CN101803611B - Citric acid iodine disinfectant and method for preparing same - Google Patents
Citric acid iodine disinfectant and method for preparing same Download PDFInfo
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- CN101803611B CN101803611B CN201010163683.4A CN201010163683A CN101803611B CN 101803611 B CN101803611 B CN 101803611B CN 201010163683 A CN201010163683 A CN 201010163683A CN 101803611 B CN101803611 B CN 101803611B
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Abstract
The invention discloses a citric acid iodine disinfectant. The citric acid iodine disinfectant is characterized by consisting of the following components in percentage by weight: 10 to 50 percent of citric acid, 0.5 to 2.5 percent of iodine, 10 to 50 percent of ethanol, and 1 to 65 percent of water. The preparation method comprises the following steps of: dissolving citric acid and iodine in ethanol to obtain uniform liquid, pouring the uniform liquid in a reaction kettle, adding water, stirring the mixed solution for about 2 to 5 hours to obtain solution which is homogeneous, clear and bright. The citric acid iodine disinfectant has the advantages of broad disinfection spectrum, high disinfecting capability, high acting speed, good stability, safety to people and animals and low environmental pollution, so that the citric acid iodine disinfectant is an environmentally-friendly citric acid iodine disinfectant.
Description
Technical field
The invention belongs to disinfectant field, particularly a kind of compound lemon acid iodine disinfectant and preparation method thereof for livestock and poultry, aquaculture and public place sterilization.
Background technology
In recent years; because of the factor such as environment and drug abuse; the various infectious disease of livestock and poultry breeding industry is caused to take place frequently; to such an extent as to the relevant industries such as livestock and poultry breeding industry, veterinary drug production and operation are subject to great impact; along with the layer of food safety affair go out, the propagation of zoonosis, the development of large-scale cultivation; and people " prevent overweighting controlling " continually strengthening of medication idea; in the urgent need to for improving feeding environment, prophylactic green safety disinfectant; effectively should kill virus, again to livestock and poultry, aquatic products without stress.
Iodine is used for the history that body sterilizing has 150 years, and since latter half in 19th century, many people have spoken highly of the usefulness of iodine as antibacterial agent, and this is mainly because it has the unexistent and inaccessiable bactericidal effect of many bactericide.Its has a broad antifungal spectrum, little to tissue toxicity, be widely used, its sterilizing scope relates to clinical, health, daily life, livestock and poultry cultivation, aquaculture, public place and drinking water etc., different classes of, different dosage form, different efficacies iodine sterilizing medicine is just being widely used in practice, as for the sterilization of human body skin, wound surface, mucomembranous surface, surgical instruments, Chi Shui, drinking water and the sanitized of tableware, be used for treating the various diseases of the various mankind etc.
Citric acid has another name called citric acid, is first acid in organic acid, due to the performance of physical property, chemical property, derivative, is be widely used in the most important organic acids of industry such as food, medicine, daily use chemicals.Be mainly used in food, beverage industry as acid, flavor enhancement and preservative, antistaling agent; Antioxidant, plasticizer, washing agent etc. are used as in chemical industry, cosmetic industry and washing industry; All have been widely used in environmental protection, poultry, aquaculture sterilization, medicine etc.
Iodine and citric acid are all distributed widely in occurring in nature, all contain iodine in air, water, soil, rock and animal and plant body, a variety of fruits and vegetables, all contain more citric acid in the fruit of especially Citrus.Citric acid has pleasant tart flavour, and mouthfeel is frank, and tart flavour without issue, safety non-toxic, the solvability in water is high, can by the direct Absorption And Metabolism of organism.How the two combination to be utilized, be a problem of great practical value.
Summary of the invention
The object of this invention is to provide a kind of new disinfectant, have that fungicidal spectrum is wide, sterilizing ability is strong, speed of action is fast, good stability, to humans and animals safety, environmental pollution degree is low, citric acid iodine disinfectant of the advantages such as environmentally friendly type and preparation method thereof.
The present invention adopts following technical scheme to realize above-mentioned purpose:
Citric acid iodine disinfectant of the present invention, is characterized in that: it contains following component, and the percentage by weight of each component is as follows:
Citric acid 10-50%,
Iodine 0.5-2.5%,
Ethanol 10-50%,
Water 1-65%.
Citric acid iodine disinfectant preparation method of the present invention is, first flow into reactor with the uniform liquid that ethanol dissolves after each component, then adds appropriate water, be uniformly mixed 2-5 hours, become the liquid that homogeneous phase is clear and bright.
The beneficial effect that the present invention adopts above technical scheme to reach is:
Citric acid iodine disinfectant of the present invention is a kind of by liquid sterilization disinfectant formulated to citric acid, iodine, ethanol, water, it has the double sterilization effect of citric acid and Operand, sterilizing ability is strong, speed of action is fast, good stability, and to humans and animals safety, environmental pollution degree is low; Its preparation method is simple, and production cost is low, and product has use value widely.
Embodiment
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 10%, iodine 1%, ethanol 29%, water 60%, first the citric acid in ethanol dissolved constituent and iodine is used, the uniform liquid of formation is flow into reactor, then adds water and be uniformly mixed 2 hours, become the liquid that homogeneous phase is clear and bright.
Embodiment 2:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 20%, iodine 0.5%, ethanol 29.5%, water 50%, flow into reactor with the uniform liquid that ethanol dissolves after each component, add appropriate water, be then uniformly mixed 3 hours, become the liquid that homogeneous phase is clear and bright.
Embodiment 3:
Citric acid iodine disinfectant of the present invention, it contains following component, citric acid 40%, iodine 1.5%, ethanol 10%, water 48.5%, flow into reactor with the uniform liquid that ethanol dissolves after each component, add appropriate water, be then uniformly mixed 4 hours, become the liquid that homogeneous phase is clear and bright.
Citric acid iodine disinfectant bactericidal effect of the present invention can embody from following bactericidal assay:
1 materials and methods
1.1 test equipment
1.1.1 citric acid iodine disinfectant is provided by Zhengdian Biological Tech. Co., Ltd., Foshan City.
1.1.2 test strain Escherichia coli (8099) and staphylococcus aureus (ATCC6538), cultivated for 6th ~ 8 generations; Bacillus subtilis var (ATCC9372), cultivated for the 4th generation, preparation brood cell.
1.2 method
1.2.1 staphylococcus aureus (ATCC6538) and Escherichia coli (8099) 24h fresh cultured thing and bacillus subtilis var (ATCC9372) spore suspension are got in the preparation of bacteria suspension, for subsequent use with the bacteria suspension being mixed with experimental concentration containing the dilution of 10g/L peptone phosphate buffer.
1.2.2 neutralizer Selection experiment take Escherichia coli as representative.Under 20 DEG C of conditions, if parallel 6 groups of tests, undertaken by Suspension quantitative bactericidal test program.1. thimerosal+bacteria suspension; 2. (thimerosal+bacteria suspension)+neutralizer; 3. neutralizer+bacteria suspension; 4. (thimerosal+neutralizer)+bacteria suspension; 5. dilution+bacteria suspension (normal bacteria contrast); 6. dilution+neutralizer+medium is as negative control.Result of the test, with the 1st group of not long bacterium or only there is only a few colony growth; 2nd group has colony growth, and comparatively the 1st group is many, but is few compared with the 3rd, 4,5 group; 3rd, 4,5 groups of bacterium numbers are similar, error rate≤10%; 6th group of asepsis growth, for selected neutralizer and concentration thereof are suitable for.Test repetition 3 times.
1.2.3 Suspension quantitative bactericidal test is under 20 DEG C of conditions, organic interfering substance and bacteria suspension 1: 1 mix for subsequent use, mix with the ratio (positive control is hard water) of 4ml disinfectant in every test tube 1ml bacteria suspension, effect, to the scheduled time, is drawn 0.5ml bacterium medicine and is added in 4.5ml neutralizer and mix.Neutralization 10min, gets this liquid 1ml and inoculates plate, pour into corresponding agar medium, cultivates 48h (bacillus subtilis black variety bud cell is 72h) for 37 DEG C, calculates clump count, calculate kill oncomelania.Test repetition 3 times.
2 results
2.1 neutralizer Selection experiment result of the tests show, under 20 DEG C of conditions, the aseptic PBS solution of 1% lecithin+1% Tween 80+0.5% sodium thiosulfate, effectively can neutralize residual thimerosal residual action, and neutralizer and neutralized reaction product have no significant effect test bacterial growth and medium.
2.2 Suspension quantitative bactericidal test result of the tests show, under 20 DEG C of conditions, available iodine is that 100mg/L thimerosal dilution acts on 3min respectively to Escherichia coli, staphylococcus aureus, kill oncomelania >=5.0; Available iodine be 500mg/L thimerosal dilution to bacillus subtilis black variety bud cell effect 5min, kill oncomelania >=5.0, in table 1.
Table 1 citric acid iodine disinfectant bactericidal effect
Note: test temperature is 20 DEG C, Negative control Sterile grows, and result is 3 test mean values.
3 discuss
This experimental study citric acid iodine disinfectant available iodine is that the dilution of 500mg/L has good killing effect to microorganism.
Above embodiment is only in order to illustrate that technical scheme of the present invention is not intended to limit; Although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the field are to be understood that.Still can modify to the embodiment of invention or portion of techniques feature be carried out to equivalent replacement; And not departing from the spirit of technical solution of the present invention, it all should be encompassed in the middle of the technical scheme scope of request of the present invention protection.
Claims (1)
1. the preparation method of a citric acid iodine disinfectant, it is characterized in that, it will back up the citric acid 40% of ratio by weight, iodine 1.5%, ethanol 10%, water 48.5%, reactor is flow into the uniform liquid that ethanol dissolves after each component, add appropriate water, be then uniformly mixed 4 hours, become the liquid that homogeneous phase is clear and bright.
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| CN201010163683.4A CN101803611B (en) | 2010-05-06 | 2010-05-06 | Citric acid iodine disinfectant and method for preparing same |
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| CN101803611B true CN101803611B (en) | 2015-01-28 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107501078A (en) * | 2016-06-14 | 2017-12-22 | 佛山市正典生物技术有限公司 | A kind of citric acid iodo-complexes and preparation method thereof |
| CN110937937A (en) * | 2019-12-03 | 2020-03-31 | 杭州三得农业科技有限公司 | Special tea fertilizer process for improving theanine content |
| CN112704080B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with stable component content and preparation method thereof |
| CN112640913B (en) * | 2020-12-30 | 2022-02-22 | 佛山市正典生物技术有限公司 | Iodine-containing disinfectant with long-term component stability and preparation method thereof |
| CN112806387B (en) * | 2020-12-31 | 2022-02-25 | 佛山市正典生物技术有限公司 | Preparation method of iodine-containing disinfectant with stable component content |
| CN112841181B (en) * | 2020-12-31 | 2022-06-17 | 佛山市正典生物技术有限公司 | Stable iodine-containing disinfectant and preparation method thereof |
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| CN1193484A (en) * | 1997-03-14 | 1998-09-23 | 烟台开发区天和科技有限责任公司 | Composition containing iodine and preparation thereof |
| WO2008005059A2 (en) * | 2006-07-05 | 2008-01-10 | Frio Technologies, Inc. | Treatment of mouth and urinary tract infections |
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| CN1193484A (en) * | 1997-03-14 | 1998-09-23 | 烟台开发区天和科技有限责任公司 | Composition containing iodine and preparation thereof |
| WO2008005059A2 (en) * | 2006-07-05 | 2008-01-10 | Frio Technologies, Inc. | Treatment of mouth and urinary tract infections |
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