CN103919557B - Be applied to nystagmus parameter attribute acquisition methods and the device of diagnosis of benign paroxysmal positional vertigo - Google Patents
Be applied to nystagmus parameter attribute acquisition methods and the device of diagnosis of benign paroxysmal positional vertigo Download PDFInfo
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Abstract
The invention discloses a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo, by carrying out specific positioning test to bring out that there is distinctive nystagmus to patient, image processing method is utilized to process to getting nystagmus video image information the nystagmus signal obtaining horizontal and vertical direction, the method of rectangular coordinate polarization is adopted to obtain its torsion angle to the nystagmus signal obtained, and obtain average slow phase angular velocity, nystagmus direction and torsion angle direction, specifically diagnose according to the dizzy position of above-mentioned nystagmus characteristic parameter to patient, solve and rely on doctor's micro-judgment and the Problems of Misdiagnosis that brings clinically, not only can improve the recall rate of bringing out nystagmus, and the accurate differentiation rate of semicircular duct of getting involved can also be improved.
Description
Technical field
The present invention relates to and be applied to a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo in biomedical sector, and be applied to the nystagmus parameter attribute acquisition device of diagnosis of benign paroxysmal positional vertigo, also relate to a kind of device of computer aided diagnosis of Benign paroxysmal positional vertigo.
Background technology
Benign paroxysmal positional vertigo (benignpositionalparoxysmalvertigo, BPPV) is that head movement is of short duration dizzy to what bring out during a certain ad-hoc location, is a kind of peripheral vestibular disease with self limiting.BPPV sickness rate is higher, and account for dizzy patient's 20% ~ 25%, age of onset mostly is 40 ~ 60 years old, and male/female=1/2 seldom sees child, and it is due to the otolith particle detachment on macula utriculi otolithic membrane, enters semicircular duct, disturbs caused by the flowing of normal endolymph.The general course of disease be a few hours to several weeks, can reach several months or several years individually, dizzyly can periodically increase the weight of or alleviate, the intermission be different in size, one year or the several years do not send out patient, also have and reach the more than ten years or decades do not send out patient.BPPV can be divided into pipe stone disease and ridge top calculosis according to its pathogenetic theory, can be divided into canalis semicircularis posterior, horizontal semicircular canal and canalis semicircularis anterior BPPV three types according to the feature of its nystagmus.
To happen suddenly when patient stands up after head is faced upward in a certain head position during Typical onset dizzy, and pop-off, repeat to bring out that head position is dizzy can be occurred once again, can accompany the discomforts such as nausea and vomiting perspiration, the intermission can without uncomfortable or have dizzy or top-heavy and levitation.Because the dissection of semicircular duct is different, the incidence rate that semicircular duct is got involved is different, and getting involved maximum is canalis semicircularis posterior, and canalis semicircularis anterior and lateral semicircular canal are comparatively rare.When human body is stood, canalis semicircularis posterior is positioned at the rear upper/lower positions of whole vestibular apparatus, when fragment moves than be easier to fall into vestibule below and substrate, the namely position at canalis semicircularis posterior place, canalis semicircularis posterior positional vertigo many flat crouching, sit up, bow, bend over and new line is straightened one's back time sudden onset, or it is dizzy, or swing depending on thing, or rotate, or anxious close order transfixion, or get back to the position before former standing up rapidly, nausea and vomiting can be accompanied to perspire even frightened cardiopalmus etc., when repeatedly exciting head position, dizzy and nystagmus outbreak can alleviate or not occur.Horizontal semicircular canal many horizontal position stand up suddenly (lying on one's side) to the left and right or stand and walking time quick dizzy to occurring during the rotary head of both sides suddenly.
BPPV can betide arbitrary semicircular duct of either side, also can betide bilateral, the semicircular duct of more than two simultaneously, relies on specific positioning test to bring out clinically to have distinctive nystagmus separately to differentiate BPPV type.Treatment take corresponding different Canalith repositioning maneuvers technology can obtain effective therapeutic effect for dissimilar patient.Therefore the diagnosis of BPPV must determine side, location accurately, then carry out analysis and distinguishing accurately to brought out displacement nystagmus feature and become the most key step.Video nystagmus view (video-nystagmogragh, VNG) that gets up of development in recent years directly adopt videograph and computer analysis more accurately record eye move the feature of nystagmus can the faint nystagmus that arrives of detection record.VNG can gather the whole change procedure broadcasting record nystagmus, describes the level of nystagmus and the movement locus of vertical direction, and marks out the characteristic parameters such as fast, slow phase and slow phase angular velocity, persistent period, with the diagnosis of this assist physicians to BPPV.For typicality BPPV nystagmus, be characterized in that the persistent period is shorter, characteristic nystagmus clear and definite, the nystagmus characteristic parameter that doctor can provide according to VNG carries out level diagnosis accurately to BPPV; For atypia nystagmus, be characterized in that characteristic nystagmus is thinner and more delicate, horizontal and vertical nystagmus direction is indefinite, such as, get involved for canalis semicircularis posterior and canalis semicircularis anterior, the comparatively complicated situation such as multitube is got involved, because its nystagmus is complicated, often with rotation nystagmus, the characteristic parameter on traditional electronystagmogram cannot give the objective index of doctor to carry out auxiliary positioning.Now just need doctor to have abundant clinical experience range estimation nystagmus direction of rotation, but being rotated into of nystagmus point distinguishes observation and comparison difficulty sometimes, also have scholar then to think the nystagmus situation difference observed at different directions.Therefore, for the diagnostic result of atypical nystagmus with stronger subjectivity, some doctors lacking clinical experiences are easy to can't see direction and cause mistaken diagnosis.But, at present clinically doctor to the diagnosis of BPPV except the subjective symptom of patient tentatively judges semicircular duct of getting involved, main rely on bore hole or according to the slow phase angular velocity of vertical and horizontal nystagmus direction and the single nystagmus that respectively bring out on position Electronystagmogram these intuitively characteristic index judge semicircular duct of getting involved.
But find by analyzing us, for in current existing document, be all to use on traditional horizontal and vertical nystagmus direction utilized intuitively in video frequency electronystagmograph traditional characteristic to diagnose location, do not consider that the nystagmus intensity of atypia nystagmus in horizontal and vertical nystagmus direction is little and doctor can only utilize visual observations nystagmus torsional direction to diagnose the error brought clinically.
Summary of the invention
According to prior art Problems existing, the invention solves the problem that may cause mistaken diagnosis in prior art when adopting visual observations nystagmus torsional direction to carry out the concrete disease site of subjectivity diagnosis of benign paroxysmal positional vertigo to BPPV disease clinical diagnosis process Chinese physician, and disclose a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo, comprise the following steps:
S1: patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature respectively;
S2: utilize infrared video electronystagmograph to record nystagmus video;
S3: utilize image processing method to follow the tracks of the pupil center location of nystagmus video image, obtain the nystagmus signal in horizontal and vertical direction;
S4: the nystagmus signal obtained different position provocative test respectively carries out process and obtains nystagmus characteristic parameter: horizontal semicircular canal Roll test is brought out to the nystagmus signal obtained, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV
The computing formula of slow phase angular velocity SPV:
In formula: X is the amplitude of each nystagmus slow phase, n is the lasting frame number of each nystagmus slow phase;
The computing formula of average slow phase angular velocity ASPV:
In formula: SPV
iit is the slow phase velocity of i-th nystagmus signal;
Clinically using snap shot direction as nystagmus direction, therefore by comparing nystagmus triangular wave both sides angular velocity size, nystagmus direction is determined as snap shot in side large for speed;
Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the rotation nystagmus signal of generation, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle obtaining nystagmus, be left counterclockwise by torsion angle snap shot, snap shot is to the right clockwise, thus determines the torsion angle direction of nystagmus.
Further: the method for the horizontal and vertical nystagmus polarization described in S4 is the method obtaining rotating nystagmus torsion angle, and concrete grammar is as follows:
Two width nystagmus pictures are carried out center superposition reorientation, namely will eliminate level or the vertical movement of pupil in two width nystagmus pictures, if the center coordinate of eye pupil of two width nystagmus pictures is expressed as (x
1, y
1) and (x
2, y
2), then reorientation formula:
d
x＝x
2-x
1
d
y＝y
2-y
1
Its angle can be drawn according to reorientation coordinate
, i.e. nystagmus windup-degree:
Further, be applied to a nystagmus parameter attribute acquisition device for diagnosis of benign paroxysmal positional vertigo, comprise and patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature and obtains the nystagmus video acquiring module of nystagmus video image information respectively;
Receive the vedio data information that described nystagmus video acquiring module transmits, the pupil tracking locating module following the tracks of eye pupil position, acquisition horizontal and vertical direction nystagmus signal according to image processing method;
Receive the data message that described pupil tracking locating module transmits, carry out respectively processing the nystagmus parameter attribute extraction module obtaining its nystagmus parameter attribute to the nystagmus signal that different position provocative test obtains, described nystagmus parameter attribute comprises: horizontal nystagmus direction, average slow phase angular velocity and nystagmus torsion angle direction.
Further, a kind of nystagmus parameter attribute acquisition device being applied to diagnosis of benign paroxysmal positional vertigo, described nystagmus parameter attribute extraction module carries out its nystagmus parameter attribute of process acquisition respectively to the respective distinctive nystagmus signal that has that different postural test brings out acquisition: horizontal semicircular canal rolling is brought out to the nystagmus signal obtained, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV; Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the nystagmus signal of acquisition, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle of nystagmus, and to arrange torsion angle snap shot be left counterclockwise, torsion angle snap shot is to the right for determine torsion angle direction thus clockwise.
Further, a kind of device of computer aided diagnosis of Benign paroxysmal positional vertigo comprises:
Patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature and obtains the nystagmus video acquisition unit of nystagmus video image information respectively;
Receive the vedio data information that described nystagmus video acquisition unit transmits, follow the tracks of eye pupil position according to image processing method, obtain the pupil tracking positioning unit of horizontal and vertical direction nystagmus signal;
Receive the data message that described pupil tracking positioning unit transmits, carry out respectively processing the nystagmus parameter attribute extraction unit obtaining its nystagmus parameter attribute to the nystagmus signal that different position provocative test obtains, described nystagmus parameter attribute comprises: horizontal nystagmus direction, average slow phase angular velocity and nystagmus torsion angle direction;
And judge the standard data message of Benign paroxysmal positional vertigo and the standard data storage unit of scope of data for storing, store the diagnostic criteria value information of rule nystagmus slow phase angular velocity threshold value and Benign paroxysmal positional vertigo in described standard data storage unit;
Receive the diagnosis decision unit of the nystagmus parameter attribute information that described nystagmus parameter attribute extraction unit transmits, described diagnosis decision unit extracts the data message in standard data storage unit, data message in nystagmus parameter attribute information and standard data storage unit is compared, thus the semicircular duct of getting involved of Benign paroxysmal positional vertigo patient is positioned, determines side.
Owing to have employed technique scheme, the invention discloses a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo, by carrying out specific positioning test to bring out that there is distinctive nystagmus to patient, image processing method is utilized to process to getting nystagmus video image information the nystagmus signal obtaining horizontal and vertical direction, the method of rectangular coordinate polarization is adopted to obtain its torsion angle to the nystagmus signal obtained, and obtain average slow phase angular velocity, nystagmus direction and torsion angle direction, specifically diagnose according to the dizzy position of above-mentioned nystagmus characteristic parameter to patient, solve and rely on doctor's micro-judgment and the Problems of Misdiagnosis that brings clinically, not only can improve the recall rate of bringing out nystagmus, and the accurate differentiation rate of semicircular duct of getting involved can also be improved.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present application or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, the accompanying drawing that the following describes is only some embodiments recorded in the application, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the flow chart of the nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo in the present invention.
Fig. 2 is a typical nystagmus signal graph.
Fig. 3 is that nystagmus windup-degree estimates schematic diagram.
Fig. 4 is torsion angle direction is counterclockwise schematic diagram.
Fig. 5 is torsion angle direction is clockwise schematic diagram.
Fig. 6 (a) to bring out the schematic diagram of atypical nystagmus signal for the present invention to horizontal semicircular canal Roll test left-hand rotation head.
Fig. 6 (b) to bring out the schematic diagram of atypical nystagmus signal for the present invention to horizontal semicircular canal Roll test right-hand rotation head.
Fig. 7 (a) hangs to canalis semicircularis posterior postural test the schematic diagram that atypical nystagmus signal and torsion angle thereof are brought out in head position for the present invention;
Fig. 7 (b) to bring out the schematic diagram of atypical nystagmus signal and torsion angle thereof for the present invention to canalis semicircularis posterior postural test seat;
Fig. 8 (a) hangs to canalis semicircularis anterior postural test the schematic diagram that atypical nystagmus signal and torsion angle thereof are brought out in head position for the present invention;
Fig. 8 (b) to bring out the schematic diagram of atypical nystagmus signal and torsion angle thereof for the present invention to canalis semicircularis anterior postural test seat;
Fig. 9 is the structural representation of the nystagmus parameter attribute acquisition device being applied to diagnosis of benign paroxysmal positional vertigo in the present invention;
Figure 10 is the structural representation of the device of computer aided diagnosis of a kind of Benign paroxysmal positional vertigo in the present invention.
Detailed description of the invention
For making technical scheme of the present invention and advantage clearly, below in conjunction with the accompanying drawing in the embodiment of the present invention, clear complete description is carried out to the technical scheme in the embodiment of the present invention:
As shown in Figure 1: a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo, in clinical, we judge the concrete disease condition of the Benign paroxysmal positional vertigo of patient according to the nystagmus parameter attribute obtained, and specifically comprise the following steps:
S1: patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out and has respective distinctive nystagmus respectively,
Horizontal semicircular canal postural test: patient wears video eyeshade, a flexing of lying on the back 30 °, head rotates 90 ° to side fast and keeps this position 2min, then turns 90 ° to offside and keep this position 2min fast, record left and right sides nystagmus situation;
Canalis semicircularis posterior and canalis semicircularis anterior postural test: patient is seated on examinating couch, wear video eyeshade, examiner stands on patient rear, both hands hold up its head to turn 45 ° to Ipsilateral, and assist it to become dorsal position rapidly, head is suspended from outside edge of bed backward, horizontal by 30 °, head position remain this side turn 45 ° constant, at least observe 1min or treat its nystagmus disappear till; Then make rapidly patient sit up, continue to observe nystagmus situation; Check offside with same method again, record left and right sides nystagmus is in outstanding head position and seat situation;
S2: utilize infrared video electronystagmograph to record nystagmus video; When recording, sample frequency can be arranged on 25Hz;
S3: utilize image processing method to follow the tracks of the pupil center location of nystagmus video image, obtain the nystagmus signal in horizontal and vertical direction;
Nystagmus is followed the tracks of and is mainly comprised mathematical morphology filter, maximum entropy binaryzation, the search of the pupil center of circle.First the method for image procossing is utilized to carry out mathematical morphology filter to video image, remove the noise spots such as the reflective spot in image and strengthen the discrimination of pupil and iris, then utilize maximum entropy binaryzation by pupil and other separation of images, obtain pupil binary image, pupil is finally utilized to be circular, nictation and canthus this geometric knowledge of pupil almost fan, mate binary image with estimation circle, and the home position that search coupling area is maximum within the scope of estimating searching is pupil center.
The nystagmus video that patient obtains after carrying out horizontal semicircular canal and canalis semicircularis posterior and canalis semicircularis anterior postural test obtains nystagmus track X, Y of horizontal and vertical through the process of nystagmus pupil tracking.
S4: the nystagmus signal obtained different position provocative test respectively carries out process and obtains nystagmus characteristic parameter;
Research shows that horizontal semicircular canal-BPPV does not have vertical component by the nystagmus feature that its postural test brings out and reverses composition, have severity, and nystagmus has regularity, in geotropism or apogeotropism.So bring out the nystagmus signal obtained to Roll test, only analyze the nystagmus signal of its horizontal direction.Search law nystagmus signal on horizontal direction nystagmus is also processed and obtains its nystagmus characteristic parameter: nystagmus direction and average slow phase angular velocity ASPV.
Fig. 2 is a typical nystagmus signal graph.The parameter wherein comprised is respectively: slow phase amplitude A s11; Snap shot amplitude A f12; Slow phase time ts13, snap shot time tf14; Slow phase velocity Vs=As/ts, fast phase velocity Vf=Af/tf.In the present invention, slow phase, snap shot amplitude refer to nystagmus vertical coordinate pixel value, and slow phase, snap shot time refers to slow phase, snap shot nystagmus continues frame number.
The computing formula of slow phase angular velocity SPV:
In formula: X is the amplitude of each nystagmus slow phase, n is the lasting frame number of each nystagmus slow phase;
The computing formula of average slow phase angular velocity ASPV:
SPV in formula
iit is the slow phase velocity of i-th nystagmus signal; Clinically using the direction of snap shot as the direction of nystagmus, namely snap shot to the right then nystagmus direction, therefore by comparing nystagmus triangular wave both sides angular velocity size, using side large for speed as carrying out snap shot, thus determine nystagmus direction to the right.
Complete nystagmus signal is made up of the single nystagmus signal of a lot of continuous print, and in different time, the parameter value of each nystagmus signal is different, analyzes, can obtain results needed to its change.The maximum nystagmus of the nystagmus number of nystagmus slow phase velocity within 1 ° is recorded as available rule nystagmus in the present invention.
Usually the method for video nystagmus view determination horizontal semicircular canal-BPPV Ipsilateral is utilized to be all the Hot stimulus SPV of more multiple single nystagmus clinically, but for the much the same situation of both sides nystagmus intensity, the SPV of just more single nystagmus cannot make correct judgement, so can improve diagnosis by finding rule nystagmus and calculating its ASPV.
Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the rotation nystagmus signal of generation, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle of nystagmus, be left counterclockwise by torsion angle snap shot, snap shot is to the right clockwise, thus determines the torsion angle direction of nystagmus.
Wherein the method for horizontal and vertical nystagmus polarization is the method obtaining rotating nystagmus torsion angle, and method is as follows:
Two width nystagmus pictures are carried out center superposition reorientation, namely will eliminate level or the vertical movement of pupil in two width nystagmus pictures.If the center coordinate of eye pupil of two width nystagmus pictures is expressed as (x
1, y
1) and (x
2, y
2), then reorientation formula:
d
x＝x
2-x
1
d
y＝y
2-y
1
Its angle can be drawn according to reorientation coordinate
, i.e. nystagmus windup-degree.As shown in Figure 3, the angle between two dotted lines is nystagmus windup-degree.
Said method is utilized to convert the nystagmus signal of horizontal direction and vertical direction to nystagmus torsion angle signal.Find that its torsion angle is the same with nystagmus signal by analyzing, also present the speed phase character of rule, so the characteristic parameter analytical method of nystagmus signal is applicable to torsion angle signal too, its torsion angle direction is also determined by snap shot direction.Regulation torsion angle snap shot is left counterclockwise as shown in Figure 4, and snap shot is to the right clockwise as shown in Figure 5.
The nystagmus signal brought out for canalis semicircularis posterior and canalis semicircularis anterior postural test, with rotation composition, all has nystagmus in horizontal and vertical direction.Although video nystagmus view can trace its horizontal and vertical direction nystagmus clinically, be rely on its direction of rotation of doctor's visual observations to the diagnostic method rotating nystagmus feature.But for the nystagmus that rotary speed is very fast, be difficult to accurately judge its direction of rotation, to rotating the bore hole diagnosis of nystagmus with very strong subjectivity, and add the probability of mistaken diagnosis, this makes troubles to patient undoubtedly.So the method polarized by horizontal and vertical nystagmus by the nystagmus in the horizontal and vertical direction rotating nystagmus, the torsion angle energy objective evaluation extracting nystagmus rotates nystagmus, is easy to judge its direction of rotation, reduces the subjective error of doctor.
In sum according to the acquisition methods of the above-mentioned characteristic parameter about nystagmus disclosed by the invention, in actual diagnostic procedure, the nystagmus characteristic parameter according to obtaining carries out position diagnosis to the dizzy situation of patient, such as:
Canalis semicircularis posterior-BPPV(P-BPPV): rotation nystagmus is brought out in Dix-Hallpike test, and its characteristic parameter torsion angle is counterclockwise in direction, outstanding head position, after sitting up oppositely, and tests ear for suffering from ear;
Rotation nystagmus is brought out in canalis semicircularis anterior-BPPV (A-BPPV): Dix-Hallpike test, and its characteristic parameter torsion angle be clockwise in direction, outstanding head position, after sitting up oppositely, and test ear to picking up the ears as trouble ear;
Horizontal semicircular canal-BPPV pipe calculosis (H-BPPV (Geo)): Roll test brings out horizontal nystagmus, its characteristic parameter nystagmus direction is geotropism, namely patient's head that turns left brings out left-hand nystagmus, and right-hand rotation head brings out dextrad nystagmus, and the large side of average slow phase angular velocity is for suffering from ear;
Horizontal semicircular canal-BPPV ridge top calculosis (H-BPPV (Apo)): Roll test brings out horizontal nystagmus, its characteristic parameter nystagmus direction is apogeotropism, namely patient's head that turns left brings out dextrad nystagmus, right-hand rotation head brings out left-hand nystagmus, and the side that average slow phase angular velocity is little is trouble ear;
Mixed type BPPV: the nystagmus all occurring above-mentioned feature in horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior postural test.
Fig. 6, Fig. 7 and Fig. 8 are three examples in embodiment of the present invention experimentation.
Fig. 6 (a) is the horizontal nystagmus signal after patient carries out the left-hand rotation head of its postural test.Fig. 6 (b) is the horizontal nystagmus signal after the quick rotary head to the right of patient.
By the nystagmus direction of Fig. 6 (a)-6 (b) can find out turn to right overhead left side time, bring out left-hand nystagmus, turn to right overhead right side time, bring out dextrad nystagmus, by calculate ASPV, obtain ASPV
left> ASPV
right, can judge it is left side H-BPPV (Geo), meet the diagnostic criteria of BPPV.
Can it is evident that dextrad nystagmus is better than left-hand nystagmus for typicality nystagmus, but for the much the same situation of both sides nystagmus, just more single nystagmus slow phase angle SPV cannot make correct judgement, so can improve diagnosis by finding rule nystagmus and calculating its average slow phase angle ASPV.
Fig. 7 (a) is that patient carries out right side canalis semicircularis posterior postural test and hangs the level of head position, nystagmus verticalis signal and torsion angle.Fig. 7 (b) is that patient carries out the level of right side canalis semicircularis posterior postural test seat, nystagmus verticalis signal and torsion angle.
Can find out that torsion angle torsion angle on outstanding head position is counterclockwise by Fig. 7 (a)-7 (b), seat torsion angle is clockwise, P-BPPV on the right side of when can judge with this, meets the diagnostic criteria of BPPV.
Fig. 8 (a) is that patient carries out the level of the outstanding head position of right side canalis semicircularis anterior position examination, nystagmus verticalis signal and torsion angle.Fig. 8 (b) is that patient carries out right side canalis semicircularis anterior position and takes the level of position, nystagmus verticalis signal and torsion angle for a trial.
Can find out that torsion angle torsion angle on outstanding head position is clockwise by Fig. 8 (a)-8 (b), seat torsion angle is counterclockwise, A-BPPV on the left of when can judge with this, meets the diagnostic criteria of BPPV.
The incidence rate of canalis semicircularis anterior is minimum, its nystagmus feature is jumping property under vertical, often can slightly rotatory, because the canalis semicircularis anterior of side and the canalis semicircularis posterior of offside are conjugate planes, nystagmus is all verticality, therefore have differentiate mistake possibility, to occur simultaneously two semicircular duct be easy to fail to pinpoint a disease in diagnosis, but utilize this new feature of torsion angle clearly can judge the direction of nystagmus.
As shown in Figure 9: a kind of nystagmus parameter attribute acquisition device being applied to diagnosis of benign paroxysmal positional vertigo, comprising: nystagmus video acquiring module, pupil tracking locating module and nystagmus parameter attribute extraction module.Described nystagmus video acquiring module is used for determining that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out and has respective distinctive nystagmus respectively to patient, and obtains nystagmus video image information and be sent to pupil tracking locating module.Utilize infrared video electronystagmograph to record when obtaining nystagmus video image information, during recording, sample frequency can be 25Hz.Described pupil tracking locating module receives nystagmus video image information, follows the tracks of eye pupil position according to image processing method, obtains horizontal and vertical direction nystagmus signal, and the nystagmus signal of acquisition is sent to nystagmus parameter attribute extraction module.Described nystagmus parameter attribute extraction module receives the data message that pupil tracking locating module transmits, the nystagmus signal that different position provocative test obtains carries out process respectively and obtains its nystagmus parameter attribute, the nystagmus signal obtained is brought out for horizontal semicircular canal test, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV; Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the nystagmus signal of acquisition, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle of nystagmus, and to arrange torsion angle snap shot be left counterclockwise, torsion angle snap shot is to the right for determine torsion angle direction thus clockwise.
As shown in Figure 10: a kind of device of computer aided diagnosis of Benign paroxysmal positional vertigo, nystagmus video acquisition unit, pupil tracking positioning unit, nystagmus parameter attribute extraction unit, standard data storage unit and diagnosis decision unit is comprised.
Described nystagmus video acquisition unit is used for determining that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out and has respective distinctive nystagmus respectively to patient, and obtains nystagmus video image information and be sent to pupil tracking positioning unit.Utilize infrared video electronystagmograph to record when obtaining nystagmus video image information, during recording, sample frequency can be 25Hz.Described pupil tracking positioning unit receives nystagmus video image information, follows the tracks of eye pupil position according to image processing method, obtains horizontal and vertical direction nystagmus signal, and the nystagmus signal of acquisition is sent to nystagmus parameter attribute extraction unit.Described nystagmus parameter attribute extraction unit receives the data message that pupil tracking positioning unit transmits, the nystagmus signal that different position provocative test obtains carries out process respectively and obtains its nystagmus parameter attribute, the nystagmus signal obtained is brought out for horizontal semicircular canal test, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV; Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the nystagmus signal of acquisition, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle of nystagmus, and to arrange torsion angle snap shot be left counterclockwise, torsion angle snap shot is to the right for determine torsion angle direction thus clockwise.Store the standard data message judging Benign paroxysmal positional vertigo and scope of data in described standard data storage unit, in described standard data storage unit, store the diagnostic criteria value information of rule nystagmus slow phase angular velocity threshold value and Benign paroxysmal positional vertigo.Described diagnosis decision unit receives nystagmus parameter attribute information, the data message extracted in standard data storage unit that described nystagmus parameter attribute extraction unit transmits, is compared by the data message in nystagmus parameter attribute information and standard data storage unit, thus positions the semicircular duct of getting involved of Benign paroxysmal positional vertigo patient, determine side.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (4)
1. be applied to a nystagmus parameter attribute acquisition methods for diagnosis of benign paroxysmal positional vertigo, it is characterized in that: comprise the following steps:
S1: patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature respectively;
S2: utilize infrared video electronystagmograph to record nystagmus video;
S3: utilize image processing method to follow the tracks of the pupil center location of nystagmus video image, obtain the nystagmus signal in horizontal and vertical direction;
S4: the nystagmus signal obtained different position provocative test respectively carries out process and obtains nystagmus characteristic parameter: horizontal semicircular canal Roll test is brought out to the nystagmus signal obtained, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV
The computing formula of slow phase angular velocity SPV:
In formula: X is the amplitude of each nystagmus slow phase, n is the lasting frame number of each nystagmus slow phase;
The computing formula of average slow phase angular velocity ASPV:
In formula: SPV
iit is the slow phase velocity of i-th nystagmus signal;
Clinically using snap shot direction as nystagmus direction, therefore by comparing nystagmus triangular wave both sides angular velocity size, nystagmus direction is determined as snap shot in side large for speed;
Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the rotation nystagmus signal of generation, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle obtaining nystagmus, be left counterclockwise by torsion angle snap shot, snap shot is to the right clockwise, thus determines the torsion angle direction of nystagmus.
2. a kind of nystagmus parameter attribute acquisition methods being applied to diagnosis of benign paroxysmal positional vertigo according to claim 1, is further characterized in that:
The method of the horizontal and vertical nystagmus polarization described in S4 is the method obtaining rotating nystagmus torsion angle, and method is as follows:
Two width nystagmus pictures are carried out center superposition reorientation, namely will eliminate level or the vertical movement of pupil in two width nystagmus pictures, if the center coordinate of eye pupil of two width nystagmus pictures is expressed as (x
1, y
1) and (x
2, y
2), then reorientation formula:
d
x＝x
2-x
1
d
y＝y
2-y
1
Its angle can be drawn according to reorientation coordinate
i.e. nystagmus windup-degree:
3. be applied to a nystagmus parameter attribute acquisition device for diagnosis of benign paroxysmal positional vertigo, it is characterized in that: comprise and patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature and obtains the nystagmus video acquiring module of nystagmus video image information respectively;
Receive the vedio data information that described nystagmus video acquiring module transmits, the pupil tracking locating module following the tracks of eye pupil position, acquisition horizontal and vertical direction nystagmus signal according to image processing method;
Receive the data message that described pupil tracking locating module transmits, carry out respectively processing the nystagmus parameter attribute extraction module obtaining its nystagmus parameter attribute to the nystagmus signal that different position provocative test obtains, described nystagmus parameter attribute comprises: horizontal nystagmus direction, average slow phase angular velocity and nystagmus torsion angle direction;
Described nystagmus parameter attribute extraction module carries out its nystagmus parameter attribute of process acquisition respectively to the respective distinctive nystagmus signal that has that different postural test brings out acquisition: horizontal semicircular canal rolling is brought out to the nystagmus signal obtained, search law nystagmus on nystagmus in the horizontal direction, determine nystagmus direction, and calculate its average slow phase angular velocity ASPV; Canalis semicircularis posterior and canalis semicircularis anterior postural test are brought out to the nystagmus signal of acquisition, by the method that the nystagmus in the horizontal and vertical direction of its nystagmus is polarized by horizontal and vertical nystagmus, extract the torsion angle of nystagmus, and to arrange torsion angle snap shot be left counterclockwise, torsion angle snap shot is to the right for determine torsion angle direction thus clockwise.
4. a device of computer aided diagnosis for Benign paroxysmal positional vertigo, is characterized in that comprising:
Patient is determined that the specific positioning test of horizontal semicircular canal, canalis semicircularis posterior and canalis semicircularis anterior brings out the nystagmus with respective feature and obtains the nystagmus video acquisition unit of nystagmus video image information respectively;
Receive the vedio data information that described nystagmus video acquisition unit transmits, follow the tracks of eye pupil position according to image processing method, obtain the pupil tracking positioning unit of horizontal and vertical direction nystagmus signal;
Receive the data message that described pupil tracking positioning unit transmits, carry out respectively processing the nystagmus parameter attribute extraction unit obtaining its nystagmus parameter attribute to the nystagmus signal that different position provocative test obtains, described nystagmus parameter attribute comprises: horizontal nystagmus direction, average slow phase angular velocity and nystagmus torsion angle direction;
And judge the standard data message of Benign paroxysmal positional vertigo and the standard data storage unit of scope of data for storing, store the diagnostic criteria value information of rule nystagmus slow phase angular velocity threshold value and Benign paroxysmal positional vertigo in described standard data storage unit;
Receive the diagnosis decision unit of the nystagmus parameter attribute information that described nystagmus parameter attribute extraction unit transmits, described diagnosis decision unit extracts the data message in standard data storage unit, data message in nystagmus parameter attribute information and standard data storage unit is compared, thus the semicircular duct of getting involved of Benign paroxysmal positional vertigo patient is positioned, determines side.
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