CN103861044A - Method for preparing soft material of gynecologic inflammation treatment preparation - Google Patents
Method for preparing soft material of gynecologic inflammation treatment preparation Download PDFInfo
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- CN103861044A CN103861044A CN201410129398.9A CN201410129398A CN103861044A CN 103861044 A CN103861044 A CN 103861044A CN 201410129398 A CN201410129398 A CN 201410129398A CN 103861044 A CN103861044 A CN 103861044A
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Abstract
The invention discloses a method for preparing a soft material of a gynecologic inflammation treatment preparation. The method comprises the following steps: preparing 11 traditional Chinese medicinal materials required for production of gynecologic inflammation treatment tablets according to pharmacopeia, putting the traditional Chinese medicinal materials in an extraction tank and performing reflux extraction with hot water, performing intermittent type vacuumizing and vacuum breaking on the extraction tank in the extracting process, and strengthening mass transfer by utilizing vacuum pulse; (2) preparing yam and curcuma zedoary (vinegar roasted) powder: drying yam and curcuma zedoary, and crushing by using a supersonic airflow grinding system and a cold slurry crushing system; (3) preparing the soft material: mixing the yam powder, the curcuma zedoary powder and the gynecologic inflammation preparation extract to prepare the soft material. According to the preparation method, the extraction tank is subjected to intermittent type vacuumizing and vacuum breaking, so that the extraction time can be effective shortened, the extraction rate of effective components in traditional Chinese medicines, in particular matrine can be increased, and the quality and yield of products can be improved; the yam and curcuma zedoary are crushed by adopting the supersonic airflow grinding system and the cold slurry crushing system, so that the crushing effect is good, and the sterilizing step can be omitted.
Description
Technical field
The present invention relates to a kind of FUYANKANG soft material preparation method in Chinese medicine FUYANKANG PIAN production process.
Background technology
Chinese crude drug is extracted, and extracting solution is through the concentrated extractum that makes, then extractum is made to soft material through batching is the necessary technological processes of most Chinese medicinal tablets, and FUYANKANG PIAN is no exception.
FUYANKANG PIAN is to make extractum with water extraction by a certain percentage by these 11 kinds of prepared slices of Chinese crude drugs of Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), Cortex Phellodendri and Radix Salviae Miltiorrhizae, then a certain proportion of prepared slices of Chinese crude drugs Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) are broken into powder, by extractum and powder ingredients and make soft material, make finally by pelletize, tabletting and coating again.
At present, in the preparation process of FUYANKANG soft material, exist following technical problem to hinder development and the quality-improving of FUYANKANG PIAN industry:
The one, adopt traditional hot water return to extract, extraction time, temperature long and water was high, not only energy consumption is high, effective ingredient in considerable damage medical material, and because resistance to mass tranfer is larger, often cause in medical material some main active component as lower in the extraction ratio of matrine, and the extractum dosage obtaining is large, water-solubility impurity is many, and color is dark.The conventional lower reason of hot water return extraction method extraction ratio is: the main component of Chinese crude drug cell tissue is the materials such as cellulose and pectin, Effective Component of Chinese Medicine is wrapped up by the plant cell tissue that is main component with cellulose and pectin again, thereby in leaching process, water removes to dissolve Effective Component of Chinese Medicine through plant cell tissue and has certain resistance to mass tranfer.
The 2nd, adopt conventional mechanical activation comminution DUISHANYAO and Rhizoma Curcumae to play powder operation, take a lot of work, time-consuming and weak effect, owing to there being the more material such as cellulose and pectin in Rhizoma Dioscoreae and Rhizoma Curcumae cell tissue, these materials can hinder pulverizing, thereby often need repeatedly to pulverize and change sieve plate, and the particle diameter after pulverizing is thicker, is unfavorable for soft material processed, particle diameter greatly also exists human body to be difficult to the defect absorbing.
Thereby prior art can not meet the demand that FUYANKANG PIAN quality promotes and develops, and is further improved and promotes.
Summary of the invention
For the problem that the prior art solving in above-mentioned FUYANKANG soft material preparation process exists, the inventor, through a large amount of scientific practices, invents a kind of preparation method of FUYANKANG soft material finally, uses the method can effectively overcome the defect existing in prior art.
The present invention includes following step:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of FUYANKANG PIAN, material is placed in to extraction pot, carry out evacuation processing, extract the part air in tank body and plant cell out, resorb medical material gross mass 2-8 drinking water doubly, soak after 20-40 minute and heat and reflux, extract, 2-6 hour, repeat said extracted operation 1-3 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, extraction pot is carried out to step evacuation and vacuum breaker, utilize vacuum pulsation strengthening mass transfer.The mechanism of vacuum pulsation strengthening mass transfer is: when evacuation, Chinese crude drug histiocyte internal pressure is greater than outside Chinese crude drug histiocyte, and the solvent that has dissolved Effective Component of Chinese Medicine can be forced through Chinese crude drug cell tissue under differential pressure action; In the time of vacuum breaker, it is intrinsic pressure that Chinese crude drug histiocyte external pressure is greater than Chinese crude drug histiocyte, solvent outside Chinese crude drug histiocyte enters rapidly Chinese crude drug histiocyte inside and removes to dissolve Effective Component of Chinese Medicine because of differential pressure action, the alternate of this Chinese crude drug histiocyte external and internal pressure has been strengthened solvent and has been dissolved in the Effective Component of Chinese Medicine mass transfer in solvent, and extraction efficiency raising, residual rate are reduced.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 5%-10% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 150-200 mesh sieve, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder that step (2) is made and Rhizoma Curcumae (processed with vinegar) powder are put into wet granulator, start is stirred after 5-15 minute and is shut down, then the FUYANKANG extractum that adds step (1) to make stirs and obtain FUYANKANG soft material.
Compared with prior art, the invention has the beneficial effects as follows:
1, extraction pot is carried out to step evacuation and vacuum breaker, adopt vacuum pulsation strengthening mass transfer, can effectively shorten extraction time, improve the extraction ratio of Effective Component of Chinese Medicine, make the drug effect of FUYANKANG PIAN better; Carry out step evacuation and vacuum breaker also not high to the requirement of equipment, common reflux, extract, tank can be realized through simple transformation
2, extraction pot is carried out to step evacuation and vacuum breaker, adopt vacuum pulsation strengthening mass transfer, improve significantly the extraction ratio of FUYANKANG PIAN index components matrine, conforming product rate in FUYANKANG PIAN production process is improved, the FUYANKANG PIAN that general plate core weight is 0.25 gram, every can reach 0.30mg containing matrine more than.(FUYANKANG PIAN that plate core weight is 0.25 gram, pharmacopeia the inside require every must not be lower than 0.25mg containing matrine)
3, extraction pot is carried out to evacuation processing, effectively reduce the temperature that hot water return extracts, the color of extractum is shoaled, improved the quality of extractum.
4, adopt supersonic jet mill system and cold slurry crushing system DUISHANYAO and Rhizoma Curcumae to pulverize, operation is simple, and the powder obtaining is pulverized thinner than Mechanical Method, be more suitable for soft material processed, is also more conducive to absorption of human body effective ingredient wherein.
5, adopt supersonic jet mill system and cold slurry crushing system DUISHANYAO and Rhizoma Curcumae to pulverize, because supersonic jet mill system and cold slurry crushing system have killing action to antibacterial, thereby needn't carry out independent disinfecting action, can save the sterilization steps in soft material making, and the soft material obtaining can not exceed standard in microorganism, reduce intermediate link, reduced cost.
6, this technique is improvement and the lifting of carrying out within the scope of the FUYANKANG PIAN technological process of production of recording in the Pharmacopoeia of the People's Republic of China, do not exceed the processing range that pharmacopeia is recorded, thereby actual operation is stronger, even can just directly apply to without Bureau of Drugs Supervision's examination & approval the production of FUYANKANG PIAN.
Detailed description of the invention
Below a kind of preparation method of FUYANKANG soft material is elaborated.
Embodiment 1:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of FUYANKANG PIAN, material is placed in to extraction pot, carry out evacuation processing, extract the part air in tank body and plant cell out, resorb the drinking water of 3 times of medical material gross masses, soak and after 38 minutes, heat and reflux, extract, 3 hours, repeat said extracted operation 2 times, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, extraction pot is carried out to step evacuation and vacuum breaker, utilize vacuum pulsation strengthening mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 8.9% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 180 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder that step (2) is made and Rhizoma Curcumae (processed with vinegar) powder are put into wet granulator, start is stirred after 14 minutes and is shut down, then the FUYANKANG extractum that adds step (1) to make stirs and obtain FUYANKANG soft material.
Embodiment 2:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of FUYANKANG PIAN, material is placed in to extraction pot, carry out evacuation processing, extract the part air in tank body and plant cell out, resorb the drinking water of 7.5 times of medical material gross masses, soak and after 30 minutes, heat and reflux, extract, 5.5 hours, repeat said extracted operation 3 times, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, extraction pot is carried out to step evacuation and vacuum breaker, utilize vacuum pulsation strengthening mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 7% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 160 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder that step (2) is made and Rhizoma Curcumae (processed with vinegar) powder are put into wet granulator, start is stirred after 10 minutes and is shut down, then the FUYANKANG extractum that adds step (1) to make stirs and obtain FUYANKANG soft material.
Embodiment 3:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of FUYANKANG PIAN, material is placed in to extraction pot, carry out evacuation processing, extract the part air in tank body and plant cell out, resorb the drinking water of 5 times of medical material gross masses, soak and after 21 minutes, heat and reflux, extract, 4 hours, repeat said extracted operation 1 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated.
In said extracted process, extraction pot is carried out to step evacuation and vacuum breaker, utilize vacuum pulsation strengthening mass transfer; Material carries out break process before being placed in extraction pot.
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 5.2% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 200 mesh sieves, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product.
(3) preparation of soft material: the Rhizoma Dioscoreae powder that step (2) is made and Rhizoma Curcumae (processed with vinegar) powder are put into wet granulator, start is stirred after 6 minutes and is shut down, then the FUYANKANG extractum that adds step (1) to make stirs and obtain FUYANKANG soft material.
Claims (3)
1. a preparation method for FUYANKANG soft material, is characterized in that comprising following step:
(1) preparation of FUYANKANG extractum: by Radix Paeoniae Rubra, Rhizoma Smilacis Glabrae, Rhizoma Sparganii (processed with vinegar), Fructus Toosendan (stir-fry), Rhizoma Corydalis (processed with vinegar), Semen Euryales (stir-fry), Radix Angelicae Sinensis, Radix Sophorae Flavescentis, Rhizoma Cyperi (processed with vinegar), these 11 kinds of prepared slices of Chinese crude drugs of Cortex Phellodendri and Radix Salviae Miltiorrhizae are pressed the Pharmacopoeia of the People's Republic of China after the standard batching of FUYANKANG PIAN, material is placed in to extraction pot, carry out evacuation processing, extract the part air in tank body and plant cell out, resorb medical material gross mass 2-8 drinking water doubly, soak after 20-40 minute and heat and reflux, extract, 2-6 hour, repeat said extracted operation 1-3 time, merge extractive liquid, extracting solution obtains FUYANKANG extractum after economic benefits and social benefits are concentrated,
In said extracted process, extraction pot is carried out to step evacuation and vacuum breaker, utilize vacuum pulsation strengthening mass transfer;
(2) preparation of Rhizoma Dioscoreae and Rhizoma Curcumae (processed with vinegar) powder: it is 5%-10% that Rhizoma Dioscoreae and Rhizoma Curcumae are dried to moisture content, puts into supersonic jet mill system and pulverizes once, crosses 150-200 mesh sieve, and unsifted component adds in cold slurry crushing system to be pulverized once and get final product;
(3) preparation of soft material: the Rhizoma Dioscoreae powder that step (2) is made and Rhizoma Curcumae (processed with vinegar) powder are put into wet granulator, start is stirred after 5-15 minute and is shut down, then the FUYANKANG extractum that adds step (1) to make stirs and obtain FUYANKANG soft material.
2. the preparation method of FUYANKANG soft material according to claim 1, is characterized in that: before material is placed in to extraction pot, medical material is carried out to break process.
3. the FUYANKANG soft material that the preparation method of FUYANKANG soft material makes according to claim 1, is characterized in that: the FUYANKANG PIAN of the 0.25g of plate core weight being made by this soft material, matrine is greater than 0.3mg.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082822A (en) * | 2014-07-22 | 2014-10-08 | 湖南湘泉药业股份有限公司 | Rhizome polygonati, medlar and ginseng solid beverage and preparation method thereof |
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|---|---|---|---|---|
| CN1820780A (en) * | 2005-02-19 | 2006-08-23 | 李砚秋 | Method for preparing Fuyankang extract |
| CN102284033A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Suoquan pill dosage form |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820780A (en) * | 2005-02-19 | 2006-08-23 | 李砚秋 | Method for preparing Fuyankang extract |
| CN102284033A (en) * | 2010-06-17 | 2011-12-21 | 苏州知微堂生物科技有限公司 | Preparation technology and production method of integrated novel Suoquan pill dosage form |
Non-Patent Citations (1)
| Title |
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| 喻雄华等: "妇炎康片提取工艺的研究", 《湖南中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104082822A (en) * | 2014-07-22 | 2014-10-08 | 湖南湘泉药业股份有限公司 | Rhizome polygonati, medlar and ginseng solid beverage and preparation method thereof |
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