CN103877229B - A kind of compound Chinese medicine extract and application thereof preventing and treating an avian colibacillosis - Google Patents
A kind of compound Chinese medicine extract and application thereof preventing and treating an avian colibacillosis Download PDFInfo
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Abstract
The present invention relates to animal compound technical field of traditional Chinese medicines, specifically disclose a kind of compound Chinese medicine extract preventing and treating an avian colibacillosis and its preparation method and application. Described compound Chinese medicine extract is formulated according to certain ratio by medicines such as the root of large-flowered skullcap, golden cypress, Herba Andrographis, Herba Houttuyniae, the Radix Astragali, taraxacum, Root of Chinese Pulsatilla, Radix Glycyrrhizaes. The cooperation of all medicines has clearing heat and detoxicating, wet treating stranguria, eliminating pathogenic factor for supporting vital QI effect of the carbuncle that disappears dissipating bind, profit. The present invention is difficult to absorption and digestion according to the poultry physiological characteristic feature that especially poultry reproductive tract is short, centering drug fiber element, and medicine is made Chinese medical extract, by drinking water administration, facilitate and it is convenient to absorb, it is possible to play rapidly the object for the treatment of, there is good economic benefit and social benefit.
Description
Technical field
The present invention relates to animal compound technical field of traditional Chinese medicines, particularly relate to a kind of compound Chinese medicine extract preventing and treating an avian colibacillosis and its preparation method and application.
Background technology
Family's avian colibacillosis is by a class disease general name of the poultry caused by some bacterial strain of Escherichia coli, intestinal bacteria exist in nature widely, it is a class cause of disease of preferential defense in mankind's public health, but the intestinal bacteria in Animal husbandry production environment are often ignored. This disease all can occur throughout the year, cold multiple for changeable season with temperature with Winter-Spring, and the young fowl morbidity before and after 1 monthly age is more, but age on the 1st, young fowl can infect. The contagium of this disease is disease fowl and the bird that carries disease germs, the poultry that carries disease germs pollutes feed, drinking-water and utensil by respiratory tract and ight soil toxin expelling, powerful e. coli contamination source is formed in house, pouity dwelling place and a large amount of pathogenic colon bacillus of the medium-term and long-term existence of surrounding environment thereof, the poultry moment is under coli-infection threat, and this also can cause the repeated infection of intestinal bacteria. The topmost route of transmission of colibacillosis is respiratory tract, and other comprise digestive tube, vertical transmission in ovum, and eggshell penetrates and infects with mating. It is one of clinical common family's poultry diease of China, there is feature fast, mortality ratio height, course of disease length of falling ill, cause great harm to aviculture.
Family's avian colibacillosis Clinical types is numerous, and pathological change is complicated. This disease has following type clinically: acute septic, visceratonia, yolk peritonitis type, reproduction type (salpingitis, ovaritis, uterine tube tumour), sacroiliitis or the swollen type of foot pad, escherichia coli granuloma, nervous system type (encephalitis type), ophthalmia type, skin-type, swollen head dummy, enteritis type, osteomyelitis type, yolk sac inflammation and omphalitis type etc.
At present for colibacillosis many employings antibiotic treatment, but the unreasonable use due to this type of medicine, the resistance spectrum of intestinal bacteria has been caused constantly to expand, the medicine that some original anti-microbial effects are very strong is made progressively to become not insensitive medicine, as the drug sensitive test of multiple strain isolated intestinal bacteria is proved, kantlex, gentamicin, penbritin etc. are all had resistance in various degree by bacterium, and this bacterium is not acted on by tsiklomitsin, Streptomycin sulphate, erythromycin substantially. The problems such as the residual brought along with synthetic antibacterial agents, microbiotic life-time service, resistance, toxic side effect are strong day by day serious, reduces meat egg product quality, have impact on human health and public health security. Clinical practice shows, herbal medicine is by the normal substance metabolism of interference pathogenic micro-organism, or by suppressing nucleic acid of pathogenic microorganism and protein synthesis, or by strengthening the function of animal body immunity system, come anti-bacteria, fungi and viral proliferation, reach the object of directly or indirectly suppression or kill bacteria, fungi and virus, avian colibacillosis is had good prevention effect, and there is the features such as low residue, hypotoxicity, curative ratio height, not easily generation resistance.
The present invention intends genesis mechanism and the poultry Digestive tract feature of, herbal medicine characteristic theoretical according to Chinese veterinarian's medicine and family's avian colibacillosis, it is provided that the compound Chinese medicine extract of a kind of prevention and therapy man's avian colibacillosis and its preparation method.Meet the industry requirement of the green cultivation that current society advocates, have vast potential for future development.
Summary of the invention
For the deficiencies in the prior art, it is desirable to provide compound Chinese medicine extract of a kind of prevention and therapy man's avian colibacillosis and its preparation method and application, by selecting suitable medicinal material and proportioning thereof and formulate the extracting method of its patent medicine, reach safe and effective treatment and prevention man's avian colibacillosis and make it be suitable for and apply clinically.
In order to achieve the above object, the present invention is by the following technical solutions:
A compound Chinese medicine extract for prevention and therapy man's avian colibacillosis, is prepared from by the Chinese medicinal materials of following weight:
Root of large-flowered skullcap 8-16 part,
Golden cypress 8-16 part,
Herba Andrographis 8-16 part,
Herba Houttuyniae 8-16 part,
Radix Astragali 8-16 part,
Taraxacum 8-16 part,
Spica Prunellae 7-14 part,
Radix bupleuri 7-14 part,
Purslane 7-14 part,
Poria cocos 7-14 part,
Gypsum 7-14 part,
Chinese ephedra 6-12 part,
Root of Chinese Pulsatilla 6-12 part,
Radix Glycyrrhizae 5-10 part.
Best, described compound Chinese medicine extract is prepared from by the Chinese medicinal materials of following weight: the root of large-flowered skullcap 10 parts, golden cypress 10 parts, Herba Andrographis 12 parts, Herba Houttuyniae 12 parts, the Radix Astragali 10 parts, taraxacum 12 parts, Spica Prunellae 8 parts, radix bupleuri 8 parts, purslane 8 parts, 10 parts, Poria cocos, 10 parts, gypsum, 8 parts, Chinese ephedra, Root of Chinese Pulsatilla 9 parts, 8 parts, Radix Glycyrrhizae.
Preparation method's step of described compound Chinese medicine extract is as follows:
Taking each Chinese medicinal materials of described weight part, mixing, the water soaking of 60-65 DEG C adding each Chinese medicinal materials gross weight 2-3 times is after 1 hour, the water adding each Chinese medicinal materials gross weight 12 times again, in 92 DEG C of refluxing extraction 10 hours, then by 3 times of concentrated for feed liquid most each Chinese medicinal materials gross weight, leaves standstill 12h, make precipitation, get supernatant liquor and it is evaporated to relative density 1.15��1.20 (55-60 DEG C), spraying dry, receive powder, pulverize, cross 50 order sieves, mixed even, to obtain final product.
The present invention is guidance according to genesis mechanism and the poultry Digestive tract feature of China's traditional Chinese veterinarian medicine " rarity " herbal medicine characteristic theoretical, Chinese and family's avian colibacillosis, according to rigorous formulas such as the monarch of Chinese medicine, seven human emotions compatibilities, making it divide the work clearly, Each performs its own functions; The compound Chinese medicine extract of a kind of prevention and therapy man's avian colibacillosis simultaneously screened one by one in a large amount of clinical trial. The pharmacological action of extract of the present invention formula: in this prescription, the root of large-flowered skullcap has heat-clearing and damp-drying drug, eliminating fire and detoxication, antiabortive, cooling blood for hemostasis; Golden cypress has heat-clearing and damp-drying drug, and purging intense heat is except steaming, and effect of detoxification sore treatment, the root of large-flowered skullcap, golden cypress, Radix Glycyrrhizae, gypsum have synergy. Herba Andrographis, Herba Houttuyniae, taraxacum, Root of Chinese Pulsatilla have clearing heat and detoxicating, anti-inflammatory, swelling and pain relieving effect, inducing diuresis for treating stranguria syndrome. Spica Prunellae has clearing liver, dissipating bind, diuresis, radix bupleuri: evacuate and bring down a fever, rise the easypro liver of sun, purslane has clearing heat and promoting diuresis, detoxify and promote the subsdence of swelling, anti-inflammatory, quenches the thirst, diuretic properties, Poria cocos has the function of promoting diuresis to eliminate damp pathogen, benefit spleen and stomach, tranquillizing by calming the heart, and it is loose cold that Chinese ephedra has sweating, freeings lung and relieving asthma, inducing diuresis to remove edema, all medicines coordinate the effect with blood clearing heat and detoxicating, cool, only dysentery, antibacterial, anti-inflammatory, profit water.
Compared with prior art, advantage of the present invention is:
1, pure traditional Chinese medicine extraction preparation, nontoxic, to poultry internal organs not damaged; Have no drug resistance, efficiently solve the problem of the current family resistance to chemical drug of avian escherichia coli; Search out a kind of problem solving family's avian colibacillosis in cultivation novel, effective;
2, drug residue free, the poultry prod green safety produced, efficiently solves a series of food-safety problems that chemical drug brings, and meets current compatriots to the consumption requirement of poultry prod;
3, medicine being made Chinese medical extract, it may also be useful to convenient, efficiently solve poultry digestive tube short, centering drug fiber element is difficult to the problem of absorption and digestion, easily absorb, and absorb fast, it is possible to play rapidly the object for the treatment of, curative effect time is long, and prescription Chinese traditional medicine formula is reasonable, and drug effect is obvious;
4, prevention and curative ratio height, clinical trial reaches the curative ratio of 94%, is better than an Enrofloxacin pharmaceutical chemicals for avian colibacillosis U.S. FDA recommendation.
Embodiment
In order to make those skilled in the art better understand and implement the present invention, below in conjunction with specific embodiment, the present invention is described further. But following content should not be understood to the restriction to claims of the present invention request protection domain in any degree.
Embodiment 1
A compound Chinese medicine extract for prevention and therapy man's avian colibacillosis, is prepared from by the Chinese medicinal materials of following weight:
The root of large-flowered skullcap 8 parts, golden cypress 8 parts, Herba Andrographis 8 parts, Herba Houttuyniae 8 parts, the Radix Astragali 8 parts, taraxacum 8 parts, Spica Prunellae 7 parts, radix bupleuri 7 parts, purslane 7 parts, 7 parts, Poria cocos, 7 parts, gypsum, 6 parts, Chinese ephedra, Root of Chinese Pulsatilla 6 parts, 5 parts, Radix Glycyrrhizae.
Preparation method's step of described compound Chinese medicine extract is as follows:
The Chinese medicinal materials of above-mentioned weight is mixed, warm water (60-65 DEG C) immersion adding medicinal material gross weight 2.5 times is after 1 hour, add medicinal material gross weight 12 times of water again in extracting in concentrated unit 92 DEG C of heating and refluxing extraction 10 hours, then feed liquid is concentrated 3 times to medicinal material gross weight, feed liquid vacuum pump after concentrated is evacuated to setting tank, leave standstill 12h, make precipitation, getting supernatant liquor, to be evaporated to relative density be 1.15��1.20 (55-60 DEG C), spraying dry, receives powder, pulverizes, 50 orders sieve mixed even, to obtain final product.
Embodiment 2
A compound Chinese medicine extract for prevention and therapy man's avian colibacillosis, is prepared from by the Chinese medicinal materials of following weight:
The root of large-flowered skullcap 10 parts, golden cypress 10 parts, Herba Andrographis 12 parts, Herba Houttuyniae 12 parts, the Radix Astragali 10 parts, taraxacum 12 parts, Spica Prunellae 8 parts, radix bupleuri 8 parts, purslane 8 parts, 10 parts, Poria cocos, 10 parts, gypsum, 8 parts, Chinese ephedra, Root of Chinese Pulsatilla 9 parts, 8 parts, Radix Glycyrrhizae. Compound Chinese medicine extract is prepared by the preparation method of embodiment 1.
Embodiment 3
A compound Chinese medicine extract for prevention and therapy man's avian colibacillosis, is prepared from by the Chinese medicinal materials of following weight:
The root of large-flowered skullcap 13 parts, golden cypress 13 parts, Herba Andrographis 11 parts, Herba Houttuyniae 13 parts, the Radix Astragali 15 parts, taraxacum 13 parts, Spica Prunellae 10 parts, radix bupleuri 10 parts, purslane 7 parts, 9 parts, Poria cocos, 10 parts, gypsum, 10 parts, Chinese ephedra, Root of Chinese Pulsatilla 7 parts, 6 parts, Radix Glycyrrhizae. Compound Chinese medicine extract is prepared by the preparation method of embodiment 1.
Embodiment 4
A compound Chinese medicine extract for prevention and therapy man's avian colibacillosis, is prepared from by the Chinese medicinal materials of following weight:
The root of large-flowered skullcap 16 parts, golden cypress 16 parts, Herba Andrographis 16 parts, Herba Houttuyniae 16 parts, the Radix Astragali 16 parts, taraxacum 16 parts, Spica Prunellae 14 parts, radix bupleuri 14 parts, purslane 14 parts, 14 parts, Poria cocos, 14 parts, gypsum, 12 parts, Chinese ephedra, Root of Chinese Pulsatilla 12 parts, 10 parts, Radix Glycyrrhizae. Compound Chinese medicine extract is prepared by the preparation method of embodiment 1.
In order to determine that optimum amount proportioning combines, embodiment 1-4 gained compound Chinese medicine extract is carried out clinical effect trial, has carried out checking and illustrate:
Test 1
Experimental animal:
Select healthy chicken 500 age on the 1st, raise in cages and raise to age on the 21st, routine immunization.According to NRC(1994) trophic level, the feed of antibiotic-free of feeding and free choice feeding, the drinking-water of fowl.
Test strain:
Intestinal bacteria O78(C84008) type reference culture, is purchased from veterinary drug supervision institute of China.
Animal experiment grouping and process
The chick 550 selecting body weight close, healthy, random choose 500 only injects intestinal bacteria nutrient solution (1.0 �� 10 according to 0.5mL/kg chest12CFU/mL) carry out challenge test, the spirit of viewing test chicken, the clinical settings such as drinking-water, breathing of searching for food, in attacking poison the 2nd day random choose obvious chicken of ehec infection sequela symptom 350, it is divided into 7 groups, often organizes 50. I-IV group adopts the Chinese medical extract that in the present invention prepared by embodiment 1-4 to treat respectively, freely drinks water to add 2g extract whole day in every 1L water; V group for freely to drink water to add 0.1g Enrofloxacin whole day in every 1L water; VI group for freely to drink water to add 0.1g florfenicol whole day in every 1L water; Attack poison not administration group for VII group; VIII group is 50 and does not attack poison not administration group; Each test group is isolated all separately, does not interfere with each other between each group. Successive administration treats 5 days, within every 6 hours, observes, records clinical change and death condition, calculates mortality ratio and curative ratio.
Treatment result: each group result for the treatment of is in table 1:
Table 1
Test-results shows: the compound Chinese medicine extract of the present invention's development is better to the clinical efficacy of manual-induced chicken colibacillosis, curative ratio is up to 94%, obviously it is better than Enrofloxacin and florfenicol group, and embodiment 1-4 has good clinical efficacy, but embodiment 2 is relatively more better by contrast, therefore using the consumption proportion of embodiment 2 as optimum amount ratio. There is not any untoward reaction in compound extract test group chicken group of the present invention, shows the security of Ben Faming.
In order to verify that the present invention is in conjunction with clinical therapeutic efficacy further, carry out verification experimental verification further
Test 2
Experimental animal and feed:
Select 1 Ling Sanhuang healthy chick 300, raise in cages and raise to age on the 21st, routine immunization. According to NRC(1994) trophic level, the feed of antibiotic-free of feeding and free choice feeding, the drinking-water of fowl.
Test strain:
Intestinal bacteria O78(C84008) type reference culture, is purchased from veterinary drug supervision institute of China.
Animal experiment grouping and process
The chick 350 selecting body weight close, healthy, random choose 300 only injects intestinal bacteria nutrient solution (1.0 �� 10 according to 0.5mL/kg chest12CFU/mL) carry out challenge test, the spirit of viewing test chicken, the clinical settings such as drinking-water, breathing of searching for food, in attacking poison the 2nd day random choose obvious chicken of ehec infection sequela symptom 200, it is divided into 4 groups, often organizes 50. I group adopts optimum proportioning of the present invention to prepare Chinese medical extract (embodiment 2), freely drink water so that every 1L water to add 2g extract whole day, II group for freely to drink water to add 0.1g Enrofloxacin whole day in every 1L water, for freely to drink water so that every 1L water to add 0.1g florfenicol whole day, attack poison not administration group for IV group for III group; Choosing 50 chick not attacking poison for V group, also not administration simultaneously, each test group is isolated all separately, does not interfere with each other between each group. Successive administration treats 5 days, within every 6 hours, observes, records clinical change and death condition, calculates mortality ratio and curative ratio.
Treatment result: each group result for the treatment of is in table 2.
Table 2
Result shows, optimum proportioning of the present invention is prepared Chinese medical extract and is treated family's avian colibacillosis curative ratio height, difference is extremely remarkable compared with current clinical conventional chemical drug group (Enrofloxacin, florfenicol), and result for the treatment of is obviously better than clinical conventional chemical drug Enrofloxacin, florfenicol.There is not any untoward reaction in compound extract test group chicken group of the present invention, shows the security of product of the present invention.
For checking the present invention is to the clinical efficacy of natural occurrence, carry out verification experimental verification further:
Test 3
Experimental animal: in October, 2012, chicken field, Fuyang City Jieshou City 3000 chicken generation colibacillosiss age on the 18th, once with 3 kinds of antimicrobial drug treatment 4d without positive effect, death toll rises to 156/d from l9/d, and dead 329 altogether is O by isolation identification78��O2Type coli-infection is fallen ill, and is tested by residue chicken.
Remedy measures: the broiler chicken of morbidity Ji Chang is used Chinese medical extract (embodiment 2) prepared by optimum proportioning of the present invention, freely drinks water to add 2g extract whole day in every 1L water. Stopping dead by the 5th day after Ji Chang application the present invention of generation colibacillosis drinks water treatment, curative ratio reaches 93.4%, has obvious result for the treatment of, the results are shown in Table 3.
Table 3
Claims (2)
1. the compound Chinese medicine extract of prevention and therapy man's avian colibacillosis, it is characterised in that, it is prepared from by the Chinese medicinal materials of following weight:
Root of large-flowered skullcap 8-16 part,
Golden cypress 8-16 part,
Herba Andrographis 8-16 part,
Herba Houttuyniae 8-16 part,
Radix Astragali 8-16 part,
Taraxacum 8-16 part,
Spica Prunellae 7-14 part,
Radix bupleuri 7-14 part,
Purslane 7-14 part,
Poria cocos 7-14 part,
Gypsum 7-14 part,
Chinese ephedra 6-12 part,
Root of Chinese Pulsatilla 6-12 part,
Radix Glycyrrhizae 5-10 part;
The preparation method of described compound Chinese medicine extract, step is as follows:
Taking each Chinese medicinal materials of described weight part, mixing, the water soaking of 60-65 DEG C adding each Chinese medicinal materials gross weight 2-3 times is after 1 hour, the water adding each Chinese medicinal materials gross weight 12 times again, in 92 DEG C of refluxing extraction 10 hours, then by 3 times of concentrated for feed liquid most each Chinese medicinal materials gross weight, leaves standstill 12h, make precipitation, get supernatant liquor be evaporated to 55-60 DEG C at relative density 1.15��1.20, spraying dry, receive powder, pulverize, cross 50 order sieves, mixed even, to obtain final product.
2. compound Chinese medicine extract as claimed in claim 1, it is characterised in that, it is prepared from by the Chinese medicinal materials of following weight: the root of large-flowered skullcap 10 parts, golden cypress 10 parts, Herba Andrographis 12 parts, Herba Houttuyniae 12 parts, the Radix Astragali 10 parts, taraxacum 12 parts, Spica Prunellae 8 parts, radix bupleuri 8 parts, purslane 8 parts, 10 parts, Poria cocos, 10 parts, gypsum, 8 parts, Chinese ephedra, Root of Chinese Pulsatilla 9 parts, 8 parts, Radix Glycyrrhizae.
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| CN105878875A (en) * | 2014-12-15 | 2016-08-24 | 沈阳伟嘉牧业技术有限公司 | Traditional Chinese medicine ultra-micro powder granules for preventing and treating necrotic enteritis of poultry and preparation method thereof |
| CN106721402A (en) * | 2015-11-19 | 2017-05-31 | 武汉市畜牧兽医科学研究所 | A kind of compound Chinese herb formula for preventing and treating laying hen peritonitis and its application |
| CN108403972A (en) * | 2018-05-03 | 2018-08-17 | 鲁东大学 | A kind of production method for treating chicken colibacillosis Chinese herbal and crude drugs preparations |
| CN108653340A (en) * | 2018-07-06 | 2018-10-16 | 山东省农业科学院家禽研究所 | The construction method of one breeder yinfen syndrome model |
| CN113940966B (en) * | 2021-11-09 | 2023-07-07 | 江西普正制药股份有限公司 | Callicarpa nudiflora composition for treating escherichia coli infection and preparation method and application thereof |
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| CN1364613A (en) * | 2001-10-03 | 2002-08-21 | 唐善强 | Veterinary medicine |
| CN102258614A (en) * | 2011-07-15 | 2011-11-30 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating white diarrhea and chronic respiratory disease and preparation method thereof |
| CN102342981A (en) * | 2011-10-13 | 2012-02-08 | 四川农业大学 | Traditional Chinese medicine oral solution for prevention and treatment of avian colibacillosis and preparation method of same |
| CN102406729A (en) * | 2011-11-28 | 2012-04-11 | 河南省康星药业有限公司 | Normal temperature preparation method of ultrafine Maxingshigan powder and special bidirectional air flow screening machine for same |
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| CN1364613A (en) * | 2001-10-03 | 2002-08-21 | 唐善强 | Veterinary medicine |
| CN102258614A (en) * | 2011-07-15 | 2011-11-30 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating white diarrhea and chronic respiratory disease and preparation method thereof |
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