CN104013700A - Traditional Chinese medicine composition for treating damp-heat type yellow and white scour of piglets as well as preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating damp-heat type yellow and white scour of piglets as well as preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating damp-heat type yellow and white scour of piglets. The traditional Chinese medicine composition consists of the following components in parts by weight: 1-5 parts of golden thread, 2-6 parts of dark plum fruit and 2-5 parts of berberis julianae schneid. The invention also discloses an oral liquid preparation prepared from the traditional Chinese medicine composition and a preparation method of the oral liquid preparation. The preparation method comprises the steps of mixing dark plum fruit, golden thread and berberis julianae schneid in proportion, crushing, then adding water for boiling, then filtering decoction, concentrating filtrate to ensure that the dose of primary medicaments contained in per 1000ml is 500-1000g, refrigerating and placing, then centrifuging, taking supernatant liquor, adding preservatives, boiling, and filtering to prepare oral liquid. The traditional Chinese medicine composition disclosed by the invention combines the three medicaments namely golden thread, golden thread and berberis julianae schneid, has the effects of clearing away heat and drying dampness, and astringing to arrest diarrhea, and is mainly used for treating dysentery, diarrhea and the like caused by dampness-heat. Clinical trials show that when the traditional Chinese medicine oral liquid disclosed by the invention is used for treating yellow and white scour caused by dampness-heat of the piglets, the recovery rate can reach more than 90%, and medicament tolerance can not be generated.
Description
Technical field
The invention belongs to herbal medicine field of pharmaceutical technology, be specifically related to a kind of Chinese medicine composition and preparation and preparation method that is used for the treatment of piglet humid HUANGBAI(sic) dysentery.
Background technology
Yellow and white dysentery of piglet is the abbreviation of yellow scour of piglet, Hakuri.General piglet is born, and within latter 7 days, to take the dysentery of interior generation be yellow scours, and 7 days above Hakuri that are called that dysentery occurs of birth, the two is all because a kind of acute infectious intestinal disease of damp and hot and the newborn piglet that Escherichia coli causes, if treatment not in time, be easy to cause piglet dead, bring huge economic loss to pig farm and raiser.The medicine that is used for the treatment of at present such disease is a lot, but mainly take chemical classes medicine as main, and the clinical non-rational use of drug due to long-term, causes drug resistance to strengthen year by year, and it is even invalid that its curative effect also reduces gradually.Therefore, adopt herbal medicine preparation to treat piglet humid HUANGBAI(sic) dysentery and become goal in research in recent years.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition and preparation and preparation method that is used for the treatment of piglet humid HUANGBAI(sic) dysentery, treatment is because of the damp and hot yellow and white dysentery of piglet causing, clinical effectiveness is good, good stability, and the generation that has no drug resistance.
For achieving the above object, the invention provides following technical scheme:
The invention discloses a kind of Chinese medicine composition that is used for the treatment of piglet humid HUANGBAI(sic) dysentery, described Chinese medicine composition is composed of the following components by weight: 1 ~ 5 part of Rhizoma Coptidis, 2 ~ 6 parts of Fructus Mumes, 2 ~ 5 parts of Radix Berberidis.
Further, described Chinese medicine composition is composed of the following components by weight: 3 parts of Rhizoma Coptidis, 4 parts of Fructus Mumes, 3 parts of Radix Berberidis.
The invention also discloses the preparation of being prepared by described Chinese medicine composition.
Further, described preparation is oral liquid.
Further, in every 1000 milliliters of oral liquids, containing primary dose, it is 500 ~ 1000 grams.
The invention also discloses the preparation method of described oral liquid formulations, after being mixed in proportion to pulverizing, Fructus Mume, Rhizoma Coptidis and Radix Berberidis decoct with water, then decocting liquid is filtered, filtrate being concentrated in every 1000 milliliters is 500 ~ 1000 grams containing primary dose again, cold preservation is centrifugal after placing, get supernatant and add antiseptic, boil, filter and make oral liquid.
Further, decoct with water three times after Fructus Mume, Rhizoma Coptidis and Radix Berberidis are mixed in proportion to pulverizing, add the water of 6～10 times of weight that are equivalent to primary dose at every turn, respectively decoct 1 hour at every turn, merge the decocting liquid decocting.
Beneficial effect of the present invention is:
Rhizoma Coptidis: Latin formal name used at school Coptis chinensis Franch.; Have eliminating fire and detoxication, heat clearing and damp drying effect, the diseases such as row pyretic toxicity in the time of can controlling, high heat agitation, dysentery, have the effect of the pathogenic bacterium such as inhibition escherichia coli, Salmonella; Rhizoma Coptidis is containing multiple alkaloids such as berberine, coptisine, separately containing compositions such as obacunone, obakulactones.
Fructus Mume: Latin formal name used at school DarkPlumFruit; Main containing being rich in organic acid, the effect that has convergence to promote the production of body fluid.
Radix Berberidis: Latin formal name used at school Berberis sargentiana Schneid; Containing berberine, berbamine etc.
Three medicines share, and have the merit of heat clearing and damp drying, astringing to arrest diarrhea, cure mainly damp and hot due to dysentery, diarrhoea etc.The damp and hot HUANGBAI(sic) dysentery causing of Chinese medicine oral liquid treatment piglet of the present invention is used in clinical trial, and its cure rate can reach more than 90%, and the generation that has no drug resistance.
The specific embodiment
To be described in detail the preferred embodiments of the present invention below.
embodiment 1
Take 300 grams of Rhizoma Coptidis, 300 grams of 400 grams of Fructus Mumes and Radix Berberidis, coarse pulverization after being mixed, decoct with water three times, add first water and be 10 times of primary dose, it is 8 times of primary dose that secondary adds water, adds water for three times and be 6 times of primary dose, respectively decoct 1 hour at every turn, merge the decocting liquid decocting for three times, filter, then filtrate heating is concentrated into containing primary dose is 0.8g/ml, place 4 ℃ of cold preservations 48 hours, with 10000 revs/min centrifugal 30 minutes, get supernatant and add antiseptic, boil 5 minutes, filter, obtain oral liquid.
embodiment 2
The clinical trial result checking of Chinese medicine oral liquid treatment yellow and white dysentery of piglet of the present invention:
Select that parity, age in days, the young number of nest are close, 140 of the purebred York piglets that are diagnosed as the damp and hot HUANGBAI(sic) dysentery causing, be divided into 3 groups, 60 of Chinese medicine oral liquid test group, 60 of poplar flower oral liquid matched groups, 20 of the not administration matched groups of falling ill.The dosage of poplar flower oral liquid is 10ml/ head, and Chinese medicine oral liquid (oral liquid that embodiment 1 makes) test group is 5ml/ head, within 1st, take 2 times, and within 3 days, be a course for the treatment of.
Duration of test, the clinical manifestation of viewing test animal and physical signs, as the mental status, appetite, feces, body temperature, breathing etc., and itemized record, observe 7 days after treating a course for the treatment of.
Clinical efficacy criterion:
Cure: a course for the treatment of of continuous use, sick pig cardinal symptom disappears, and feces is shaped, and spirit, appetite, body temperature etc. recover normally.In 7 days, do not recur, be judged to healing.The ratio that accounts for total group test pig according to healing pig is calculated cure rate.
Effective: a course for the treatment of of continuous use, sick pork chop excrement number of times reduces, feces is than former retrogradation, and spirit, body temperature, diet are wanted obviously to improve, and is judged to effectively, accounts for the ratio calculating obvious effective rate of total group test pig according to effective pig.
Invalid: a course for the treatment of of continuous use, sick pig is not felt any better, and spirit, body temperature, diet wish etc. are not improved, even occur that pig is dead, it is invalid to be judged to, and the ratio that accounts for total group test pig according to invalid pig is calculated inefficiency.
Itemized record are respectively organized test data, after having tested, test cure rate, obvious effective rate and inefficiency are carried out to data statistics.Relevant data is in Table 1.
Finally explanation is, above preferred embodiment is only unrestricted in order to technical scheme of the present invention to be described, although the present invention is described in detail by above preferred embodiment, but those skilled in the art are to be understood that, can to it, make various changes in the form and details, and not depart from the claims in the present invention book limited range.
Claims (7)
1. a Chinese medicine composition that is used for the treatment of piglet humid HUANGBAI(sic) dysentery, is characterized in that: described Chinese medicine composition is composed of the following components by weight: 1 ~ 5 part of Rhizoma Coptidis, 2 ~ 6 parts of Fructus Mumes, 2 ~ 5 parts of Radix Berberidis.
2. the Chinese medicine composition that is used for the treatment of piglet humid HUANGBAI(sic) dysentery according to claim 1, is characterized in that: described Chinese medicine composition is composed of the following components by weight: 3 parts of Rhizoma Coptidis, 4 parts of Fructus Mumes, 3 parts of Radix Berberidis.
3. the preparation of being prepared by Chinese medicine composition described in claim 1 or 2.
4. preparation according to claim 3, is characterized in that: described preparation is oral liquid.
5. preparation according to claim 4, is characterized in that: in every 1000 milliliters of oral liquids, containing primary dose, be 500 ~ 1000 grams.
6. the preparation method of preparation according to claim 5, it is characterized in that: after Fructus Mume, Rhizoma Coptidis and Radix Berberidis are mixed in proportion to pulverizing, decoct with water, then decocting liquid is filtered, filtrate being concentrated in every 1000 milliliters is 500 ~ 1000 grams containing primary dose again, cold preservation is centrifugal after placing, get supernatant and add antiseptic, boil, filter and make oral liquid.
7. preparation method according to claim 6, it is characterized in that: after Fructus Mume, Rhizoma Coptidis and Radix Berberidis are mixed in proportion to pulverizing, decoct with water three times, the water that at every turn adds 6～10 times of weight that are equivalent to primary dose respectively decocts 1 hour at every turn, merges the decocting liquid decocting.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266044A (en) * | 2016-08-30 | 2017-01-04 | 重庆市畜牧科学院 | A kind of herbal medicine powder for treating piglet humid HUANGBAI(sic) dysentery and preparation method thereof |
| CN107737171A (en) * | 2017-09-18 | 2018-02-27 | 颍上庆丰农牧发展有限公司 | It is a kind of to be used to treat parenteral solution of the black pig piglet yellow scour in Anhui north and preparation method thereof |
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| CN101396485A (en) * | 2007-09-29 | 2009-04-01 | 张勇 | Traditional Chinese medicine formula for treating yellow and white scour of suckling pigs |
| WO2012131643A1 (en) * | 2011-04-01 | 2012-10-04 | Raula Ananda Chandra | Herbal compositions comprising pedilanthus tithymaloides for treatment prevention of gastrointestinal disorder |
| CN103690625A (en) * | 2013-12-19 | 2014-04-02 | 重庆市畜牧科学院 | Traditional Chinese medicine rhizoma coptidis granules for treating damp-hot yellow and white diarrhea of piglets |
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| CN101396485A (en) * | 2007-09-29 | 2009-04-01 | 张勇 | Traditional Chinese medicine formula for treating yellow and white scour of suckling pigs |
| WO2012131643A1 (en) * | 2011-04-01 | 2012-10-04 | Raula Ananda Chandra | Herbal compositions comprising pedilanthus tithymaloides for treatment prevention of gastrointestinal disorder |
| CN103690625A (en) * | 2013-12-19 | 2014-04-02 | 重庆市畜牧科学院 | Traditional Chinese medicine rhizoma coptidis granules for treating damp-hot yellow and white diarrhea of piglets |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266044A (en) * | 2016-08-30 | 2017-01-04 | 重庆市畜牧科学院 | A kind of herbal medicine powder for treating piglet humid HUANGBAI(sic) dysentery and preparation method thereof |
| CN107737171A (en) * | 2017-09-18 | 2018-02-27 | 颍上庆丰农牧发展有限公司 | It is a kind of to be used to treat parenteral solution of the black pig piglet yellow scour in Anhui north and preparation method thereof |
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