CN103766399A - Iodine-containing disinfectant and preparation method thereof - Google Patents
Iodine-containing disinfectant and preparation method thereof Download PDFInfo
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- CN103766399A CN103766399A CN201210406246.XA CN201210406246A CN103766399A CN 103766399 A CN103766399 A CN 103766399A CN 201210406246 A CN201210406246 A CN 201210406246A CN 103766399 A CN103766399 A CN 103766399A
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Abstract
The invention provides an iodine-containing disinfectant and a preparation method thereof. The iodine-containing disinfectant comprises a single chain quaternary ammonium salt and/or double chain quaternary ammonium salt, iodine, a nonionic surfactant, acid and a pharmaceutically acceptable carrier. Compared with a conventional iodine-containing disinfectant, the disinfectant provided by the invention has the advantages of an improved bactericidal effect and low yellow staining performance. The invention further provides a preparation method for the composite disinfectant of the quaternary ammonium salt and iodine and application of the composite disinfectant in disinfection of animal buildings and environments.
Description
Technical field
The present invention relates to disinfectant field, be specifically related to a kind of containing iodine disinfectant.
Background technology
Along with the development of modern intensive aquaculture, it is more and more serious that intensive cultivating condition makes livestock and poultry be subject to the threat of pathogenic microorganisms, although drop into a large amount of funds on vaccine and medicine, but still cannot avoid the harm of disease to animal body, the health that these diseases are also threatening the mankind when existence.Basic factor is exactly pathogenic microorganism, especially in feces of livestock and poultry, contain the raw mosquitos and flies of a large amount of pathogenic microorganisms, parasitic ovum and evil, these all can make, and cause of disease kind in environment increases, amount of bacteria increases, cause spreading of people, animal infectious disease, especially zoonosis, to the harm of bringing on a disaster property of people and animals.
Quaternary ammonium disinfectant is synthetic first by American scholar one as far back as 1915, it is a cationoid surfactant, positively charged in water, can be adsorbed in forcefully various fungies, bacterium, virus surface, change the permeability of fungi, bacterium, the thin spore of virion, endobacillary lonely coenzyme and Metabolic Intermediate product are overflowed, hinder breathing and the glycolytic cycle of mushroom, and make mycoprotein sex change, thereby reach bactericidal action.
Quaternary ammonium disinfectant comprises strand quaternary ammonium salt and double-chain quaternary ammonium salt two classes.But quaternary ammonium disinfectant can not killing fungus, tubercle bacillus, hydrophilic viruses and bacterial spore, belongs to low effect disinfectants.But quaternary ammonium disinfectant Disinfection Effect in the time using is separately bad, be usually vulnerable to the impact of the factor such as kind, pH value, temperature, concentration and organic matter of microorganism.And while using quaternary cationic surfactant separately, because belonging to low effect disinfectants, it is easy to produce antibody-resistant bacterium.
Iodine has very strong sterilizing power and very fast sterilization speed under sour environment, and Operand becomes a kind of disinfectant of function admirable.But the shortcoming of Operand is also apparent, as very little in the solvability in water, can not be mixed with water formulation and uses; Preparation is unstable, the iodine inefficacy that easily distils; Iodine is stronger to the excitant of skin; There is xanthochromia etc.
Iodine has had the history of 150 years for body sterilization, but because the solvability of iodine in water is very little; At room temperature easily distillation, content is unstable; To the mucocutaneous shortcoming such as irritant and limited its extensive use.At present, widely used Iodophor class disinfectant is take organic polymer or surface reactive material as carrier mostly, by the network structure or the micella that form between carrier molecule, with the conformational effect in electronics and space by iodine " constraint " in wherein, thereby change the free state of iodine in general Operand, its stability and bactericidal action enhancing, excitant and xanthochromia are reduced.But original micella power can be destroyed after dilution for the product of this class take surface reactive material as carrier, makes the stability decreases of active iodine, thereby affect its sterilization effect.But the general molecular weight of organic polymer large (up to 70000-100000) is difficult to be biodegradable, long-term use can be to environment.
For overcome single component defect, improve Disinfection Effect, make disinfectant wide spectrum, efficient, stable, easy to use, safe, anti-interference, cost is moderate, compound contains iodine disinfectant has become the focus of current research.
Chinese patent CN1883273 provides a kind of preparation method containing iodine compound disinfectant, for the sterilization of the pathogenic microorganismss of livestock and poultry and the susceptible virus of aquaculture, bacterium and environment virus, bacterium.It mainly, take iodine and benzalkonium bromide as main active, is equipped with other active factorses and forms, and its component and content are: benzalkonium bromide 5%-45%, Radix Sophorae Flavescentis extractive liquid 1%-2%, ethanol 5%-10%, potassium iodide 0.1% one 1%, iodine 0.5%-3%, phosphatase 11 %-3%, water full dose.Its shortcoming is: 1) prepare the antagonist that the potassium iodide adding in prescription is benzalkonium bromide.2) in prescription, add Chinese medical extract Radix Sophorae Flavescentis extractive liquid 1%-2%, after dilution, use without bactericidal action.
Chinese patent CN 1238909A provides a kind of preparation method of quaternary ammonium salt chelated iodine disinfectant,
The method of obtaining this complex compound disinfectant is: the compound that general formula (I) is represented and iodine are mixed together to stir and react after 1-2 hour and obtain product.This disinfectant has season by the double sterilization effect of salt compound and Operand, is applicable to the sterilizing of culture fishery and livestock and poultry breeding industry.Its shortcoming is: 1) in preparation process, there is no ready-made raw material, need first synthetic intermediate general formulas (I), then the agent raw material that carries out disinfection is synthetic, reactions steps is more, difficult quality control.2) in preparation process, temperature is 70-80 ℃ of reaction 1h, and iodine easily distils.
Therefore, in livestock and poultry cultivation place in the urgent need to a kind of wide spectrum, the disinfectant that efficient, stable, easy to use, safe, anti-interference, cost is moderate.
Summary of the invention
The object of the present invention is to provide a kind of wide spectrum, efficient, stable containing iodine disinfectant.In quaternary ammonium salt iodine disinfectant technology of preparing, add potassium iodide to make preparation stabilization, but add potassium iodide to have antagonism to the virus killing effect of quaternary ammonium salt, in the present invention, in the preparation of quaternary ammonium salt iodine disinfectant, remove potassium iodide, added non-ionic surface active agent to make preparation stabilization simultaneously.The present invention is intended to overcome technology prejudice, provides one to have synergistic quaternary ammonium salt iodine disinfectant, and disinfectant prepared by the present invention is with existing containing compared with iodine disinfectant, and bactericidal action strengthens, and xanthochromia is low.
The invention provides a kind ofly containing iodine disinfectant, in addition, the present invention also provides a kind of described preparation method containing iodine disinfectant, and application in poultry house and environment disinfected.
The invention provides a kind of iodine disinfectant that contains, by 100 mass parts, comprise following component:
Surplus is acceptable carrier pharmaceutically.
Described strand quaternary ammonium salt is selected from least one in following compound: alkyl dimethyl benzyl ammonium chloride (benzalkonium chloride), or for fragrant ring hydrogen being substituted by the replacement zephiran that chlorine, methyl or ethyl form; Be preferably alkyl dimethyl benzyl ethyl ammonium chloride.
Described double-chain quaternary ammonium salt is selected from least one in following compound: two octyl group quaternary ammonium salts, two decyl quaternary ammonium salt, two dodecyl quaternary ammonium salt or octyl-decyl quaternary ammonium salt.
Preferably, described double-chain quaternary ammonium salt is selected from least one in following compound: two decyl dimethyl ammonium bromides, two decyl alkyl dimethyl ammonium chloride, dimethyl benzyl ammonium chloride, two (dodecyl dimethyl) ethylene two ammoniums of bromination, 2-(2-phenoxy group ethyoxyl) ethyl-trimethyl salmiac, benzalkonium bromide or Benzalkonii Chloridum.
Non-ionic surface active agent of the present invention is selected from least one in following compound: fatty alcohol-polyoxyethylene ether (AEO), polyethylene glycol (PEG), alkylphenol polyoxyethylene (NP or OP), poloxamer, lauric acid polyoxyethylene ester or castor oil polyoxyethylene ether.
Acid of the present invention is selected from least one in hydrochloric acid, sulfuric acid or phosphoric acid.
Pharmaceutically acceptable carrier of the present invention is alcoholic solution, the alcoholic solution that preferred volume mark is 50%.
Described alcohol is selected from least one in following compound: glycerine, propane diols, ethanol or ethylene glycol.
Of the present invention containing iodine composite disinfectant, its preparation method is as follows:
A) take 5-40 mass parts quaternary ammonium salt;
B) take 10-30 mass parts non-ionic surface active agent, acceptable carrier pharmaceutically described in then adding;
C) by above-mentioned steps a) and b) two kinds of solution mix, add the acid of 0.5-6.5 mass parts;
D) take the iodine of 0.3-3.0 mass parts, the solution that adds step c) to prepare, is heated to 50 ℃, is stirred to and dissolves clarification completely, adds described pharmaceutically acceptable carrier to 100 mass parts of surplus, mixes.
Described containing the application of iodine composite disinfectant in poultry house and environment disinfected.
Beneficial effect of the present invention:
1) the present invention utilizes the combination of quaternary cationic surfactant and iodine, has given play to the powerful function of killing the virus, and has the double sterilization disinfection efficacy of benzalkonium bromide and iodine.Benzalkonium bromide and iodine are brought into play the effect of disinfection jointly, and sterilizing ability is strengthened greatly.Thereby can effectively kill hydrophily, lipophilic virus, bacterium.Suitably add doses surfactant softex kw,, can strengthen the effect of iodine kill virus under certain condition, raise the efficiency approximately 3.6 times.There are the quick-acting effects of notable synergistic.Quaternary ammonium salt iodine composite disinfectant is a kind of efficient, safe, bland disinfectant.
2) use liquor strength low, after 3200 times of dilutions, use, can reach bactericidal action.Sterilization, bactericidal range is wide, use safe, nontoxic, environmentally safe, and stable in properties.Good product performance, cost are low, easy to use, can wide popularization and application.
3) disinfectant of the present invention has certain broad spectrum activity, germ, virus, the noxious bacteria gemma that can effectively kill the germ, virus of all kinds of harm livestock and poultry and make a variation because of environmental deterioration; Can also effectively kill and suppress the viral germ such as bird flu, streptococcus that people livestock and poultry suffer from altogether.Solve the drawback that uses traditional thimerosal to expose in China's livestock-raising, slaughtering industry.
Embodiment
Below in conjunction with embodiment, the present invention is described in detail, but the present invention is not limited to following examples.
The embodiment that technical scheme according to the present invention is taked is as follows:
Embodiment 1
The disinfectant of the present embodiment comprises following component:
Its preparation method is as follows:
1) take 10 mass parts benzalkonium bromides (after pure), the two decyl dimethyl ammonium bromides of 10 mass parts (after pure), add water or glycerine wiring solution-forming.
2) take 30 mass parts AEO-9, then add 50%(volume fraction) glycerine.
3) by above-mentioned steps 1) and 2) two kinds of solution mix, and add 1.7 mass parts phosphoric acid.
4) take 0.9 mass parts iodine, the solution that adds step 3) to prepare, is heated to 50 ℃, is stirred to and dissolves clarification completely, adds 50% glycerine to 100 mass parts, mixes, and measures pH value.
Embodiment 2
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 3
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 4
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 5
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 6
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 7
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Embodiment 8
The disinfectant of the present embodiment comprises following component (in table 1):
Preparation method is with embodiment 1.
Comparative example
20% AEO-9 in embodiment 6 is replaced by 3.6% KI, the disinfectant of preparation is contrast disinfectant.
The disinfectant composition of table 1 embodiment 2-8
Embodiment 9: disinfectant of the present invention and the Disinfection Effect comparative test that contrasts disinfectant
1) test method
Test with reference to Ministry of Agriculture's " disinfectant for animals approval test technical specification " method, adopt bacterial suspension quantitative
2) test strain: comprise Escherichia coli, staphylococcus aureus, hemolytic streptococcus, be purchased from Chinese veterinary medicament
3) test procedure:
1. the bacterium liquid of preparation is carried out to viable bacteria technology, be then diluted to containing bacterium 10 with the phosphate buffer of 0.03M
6the test organisms liquid of CFU/mL;
2. draw 0.5m1 bacterium liquid in the disinfectant solution 4.5m1 of test concentrations;
3. put in 20 ℃ of water-baths and act on 5min;
4. draw immediately above-mentioned bacterium medicine mixed liquor 1.0ml, add in 9.0ml neutralizer and mix;
5. replace thimerosal with 0.03M phosphate buffer, carry out above steps simultaneously.As a control group.
6. in and after 10min, carry out count plate, calculate sterilizing rate.
Disinfectant of the present invention to the killing effect of different strains in table 2
Table 2 disinfectant of the present invention and the sterilizing rate of comparative example to different strain
Ministry of Agriculture disinfectant for animals approval test technical specification regulation, test its virus killing performance sterilizing rate arrive 99.9% with, when lower than this standard, should improve the concentration of disinfectant or extend action time.
Conclusion: from the experimental results, disinfectant of the present invention still can reach more than 99.9% bacterial inactivation rate through 3200 times of dilutions, and comparative example just can reach more than 99.9% bacterial inactivation rate through 800 times of dilutions.In the present invention, quaternary ammonium salt iodine disinfectant, compared with comparative example's bactericidal effect, can obviously improve the bactericidal effect of composition.
Embodiment 10: the acute eye irritation test of the composition of preparing according to embodiment 6
Experimental animal: 3 of healthy rabbits, body weight 2.0-2.5kg;
Test method: cancel the solution 0.1ml of 10 times of the highest application concentration of toxic agent, drip in rabbit one branch hole conjunctival sac, another branch hole is using physiological saline as normal control.Drip after tested material, by passive eye closed 4s, after 30s, use triumph normal saline washing.1h after eye drip, 24h, 48h, 72h, 7d, 14d and 21d, visually observe damage and the recovery situation of rabbit eyes conjunctiva, iris and cornea.If there is not irritant reaction in 72h, or 7d or 14d, the eye irritation recovery that reacts completely, can premature termination test.Carry out eye by the regulation of acute eye irritation test under 2.3.4 item in SSICl/1 version " disinfection technology standard " and stimulate scoring and stimulus intensity classification.
Result of the test: 3 animal 24h, 48h, the average score of tri-time points of 72h is: corneal injury 0.6, iris 0., 3, conjunctival congestion 1.0, chemosis 0.5, corneal injury <1, iris <1, conjunctival congestion <2, chemosis <2, belong to nonirritant), prove this disinfectant nonirritant.
Embodiment 11: the composition toxicity test of preparing according to embodiment 6
Experimental animal: 20 of healthy Kunming mouses, male and female half and half, body weight 18-22g.
Trial drug: 5000mg/kg body weight.
Test method: adopt disposable limitation administration by gavage to per os gastric infusion of mouse, administration volume 20m1/kg
Body weight, Continuous Observation 14d after administration, records poisoning manifestations and the death condition of mouse.
Result of the test: statistical analysis, carry out toxicity grading, result is with reference to disinfection technology standard " in evaluate regulation under 6, the results are shown in Table 3.
Table 3 disinfectant of the present invention is to chmice acute Oral toxicity result of the test
Conclusion: toxicity test result proves, disinfectant prepared by embodiment 6 is substantially nontoxic.
Embodiment 12: disinfectant prepared by employing embodiment 6 application in livestock and poultry farm sterilization
The selection of test site
Select the colony house of 1 letting animals feed, rinse ground with running water, after 1 hour, carry out formal test.
Test material
Cotton swab, martin's bouillon, Martin's agar, neutralizer
The preparation of disinfectant: get prepared by 1ml embodiment 1 disinfectant add the solution (1:1000) of 1000ml aseptic deionized water.
The method of sampling
Before sterilization, with latter 20,40,60 minutes of sterilization, different local samplings the on livestock and poultry colony house ground respectively, after cotton swab being soaked with neutralizer when sampling, were 5 × 5cm at area
2the ground wiping 10 times of exerting oneself, and constantly change swab wiping surface, swab cotton end is cut in sample solution with forced oscillation 100 times, by bacterium wash-out, washing lotion normal saline dilution, in the Martin's agar plate that contains 10% serum, count plate is done in cultivation.
Interpretation of result
Viable count × 100% before sterilizing rate %=(the rear viable count of viable count-sterilization before sterilization)/sterilization
On-site disinfection test result
On-site disinfection test the results are shown in Table 4.
The on-the-spot disinfection experiment result of disinfectant that table 4 adopts embodiment 6 to prepare
| Time | C1 | C2 | C3 | C4 |
| Sterilization 20min sterilizing rate | 98.67% | 97.55% | 98.45% | 94.12% |
| Sterilization 40min sterilizing rate | 99.75% | 99.67% | 99.82% | 99.75% |
| Sterilization 60min sterilizing rate | 99.99% | 99.92% | 99.96% | 99.98% |
C1, C2, C3, C4 are the numbering of 4 sampled points.
Conclusion: disinfectant prepared by the present invention has killing effect well in production application to the bacterium in plant.
Composition, single preparations of ephedrine and comparative example's bactericidal effect prepared by embodiment 13: embodiment 6
The composition (prescription 1) making according to embodiment 6 and single preparations of ephedrine benzalkonium bromide solution (prescription 2), single preparations of ephedrine iodine solution (prescription 3), is replaced by its Comparison of effect on sterilization of KI (prescription 4) of 3.6% in table 5 by 20% AEO-9 in embodiment 6.
Composition, single preparations of ephedrine and comparative example's bactericidal effect prepared by table 5 embodiment 6
Conclusion: quaternary ammonium salt and iodine have synergy effect by the composition that adds non-ionic surface active agent and prepare compared with single preparations of ephedrine, is used non-ionic surface active agent to substitute potassium iodide can to significantly improve the bactericidal effect of composition.
Composition xanthochromia prepared by embodiment 14: embodiment 6
The composition (prescription 1) making according to embodiment 6 and single preparations of ephedrine benzalkonium bromide solution (prescription 2), relatively its xanthochromia to fabric of single preparations of ephedrine iodine solution (prescription 3) and comparative example.
Adopt soaking disinfection, measure 10 (each 5 of warp-wise and broadwise) for every group, sterilization group is soaked 24h by disinfectant typical concentrations (100 times of dilutions) room temperature (20～25 ℃), and then rinsing is dried.Sterilize respectively 10 times, 20 times, 30 times, 40 times, 50 times.Control group adopts the fabric at the contiguous position of experimental group, replaces disinfectant to disinfect equally with aqueous solvent.After sterilization, rinse and dry, measure.The results are shown in Table 6.
Conclusion: the xanthochromia that the disinfectant of preparing by the present invention and comparative example compare fabric is lower.
Composition xanthochromia prepared by table 6 embodiment 6
Claims (10)
1. containing an iodine disinfectant, by 100 mass parts, comprise following component:
Surplus is acceptable carrier pharmaceutically.
2. disinfectant according to claim 1, is characterized in that, described strand quaternary ammonium salt is selected from least one in following compound: alkyl dimethyl benzyl ammonium chloride or fragrant ring hydrogen is substituted by chlorine, methyl or ethyl and the replacement zephiran that forms; Be preferably alkyl dimethyl benzyl ethyl ammonium chloride.
3. disinfectant according to claim 1 and 2, is characterized in that, described double-chain quaternary ammonium salt is selected from least one in following compound: two octyl group quaternary ammonium salts, two decyl quaternary ammonium salt, two dodecyl quaternary ammonium salt or octyl-decyl quaternary ammonium salt.
4. disinfectant according to claim 3, it is characterized in that, described double-chain quaternary ammonium salt is selected from least one in following compound: two decyl dimethyl ammonium bromides, two decyl alkyl dimethyl ammonium chloride, dimethyl benzyl ammonium chloride, two (dodecyl dimethyl) ethylene two ammoniums of bromination or 2-(2-phenoxy group ethyoxyl) ethyl-trimethyl salmiac.
5. according to the disinfectant described in claim 1,2 or 4, it is characterized in that, described non-ionic surface active agent is selected from least one in following compound: fatty alcohol-polyoxyethylene ether, polyethylene glycol, alkylphenol polyoxyethylene, poloxamer, lauric acid polyoxyethylene ester or castor oil polyoxyethylene ether.
6. according to the disinfectant described in claim 1,2 or 4, it is characterized in that, described acid is selected from least one in hydrochloric acid, sulfuric acid or phosphoric acid.
7. according to the disinfectant described in claim 1,2 or 4, it is characterized in that, described pharmaceutically acceptable carrier is alcoholic solution, the alcoholic solution that preferred volume mark is 50%.
8. disinfectant according to claim 7, is characterized in that, described alcoholic solution is selected from least one in following compound: glycerine, propane diols, ethanol or ethylene glycol.
9. according to the preparation method containing iodine composite disinfectant described in any one in claim 1-8, comprise the steps:
A) take 5-45 mass parts quaternary ammonium salt;
B) take 10-30 mass parts non-ionic surface active agent, acceptable carrier pharmaceutically described in then adding;
C) by above-mentioned steps a) and b) two kinds of solution mix, add the acid of 0.5-6.5 mass parts;
D) take the iodine of 0.3-3.0 mass parts, the solution that adds step c) to prepare, is heated to 50 ℃, is stirred to and dissolves clarification completely, adds described pharmaceutically acceptable carrier to 100 mass parts of surplus, mixes.
One kind according to described in any one in claim 1-8 containing the application of iodine composite disinfectant in poultry house and environment disinfected.
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| CN105663158A (en) * | 2016-03-15 | 2016-06-15 | 浙江海正药业股份有限公司 | High-concentration iodine disinfection solution and preparation method thereof |
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
| CN107258839A (en) * | 2017-07-12 | 2017-10-20 | 合肥华盖生物科技有限公司 | A kind of composite disinfectant and preparation method thereof |
| CN108566947A (en) * | 2017-03-10 | 2018-09-25 | 洛阳惠中兽药有限公司 | A kind of foam disinfectant auxiliary agent, preparation method and foamaseptic prepared therefrom |
| CN109042728A (en) * | 2018-09-19 | 2018-12-21 | 青岛安特斯生物制药有限公司 | A kind of iodine class disinfectant and its preparation and application |
| CN109601535A (en) * | 2018-12-30 | 2019-04-12 | 北京盛大康成医疗技术有限公司 | Disinfectant, preparation method and sterilized articles therefrom |
| CN111328806A (en) * | 2020-03-07 | 2020-06-26 | 郑州大学 | Double-linear alkyl quaternary ammonium salt complex iodine bactericide |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN114681586A (en) * | 2020-12-25 | 2022-07-01 | 黑龙江省儒中医疗科技有限公司 | Influenza external vaccine and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105663158A (en) * | 2016-03-15 | 2016-06-15 | 浙江海正药业股份有限公司 | High-concentration iodine disinfection solution and preparation method thereof |
| CN105663158B (en) * | 2016-03-15 | 2019-06-28 | 浙江海正动物保健品有限公司 | A kind of high concentration iodic disinfecting liquid and preparation method thereof |
| CN106581051A (en) * | 2016-11-08 | 2017-04-26 | 太原市诚诚科技有限公司 | Nano microemulsion iodine and preparation method thereof |
| CN108566947A (en) * | 2017-03-10 | 2018-09-25 | 洛阳惠中兽药有限公司 | A kind of foam disinfectant auxiliary agent, preparation method and foamaseptic prepared therefrom |
| CN107258839A (en) * | 2017-07-12 | 2017-10-20 | 合肥华盖生物科技有限公司 | A kind of composite disinfectant and preparation method thereof |
| CN109042728A (en) * | 2018-09-19 | 2018-12-21 | 青岛安特斯生物制药有限公司 | A kind of iodine class disinfectant and its preparation and application |
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| CN111328806A (en) * | 2020-03-07 | 2020-06-26 | 郑州大学 | Double-linear alkyl quaternary ammonium salt complex iodine bactericide |
| CN114681586A (en) * | 2020-12-25 | 2022-07-01 | 黑龙江省儒中医疗科技有限公司 | Influenza external vaccine and preparation method thereof |
| CN112640913A (en) * | 2020-12-30 | 2021-04-13 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112640913B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
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