CN111760004B - Traditional Chinese medicine granules for preventing and treating livestock and poultry influenza and application thereof - Google Patents

Traditional Chinese medicine granules for preventing and treating livestock and poultry influenza and application thereof Download PDF

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CN111760004B
CN111760004B CN202010804212.0A CN202010804212A CN111760004B CN 111760004 B CN111760004 B CN 111760004B CN 202010804212 A CN202010804212 A CN 202010804212A CN 111760004 B CN111760004 B CN 111760004B
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traditional chinese
chinese medicine
poultry
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CN111760004A (en
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张作栋
李爱民
徐涛凡
张宪磷
黄顺明
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Xinxiang Hexie Animal Pharmaceutical Co ltd
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract

The invention provides a traditional Chinese medicine granule for preventing and treating livestock and poultry influenza and application thereof, and relates to the technical field of veterinary medicines. The traditional Chinese medicine granules mainly comprise the following components in parts by weight: 5-15 parts of isatis root, 5-15 parts of folium isatidis, 1-10 parts of codonopsis pilosula, 1-10 parts of polygonum cuspidatum, 5-15 parts of radix bupleuri, 5-15 parts of baked ginger, 5-15 parts of subprostrate sophora, 5-15 parts of lonicera confusa, 5-15 parts of groundsel, 5-15 parts of malaysia japonica, 1-10 parts of geum japonicum, 1-10 parts of folium artemisiae argyi, 1-10 parts of radix sileris and 1-10 parts of schizonepeta; the invention selects a plurality of genuine medicinal materials, is obtained by reasonably matching according to the principle of differentiation and treatment of symptoms and signs of the traditional Chinese medicine, fully exerts the functions of all the medicaments, and coordinates all the medicaments together to gain the medicament effect. The traditional Chinese medicine granules can obviously relieve the symptoms of sick livestock and poultry, improve the mental status, improve the feed intake, reduce the death rate and have more obvious treatment effect. The traditional Chinese medicine granule has the effects of clearing away heat and toxic materials, reducing swelling, resolving masses, resisting viruses and enhancing the immunity of the organism. The invention is prepared from pure Chinese medicaments, and has the advantages of definite curative effect, no medicament resistance, no residue and no toxic or side effect.

Description

Traditional Chinese medicine granules for preventing and treating livestock and poultry influenza and application thereof
Technical Field
The invention relates to the technical field of veterinary drugs, and in particular relates to a traditional Chinese medicine granule for preventing and treating livestock and poultry influenza and application thereof.
Background
Influenza virus can cause influenza (called influenza for short), and influenza is a respiratory tract infection disease with strong infectivity and high transmission speed and can cause higher morbidity and mortality. Livestock and poultry flu is a highly contagious disease of poultry, wild birds and swine livestock infection caused by influenza a virus. In recent years, with the continuous expansion of livestock and poultry breeding scale, the breeding mode is greatly changed, the concentrated and large-scale breeding is mainly used for the livestock and poultry breeding at present, but the breeding density is too high, the breeding environment is severe, the propagation of bacteria and viruses is provided with favorable opportunities, the probability of cross infection is increased, the livestock and poultry flu is concentrated almost every year, and the livestock and poultry flu can be attacked by infection regardless of age and season. The low-pathogenicity livestock and poultry influenza can cause the poultry to have mild respiratory symptoms, reduce the food intake, reduce the egg yield and cause sporadic death. The highly pathogenic livestock and poultry influenza is the most serious, the morbidity and the mortality are high, the mortality of poultry chicken infection is almost 100 percent, none is fortunate, and the highly pathogenic livestock and poultry influenza can enter the human body, destroy the immune system and harm the health of the human body.
At present, antibiotics and other chemicals are mainly used for preventing and treating livestock and poultry influenza clinically, and the abuse of the antibiotics causes pollution and deterioration of the breeding environment; meanwhile, the problems of drug resistance generation of pathogenic microorganisms, low body immunity and disease resistance, overproof drug residues of meat products and the like can be caused, and the direct threat to the health and safety of human beings is caused. And the long-term use of antibiotics by livestock and poultry can generate drug resistance to the antibiotics, so that the immunity is low, and the survival rate is reduced.
The traditional Chinese medicine is a natural medicine, contains various effective bioactive substances such as alkaloid, polysaccharide and the like, can exert the effect of chiral structure which cannot be achieved by a synthetic medicine, has the advantages of wide antiviral spectrum, small toxic and side effects, no environmental pollution and the like, and also contains mineral substances, vitamins and unknown nutritional factors, and plays multiple roles of prevention, treatment and nutrition. At present, Chinese patent medicines for preventing and treating livestock and poultry influenza exist in the market, but the Chinese patent medicines are slowly absorbed after being taken, have no obvious virus inhibition effect and have unsatisfactory treatment effect.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the traditional Chinese medicine granule for preventing and treating the livestock and poultry influenza, which has definite curative effect, no drug resistance and no toxic or side effect, and the application thereof.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme:
the traditional Chinese medicine granule for preventing and treating livestock and poultry influenza mainly comprises the following traditional Chinese medicine components in parts by weight: 5-15 parts of isatis root, 5-15 parts of dyers woad leaf, 1-10 parts of codonopsis pilosula, 1-10 parts of giant knotweed, 5-15 parts of radix bupleuri, 5-15 parts of baked ginger, 5-15 parts of subprostrate sophora, 5-15 parts of lonicera confusa, 5-15 parts of groundsel, 5-15 parts of malaysia japonica, 1-10 parts of geum japonicum, 1-10 parts of folium artemisiae argyi, 1-10 parts of divaricate saposhnikovia root and 1-10 parts of schizonepeta.
Further, as the optimization of the traditional Chinese medicine granules for preventing and treating the livestock and poultry influenza, the traditional Chinese medicine granules comprise the following traditional Chinese medicines in parts by weight: 8-12 parts of isatis root, 8-12 parts of folium isatidis, 3-8 parts of codonopsis pilosula, 3-8 parts of polygonum cuspidatum, 8-12 parts of radix bupleuri, 6-12 parts of baked ginger, 6-12 parts of subprostrate sophora, 6-12 parts of lonicera confusa, 6-12 parts of groundsel, 6-12 parts of malaysia japonica, 3-8 parts of geum japonicum, 3-8 parts of folium artemisiae argyi, 3-8 parts of radix sileris and 3-8 parts of schizonepeta.
Further, as the optimization of the traditional Chinese medicine granules for preventing and treating the livestock and poultry influenza, the traditional Chinese medicine granules comprise the following traditional Chinese medicines in parts by weight: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum japonicum, 5 parts of folium artemisiae argyi, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
On the other hand, the invention provides a preparation method of Chinese medicinal granules for treating influenza of Chinese ark livestock and poultry, which comprises the following steps: taking the following medicinal materials in parts by weight: 5-15 parts of isatis root, 5-15 parts of folium isatidis, 1-10 parts of codonopsis pilosula, 1-10 parts of polygonum cuspidatum, 5-15 parts of radix bupleuri, 5-15 parts of baked ginger, 5-15 parts of subprostrate sophora, 5-15 parts of lonicera confusa, 5-15 parts of groundsel, 5-15 parts of malaysia japonica, 1-10 parts of geum japonicum, 1-10 parts of folium artemisiae argyi, 1-10 parts of radix sileris and 1-10 parts of schizonepeta; adding 15 times of water for decocting for three times, each time for 2.5 hours, then merging decoction, filtering, standing for 24 hours, taking supernate, concentrating under reduced pressure until the relative density is 1.30-1.32, adding dextrin or starch which is 0.2-0.3 times of the total weight, uniformly mixing, drying to form dry paste, crushing to form fine powder, sterilizing and packaging to obtain the traditional Chinese medicine granule.
The invention also provides application of the traditional Chinese medicine granules for treating livestock and poultry influenza, wherein the traditional Chinese medicine granules are used for preventing and treating the livestock and poultry influenza, and the specific dosage is as follows: 300 jin of water is added into every 100g of the traditional Chinese medicine granules, and the traditional Chinese medicine granules are fed by adopting free drinking water.
The traditional Chinese medicine granule of the invention has the following pharmacological actions of the traditional Chinese medicine components:
radix isatidis: cold in nature, bitter in taste, entering heart and stomach meridians; has effects of clearing away heat and toxic materials, cooling blood, and relieving sore throat, and can be used for treating pestilence, toxin, carbuncle, macula, erysipelas, and wind-heat syndrome. It contains indigo, indirubin, beta-sitosterol, sinigrin, indioside, tryptanthrin, palmitic acid, sucrose, 1-thiocyanic acid-2-hydroxybut-3-ene and various amino acids, and the indioside is the main antiviral component. Radix Isatidis has strong antiviral, antibacterial, immunity enhancing, endotoxin resisting, anticancer, and antipyretic effects.
Folium isatidis: bitter taste and cold nature, entering liver, heart, stomach and spleen meridians; has the effects of clearing away heat and toxic materials, cooling blood and removing ecchymoses; can be used for treating fever, hyperpyrexia, polydipsia, macula, jaundice, dysentery, erysipelas, and aphtha; it contains indole, quinazolone, sinapside, etc. and has antibacterial, antiviral, antiendotoxin, anticancer, immunity enhancing, etc. effects.
Codonopsis pilosula: sweet in taste and mild in nature; spleen and lung meridian entered; has the effects of invigorating spleen and replenishing qi, invigorating spleen and benefiting lung, nourishing blood and promoting fluid production; the feed additive contains components such as saccharides, glycosides, alkaloids, amino acids, trace elements and the like, can obviously enhance the immunity of animals, improves the production performance of the animals, enhances the anti-stress capability of the animals, has the sterilization capability and has higher nutrition function.
Giant knotweed rhizome: slightly bitter in taste and cold in nature, entering liver, gallbladder and lung meridians; has effects in eliminating dampness, removing jaundice, clearing away heat and toxic materials, dispelling blood stasis, relieving pain, relieving cough, and eliminating phlegm; can be used for treating jaundice due to damp-heat pathogen, rheumatalgia, carbuncle, suppurative sore, and cough due to lung heat; the polygonum cuspidatum contains chemical components such as anthraquinone, resveratrol, polydatin, flavonoid and the like, and modern pharmacology shows that the polygonum cuspidatum has the effects of regulating blood fat, resisting liver injury, shock, bacteria, cough, asthma, bacteria, virus and tumor and the like.
Bupleurum root: bitter and pungent in flavor, slightly cold in nature, entering liver and gallbladder meridians; has the effects of harmonizing exterior and interior, soothing liver-qi stagnation, lifting yang and sinking, abating fever and preventing malaria; can be used for treating common cold, fever, distending pain in chest and hypochondrium, menoxenia, uterine prolapse, and proctoptosis; it contains various effective components such as volatile oil, saponins, and flavonoids; modern pharmacology proves that the bupleurum has the effects of resisting inflammation, tumors, bacteria, viruses, fever, sedation, analgesia, relieving cough and the like, and has the regulation effect on liver, gastrointestinal tract, immunologic function, blood fat and the like.
Baked ginger: pungent and warm property, it enters spleen, stomach and kidney meridians; has effects in warming channels, stopping bleeding, warming middle-jiao, and relieving pain; can be used for treating yang deficiency, hemorrhage, hematemesis, metrorrhagia, metrostaxis, spleen and stomach deficiency cold, abdominal pain, emesis, and diarrhea.
Subprostrate sophora root: bitter taste and cold nature, and enters lung and stomach channels, and has the effects of clearing away heat and toxic materials, relieving swelling and relieving sore throat; can be used for treating fire toxin accumulation, tonsillitis pharyngitis, sore throat, gingival swelling and pain, and aphtha of the mouth and tongue; the subprostrate sophora root is mainly used as the root and rhizome of the medicinal material, is rich in effective components such as plant polysaccharide, alkaloid, flavone, oleanolic acid and phenols, and has the effects of resisting inflammation, inhibiting bacteria, resisting hepatitis B virus, resisting tumor, improving immunity, etc.
Wild honeysuckle flower: cold in nature, sweet in flavor, entering lung, heart and stomach meridians; has effects of clearing away heat and toxic materials, and dispelling pathogenic wind and heat; can be used for treating carbuncle, swelling, sore, erysipelas, dysentery with bloody stool, wind-heat type common cold, epidemic febrile disease, and fever; the compound essential oil contains various volatile oil and flavonoid chemical components, and modern pharmacology shows that the compound essential oil has the effects of resisting bacteria, resisting pathogenic microorganisms, resisting viruses, resisting inflammation, relieving fever, promoting phagocytic function of inflammatory cells and enhancing the immunologic function of organisms.
Groundsel: bitter taste and cold nature, entering lung and liver meridians; has the effects of clearing away heat and toxic materials, improving eyesight, removing dampness by diuresis, killing parasites and relieving pain; can be used for treating carbuncle, swelling, sore, fever, common cold, conjunctival congestion, swelling and pain, diarrhea, dysentery, and skin eczema; mainly contains components such as moleplant alkaloid, lupenone, oleanane, beta-sitosterol, daucosterol, alkaloid, p-hydroxyphenylacetic acid, hyperin, linarin, oleanol, quercetin, racemic syringyl, emodin, chlorogenic acid, caffeic acid and the like, and has strong antibacterial effect on staphylococcus aureus, typhoid bacillus, paratyphoid bacillus A, paratyphoid bacillus B, shigella dysenteriae, dysentery bacillus baumannii and dysentery bacillus sonnei.
And (3) Maranta: pungent in flavor and cool in nature, and enter lung, liver, stomach and large intestine meridians; has effects in cooling blood, stopping bleeding, clearing away heat, promoting diuresis, removing toxic materials, and relieving swelling; can be used for treating hematemesis, epistaxis, bloody dysentery, metrorrhagia, traumatic hemorrhage, jaundice, edema, common cold, and cough.
Red bayberry: bitter and astringent taste, cool in nature, and enter spleen, stomach and large intestine meridians; has effects in clearing away heat, promoting diuresis, removing toxic materials, and relieving swelling; is mainly used for treating damp-heat diarrhea, dysentery, eczema, sore furuncle pyogenic infections, toothache due to pathogenic wind-fire, traumatic injury, traumatic hemorrhage, etc.; modern pharmacological research shows that the geum japonicum has better pharmacological activities of resisting tumor, oxidation, virus, bacteria and the like.
Folium artemisiae argyi: warm in nature, pungent and bitter in flavor, entering liver, spleen and kidney meridians; the internal medicine has the effects of warming channels, stopping bleeding, dispelling cold and relieving pain, and the external medicine has the effects of eliminating dampness and relieving itching; it is mainly used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy, lower abdomen psychroalgia, menoxenia, infertility due to cold womb, and skin pruritus; the main active pharmaceutical ingredients of the folium artemisiae argyi comprise volatile oil, flavonoid compounds, tannin compounds, polysaccharide compounds, triterpenoid compounds, trace elements, chlorogenic acid and the like, and modern pharmacological studies show that the folium artemisiae argyi has the effects of stopping bleeding, resisting coagulation, exciting uterus, resisting bacteria and viruses, relieving cough and asthma, relieving pain and inflammation, improving the immunocompetence and the like.
Wind prevention: pungent, slightly sweet and warm in nature, entering the four meridians of bladder, spleen, lung and liver; has the effects of relieving exterior syndrome, dispelling pathogenic wind, relieving spasm, and eliminating dampness; can be used for treating wind cold, general pain, arthralgia due to wind-cold-dampness, and arthralgia; the active ingredients in the divaricate saposhnikovia root are chromone, polysaccharide, volatile oil, polyacetylene and coumarin, and modern pharmacological research shows that the divaricate saposhnikovia root has the effects of resisting oxidation, relieving fever and pain, resisting inflammation, resisting tumors and the like.
Herba schizonepetae: pungent and bitter in flavor, slightly warm in nature, entering lung and liver meridians; has effects in relieving exterior syndrome, expelling pathogenic wind, promoting eruption, and stopping bleeding; the main active ingredients in the schizonepeta are volatile oil and flavonoid compounds, and the schizonepeta has obvious effects of sweating, relieving fever, resisting inflammation and easing pain; the effective components in herba Schizonepetae can inhibit the content of related inflammatory factors, shorten the cell growth cycle, and further exert antibacterial, antiviral, and antitumor effects.
(III) advantageous effects
The invention provides a traditional Chinese medicine granule for preventing and treating livestock and poultry influenza and application thereof. The traditional Chinese medicine granule is prepared by combining modern and traditional extraction processes and reasonably matching by applying the traditional Chinese medicine dialectical treatment principle, the effects of all the medicines are fully exerted, and all the medicines are coordinated together to gain the efficacy. The traditional Chinese medicine granule is used for treating and relieving viral diseases such as influenza of livestock and poultry, and animal experiments and clinical experiments can well show that the traditional Chinese medicine granule can obviously relieve symptoms of sick livestock and poultry, improve mental conditions, improve feed intake, reduce death rate and has more obvious treatment effect. The traditional Chinese medicine granule has the effects of clearing heat and removing toxicity, relieving swelling and resolving masses and resisting viruses, has an enhancement effect on immune organs of organisms, effectively improves the immunity of the organisms, and provides a powerful material basis for livestock and poultry to resist virus infection. The invention is prepared from pure Chinese medicaments, has quick curative effect, no medicament resistance, no residue and no toxic or side effect, and is beneficial to human health.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A traditional Chinese medicine granule for preventing and treating livestock and poultry influenza is prepared according to the following steps:
taking the following medicinal materials in parts by weight: 5 parts of isatis root, 5 parts of dyers woad leaf, 1 part of codonopsis pilosula, 1 part of giant knotweed rhizome, 5 parts of radix bupleuri, 5 parts of baked ginger, 5 parts of subprostrate sophora, 5 parts of lonicera confusa, 5 parts of groundsel, 5 parts of malan grass, 1 part of geum japonicum, 1 part of folium artemisiae argyi, 1 part of divaricate saposhnikovia root and 1 part of schizonepeta; adding 15 times of water for decocting for three times, each time for 2.5 hours, then merging decoction, filtering, standing for 24 hours, taking supernate, concentrating under reduced pressure until the relative density is 1.30-1.32, adding dextrin or starch which is 0.2-0.3 times of the total weight, uniformly mixing, drying to form dry paste, crushing to form fine powder, sterilizing and packaging to obtain the traditional Chinese medicine granule.
Example 2
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 15 parts of isatis root, 15 parts of dyers woad leaf, 10 parts of codonopsis pilosula, 10 parts of giant knotweed rhizome, 15 parts of radix bupleuri, 15 parts of baked ginger, 15 parts of subprostrate sophora, 15 parts of lonicera confusa, 15 parts of groundsel, 15 parts of malan grass, 10 parts of geum, 10 parts of folium artemisiae argyi, 10 parts of divaricate saposhnikovia root and 10 parts of fineleaf schizonepeta herb.
Example 3
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 12 parts of isatis root, 12 parts of dyers woad leaf, 8 parts of codonopsis pilosula, 8 parts of giant knotweed rhizome, 12 parts of radix bupleuri, 12 parts of baked ginger, 12 parts of subprostrate sophora, 12 parts of lonicera confusa, 12 parts of groundsel, 12 parts of malan grass, 8 parts of geum japonicum, 8 parts of folium artemisiae argyi, 8 parts of divaricate saposhnikovia root and 8 parts of fineleaf schizonepeta herb.
Example 4
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 8 parts of isatis root, 8 parts of dyers woad leaf, 3 parts of codonopsis pilosula, 3 parts of giant knotweed rhizome, 8 parts of radix bupleuri, 6 parts of baked ginger, 6 parts of subprostrate sophora, 6 parts of lonicera confusa, 6 parts of groundsel, 6 parts of malan grass, 3 parts of geum japonicum, 3 parts of folium artemisiae argyi, 3 parts of divaricate saposhnikovia root and 3 parts of fineleaf schizonepeta herb.
Example 5
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum japonicum, 5 parts of folium artemisiae argyi, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
Example 6
This embodiment is different from embodiment 1 in that
Raw materials (by weight portion): 8 parts of isatis root, 12 parts of dyers woad leaf, 4 parts of codonopsis pilosula, 4 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 10 parts of baked ginger, 6 parts of subprostrate sophora, 10 parts of lonicera confusa, 10 parts of groundsel, 6 parts of malan grass, 4 parts of geum japonicum, 6 parts of folium artemisiae argyi, 3 parts of divaricate saposhnikovia root and 4 parts of schizonepeta.
The invention adopts the theory of traditional Chinese medicine, selects medicinal materials and makes the prescription of the medicinal materials, and because the experimental data is more, the prescription is adjusted and tested for many times, only a plurality of groups of prescriptions with higher curative effect are listed and compared with the prescription of the invention.
Formula 1: 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of Chinese thorowax root, 8 parts of baked ginger, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum, 5 parts of folium artemisiae argyi and 5 parts of divaricate saposhnikovia root.
And (2) formula: 10 parts of isatis root, 5 parts of giant knotweed, 10 parts of Chinese thorowax root, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum, 5 parts of Chinese mugwort leaf, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
And (3) formula: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 10 parts of radix bupleuri, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum, 5 parts of folium artemisiae argyi and 5 parts of schizonepeta.
And (4) formula: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 5 parts of geum, 5 parts of folium artemisiae argyi, 5 parts of divaricate saposhnikovia root and 5 parts of schizonepeta.
And (5) formula: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
The formula of the invention is as follows: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum japonicum, 5 parts of folium artemisiae argyi, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
The Chinese medicinal preparations are respectively prepared according to the formulas, the preparation steps are prepared according to the steps of example 1, and the Chinese medicinal granules under each formula are respectively obtained.
The test method comprises the following steps:
2800 feathers of 20-day-old broilers are randomly divided into 7 groups, namely a blank group, a formula 1 group, a formula 2 group, a formula 3 group, a formula 4 group, a formula 5 group and a formula group of the invention, wherein each group has 400 feathers. Before the test, the chicken had flu symptoms, manifested as depressed spirit, loose feathers, swollen head and face, increased body temperature, greenish yellow and loose stools, decreased feed intake, etc. The blank group is fed with normal saline, the formula groups 1-5 and the formula group of the invention are fed with traditional Chinese medicine granules prepared according to corresponding formula, every 300 jin of water is mixed with 100g of traditional Chinese medicine granules, water is freely drunk, and the rest feeding conditions are kept consistent. Continuously feeding for 7 days, and observing the change and health condition of chicken flocks every day.
The therapeutic effect judgment standard is as follows:
and (3) curing: the body temperature is normal, the food intake is normal, the spirit is normal, and the external symptoms such as cockscomb and the like are recovered to be normal;
the method has the following advantages: the body temperature is normal, the feed intake is increased, the spirit is basically recovered, and the external symptoms such as cockscomb are obviously improved;
and (4) invalidation: the body temperature is continuously higher, the feed intake is reduced, the spirit is depressed, and the external symptoms such as cockscomb and the like are not improved.
The treatment effect of the traditional Chinese medicine granules on broiler chickens with avian influenza is shown in table 1.
Table 1 therapeutic effect of the present invention on broiler chicken with avian influenza
Grouping Quantity (only) Cure (only) Effective (only) Invalid (only) Death (only) Cure rate (%) Mortality (%)
Blank group 400 － － － 341 － 85.25
Formulation 1 group 400 342 368 28 4 85.50 1.00
Formulation 2 group 400 336 348 32 10 84.00 2.50
Formulation 3 group 400 327 366 21 13 81.75 3.25
Formulation 4 group 400 339 358 36 6 84.75 1.50
Formulation 5 group 400 321 371 21 8 80.25 2.00
The invention formula 400 373 394 4 2 93.25 0.50
From the blank group results, the mortality rate of the broiler group reaches 85.25% under the condition that no treatment measures are taken for the broilers with avian influenza; compared with the blank group, the formula 1-5 groups and the formula group of the invention show that after the traditional Chinese medicine granules are used for treatment, the cure rate of the sick chicken flocks in each group can reach more than 80%, the death rate is obviously reduced compared with the blank group, the death rate of each treatment group does not exceed 3.25%, and the results show that the traditional Chinese medicine granules in each formula have obvious effect on treating the chicken flocks with the avian influenza. The traditional Chinese medicine granules prepared by the formula 1-5 groups are all lack of individual components in the traditional Chinese medicine granules, and the comparison between the formula 1-5 groups shows that the cure rate of the formula 1-5 groups is about 80-85% and 93.25% of the formula and the cure rate of the formula 1-5 groups is obviously higher than that of the formula 1-5 groups; meanwhile, the mortality rate of the formula group is only 0.5 percent, the mortality rate of the formula groups 1-5 is about 1-3.25 percent, and the mortality rate of the formula group is obviously lower than that of the formula groups 1-5; and the effective number of the formula group is obviously higher than that of the formula 1-5 groups, and the ineffective number of the formula group is obviously lower than that of the formula 1-5 groups. The results show that the traditional Chinese medicine granules can obviously reduce the disease symptoms of sick broilers, improve the mental status, improve the feed intake, reduce the death rate and have more obvious treatment effect. The traditional Chinese medicine granules are prepared from isatis root, indigowoad leaf, codonopsis pilosula, polygonum cuspidatum, radix bupleuri, baked ginger, subprostrate sophora, lonicera confusa, climbing groundsel herb, malaysia japonica, myrica rubra, folium artemisiae argyi, divaricate saposhnikovia root and schizonepeta herb by reasonably matching according to the traditional Chinese medicine syndrome differentiation treatment principle, the effects of all the medicines are fully exerted, all the medicines coordinate and gain the medicine effect, and all the components in the formula are absolutely absent.
In order to further illustrate the therapeutic effect of the traditional Chinese medicine granules on livestock and poultry suffering from livestock and poultry influenza, animal experiments are provided as an illustration below. The following reference to the traditional Chinese medicine granules of the invention are all prepared according to example 5.
1 the influence of the traditional Chinese medicine particles on the broiler immune organ and the avian influenza antibody titer
1.1 materials and methods
1.1.1 test drugs: the traditional Chinese medicine granule of the invention; 10% amoxicillin soluble powder
1.1.2 test animals: 150 AA broiler chickens with age of 20 days
1.1.3 test design
150 AA broilers of 20 days old are randomly divided into 3 groups, namely a blank control group (normal saline), the traditional Chinese medicine granules (0.67 g/L aqueous solution) and a medicine control group (0.5 percent of amoxicillin aqueous solution); on the basis of the original immunity, 0.5mL of avian influenza inactivated vaccine is injected. The groups were dosed with water, normal drinking water for the remainder of the time, other feeding conditions and conditions were kept consistent, dosing was continued for 20 days, then drug was discontinued, feeding was continued for 10 days for a total of 30 days. Feeding 10 chickens in each group randomly one day before administration, to 30 days old (namely, administration day 0), 40 days old (administration day 20) and 50 days old (administration day 30), collecting blood of the inferior pterygoid vein of each chicken, taking 0.5mL of each chicken, centrifuging after agglutination, separating serum, measuring the hemagglutination inhibition titer of a serum sample according to a method specified in highly pathogenic avian influenza prevention and treatment technical Specification, and carrying out statistical analysis. And (3) when the chickens are raised to 50 days old, bleeding all chickens, taking bursa of fabricius, thymus and spleen, removing fat, weighing and recording. And calculating the indexes of bursa of Fabricius, thymus and spleen.
Immune organ index (g/kg) = immune organ weight (mg)/animal body weight (g)
1.1.4 data analysis
Data were processed using SPSS 17.0 and expressed as mean ± standard deviation.
2.1 results and discussion
2.1.1 Effect of the Chinese medicinal granule of the present invention on avian influenza antibody
As can be seen from the results in Table 2, the antibody levels in the chickens of each group were substantially identical and did not significantly differ before immunization: (P>0.05); compared with a blank control group, the traditional Chinese medicine granule group and the medicine control group of the invention have obviously increased avian influenza antibody level in chicken serum at the age of 30 days,with significant difference (P<0.05), and the antibody level of the traditional Chinese medicine granule group is obviously higher than that of the drug control group, and has significant difference (P<0.05). With the increase of the administration time, the antibody levels in the chicken serum of the traditional Chinese medicine granule group and the chicken serum of the drug control group are still continuously increased at the age of 40 days, and the antibody level of the traditional Chinese medicine granule group is still obviously higher than that of the drug control group, and the significant difference is shown (the administration time is short), (the administration time is short, the antibody level of the traditional Chinese medicine granule group is high, and the antibody level of the traditional Chinese medicine granule group is highP<0.05). After stopping taking the medicine for 10 days, namely 50 days old, the antibody level in the chicken serum of the traditional Chinese medicine granule group is kept at a higher level and is not reduced; the chicken serum antibody level of the drug control group is slightly reduced; the results show that the traditional Chinese medicine granules can improve the titer of the AIV hemagglutination inhibition antibody of the organism, can maintain the high level of the titer of the avian influenza antibody of the chicken body for a long time, and are all superior to amoxicillin.
TABLE 2 Effect of the inventive Chinese medicinal granule on the titer of avian influenza antibody
Figure DEST_PATH_IMAGE002
Note: the same column marked with different letters shows significant difference (P<0.05）。
2.1.2 Effect of the Chinese medicinal granule of the invention on immune organs of broilers
As can be seen from the results in Table 3, the spleen index, bursa of Fabricius index and thymus index of the granule group and the control group of the present invention are significantly higher than those of the blank control group, and there is a significant difference (P<0.05); and each immune organ index of the traditional Chinese medicine granule group is higher than that of the drug control group, and the difference is obvious (P<0.05). The results show that the traditional Chinese medicine granules have an enhancement effect on immune organs of the body, and the enhancement effect is better than that of amoxicillin.
TABLE 3 Effect of the present invention on immune organs of broiler chickens
Group of Spleen index Bursal index Index of thymus
Blank control group 1.32±0.06a 1.43±0.12a 1.71±0.09a
The invention relates to a traditional Chinese medicine granule group 1.44±0.10b 1.69±0.09b 2.19±0.17b
Drug control group 1.38±0.07c 1.57±0.04c 1.97±0.11c
Note: the same column marked with different letters shows significant difference (P<0.05）。
The tests can prove that the traditional Chinese medicine granule has the effect of improving the level of the avian influenza antibody, and the immune effect is mainly realized by improving the body condition and enhancing the function of immune organs. The traditional Chinese medicine granules have positive influence on immune organ indexes of the broiler chicken, can well promote the development of immune organs of organisms and enhance the immune capacity of the immune organs, and have good material basis for resisting virus infection.
And (3) clinical trials:
selecting 100-120 days old sick pigs with confirmed swine influenza diagnosis, wherein the clinical symptoms of the sick pigs are as follows: anorexia, depression, hyperthermia, cough, asthma, dyspnea, muscle pain, unwilling to stand, constipation, etc. The sick pigs are divided into 3 groups at random, namely a blank control group, a test group 1 and a test group 2, wherein each group comprises 20 pigs. Wherein the blank control group is fed normally without medicine, and is fed freely with water; test group 1 was administered the present Chinese medicinal granule in an amount of 1.5g/L aqueous solution; test group 2 was administered moroxydine hydrochloride injection at 1 mL/dose twice a day; the administration was continued for 5 days in test 1 and test 2 groups, and the feeding conditions and environment were kept consistent in each group.
The therapeutic effect judgment standard is as follows: (1) the method has the following advantages: the body temperature returns to normal, the spirit returns to normal, the food intake returns to normal, and the cough and asthma symptoms are relieved; (2) and (3) curing: normal body temperature, good mental state, increased feed intake, no cough and asthma symptoms and being willing to stand; (3) the body temperature is continuously high, the spirit is deep and depressed, the food intake is not obviously changed, the cough and asthma symptoms are not disappeared, and the patient is not willing to stand.
The therapeutic effect of the traditional Chinese medicine granules on swine with swine influenza is shown in table 4. After the sick pigs in the test group 1 and the test group 2 are treated by the medicament, the clinical symptoms and physical signs are obviously improved and cured; wherein the cure rate of the test group is 85.0 percent, the effective rate is 95.0 percent, and the cure rate and the effective rate are all higher than those of the test group 2; and the inefficiency of test group 1 was 5.0%, much lower than that of test group 2; the difference between test group 1 and test group 2 was significant. The results show that the traditional Chinese medicine granules have obvious treatment effect on sick pigs suffering from swine influenza, and the treatment effect is superior to that of antibiotics.
TABLE 4 therapeutic effect of the present Chinese medicinal granule on swine influenza
Grouping Quantity (head) Cure (head) Effective (head) Invalid (head) Cure rate (%) Effective rate (%) Inefficiency (%)
Blank control group 20 － － － － － －
Test group 1 20 17 19 1 85.0 95.0 5.0
Test group 2 20 14 17 3 70.0 85.0 15.0
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (3)

1. The traditional Chinese medicine granule for treating livestock and poultry influenza is characterized by comprising the following traditional Chinese medicine components in parts by weight: 5-15 parts of isatis root, 5-15 parts of dyers woad leaf, 1-10 parts of codonopsis pilosula, 1-10 parts of giant knotweed, 5-15 parts of radix bupleuri, 5-15 parts of baked ginger, 5-15 parts of subprostrate sophora, 5-15 parts of lonicera confusa, 5-15 parts of groundsel, 5-15 parts of malaysia japonica, 1-10 parts of geum japonicum, 1-10 parts of folium artemisiae argyi, 1-10 parts of divaricate saposhnikovia root and 1-10 parts of schizonepeta.
2. The traditional Chinese medicine granule for treating livestock and poultry influenza according to claim 1, which is characterized by comprising the following traditional Chinese medicines in parts by weight: 8-12 parts of isatis root, 8-12 parts of folium isatidis, 3-8 parts of codonopsis pilosula, 3-8 parts of polygonum cuspidatum, 8-12 parts of radix bupleuri, 6-12 parts of baked ginger, 6-12 parts of subprostrate sophora, 6-12 parts of lonicera confusa, 6-12 parts of groundsel, 6-12 parts of malaysia japonica, 3-8 parts of geum japonicum, 3-8 parts of folium artemisiae argyi, 3-8 parts of radix sileris and 3-8 parts of schizonepeta.
3. The traditional Chinese medicine granule for treating livestock and poultry influenza according to claim 1, which is characterized by comprising the following traditional Chinese medicines in parts by weight: 10 parts of isatis root, 10 parts of dyers woad leaf, 5 parts of codonopsis pilosula, 5 parts of giant knotweed rhizome, 10 parts of radix bupleuri, 8 parts of baked ginger, 8 parts of subprostrate sophora, 8 parts of lonicera confusa, 8 parts of groundsel, 8 parts of malan grass, 5 parts of geum japonicum, 5 parts of folium artemisiae argyi, 5 parts of divaricate saposhnikovia root and 5 parts of fineleaf schizonepeta herb.
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