CN104147152B - Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof - Google Patents
Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof Download PDFInfo
- Publication number
- CN104147152B CN104147152B CN201410344472.9A CN201410344472A CN104147152B CN 104147152 B CN104147152 B CN 104147152B CN 201410344472 A CN201410344472 A CN 201410344472A CN 104147152 B CN104147152 B CN 104147152B
- Authority
- CN
- China
- Prior art keywords
- weight portion
- radix
- punica granatum
- hydrogel
- quintessence oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses Punica granatum L. quintessence oil hydrogel plaster, be made up of carrier and Chinese medicine ointment；Described Chinese medicine ointment is made up of Folium camelliae assamicae, Semen Cassiae, Folium Nelumbinis, Fructus Crataegi, Semen Phaseoli Vulgaris, Radix Oenotherae erythrosepalae, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and Pu-erh tea essential oil；Described carrier is hydrogel；Described Chinese medicine ointment raw material through boiling, filter, be condensed into cream, obtain Chinese medicine ointment；Then described Chinese medicine ointment being mixed with described hydrogel, final to prepare transdermal absorption factor high, and anaphylaxis rate is low, the Punica granatum L. quintessence oil hydrogel plaster that breast enlargement, effect of enriching blood are the most fairly obvious.
Description
Technical field
The present invention relates to medical health care products field, be specifically related to Punica granatum L. quintessence oil hydrogel plaster and making side thereof
Method.
Background technology
Along with improving constantly of living standard, people the most increasingly pay attention to for the form of self.Have tall and straight,
Plentiful breast is the hope of each women, but truth is that a lot of women is because of various former
Cause, the breast causing self is modest, flat, lax or sagging.
Breast is modest, flat, lax, sagging annoyings many women, and reason can be summarized as three aspects: one,
Girlhood breast development is incomplete；Two, maintain after suckling not in place；Three, before and after climacteric, estrogen divides
Secrete not.Now, the method for breast enlargement substantially has three kinds:
One, operation breast enlargement: the goods such as chest filling gel i.e. reach breast enlargement purpose, breast-enlarging operation needs to cut
Go out wound to put into wadding.Although Augmentation Mammaplasty is the most ripe now, but it is intended on the person dynamic all the time
With operation, as the saying goes that any operation all has certain risk, it is perfectly safe to be difficult to ensure；It is meanwhile, postoperative,
Also need to periodically be corrected operation, both increased Operation Fee, the misery performed the operation again.
Two, dietetic therapy breast enlargement: i.e. by adjusting dietary, use the nutrient substance inside vegetable and reach breast enlargement
Purpose.This kind of breast enlarging method health, has no side effect, but DeGrain.
Three, medicine breast enlargement: this kind of method is divided into again for oral administration and external application, for oral administration i.e. take the medicines such as breast enlargement and carries out
Breast enlargement；External application will be correlated with the drug external breast of breast enlargement to reach breast enlargement purpose.
Currently on the market, having the product of many strong breasts breast enlargement, but mostly be synthetic hormone, its curative effect is owed
Good, life-time service can cause endocrine regulation, damages hepatic and renal function, causes chloasma, acne etc. to damage U.S.'s property
Dermatosis, even induction carcinoma of endometrium and breast carcinoma；Also there are some herbal product, but effect there are no
The most outstanding.Therefore, anxious the most yet-to-be developed go out a to match with female pathology, effect stability, do not harm people
The breast enlargement product that body is healthy.
Number of patent application is the patent of invention of CN201410124138.2, discloses a kind of Chinese medicine composition, bag
Include Flos Rosae Rugosae, Radix Puerariae, Fructus Chaenomelis, Folium Mori, the Radix Astragali and dry Folium Nelumbinis；Although this Chinese medicine composition has certain
Breast enlargement effect, but it is slow to take effect, and medicinal component absorbs low, and breast enlargement effect is not very good.
Summary of the invention
For above the deficiencies in the prior art, the invention provides that breast enlargement effect is obvious, transdermal absorption factor is high,
Medicinal component long action time and the minimum Punica granatum L. quintessence oil hydrogel plaster of side effect and preparation method thereof.
The technical solution used in the present invention is Punica granatum L. quintessence oil hydrogel plaster, is made up of carrier and Chinese medicine ointment,
Described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Punica granatum L. 10～100 weight portion, Fructus Foeniculi XIANGZI
10～100 weight portions, Radix Puerariae 10～100 weight portion, Folium Kaki 10～100 weight portion, Fructus Caricae 10～100
Weight portion, Radix Notoginseng 10～100 weight portion, the Radix Paeoniae Alba 10～100 weight portion, Fructus Ligustri Lucidi 10～100 weight portion,
Radix Angelicae Sinensis 10～100 weight portion, the Radix Astragali 10～100 weight portion, Radix Scutellariae 2～20 weight portion, Radix Glycyrrhizae 2～20 weight
Part, Radix Stephaniae Tetrandrae 2～20 weight portion and Punica granatum L. quintessence oil 4～24 weight portion.
Preferably, described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Punica granatum L. 40～60 weight
Part, Fructus Foeniculi XIANGZI 40～60 weight portion, Radix Puerariae 40～60 weight portion, Folium Kaki 40～60 weight portion, kind
Fructus Chaenomelis 40～60 weight portion, Radix Notoginseng 50～70 weight portion, the Radix Paeoniae Alba 50～70 weight portion, Fructus Ligustri Lucidi 50～70
Weight portion, Radix Angelicae Sinensis 50～70 weight portion, the Radix Astragali 50～70 weight portion, Radix Scutellariae 8～12 weight portion, Radix Glycyrrhizae 8～12
Weight portion, Radix Stephaniae Tetrandrae 8～12 weight portion and Punica granatum L. quintessence oil 10～14 weight portion.
Preferably, in order to improve the transdermal absorption factor of this lowering blood-fat and reducing weight traditional Chinese medicine plaster, described carrier is water-setting
Glue.
Preferably, described hydrogel is made up of following raw material and parts by weight thereof: glycerol 60～600 weight portion,
Sodium polyacrylate 15～150 weight portion, ethylene glycol 5～50 weight portion, polyvinylpyrrolidone 5～50 weight portion,
Crospolyvinylpyrrolidone 1～10 weight portion, xanthan gum 1～10 weight portion, aluminum glycinate 0.1～1 weight portion,
Oxalic acid triethylammonium tetrakis disodium 0.1～1 weight portion, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion,
Imidazoles hydroxyurea 0.05～0.5 weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight
Part and purified water 120～1200 weight portion.
Preferably, described hydrogel is made up of following raw material and parts by weight thereof: described hydrogel is by following former
Material and parts by weight thereof are made: glycerol 200～400 weight portion, sodium polyacrylate 60～80 weight portion, second two
Alcohol 20～40 weight portion, polyvinylpyrrolidone 20～40 weight portion, crospolyvinylpyrrolidone 4～6 weight
Amount part, xanthan gum 4～6 weight portion, aluminum glycinate 0.4～0.6 weight portion, oxalic acid triethylammonium tetrakis disodium 0.4～0.6
Weight portion, tartaric acid 0.4～0.6 weight portion, aluminum sulfate 0.2～0.4 weight portion, imidazoles hydroxyurea 0.2～0.4 weight
Amount part, methyl hydroxybenzoate 0.2～0.4 weight portion, malic acid 0.2～0.4 weight portion and purified water 600～800 weight
Part.
The preparation method of a kind of above-mentioned Punica granatum L. quintessence oil hydrogel plaster, comprises the steps:
A, Punica granatum L. is pulverized and puts in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Punica granatum L. quintessence oil, stand-by；
B, by weight, weigh Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Radix Puerariae, Folium Kaki,
Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described stone
Pomegranate fruit quintessence oil；Then by described Chinese medicine ointment raw material boiling, filter, be condensed into cream, obtain Chinese medicine ointment,
Stand-by；
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinyl pyrrole
Alkanone, crospolyvinylpyrrolidone, xanthan gum, aluminum glycinate, oxalic acid triethylammonium tetrakis disodium, tartaric acid,
Aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water；Then described hydrogel raw material is mixed
Conjunction is mixed thoroughly, obtains hydrogel, stand-by；
D, described Chinese medicine ointment is mixed with described hydrogel, coated, cut into slices, solidify, obtain Punica granatum L.
Quintessence oil hydrogel plaster.
Preferably, so that described Chinese medicine ointment can preferably mix with described hydrogel, described step b
In, the relative proportion of Chinese medicine ointment is 1.15～1.45.
Preferably, in order to get rid of the gas in hydrogel, in described step c, when mixing is mixed thoroughly, use
Equipment be hydrogel de-airing mixer；During mix and blend, pressure is 0.06～0.08Mpa, and temperature is
35～55 DEG C, the time is 54～74min.
Preferably, for the beneficially human body absorption to medicinal active ingredient, in described step d, Chinese medicine ointment
Mass ratio when mixing with hydrogel is 2.5～3.5:18～22.
Punica granatum L., has heat clearing away, hemostasis, effect of dampness, is used for treating hemorrhage, damp-heat syndrome；Punica granatum L.
Polyphenol extract is a class powerful antioxidant, contributes to improving joint elastic force and skin elasticity, strengthening tremulous pulse,
Vein and blood capillary, have good curative effect to the inflammation of arthritis and sport injury；Punica granatum L. fruit oil contains
Having the highly unsaturated fatty acid that substantial amounts of (about 68%) is unique, it is conjugation that this fatty acid is otherwise known as
Fatty acid, because he ought to not exist in the world of plant, this is the hypo-linolenic acid of a kind of deformation, with
Article three, conjugated double bond (punicic acid), the most important composition phytohormone 17 alpha-estradiol.
This is the strongest a kind of antioxidant, has the regulation effect of strength to hormone；But 17 α of Punica granatum L. fruit oil weight-
Estradiol and 17 beta estradiols (estrogen of autologous generation) that can be carcinogenic are different, therefore can swash with female
On the unbalance malignancy disease caused of element；Through phytosterol, flavonoid substances and cupreol (β
-sistosterol, a kind of antiinflammatory agents, it also is able to affect the material of hormone equally) it is respectively provided with the work regulating hormone
With；Meanwhile, natural estrogen 17 alpha-estradiol contained in Punica granatum L., is the He Er with breast enlargement effect
One of cover.
Fructus Foeniculi XIANGZI, has warming kidney for dispelling cold, effect of regulating the stomach to normalize QI；Primary treatment cold syndrome of the stomach is suffered from abdominal pain, colic of cold type is had a pain,
The diseases such as cold syndrome of the stomach poor appetite；It is logical that Fructus Foeniculi XIANGZI dissipates temperature, and in being apt to warm up, lower two is burnt, is especially good at soothing the liver dispersing cold for relieving pain, for
Control colic of cold type key medicine；Fennel essential oil contributes to stimulating development of breast, the secretory function of enhancing prolactin antagonist, and right
For women breast enlargement, U.S. breast, there is certain effect, the size of female chest can be increased, exist simultaneously
Women can improve the more milk of secretion of women in puerperal puerperal well.
Radix Puerariae, having induces sweat brings down a fever, promote the production of body fluid, rash, effect of yang invigorating antidiarrheal, for fever caused by exogenous pathogens headache,
Hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels, it contains " phytoestrogen "
And derivant.Radix Puerariae by promoting mammary gland and acinus to grow to increase, promote fat to pile up at chest,
The aspects such as the elasticity of recovery breast portion skin reach the effect of breast enlargement U.S. breast；Radix Puerariae also have taste body be healthy and strong,
The effects such as defying age, blood pressure lowering, blood sugar lowering, blood fat reducing, increase skin elasticity, skin moistening；Institute's isoflavone-containing in Radix Puerariae
There is skin care, the effect of recovery skin elasticity, it is also possible to slow down the aging of skeletal tissue's cell, help
In calcareous absorption, reduce bone calcium and lose, increase bone density and to stop the hollow of skeleton to disappear molten, thus away from
Osteoporosis；Active component in Radix Puerariae can prevent cardio-cerebrovascular diseases and effectively alleviation climacteric to combine
Close disease, again can life lengthening, improve health, be female middle-aged daily health caring, the ideal improved the quality of living
Select.It will be appreciated that women often eats Radix Puerariae, breast development can be promoted to increase, this is exactly mainly
The contribution of isoflavone.
Fructus Caricae, have suppressing the hyperactive liver and easing the stomach, relaxing muscles and tendons network, live muscles and bones, effect of blood pressure lowering, for strengthening the spleen to promote digestion,
Anti-epidemic disease parasite killing, lactogenesis are anticancer, extra-nutrition, improve resistance against diseases, spasmolytic.Chymosin in Fructus Chaenomelis has
Lactogenesis effect, carpaine has a merit of antiangiogenic property leukemia, therefore can be used for lactogenesis and treat lymphocytic in vain
Disorders of blood (leukemia).
Folium Kaki, in addition to containing appreciable protein, aminoacid and multivitamin, possibly together with being higher than
Several times of the ordinary tea leaves even natural Vc of tens times, and the 17 of rutin, choline, flavonoid glycoside and needed by human
Kind of amino acid whose content is also high tens times than water fruits and vegetables, common beverages.Natural Vc promotes that human body is the oldest
Metabolism, has certain curative effect to vitamin C deficiency, cardiovascular diseases and cancer etc.；Rutin, choline have vessel softening, prevent
The only effect of arteriosclerosis；Flavonoid glycoside can reduce blood pressure, increase blood flow volume, has golden yellow staphylococcus
Significantly inhibitory action.
Radix Notoginseng, has effect of hemostasis, dissipating blood stasis, detumescence, analgesic therapy, cures mainly haematemesis, hemoptysis, epistaxis, just
Blood, dysentery, metrorrhagia, abdominal mass, puerperal blood faints, retention of lochia, fall flutter blood stasis, traumatic hemorrhage, carbuncle pain
Bitterly.Modern pharmacology: (1) has good hemostasia effect, significant hemopoietic function；(2) hat can be tightened and improved
Faint pulse circulates, the effect of expansion blood vessel；(3) have stronger analgesic activity, have resisting fatigue, improve study and
The effect of memory ability；(4) anti-inflammatory effect；(5) there is the effect of immunomodulator, can make too high or too low
Immunoreation return to normally, but the not normal immunoreation of interference body；(6) antitumor action；(7) anti-
Old and feeble, antioxidation；(8) blood fat and cholesterol effect are reduced；(9) the liver protecting.
The Radix Paeoniae Alba, has nourishing blood to suppress the hyperactive liver, slow middle pain relieving, effect of yin fluid astringing receipts antiperspirant, controls the chest and abdomen pain over the hypochondriac region, rushes down
Dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia；Paeoniflorin has significant antiinflammatory
Effect.
Fructus Ligustri Lucidi, has nourishing YIN and benefiting blood, effect of easing the affected liver improving eyesight, cure mainly the dizziness of deficiency of the liver and kindey, tinnitus,
The diseases such as mesh paste, weak, early whitening of hair；Drum, III type, type Ⅳ allergy are all had significantly by Fructus Ligustri Lucidi
Inhibitory action.This product has obvious inhibitory action to Experimental Inflammation, and its anti-inflammatory mechanisms is: 1. activate hypophysis
One interrenal system, promotes the release of 17-hydroxy-11-dehydrocorticosterone；2. reduce generation and the release of prostaglandin, press down
The increase of the vascular permeability that the inflammatory mediators such as histamine processed cause.
Radix Angelicae Sinensis, have enrich blood, invigorate blood circulation, effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation；Cure mainly blood deficiency, blood stasis all
Disease, dizziness and headache, cardiopalmus limb fiber crops, menoxenia, amenorrhea, dysmenorrhea, metrorrhagia, knot are poly-, asthenia cold abdominalgia,
Weight, dryness of the intestine dyschezia, treating swelling and pain by traumatic injury, ulcer sores after flaccidity syndrome and arthralgia syndrome, bloody dysentery.
The Radix Astragali, has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation, weak for the deficiency of vital energy,
Anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty burst,
Burst for a long time do not hold back, blood deficiency dull yellowish colored skin, interior-heat are quenched one's thirst, chronic nephritis proteinuria, diabetes.
Radix Scutellariae, has that heat clearing and damp drying, removing heat from blood be antiabortive, effect of removing toxic substances, cures mainly epidemic febrile disease, upper respiratory tract sense
Dye, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle
The diseases such as furuncle skin ulcer, baicalin has (1) antiinflammatory, antiallergic, antiallergic action, protection sclerotin；(2) antipyretic,
Removing toxic substances and antipathogen；(3) function of gallbladder promoting, protect the liver and blood fat reducing；(4) calmness, blood pressure lowering, spasmolytic, diuresis, anticoagulant；
(5) antioxidation, anti-cataract, anticancer.
Radix Glycyrrhizae, has invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, relieving spasm to stop pain, the mitigation property of medicine, effect of coordinating the actions of various ingredients in a prescription,
Radix Glycyrrhizae agent has the function of antiinflammatory and antiallergic action；Radix Glycyrrhizae or enoxolone have desoxycortone class effect；Sweet
The flavone of grass has antiinflammatory, spasmolytic and antiacid effect.
Radix Stephaniae Tetrandrae, tetrandrine have antiallergic (tetrandrine is an Anaphylactic mediator antagonist,
Be again an Anaphylactic mediator blocker, anaphylaxis had reliably antagonism and therapeutical effect), resisting hypertension
Deng effect.
Punica granatum L. quintessence oil, has different physiological roles, has the Transdermal absorption promoting active component, tool simultaneously
There is the strongest penetration power.
The beneficial effects of the present invention is: use above Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Herba Gelsemii Elegantis
Root, Folium Kaki, Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, the Chinese
The Chinese medicine ointment that Radix Stephaniae Tetrandrae and Punica granatum L. quintessence oil and production technology produce, because utilize is the antiinflammatory one-tenth of pure plant
Point, so while having breast enlargement, effect of enriching blood, side effect is minimum, allergy rate is extremely low；Meanwhile, will
After described Chinese medicine ointment mixes with the hydrogel using above specific components and production technology to produce, the stone prepared
Pomegranate fruit hydrogel note, has efficient transdermal absorption factor so that medical active composition can enter human body in a large number；
Meanwhile, the oral side effect caused is not only reduced, moreover it is possible to make part medical active composition not by liver
First pass effect and inactivate, so that active ingredient reaches higher bioavailability.
Detailed description of the invention
For making those skilled in the art understand technique effect and the production technology thereof of the present invention in detail, below with tool
The production instance of body is further described application and the technique effect of the present invention.
Embodiment 1
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 100g, Fructus Foeniculi XIANGZI 100g, Radix Puerariae 100g, Folium Kaki 100g, Fructus Caricae 100g,
Radix Notoginseng 100g, Radix Paeoniae Alba 100g, Fructus Ligustri Lucidi 100g, Radix Angelicae Sinensis 100g, Radix Astragali 100g, Radix Scutellariae 20g, sweet
Grass 20g, Radix Stephaniae Tetrandrae 20g and the Punica granatum L. quintessence oil 40g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., the most past
Described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 5300g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, keeping boiling 3.5h
After, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil the 5300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；
Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, filtration at once；By gained filtering residue
During 2 insert again and boil and irrigate by lifting water to a higher level with a water pump, etc., then boil the 5300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating irrigate by lifting water to a higher level with a water pump, etc. to fill in molten
Liquid seethes with excitement, and after keeping boiling 3.5h, filters at once；Three gained filtrates are merged, loads in concentration tank
Concentrate, until its relative proportion is 1.2, obtain Chinese medicine ointment finished product 520g；It is cooled to room temperature, adds
5.2g ethanol, carries out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 600g, sodium polyacrylate 150g, ethylene glycol 50g, polyvinylpyrrolidone 50g, friendship
Connection polyvinylpyrrolidone 10g, xanthan gum 10g, aluminum glycinate 1g, oxalic acid triethylammonium tetrakis disodium 1g, wine
Stone acid 1g, aluminum sulfate 0.5g, imidazoles hydroxyurea 0.5g, methyl hydroxybenzoate 0.5g, malic acid 0.5g and purified water
1200g., then mix homogeneously, then insert in hydrogel de-airing mixer and stir；During stirring, pressure is
0.05Mpa, temperature is 30 DEG C, after 50min, obtains hydrogel 1930g, stand-by.
4, the preparation of finished product:
Weigh described hydrogel 1930g and Chinese medicine ointment 270g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 66 hours, and solidification, get product Punica granatum L. quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 2
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 250g, Fructus Foeniculi XIANGZI 250g, Radix Puerariae 250g, Folium Kaki 250g, Fructus Caricae 250g,
Radix Notoginseng 200g, Radix Paeoniae Alba 200g, Fructus Ligustri Lucidi 200g, Radix Angelicae Sinensis 200g, Radix Astragali 200g, Radix Scutellariae 50g, sweet
Grass 50g, Radix Stephaniae Tetrandrae 50g and the Punica granatum L. quintessence oil 70g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then toward institute
State boil irrigate by lifting water to a higher level with a water pump, etc. in add water 11300g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h,
Filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil the 11300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；
Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, filtration at once；By gained filtering residue
During 2 insert again and boil and irrigate by lifting water to a higher level with a water pump, etc., then boil the 11300g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling
Solution seethes with excitement, and after keeping boiling 4h, filters at once；Three gained filtrates are merged, loads in concentration tank
Concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 1200g；It is cooled to room temperature, then adds
Enter 12g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 1000g, sodium polyacrylate 400g, ethylene glycol 150g, polyvinylpyrrolidone 150g,
Crospolyvinylpyrrolidone 30g, xanthan gum 30g, aluminum glycinate 3g, oxalic acid triethylammonium tetrakis disodium 3g,
Tartaric acid 3g, aluminum sulfate 1g, imidazoles hydroxyurea 1g, methyl hydroxybenzoate 1g, malic acid 1g and purified water 5000g,
Then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs；During stirring, pressure is 0.06Mpa, temperature
Degree is 35 DEG C, after 50min, obtains hydrogel 6400g, stand-by.
4, the preparation of finished product:
Weigh described hydrogel 6400g and Chinese medicine ointment 1000g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 68 hours, and solidification, get product Punica granatum L. quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 3
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 400g, Fructus Foeniculi XIANGZI 400g, Radix Puerariae 400g, Folium Kaki 400g, Fructus Caricae 400g,
Radix Notoginseng 500g, Radix Paeoniae Alba 500g, Fructus Ligustri Lucidi 500g, Radix Angelicae Sinensis 500g, Radix Astragali 500g, Radix Scutellariae 80g, sweet
Grass 80g, Radix Stephaniae Tetrandrae 80g and the Punica granatum L. quintessence oil 100g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., the most past
Described boil irrigate by lifting water to a higher level with a water pump, etc. in add water 23000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, keeping boiling 4.5h
After, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in irrigating by lifting water to a higher level with a water pump, etc. and add water
23000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, filtration at once；By institute
During filtering residue 2 inserts again and boils and irrigate by lifting water to a higher level with a water pump, etc., then boil the 23000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc.
Solution boiling to filling, after keeping boiling 3.5h, filtration at once；Three gained filtrates are merged, loads
Concentration tank concentrates, until its relative proportion is 1.3, obtains Chinese medicine ointment finished product 2200g；Often it is cooled to
Temperature, adds 22g ethanol, carries out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 2000g, sodium polyacrylate 600g, ethylene glycol 200g, polyvinylpyrrolidone 200g,
Crospolyvinylpyrrolidone 40g, xanthan gum 40g, aluminum glycinate 4g, oxalic acid triethylammonium tetrakis disodium 4g,
Tartaric acid 4g, aluminum sulfate 2g, imidazoles hydroxyurea 2g, methyl hydroxybenzoate 2g, malic acid 2g and purified water 6000g,
Then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs；During stirring, pressure is 0.06Mpa, temperature
Degree is 38 DEG C, after 58min, obtains hydrogel 8500g, stand-by.
4, the preparation of finished product:
Weigh described hydrogel 8500g and Chinese medicine ointment 1100g, the most uniformly mixing, then insert hydrogel on foot
In step microtome, being coated with, cut into slices, ambient temperatare is put 69 hours, and solidification, get product Punica granatum L. quintessence oil water
Gel rubber plaster, then encapsulates preservation.
Embodiment 4
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 500g, Fructus Foeniculi XIANGZI 500g, Radix Puerariae 500g, Folium Kaki 500g, Fructus Caricae 500g,
Radix Notoginseng 600g, Radix Paeoniae Alba 600g, Fructus Ligustri Lucidi 600g, Radix Angelicae Sinensis 600g, Radix Astragali 600g, Radix Scutellariae 100g, sweet
Grass 100g, Radix Stephaniae Tetrandrae 100g and the Punica granatum L. quintessence oil 120g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then
The 29600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. is boiled toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, keeping boiling 5h
After, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in irrigating by lifting water to a higher level with a water pump, etc. and add water
29600g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4.5h, filtration at once；Will
Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., and then boils the 29600g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and carry
Fill to filling solution boiling, after keeping boiling 3.5h, filtration at once；Three gained filtrates are merged, dress
Enter in concentration tank and concentrate, until its relative proportion is 1.3, obtain Chinese medicine ointment finished product 2700g；It is cooled to
Room temperature, reenters 27g ethanol, carries out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 3000g, sodium polyacrylate 700g, ethylene glycol 300g, PVPK30 0g,
Crospolyvinylpyrrolidone 50g, xanthan gum 50g, aluminum glycinate 5g, oxalic acid triethylammonium tetrakis disodium 5g,
Tartaric acid 5g, aluminum sulfate 3g, imidazoles hydroxyurea 3g, methyl hydroxybenzoate 3g, malic acid 3g and purified water 7000g,
Then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs；During stirring, pressure is 0.07Mpa, temperature
Degree is 40 DEG C, after 55min, obtains hydrogel 10000g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 10000g and Chinese medicine ointment 1500g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 70 hours, and solidification, get product Punica granatum L. quintessence oil
Hydrogel plaster, then encapsulates preservation.
Embodiment 5
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 600g, Fructus Foeniculi XIANGZI 600g, Radix Puerariae 600g, Folium Kaki 600g, Fructus Caricae 600g,
Radix Notoginseng 700g, Radix Paeoniae Alba 700g, Fructus Ligustri Lucidi 700g, Radix Angelicae Sinensis 700g, Radix Astragali 700g, Radix Scutellariae 120g, sweet
Grass 120g, Radix Stephaniae Tetrandrae 120g and the Punica granatum L. quintessence oil 140g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then
The 37000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. is boiled toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, keeping boiling 4h
After, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in irrigating by lifting water to a higher level with a water pump, etc. and add water
37000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, filtration at once；By institute
During filtering residue 2 inserts again and boils and irrigate by lifting water to a higher level with a water pump, etc., then boil the 37000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc.
Solution boiling to filling, after keeping boiling 4h, filtration at once；Three gained filtrates are merged, loads dense
Contracting tank concentrates, until its relative proportion is 1.3, obtains Chinese medicine ointment finished product 3300g；It is cooled to room temperature,
Add 33g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 4000g, sodium polyacrylate 800g, ethylene glycol 400g, PVP 0g,
Crospolyvinylpyrrolidone 60g, xanthan gum 60g, aluminum glycinate 6g, oxalic acid triethylammonium tetrakis disodium 6g,
Tartaric acid 6g, aluminum sulfate 6g, imidazoles hydroxyurea 4g, methyl hydroxybenzoate 4g, malic acid 4g and purified water 8000g,
Then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs；During stirring, pressure is 0.07Mpa, temperature
Degree is 40 DEG C, after 60min, obtains hydrogel 12300g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 12300g and Chinese medicine ointment 1800g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 70 hours, and solidification, get product Punica granatum L. quintessence oil
Hydrogel plaster, then encapsulates preservation.
Embodiment 6
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 800g, Fructus Foeniculi XIANGZI 800g, Radix Puerariae 800g, Folium Kaki 800g, Fructus Caricae 800g,
Radix Notoginseng 800g, Radix Paeoniae Alba 800g, Fructus Ligustri Lucidi 800g, Radix Angelicae Sinensis 800g, Radix Astragali 800g, Radix Scutellariae 150g, sweet
Grass 150g, Radix Stephaniae Tetrandrae 150g and the Punica granatum L. quintessence oil 180g produced, then insert in boiling and irrigating by lifting water to a higher level with a water pump, etc., then
The 43000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. is boiled toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, keeping boiling 4.5h
After, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in irrigating by lifting water to a higher level with a water pump, etc. and add water
43000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, filtration at once；By institute
During filtering residue 2 inserts again and boils and irrigate by lifting water to a higher level with a water pump, etc., then boil the 43000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc.
Solution boiling to filling, after keeping boiling 3.5h, filtration at once；Three gained filtrates are merged, loads
Concentration tank concentrates, until its relative proportion is 1.25, obtains Chinese medicine ointment finished product 4000g；Often it is cooled to
Temperature, adds 40g ethanol, carries out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 5000g, sodium polyacrylate 1200g, ethylene glycol 450g, polyvinylpyrrolidone 450g,
Crospolyvinylpyrrolidone 90g, xanthan gum 90g, aluminum glycinate 9g, oxalic acid triethylammonium tetrakis disodium 9g,
Tartaric acid 9g, aluminum sulfate 9g, imidazoles hydroxyurea 4.5g, methyl hydroxybenzoate 4.5g, malic acid 4.5g and purified water
11000g, then mix homogeneously, then insert in hydrogel de-airing mixer and stir；During stirring, pressure is
0.07Mpa, temperature is 45 DEG C, after 65min, obtains hydrogel 17000g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 17000g and Chinese medicine ointment 3000g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 72 hours, and solidification, get product Punica granatum L. quintessence oil
Hydrogel plaster, then encapsulates preservation.
Embodiment 7
1, the preparation of Punica granatum L. quintessence oil:
Being pulverized by Punica granatum L. puts in extractor, utilizes carbon dioxide to carry out supercritical extraction, collects extract
Obtain Punica granatum L. quintessence oil, stand-by.
2, the preparation of Chinese medicine ointment:
Weigh Punica granatum L. 1000g, Fructus Foeniculi XIANGZI 1000g, Radix Puerariae 1000g, Folium Kaki 1000g, kind wood
Melon 1000g, Radix Notoginseng 1000g, Radix Paeoniae Alba 1000g, Fructus Ligustri Lucidi 1000g, Radix Angelicae Sinensis 1000g, Radix Astragali 1000g,
Radix Scutellariae 200g, Radix Glycyrrhizae 200g, Radix Stephaniae Tetrandrae 200g and the Punica granatum L. quintessence oil 240g produced, then insert and boil
In irrigating by lifting water to a higher level with a water pump, etc., then boil the 55000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling,
After keeping boiling 5h, filter at once；Gained filtering residue 1 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil toward described in
Add water in irrigating by lifting water to a higher level with a water pump, etc. 55000g；Boil described in heating and irrigate by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 4h, at once
Filter；Gained filtering residue 2 is inserted again in boiling and irrigating by lifting water to a higher level with a water pump, etc., then boil the 55000g that adds water in irrigating by lifting water to a higher level with a water pump, etc. toward described in；Heating
Described boiling irrigates by lifting water to a higher level with a water pump, etc. to filling solution boiling, after keeping boiling 3.5h, and filtration at once；By three gained filtrates
Merge, load in concentration tank and concentrate, until its relative proportion is 1.4, obtain Chinese medicine ointment finished product 5200g；
It is cooled to room temperature, adds 52g ethanol, carry out sealing preservation, stand-by.
3, the preparation of hydrogel:
Weigh glycerol 6000g, sodium polyacrylate 1500g, ethylene glycol 500g, polyvinylpyrrolidone 500g,
Crospolyvinylpyrrolidone 100g, xanthan gum 100g, aluminum glycinate 10g, oxalic acid triethylammonium tetrakis disodium 10g,
Tartaric acid 10g, aluminum sulfate 10g, imidazoles hydroxyurea 5g, methyl hydroxybenzoate 5g, malic acid 5g and purified water 12000g,
Then mix homogeneously, then inserts in hydrogel de-airing mixer and stirs；During stirring, pressure is 0.08Mpa, temperature
Degree is 50 DEG C, after 70min, obtains hydrogel 19000g, stand-by.
4, the preparation of finished product:
Weighing described hydrogel 19000g and Chinese medicine ointment 3000g, the most uniformly mixing, then inserts hydrogel
On foot in microtome, being coated with, cut into slices, ambient temperatare is put 72 hours, and solidification, get product Punica granatum L. quintessence oil
Hydrogel plaster, then encapsulates preservation.
From embodiment 1～7, randomly choose a piece of Punica granatum L. quintessence oil hydrogel plaster respectively, be labeled as sticker 1,2,
3、4、5、6、7。
Sticker 1,2,3,4,5,6,7 is carried out microbiologic inhibition tests, refers to table 1.
Table 1
Sticker 1,2,3,4,5,6,7 is carried out hygienic chemistry detection, refers to table 2.
Table 2
Sticker 1,2,3,4,5,6,7 is carried out acute skin irritation test.
Choose regular grade new zealand white rabbit without exception 14, be randomly divided into 7 groups, be labeled as organizing 1,2,3,
4,5,6,7, often group 2.Sticker 1,2,3,4,5,6,7 respectively with group 1,2,3,4,5,
6,7 test.
During test, temperature is: 20～25 DEG C；Relative humidity: 40%～70%.
Test according to Ministry of Public Health " cosmetics health specification " (2007) acute skin irritation.24h before test,
Experimental animal back spinal column diamond wool is cut, not injured skin, each 3cm × 3cm of unhairing scope.Take tested
Thing 0.5g directly spreads upon on the side unhairing intact skin that area is 2cm × 2cm, covers with clean gauze,
Use nonirritant immobilization with adhesive tape.Opposite side skin is as comparison.Dismantle after 4h, remove residual with warm water
Stay tested material.Remove after tested material 1,24,48,72h observes and smears position dermoreaction, with animal subject
The meansigma methods of integration carries out overall merit, respectively observes time point top average according to 24,48 and 72h and judges
Skin irriate intensity, obtains table 3.
Table 3
By table 1, table 2 and table 3 it can be seen that use the Punica granatum L. essence that technology provided by the present invention is produced
Profit gel rubber plaster, its Matter Composition content complies fully with People's Republic of China's " cosmetics health specification "
(2007), the safest；Meanwhile, its to the zest of skin almost without, people can relieved use should
Product.
Clinical trial
Select the female that 280 ages have slight of stature, flat, lax or depending condition to occur in 20～60 years old breast
Property volunteer, and age bracket is 20～30 years old, 30～40 years old, 40～50 years old and 50～be respectively arranged with 70 in 60 years old.
During percent test object, following crowd is got rid of: (1) gestation or women breast-feeding their children.(2) suffers from serious disease
Affect this programme implementer.(3) other breast enlargements product person it is currently in use.(4) not by scheme medication, Bu Nengjian
Hold or the imperfect person of data.
280 volunteers are divided into 7 test group, are respectively labeled as test group 1,2,3,4,5,6,7,
And often group age bracket be 20～30 years old, 30～40 years old, 40～50 years old and 50～60 years old in be respectively arranged with 10 voluntarily
Person.Further according to the age, these 280 volunteers are divided into 4 groups, be labeled as 20～30 years old group, 30～40 years old group,
40～50 years old group and 50～60 years old group.
From embodiment 1～7, randomly choose enough Punica granatum L. quintessence oil hydrogel plasters respectively, be labeled as sticker 1.,
2., 3., 4., 5., 6., 7., be affixed on the most respectively in test group 1,2,3,4,5,6,7 from
On hope person's breast, every 3 days once, the most a piece of (specification is 8cm*8cm), each 36h.
After two months, 280 volunteers are checked, checks breast enlargement effect, and add up, refer to
Table 4.In inspection, with the size of breast, tall and straight and consolidation as observation index.And the effect standard of breast enlargement is:
Effective: relatively before test, breast increases more than 3cm；Breast substantially becomes strong；Breast substantially becomes
Consolidation.
Effective: relatively before test, breast increases 1～3cm；Breast slightly becomes strong；Breast slightly becomes tight
Real.
Invalid: relatively before test, breast does not almost increase；The firmness of breast is almost unchanged；The consolidation of breast
Spend almost unchanged.
Table 4
As can be seen from Table 4, the product that the present invention provides, applicable crowd is very wide, the old man of up to 60 years old,
Down to the youth maiden of 20 years old, this Punica granatum L. quintessence oil hydrogel note all can be used；And its breast enlargement effect also ten
Clearly demarcated aobvious.
Claims (9)
1., for the Punica granatum L. quintessence oil hydrogel plaster of breast enlargement, it is made up of carrier and Chinese medicine ointment, it is characterised in that:
Described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Punica granatum L. 10～100 weight portion, Fructus Foeniculi XIANGZI
10～100 weight portions, Radix Puerariae 10～100 weight portion, Folium Kaki 10～100 weight portion, Fructus Caricae 10～100
Weight portion, Radix Notoginseng 10～100 weight portion, the Radix Paeoniae Alba 10～100 weight portion, Fructus Ligustri Lucidi 10～100 weight portion,
Radix Angelicae Sinensis 10～100 weight portion, the Radix Astragali 10～100 weight portion, Radix Scutellariae 2～20 weight portion, Radix Glycyrrhizae 2～20 weight
Part, Radix Stephaniae Tetrandrae 2～20 weight portion and Punica granatum L. quintessence oil 4～24 weight portion.
Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 1, it is characterised in that:
Described Chinese medicine ointment is made up of following raw material and parts by weight thereof: Punica granatum L. 40～60 weight portion, Fructus Foeniculi XIANGZI
40～60 weight portions, Radix Puerariae 40～60 weight portion, Folium Kaki 40～60 weight portion, Fructus Caricae 40～60 weight
Part, Radix Notoginseng 50～70 weight portion, the Radix Paeoniae Alba 50～70 weight portion, Fructus Ligustri Lucidi 50～70 weight portion, Radix Angelicae Sinensis 50～70
Weight portion, the Radix Astragali 50～70 weight portion, Radix Scutellariae 8～12 weight portion, Radix Glycyrrhizae 8～12 weight portion, Radix Stephaniae Tetrandrae 8～12
Weight portion and Punica granatum L. quintessence oil 10～14 weight portion.
Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 1 and 2, its feature exists
In: described carrier is hydrogel.
Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 3, it is characterised in that:
Described hydrogel is made up of following raw material and parts by weight thereof: glycerol 60～600 weight portion, sodium polyacrylate
15～150 weight portions, ethylene glycol 5～50 weight portion, polyvinylpyrrolidone 5～50 weight portion, cross-link poly-second
Alkene pyrrolidone 1～10 weight portion, xanthan gum 1～10 weight portion, aluminum glycinate 0.1～1 weight portion, oxalic acid
Triethylammonium tetrakis disodium 0.1～1 weight portion, tartaric acid 0.1～1 weight portion, aluminum sulfate 0.05～0.5 weight portion, imidazoles
Hydroxyurea 0.05～0.5 weight portion, methyl hydroxybenzoate 0.05～0.5 weight portion, malic acid 0.05～0.5 weight portion and
Purified water 120～1200 weight portion.
Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 3, it is characterised in that:
Described hydrogel is made up of following raw material and parts by weight thereof: glycerol 200～400 weight portion, sodium polyacrylate
60～80 weight portions, ethylene glycol 20～40 weight portion, polyvinylpyrrolidone 20～40 weight portion, cross-link poly-second
Alkene pyrrolidone 4～6 weight portion, xanthan gum 4～6 weight portion, aluminum glycinate 0.4～0.6 weight portion, oxalic acid
Triethylammonium tetrakis disodium 0.4～0.6 weight portion, tartaric acid 0.4～0.6 weight portion, aluminum sulfate 0.2～0.4 weight portion, miaow
Azoles hydroxyurea 0.2～0.4 weight portion, methyl hydroxybenzoate 0.2～0.4 weight portion, malic acid 0.2～0.4 weight portion and pure
Change water 600～800 weight portion.
6. a preparation method for the Punica granatum L. quintessence oil hydrogel plaster for breast enlargement as claimed in claim 4,
Comprise the steps:
A, Punica granatum L. is pulverized and puts in extractor, utilize carbon dioxide to carry out supercritical extraction, collect extraction
Liquid i.e. obtains Punica granatum L. quintessence oil, stand-by；
B, by weight, weigh Chinese medicine ointment raw material Punica granatum L., Fructus Foeniculi XIANGZI, Radix Puerariae, Folium Kaki,
Fructus Caricae, Radix Notoginseng, the Radix Paeoniae Alba, Fructus Ligustri Lucidi, Radix Angelicae Sinensis, the Radix Astragali, Radix Scutellariae, Radix Glycyrrhizae, Radix Stephaniae Tetrandrae and described stone
Pomegranate fruit quintessence oil；Then by described Chinese medicine ointment raw material boiling, filter, be condensed into cream, obtain Chinese medicine ointment,
Stand-by；
C, by weight, weighs hydrogel raw materials glycerine, sodium polyacrylate, ethylene glycol, polyvinyl pyrrole
Alkanone, crospolyvinylpyrrolidone, xanthan gum, aluminum glycinate, oxalic acid triethylammonium tetrakis disodium, tartaric acid,
Aluminum sulfate, imidazoles hydroxyurea, methyl hydroxybenzoate, malic acid and purified water；Then described hydrogel raw material is mixed
Conjunction is mixed thoroughly, obtains hydrogel, stand-by；
D, described Chinese medicine ointment is mixed with described hydrogel, coated, cut into slices, solidify, obtain for rich
The Punica granatum L. quintessence oil hydrogel plaster of breast.
The preparation method of the Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 6, its
Being characterised by: in described step b, the relative proportion of Chinese medicine ointment is 1.15～1.45.
The preparation method of the Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 6, its
Being characterised by: in described step c, when mixing is mixed thoroughly, the equipment of employing is hydrogel de-airing mixer；
During mix and blend, pressure is 0.06～0.08Mpa, and temperature is 35～55 DEG C, and the time is 54～74min.
The preparation method of the Punica granatum L. quintessence oil hydrogel plaster for breast enlargement the most according to claim 6, its
Being characterised by: in described step d, mass ratio when Chinese medicine ointment mixes with hydrogel is 2.5～3.5:18～22.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410344472.9A CN104147152B (en) | 2014-07-19 | 2014-07-19 | Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410344472.9A CN104147152B (en) | 2014-07-19 | 2014-07-19 | Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104147152A CN104147152A (en) | 2014-11-19 |
| CN104147152B true CN104147152B (en) | 2016-10-19 |
Family
ID=51872916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410344472.9A Expired - Fee Related CN104147152B (en) | 2014-07-19 | 2014-07-19 | Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104147152B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107029216A (en) * | 2017-04-20 | 2017-08-11 | 刘晓华 | A kind of breast-conservation liquid |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100420632B1 (en) * | 2000-05-03 | 2004-03-02 | 최서영 | Composition comprising extract of medicinal herbs for treating Behcet's disease |
| KR20080090806A (en) * | 2007-04-06 | 2008-10-09 | 김종덕 | Cosmetic composition containing natural product extracts for restoring skin condition |
| CN102406899B (en) * | 2011-11-29 | 2014-02-19 | 宋爱民 | Chinese medicine preparation for treating hyperplasia of mammary glands |
| CN103385933B (en) * | 2013-07-19 | 2014-11-05 | 苏州市天灵中药饮片有限公司 | Catechu-containing traditional Chinese medicine preparation and preparation method thereof |
| CN103816087A (en) * | 2014-03-05 | 2014-05-28 | 长春中医药大学 | Whitening, sun-resistant and spot removing cosmetic of traditional Chinese medicine composition, and preparation method thereof |
-
2014
- 2014-07-19 CN CN201410344472.9A patent/CN104147152B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104147152A (en) | 2014-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105999159A (en) | Brown sugar and saussurea involucrate composition and preparation method thereof | |
| CN104173264B (en) | Rose essence oil hydrogel patch and preparation method thereof | |
| CN105288597A (en) | Skin pigmentation treatment medicine | |
| CN102133167B (en) | Freckle removing facial mask made of traditional Chinese medicine and preparation process thereof | |
| CN104147152B (en) | Punica granatum L. quintessence oil hydrogel plaster and preparation method thereof | |
| CN105194487A (en) | Whitening and beautifying traditional Chinese medicine composition and facial mask and preparation method | |
| CN102652808B (en) | Menstruation regulating and beautifying capsule | |
| CN104127605A (en) | Aloe essential oil hydrogel anti-acne plaster and manufacturing method thereof | |
| KR20150122302A (en) | Herbal composition, method for producing therof and method for use therof | |
| CN107198727A (en) | A kind of pharmaceutical composition of beautifying face and moistering lotion promoting blood circulation for regulating menstruation and preparation method thereof | |
| CN104147186B (en) | Flos rosae multiflorae quintessence oil hydrogel plaster and preparation method thereof | |
| CN107029041A (en) | A kind of radix glycyrrhizae strengthen immunity lavipeditum powder and preparation method thereof | |
| CN106344480A (en) | Whitening and freckle-removing traditional Chinese medicine facial mask without toxic or side effect, and preparation method of traditional Chinese medicine facial mask | |
| CN102366585A (en) | Chinese herbal medicine for treating headache caused by yin deficiency of liver and kidney, hyperactivity of liver-yang and stagnation of spleen | |
| CN105534854A (en) | Eye cream for removing crow's feet and under-eye bags and preparation method thereof | |
| CN104606570A (en) | Consumptive thirst tea substitute drink suitable for diabetes patients and preparation method of consumptive thirst tea substitute drink | |
| CN104546587A (en) | Dandruff removing, hair growth promoting and hair blacking shampoo powder and production method thereof | |
| CN104147480A (en) | Externally used traditional Chinese medicine (TCM) composition for relieving pains and preparation method thereof | |
| CN108126161A (en) | A kind of Chinese herbal medicine for treating hypertension and its preparation method and application | |
| CN107737250A (en) | A kind of hypertension Chinese medicine composition and preparation method thereof | |
| CN103417836B (en) | Chinese medicine composition for the treatment of tumor and preparation method thereof | |
| CN107115410B (en) | A kind of Chinese medicine bathing formula, preparation method and application method | |
| CN105381285A (en) | Traditional Chinese medicine compound blood pressure-reducing health-care tea | |
| CN105456933A (en) | Traditional Chinese medicine capable of activating blood to remove stasis and clearing and activating channels and collaterals and preparation method of traditional Chinese medicine | |
| CN113249985A (en) | Health-care clothes and trousers for preventing and treating skin laxity and color spots and production method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20161019 Termination date: 20200719 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |