Glycyrrhizae, another name: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25 ~ 100 centimetres, diameter 0.6 ~ 3.5 centimetre.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc.Happiness is dark moist, the low dry climate of long temperature at sunshine.The many growths of Radix Glycyrrhizae are in arid, semiarid desert steppe, desert edge and loess hill area.Root and Rootstock hyoscine.Radix Glycyrrhizae is the Chinese medicine applied simply widely, has many-sided effects such as invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, eliminating fire and detoxication, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Modern medicine study shows, Radix Glycyrrhizae has antiviral, antiinflammatory, effect of protecting the liver, can be used for treating insufficiency of the spleen, cough and asthma, laryngopharynx swelling and pain, carbuncle pyogenic infections from tumour or sore etc.

Radix Angelicae Sinensis, Umbelliferae archangel, its root can be used as medicine.The property of medicine is sweet, pungent, temperature.Having enriches blood invigorates blood circulation, and menstruction regulating and pain relieving moisturizes the effect such as laxation, immunity.Its chemical composition is containing other compositions such as volatile oil, organic acid and urine purines.In Drug therapy skin pigment depigmentation of the present invention and leukodermic process, there is blood circulation promoting, and regulate and recover the effect of immunologic function.

Herba Dendrobii, another name iron sheet is blue, Herba hedyotis costatae; Stem is cylindrical, high 15 ~ 50cm, thick 4 ~ 8mm.Sheath band meat, square round shape lanceolar, long 3 ~ 6.5cm, wide 0.8 ~ 2cm, top is hook slightly.Raceme is born in tool leaf or the middle part without base of leaf, spends 2 ~ 4; Flower pistac, slightly fragrance; Long 1.2 ~ the 2cm of sepal; Petal is shorter than sepal, lip ovum shape lanceolar, the wide 7 ~ 9mm of long 1.3 ~ 1.6cm, and tip is point or short gradually point gradually, has circular purple speckle, have yellow corpus callosum in the middle of nearly bottom in the middle of nearly top.4 ~ June of florescence.

Radix Pseudostellariae, sweet; Micro-hardship; Cold nature.Effect: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus, palpitation with a distress feeling, edema, quenches one's thirst, metal fatigue.For the lack of appetite asthenia of deficiency-weakness of spleen-QI, deficiency of stomach-Yin; The deficiency of the lung cough caused by dryness of deficiency of vital energy Tianjin wound and cardiopalmus sleeplessness, deficiency-heat hyperhidrosis.Be usually used in weakness of the spleen and stomach, shy at fatigue and weakness, inappetence, dry cough few expectorant, after being ill body void, night sweat, night cry, Infantile Summer Fever etc., have the effect of tonifying QI to produce body fluid.

Rhizoma Curculiginis, bitter, light, cold in nature.Master enters liver, kidney, small intestinal three warp.Have anticancer, removing toxic substances, refrigerant, antipyretic dissipating blood stasis, the effects such as eliminating carbuncle, cure mainly various cancer, and comprising intestinal cancer, gastric cancer, hepatocarcinoma, rectal cancer etc. has good effect.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

Herba Hedyotidis Diffusae, sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

compositions E:

Flos Carthami, belongs to Compositae, Flos Carthami platymiscium, and can be used as medicine, the property of medicine is pungent, temperature.Its chemical composition comprises red with pigment that is yellow, Polyphenols, 18 kinds of volatile ingredients, various saccharides and acids.Can be used for promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, contribute to controlling amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection swell and ache.In Drug therapy skin pigment depigmentation of the present invention and leukodermic process, mutually coordinate with other components, promoting the circulation of blood blood stasis dispelling can be played, promote the effect of local blood circulation.

Rhizoma Zingiberis Recens, CORTEX ZINGIBERIS RHIZOMAE is pungent cool, controls skin edema, the row severe edema due to hypofunction of the spleen; The pungent temperature of Rhizoma Zingiberis Recens juice, pungent loose cold syndrome of the stomach strength is strong, is used for vomiting; The pungent temperature of Rhizoma Zingiberis, warming middle-JIAO is instigated cold, and recuperating depleted YANG is promoted blood circulation, and warming the spleen trembles with fear strength greatly, and Rhizoma Zingiberis Preparatum acrid in the mouth hardship does not walk table in walking, and the warm part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is cold; Carbonized Rhizoma Zingiberis (processed) is warm in nature, and relatively homoiothermy divides cold; The bitter temperature of Roast Rhizoma Zingiberis Recens, relatively warming intestines and stomach is cold.Pungent and the loose temperature of Rhizoma Zingiberis Recens, strengthening the spleen stomach, kind warming middle-JIAO to send down the adverse QI preventing or arresting vomiting, dehumidify the painful abdominal mass that disappears, and eliminating phlegm and stopping cough take stopping nausea and vomiting by lowering the adverse flow of QI as length.

Rhizoma Alpiniae Officinarum, acrid in the mouth, hot in nature.Return spleen, stomach warp.Fruit hyoscine, claims Fructus Galangae, have dry, cold expelling, the function of being amusing, helping digestion.Rhizome is hyoscine also, claims Rhizoma Alpiniae Galangae, acrid in the mouth, hot in nature, energy cold expelling, warming the stomach, pain relieving, and for stomachache with cool feeling, spleen-cold syndrome is vomited and diarrhoea.

DASHENJINCAO, expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation.Control anemofrigid-damp arthralgia, joint aches, skin numbness, tetraparesis, edema, traumatic injury.Herba Lycopodii is the whole herb with root of Lycopodiaceae herbaceous plant Lycopodium clavatum.Because it has relaxing muscles and tendons and activating QI and blood in the collateral effect, therefore obtain this name.Herba Lycopodii has expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons to promote blood circulation effect, and has certain hypotensive effect.

Radix Saposhnikoviae, umbelliferae Saposhnikovia divaricata, its root is used as medicine, and the property of medicine is pungent, sweet, tepor.The coloured ketones component of its chemical composition, Coumarins composition, polyacetylene class, volatile oil and paddy steroid etc.Can be used for rubella pruritus, insufficiency of the spleen leading to overabundance of dampness, diseases caused by exogenous pathogenic factor sign etc.Invigorating the spleen and benefiting QI is had and effects such as resolving depression of regulating the flow of vital energy in Drug therapy skin pigment depigmentation of the present invention and leukodermic process.

composition F:

Olive oil, be the natural fruit oil juice extracted by physical cold squeezing process with Fructus oleae europaeae fresh fruit, be rich in vitamin, mineral, protein, essential fatty acid, particularly unsaturated fatty acid, be rich in vitamin A. D. E, K, F, these are all the fatsoluble vitamiies being easy to be absorbed by the skin.Especially the content of vitamin E, containing 8 milligrams in every 100 grams of olive oil, is that in all plants, content is the highest.History in several thousand is had at Mediterranean Region.Due to edible health and its cosmetic values of olive oil uniqueness, be described as " liquid golden " in west, " vegetable oil queen ", " Mediterranean manna ".

Flos Rosae Rugosae, resolving depression of regulating the flow of vital energy, promoting blood circulation to remove blood stasis, menstruction regulating and pain relieving, calmness, pacifies stabilizing the emotions, antidepressant, diuresis, mitigation the intestines and stomach, looks improving and the skin nourishing.For stomachache due to hyperactive liver-QI attacking the stomach, spitting of blood of spitting blood, menoxenia, leucorrhea with red and white discharge, dysentery, the diseases such as toxic swelling.Containing 300 various chemical components in Flos Rosae Rugosae, as the alcohol of fragrance, aldehyde, fatty acid, phenol and containing the oil of essence and fat, to wake up stomach with easing the affected liver in normal food Flos Rosae Rugosae goods, have a respite and invigorate blood circulation, looks improving and the skin nourishing, make us refreshing refreshing.

In the present invention, the preparation method of the medicine of described treatment cutaneous pigmentation is:

By 20 ~ 50g Herba Centellae, 8 ~ 30g L-vitamin C, 5 ~ 15g Radix Paeoniae Alba, 1 ~ 10g Semen Coicis, 1 ~ 10g Margarita powder, 1 ~ 10g Rhizoma Dioscoreae, 1 ~ 5g Phymatopsis hastata (Thunb.) Kitag., 0.5 ~ 0.8g Herba Duchesneae Indicae, 1 ~ 5g Herba Xanthii grass, 1 ~ 2.5g Folium piperis betlis, 2 ~ 5g India skullcap, carry out respectively cleaning, pulverize, sieve; Then the ethanol-water solution adding 3 ~ 15 times is together solvent (mass fraction 60% of ethanol), under 30 ~ 50 DEG C of conditions, soak 4 ~ 10 hours, then 20 ~ 30 DEG C, ultrasonic power be the condition of 100 ~ 600W under supersound extraction 1 ~ 10h, solids removed by filtration, extraction obtains separation and purification after extracting solution, is designated as compositions A;

By 10 ~ 30g oligopeptide, 5 ~ 15g hyaluronic acid, 1 ~ 10g nano-collagen, 5 ~ 20g Fructus Psoraleae, pulverize after clean; Then being solvent (mass fraction 60% of ethanol) with ethanol-water solution, is supersound extraction 10 ~ 60min under the condition of 100 ~ 600W at ultrasonic power, solids removed by filtration, and extraction obtains separation and purification after extracting solution, is designated as compositions B;

Adopt supercritical carbon dioxide extraction method, 0.1 ~ 0.3g Fructus Toosendan, 3 ~ 5g Radix Morindae Officinalis, 3 ~ 6g Fructus Rosae Laevigatae are totally pulverized afterwards, load extraction kettle, extraction 2 ~ 4h under the condition of temperature 20 ~ 35 DEG C with pressure 18 ~ 25MPa, resolution temperature is set to 42-53 DEG C, and parsing pressure is 5-7MPa, merges extract, mix homogeneously, obtains compositions C.

1 ~ 5g arithoke, 5 ~ 10g Radix Codonopsis, 2 ~ 5g Fructus Lycii, 2 ~ 5g Radix Glycyrrhizae, 2 ~ 5g Radix Angelicae Sinensis, 5 ~ 12g Herba Dendrobii, 5 ~ 12g Radix Pseudostellariae, 1 ~ 3g Rhizoma Curculiginis, 2 ~ 5g Herba Hedyotidis Diffusae, 1 ~ 2.5g Folium piperis betlis are totally pulverized afterwards; Then being solvent (mass fraction 60% of ethanol) with ethanol-water solution, is supersound extraction 10 ~ 60min under the condition of 100 ~ 600W at ultrasonic power, solids removed by filtration, and extraction obtains separation and purification after extracting solution, is designated as compositions D;

Adopt supercritical carbon dioxide extraction method, by 10 ~ 20g Flos Carthami, 3 ~ 6g Rhizoma Zingiberis Recens, 2 ~ 4g Rhizoma Alpiniae Officinarum, 2 ~ 5g DASHENJINCAO, 1 ~ 3g Radix Saposhnikoviae, pulverize after clean, load extraction kettle, extraction 2 ~ 4h under the condition of temperature 20 ~ 35 DEG C with pressure 18 ~ 25MPa, resolution temperature is set to 37 ~ 53 DEG C, parsing pressure is 4 ~ 8MPa, merge extract, mix homogeneously, obtains compositions E.

After being squeezed the juice by 8 ~ 12g Flos Rosae Rugosae, getting its liquid, be then placed in container with 5 ~ 10g olive oil, is supersound extraction 20 ~ 50min under the condition of 300 ~ 500W at ultrasonic power, solids removed by filtration, and extraction obtains separation and purification after extracting solution, is designated as composition F.

At 25 DEG C, by compositions A, compositions B, compositions C, compositions D, compositions E, composition F, after stirring, mixed dissolution, the medicine of the cutaneous pigmentation that obtains medical treatment.

Supercritical carbon dioxide extraction method has that Extracting temperature is low, extraction ratio is high, solvent load is few and without advantages such as the three wastes, is a kind of eco-friendly extracting method.

Ultrasonic extraction principle utilizes ultrasound wave to produce in a liquid " cavitation ".Destroy plant cell and membrane structure, thus increase cellular content by the penetration capacity of cell membrane, contribute to release and the stripping of effective ingredient; Ultrasound wave makes extracting solution constantly shake, and contributes to solutes accumulation, and hyperacoustic heat effect makes water temperature substantially at 57 DEG C simultaneously, has water-bath effect, shortens extraction time, improve the extraction rate of effective ingredient and the utilization rate of raw material to raw material.Ultrasonic extraction is simple and efficient to handle, without the need to heating, extraction rate is high, speed is fast, the structure of extract is not destroyed, effective, demonstrates obvious advantage.

In one embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions A, the weight ratio of Herba Centellae and Phymatopsis hastata (Thunb.) Kitag. is 40:3.

In one embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions C, the weight ratio of Fructus Toosendan, Radix Morindae Officinalis is 0.2:3.

In one embodiment, the medicine of described treatment cutaneous pigmentation, is characterized in that,

In described compositions A, the parts by weight of each material are: Herba Centellae 30 ~ 45, L-vitamin C15 ~ 25, the Radix Paeoniae Alba 5 ~ 10, Semen Coicis 5 ~ 10, Margarita powder 3 ~ 8, Rhizoma Dioscoreae 3 ~ 8, Phymatopsis hastata (Thunb.) Kitag. 2 ~ 4, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 3, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 15 ~ 25, hyaluronic acid 5 ~ 10, nano-collagen 3 ~ 8, Fructus Psoraleae 5 ~ 12;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

In a preferred embodiment, the medicine of described treatment cutaneous pigmentation, in described compositions A, the parts by weight of each material are: Herba Centellae 40, L-vitamin C20, the Radix Paeoniae Alba 8, Semen Coicis 9, Margarita powder 8, Rhizoma Dioscoreae 7, Phymatopsis hastata (Thunb.) Kitag. 3, Herba Duchesneae Indicae 0.7, Herba Xanthii grass 3, Folium piperis betlis 2, India skullcap 3;

In described compositions B, the parts by weight of each material are: oligopeptide 20, hyaluronic acid 8, nano-collagen 7, Fructus Psoraleae 8;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.2, Radix Morindae Officinalis 3, Fructus Rosae Laevigatae 5;

In described compositions D, the parts by weight of each material are: arithoke 3, Radix Codonopsis 6, Fructus Lycii 5, Radix Glycyrrhizae 5, Radix Angelicae Sinensis 4, Herba Dendrobii 10, Radix Pseudostellariae 9, Rhizoma Curculiginis 3, Herba Hedyotidis Diffusae 4, Folium piperis betlis 2;

In described compositions E, the parts by weight of each material are: Flos Carthami 12, Rhizoma Zingiberis Recens 5, Rhizoma Alpiniae Officinarum 3, DASHENJINCAO 4, Radix Saposhnikoviae 2;

In described composition F, the parts by weight of each material are: olive oil 8, Flos Rosae Rugosae 10.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described compositions A also comprises the Radix Oryzae Glutinosae of 1 ~ 10 weight portion.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described compositions A also comprises the Herba Ophioglossi of 1 ~ 3 weight portion.

In a preferred embodiment, in the medicine of described treatment cutaneous pigmentation, described oligopeptide is selected from: the combination of one or more in oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6, oligopeptide-10, Matrixyl-3, palmityl tripeptides-1, palmityl tripeptides-5, Semen Myristicae pentapeptide-11.

Another aspect of the present invention relates to a kind of oral liquid for oral administration, with 200 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 3 ~ 20 weight portions, the compositions B of 1 ~ 10 weight portion, 1 ~ 5 weight portion, the compositions D of 30 ~ 100 weight portions, the compositions E of 1 ~ 5 weight portion, the composition F of 1 ~ 10 weight portion, the brown sugar of 5 ~ 10 weight portions, excess water.

In a preferred embodiment, oral liquid for oral administration, with 200 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 10 ~ 16 weight portions, the compositions B of 3 ~ 7 weight portions, 3 ~ 5 weight portions, the compositions D of 50 ~ 80 weight portions, the compositions E of 3 ~ 5 weight portions, the composition F of 5 ~ 8 weight portions, the brown sugar of 5 ~ 10 weight portions, excess water.

In one embodiment, the manufacture method of described oral liquid for oral administration is:

(1) at 25 ~ 40 DEG C, by the composition F of the compositions E of the compositions D of the compositions C of the compositions B of the compositions A of 3 ~ 20 weight portions, 1 ~ 10 weight portion, 1 ~ 5 weight portion, 30 ~ 100 weight portions, 1 ~ 5 weight portion, 1 ~ 10 weight portion, excess water mix and blend 1 ~ 3h;

(2) mixed solution will obtained in step (1), is cooled to room temperature, adds the brown sugar of 5 ~ 10 weight portions, after filtration, sterilization, fill, to obtain final product.

The using method of above-mentioned oral liquid for oral administration is: adult respectively drinks once every day sooner or later, each 200 ~ 500mL, each 100 ~ 300mL of child.

Ratio and each step of each component in the preparation method of oral liquid for oral administration of the present invention all have beneficial effect to effect of drugs.The present inventor finds unexpectedly, and oral liquid for oral administration of the present invention can play the activity of restraint of tyrosinase, thus the synthesis of check melanin.In addition, oral liquid for oral administration of the present invention has multiple compound vitamin, the melanic effect of fast decoupled can be played, in addition, oral liquid for oral administration of the present invention can also strengthening by means of tonics, nourish the five internal organs, strengthen resistance of human body, delicious, absorb fast.Thus, beneficial effect of the present invention is provided.

Another aspect again of the present invention relates to a kind of external application ointment, with 100 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 15 ~ 45 weight portions, the compositions B of 5 ~ 25 weight portions, 1 ~ 5 weight portion, the compositions D of 3 ~ 15 weight portions, the compositions E of 0.5 ~ 3 weight portion, the composition F of 1 ~ 5 weight portion.

In a preferred embodiment, described external application ointment, with 100 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 30 ~ 40 weight portions, the compositions B of 10 ~ 20 weight portions, 2 ~ 4 weight portions, the compositions D of 5 ~ 12 weight portions, the compositions E of 1 ~ 2 weight portion, the composition F of 2 ~ 4 weight portions.

In a preferred embodiment, the manufacture method of described external application ointment is: at 20 ~ 45 DEG C, by weight proportion by compositions A, compositions B, compositions C, compositions D, compositions E, composition F, and mix and blend 1 ~ 5h; After being uniformly mixed, load ointment box subpackage for subsequent use.

Ratio and each step of each component in the preparation method of ointment of the present invention all have beneficial effect to effect of drugs, above-mentioned steps is adopted to adopt different processing methods to each compositions, the abundant stripping of effective ingredient in each drug component of guarantee, and effectively fully interact with other associated pharmaceutical component, after making outer painting ointment, to melanin, there is good therapeutic effect.

The using method of above-mentioned outer painting ointment is: on skin after the cleaning, directly the above-mentioned ointment of outer painting, and every day is respectively coated with once sooner or later; After being coated with ointment, and suitably massage 3 ~ 5min, effect is better.

Below by embodiment, the present invention is specifically described.What be necessary to herein means out is; following examples are only for the invention will be further described; limiting the scope of the invention can not be interpreted as; some nonessential improvement and adjustment that the professional and technical personnel in this field makes according to the content of the invention described above, still belong to protection scope of the present invention.

In addition, if do not have other to illustrate, raw material of Chinese medicine used is all commercially available, is all purchased from the Shanghai hospital of traditional Chinese hospital, and following material number used is weight portion.

Embodiment

Table 1 is the parts by weight of each material composition in compositions A; Table 2 is the parts by weight of each material composition in compositions B; Table 3 is the parts by weight of each material composition in compositions C; Table 4 is the parts by weight of each material composition in compositions D; Table 5 is the parts by weight of each material composition in compositions E; Table 6 is the parts by weight of each material composition in composition F; Table 7 is content of material composition in oral liquid embodiment for oral administration; Table 8 is content of material composition in outer painting ointment embodiment.

The parts by weight of each material composition in table 1 compositions A

The parts by weight of each material composition in table 2 compositions B

The parts by weight of each material composition in table 3 compositions C

The parts by weight of each material composition in table 4 compositions D

The parts by weight of each material composition in table 5 compositions E

The parts by weight of each material composition in table 6 composition F

Adopt medicine of the present invention, between 2011 to 2014 years, treat patient 60 example between 13 years old to 60 years old altogether, wherein male 30 example, male face all has sunburn; Women 30 example, female face all has chloasma.Age, the patient between 30 ~ 50 years old accounted for 60% of total quantity, totally 40 examples.Treating by medicine of the present invention, six months is a course for the treatment of, different with medicining condition according to the state of an illness, the treatment number course for the treatment of be 2 ~ 6 courses for the treatment of not etc.In following examples, each embodiment is a man and a woman patient consumes, to test the curative effect of this medicine.

The criterion of cutaneous pigmentation therapeutic effect is as follows:

1 recovery from illness: the part of cutaneous pigmentation disappears completely, and overall skin is healthy.

2 significant curative effects: cutaneous pigmentation area more than 85% pigment disappear, and overall skin is healthy.

3 is effective: cutaneous pigmentation area more than 50% pigment disappear, and overall skin is healthy.

4 without obvious effect: cutaneous pigmentation area does not change, and overall skin is healthy.

With in 60 routine patients of Drug therapy of the present invention, patient fully recovers all.

Table 7 takes oral liquid constituent content table (200 parts by weight) orally

Table 8 ointment constituent content table (100 parts by weight)

Above-described embodiment is only illustrative, for explaining some characteristic sum application modes of medicine of the present invention, can not be used for limiting the present invention, appended claim is intended to the scope wide as far as possible that requirement it is contemplated that, term as used in the claims " comprises " and the variant of its meaning of one's words in theory also comprises different expression waies, such as but not limited to " it consists of ".Embodiment as herein described is only the embodiment that part is possible.Therefore, the claim appended by the present invention is not limited by described example.Some numerical rangies used in the claims also include the subrange within it, and the change in these scopes also should be interpreted as being covered by appended claim in the conceived case.

Claims (10)

1. treat a medicine for cutaneous pigmentation, it is characterized in that, it comprises compositions A, compositions B, compositions C, compositions D, compositions E and composition F;

In described compositions A, the parts by weight of each material are: Herba Centellae 20 ~ 50, L-vitamin C8 ~ 30, the Radix Paeoniae Alba 1 ~ 10, Semen Coicis 1 ~ 10, Margarita powder 1 ~ 10, Rhizoma Dioscoreae 1 ~ 10, Phymatopsis hastata (Thunb.) Kitag. 1 ~ 5, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 5, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 10 ~ 30, hyaluronic acid 5 ~ 15, nano-collagen 1 ~ 10, Fructus Psoraleae 5 ~ 20;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

2. treat the medicine of cutaneous pigmentation as claimed in claim 1, it is characterized in that, in described compositions A, the weight ratio of Herba Centellae and Phymatopsis hastata (Thunb.) Kitag. is 40:3.

3. treat the medicine of cutaneous pigmentation as claimed in claim 1, it is characterized in that, in described compositions C, the weight ratio of Fructus Toosendan, Radix Morindae Officinalis is 0.2:3.

4. treat the medicine of cutaneous pigmentation as claimed in claim 1, it is characterized in that, in described compositions A, the parts by weight of each material are: Herba Centellae 30 ~ 45, L-vitamin C15 ~ 25, the Radix Paeoniae Alba 5 ~ 10, Semen Coicis 5 ~ 10, Margarita powder 3 ~ 8, Rhizoma Dioscoreae 3 ~ 8, Phymatopsis hastata (Thunb.) Kitag. 2 ~ 4, Herba Duchesneae Indicae 0.5 ~ 0.8, Herba Xanthii grass 1 ~ 3, Folium piperis betlis 1 ~ 2.5, India skullcap 2 ~ 5;

In described compositions B, the parts by weight of each material are: oligopeptide 15 ~ 25, hyaluronic acid 5 ~ 10, nano-collagen 3 ~ 8, Fructus Psoraleae 5 ~ 12;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.1 ~ 0.3, Radix Morindae Officinalis 3 ~ 5, Fructus Rosae Laevigatae 3 ~ 6;

In described compositions D, the parts by weight of each material are: arithoke 1 ~ 5, Radix Codonopsis 5 ~ 10, Fructus Lycii 2 ~ 5, Radix Glycyrrhizae 2 ~ 5, Radix Angelicae Sinensis 2 ~ 5, Herba Dendrobii 5 ~ 12, Radix Pseudostellariae 5 ~ 12, Rhizoma Curculiginis 1 ~ 3, Herba Hedyotidis Diffusae 2 ~ 5, Folium piperis betlis 1 ~ 2.5;

In described compositions E, the parts by weight of each material are: Flos Carthami 10 ~ 20, Rhizoma Zingiberis Recens 3 ~ 6, Rhizoma Alpiniae Officinarum 2 ~ 4, DASHENJINCAO 2 ~ 5, Radix Saposhnikoviae 1 ~ 3;

In described composition F, the parts by weight of each material are: olive oil 5 ~ 10, Flos Rosae Rugosae 8 ~ 12.

5. treat the medicine of cutaneous pigmentation as claimed in claim 1, it is characterized in that,

In described compositions A, the parts by weight of each material are: Herba Centellae 40, L-vitamin C20, the Radix Paeoniae Alba 8, Semen Coicis 9, Margarita powder 8, Rhizoma Dioscoreae 7, Phymatopsis hastata (Thunb.) Kitag. 3, Herba Duchesneae Indicae 0.7, Herba Xanthii grass 3, Folium piperis betlis 2, India skullcap 3;

In described compositions B, the parts by weight of each material are: oligopeptide 20, hyaluronic acid 8, nano-collagen 7, Fructus Psoraleae 8;

In described compositions C, the parts by weight of each material are: Fructus Toosendan 0.2, Radix Morindae Officinalis 3, Fructus Rosae Laevigatae 5;

In described compositions D, the parts by weight of each material are: arithoke 3, Radix Codonopsis 6, Fructus Lycii 5, Radix Glycyrrhizae 5, Radix Angelicae Sinensis 4, Herba Dendrobii 10, Radix Pseudostellariae 9, Rhizoma Curculiginis 3, Herba Hedyotidis Diffusae 4, Folium piperis betlis 2;

In described compositions E, the parts by weight of each material are: Flos Carthami 12, Rhizoma Zingiberis Recens 5, Rhizoma Alpiniae Officinarum 3, DASHENJINCAO 4, Radix Saposhnikoviae 2;

In described composition F, the parts by weight of each material are: olive oil 8, Flos Rosae Rugosae 10.

6. the medicine for the treatment of cutaneous pigmentation according to claims 1 to 5, is characterized in that, described compositions A also comprises the Radix Oryzae Glutinosae of 1 ~ 10 weight portion.

7. a kind of medicine for the treatment of cutaneous pigmentation according to claim 6, it is characterized in that, described compositions A also comprises the Herba Ophioglossi of 1 ~ 3 weight portion.

8. a kind of medicine for the treatment of cutaneous pigmentation according to claim 7, it is characterized in that, described oligopeptide is selected from: the combination of one or more in oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6, oligopeptide-10, Matrixyl-3, palmityl tripeptides-1, palmityl tripeptides-5, Semen Myristicae pentapeptide-11.

9. an oral liquid for oral administration, is characterized in that, the medicine comprising the treatment cutaneous pigmentation described in any one of claim 1 ~ 8 is prepared from; With 200 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 3 ~ 20 weight portions, the compositions B of 1 ~ 10 weight portion, 1 ~ 5 weight portion, the compositions D of 30 ~ 100 weight portions, the compositions E of 1 ~ 5 weight portion, the composition F of 1 ~ 10 weight portion, the brown sugar of 5 ~ 10 weight portions, excess water.

10. an external application ointment, is characterized in that, the medicine comprising the treatment cutaneous pigmentation described in any one of claim 1 ~ 6 is prepared from; With 100 parts by weight, comprise the compositions of following weight portion: the compositions C of the compositions A of 15 ~ 45 weight portions, the compositions B of 5 ~ 25 weight portions, 1 ~ 5 weight portion, the compositions D of 3 ~ 15 weight portions, the compositions E of 0.5 ~ 3 weight portion, the composition F of 1 ~ 5 weight portion.