KR101575768B1

KR101575768B1 - Humectant made by herbs composition

Info

Publication number: KR101575768B1
Application number: KR1020150061973A
Authority: KR
Inventors: 김희택; 김정범; 김재현
Original assignee: 주식회사 자연인; 세명대학교 산학협력단
Priority date: 2014-06-30
Filing date: 2015-04-30
Publication date: 2015-12-07

Abstract

The present invention relates to a skin moisturizing supplement agent composition using natural ingredients, which is harmless to a human body to help skin moisturizing and anti-itching. The skin moisturizing supplement agent composition using natural ingredients according to the present invention is formed by mixing 45-55 wt% of water, 25-35 wt% of any one solvent selected from a group including butylene glycol, 18-22 wt% of a natural ingredient mixture including Scutellaria baicalensis, Coptis chinensis, bark of Phellodendron amurense Rupr, Glycyrrhiza uralensis Fischer, Portulaca oleracea L, Ponciri Fructus Immaturus, Forsythia koreana Nakai, and Angelica gigas Nakai independently having particle size of 80-120 meshes, and extracting at 60-70 °C for 160-200 minutes by ultrasound.

Description

{HUMECTANT MADE BY HERBS COMPOSITION}

The present invention relates to a skin moisturizing adjuvant composition, and more particularly, to a skin moisturizing adjuvant composition which can prevent skin dryness and fever by using a natural material (a medicinal substance) which is harmless to the human body, The present invention relates to a skin moisturizing adjuvant composition using a natural material capable of dissolving the skin.

Atopy has the meaning of "strange" or "inappropriate," and the cause of atopic dermatitis has not yet been clearly identified, so symptoms are also manifested in skin dryness, eczema, and the like. Atopic dermatitis, also known as fever, is a chronic condition of the skin; Asthma, and hay fever. This disease is a clinical disease that is called clinical allergic eczema, pediatric eczema, all ovarian eczema, and nerve dermatitis and is a clinical disorder that shows the clinical and histologic progression from infant eczema to typical adolescent dermatitis in adulthood, puberty and adult .

Atopy dermatitis is a chronic recurrent eczematous disease and the cause and pathogenesis of it are not clear. It is now understood that atopic dermatitis is mainly caused by a unique genetic predisposition, but the cause of the disease is not simple and is caused by multi-factors. Several environmental factors involved in the deterioration of atopic dermatitis are well known. Genetic identification of genetic predisposition and clinical and immunological patterns in patients with atopic dermatitis and their families is currently limited.

Clinically, the most characteristic findings, dry skin and eczema, are not explained by immunologic abnormalities, and it is unclear whether they are due to genetic factors or secondary changes in atopic dermatitis.

The abnormalities of the skin observed in atopic dermatitis include abnormality of the stratum corneum cell size, increase in the thickness of the epidermal layer, decrease in the water content in the stratum corneum, decrease in the water content in the epidermis, decrease in the natural moisturizing factor , Increased transepidermal water loss, and reduced amount of lipid in the stratum corneum.

Atopic dermatitis is chronically dry, so it is easily triggered by various stimuli. It has a characteristic of being prone to leaning and recurring repeatedly. These feelings and eczema are repeatedly exacerbated by dry skin, and unless properly managed, they eventually lead to subacute and chronic lesions such as fusiformis, pigmentation, and hyperopia. In addition to immunologic abnormalities, superficial folliculitis, pyritosis forum folliculitis, epidermolysis, superficial dermatophytosis, warts, recurrent herpes simplex are common.

Therefore, the use of moisturizers to improve the skin dryness of atopic dermatitis and the increased resilience of the skin barrier function are important in the treatment of atopic dermatitis.

Conventional formulation moisturizers have been used to alleviate the dry skin symptoms observed in atopic dermatitis. However, the effect is temporary due to increased moisture due to the applied moisturizing ingredient and has not shown a great effect for improving the resilience of skin barrier function .

Patent No. 10-0719761 Registration No. 10-0813781

Disclosure of the Invention The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a medicinal herb that is harmless to the human body and can prevent and heat the skin, And to provide a skin moisturizing adjuvant composition using the same.

The skin moisturizing adjuvant composition using the natural material according to the present invention comprises 45 to 55% by weight of water, 25 to 35% by weight of a solvent containing butylene glycol, 50 to 50% by weight of a mixture of gold, And 18 to 22% by weight of a mixture of natural materials made of Angelica gigas.

The skin moisturizing adjuvant composition using the natural material according to the present invention comprises 45 to 55% by weight of water, 25 to 35% by weight of a solvent containing butylene glycol, a mixture of a tosaja, hwangjeong, And 18 to 22% by weight of a mixture of natural materials.

The present invention is characterized in that water, a solvent and a mixture of natural materials are mixed and then manufactured by ultrasonic extraction at a temperature of 60 to 70 ° C for 160 to 200 minutes.

According to the skin moisturizing adjuvant composition using the natural material according to the present invention, it is possible to easily use skin medicines such as atopic dermatological medicines, which reduce or cool skin heat, It prevents dryness and moisturizes, helps to heal people with atopic diseases, helps prevent symptoms from worsening, and can prevent secondary skin diseases caused by scratching the skin due to severe dryness of the skin.

In addition, since the present invention has the characteristics of paraben, anhydrous, non-alcoholic, and colorless, it can be used safely not only by sensitive skin but also by infants.

1 to 3 show test results of a skin moisturizing adjuvant composition using a natural material according to the present invention,
Fig. 1 shows the moisture change according to the comparative example in which the present invention is not used,
FIG. 2 and FIG. 3 show moisture changes according to the embodiment of the present invention, respectively.

&Lt; Example 1 >

The skin moisturizing adjuvant composition using the natural material according to the present embodiment is made of a gypsum mixture, water and a solvent.

The present embodiment is characterized in that the skin is cooled or cooled. To meet this characteristic, the natural material mixture is composed of gold, yellowtail, yellowtail, gardenia, licorice, mashin, zisil, allium and angelica.

The golden character is cold, the taste is spicy, and there is no poison. It treats heat poisoning, osteoporosis, cold and fever. It stops the thirst of the fever and kills jaundice, dysentery, diarrhea, bloating (fever), fever (stomach fever) , Heal the gnats and fever.

Chrysanthemum is cold, tasteless, poisonous. It brightens the eyes, stops the flowing of the tears, calms the liver, clears the fever, spreads in the eyes, cures the blurring of the blurring of the blurred hairs.

Hwang Baek is temperate and tasteless and poisonous. 5 chapters, jaundice and jaundice (intestinal hemorrhoids: one of the hemorrhoids) in the forehead. Diarrhea and dysentery, red blood cells, heal the food window, killing the insecticide, scurvy, burning, fever and sickness in the eyes, and healing the inside of the mouth to eliminate osteoporosis.

The gardener is temperate and tasteless and poisonous. It heals the intense heat in the chest and the large intestine, the heat in the stomach (stomach mid-heat) and the stuffy stomach.

Licorice is fair in nature, flavorful, and not poisonous. It releases the poison of all kinds of medicine. It has the effect of harmonizing all kinds of medicines such as 72 minerals and 1,200 herbs with 9 kinds of soil energy. In chapter 5, chapter 6, there is a fraudulent scam, and it is written in 9, and it makes all the blood circulate well.

Machi-hyun is tasty and has a good quality and works on the heart / colon. It lowers fever, solves poisons, eliminates ejaculation, kills insects, and makes them pee. In pharmacological experiments, it was found that the action of arteriosclerosis, the action of increasing the blood pressure, the act of suppressing the uterus, and the action of stopping the blood.

JiSil is temperamental, flavorful and poisonous. It heals the itchy skin of the skin and the wall of the skin.

The alliance is good in nature, tastes delicious, and has no poison. Healing, hearing, sorrow, unity of heat and heat, healing solitude, drain the pus, heal the pain, stop the pain. 5 Heals the clogged groin and piss and removes the fever from the heart.

Angelica is warm in nature, flavorful, sweet, and not poisonous. Heal all the diseases, bloodshed, and hunger, and the cape breaks through the blood and produces new blood. It hurts various kyangyang (kangyang) and ironware, and it heals that the ego is gathered in the inside. Heal the temperament and see Chapter 5 and let the flesh live.

Golden (root) with these characteristics: Rhizomes (root, stem): White bark: Gardenia (fruit): Licorice (root): Machi (leaf) (Roots) are mixed in a weight ratio of 1: 0.9 to 1.1: 0.9 to 1.1: 0.9 to 1.1: 0.9 to 1.1: 0.4 to 0.6: 0.4 to 0.6: 0.4 to 0.6: 0.4 to 0.6, 1: 1: 1: 0.5: 0.5: 0.5: 0.5: 0.5, preferably in the ratio of 1: 1 to 1: Mixing ratio.

The material is extracted and used as an active ingredient through ultrasonic extraction and is pulverized to 80 to 120 mesh for optimal extraction of the active ingredient.

The natural material mixture is mixed with 18 to 22% by weight, preferably 20% by weight, based on 100% by weight of the skin moisturizing adjuvant composition using a natural material. If less than 18% by weight is mixed, It can cause skin troubles due to excessive amount.

Water is used for extracting the active ingredient of the natural material mixture, and 45 to 55% by weight of the water is added to 100% by weight of the skin moisturizing adjuvant composition using the natural material. The mixing ratio is the optimum And if the concentration is outside the above range, the concentration of the extract solution is high or low, resulting in deterioration of the problem-solving effect of skin trouble, and the productivity is decreased.

As the solvent, it is possible to use butylene glycol.

As a solvent, butylene glycol is used as a skin conditioning agent (softening agent, wetting agent) as a solvent for extracting an active ingredient of a medicinal material and is used in an amount of 25 to 35% by weight based on 100% And the mixing range is an optimum range satisfying the concentration and productivity of the extract.

In the skin moisturizing adjuvant composition using the natural material of this embodiment, the above materials (natural material mixture, water, and butylene glycol as a solvent) are used as extractions by an ultrasonic extraction method.

The ultrasonic extraction method can increase the efficiency of extraction and when extracting natural substances such as medicinal materials, it is easy to extract the active ingredient of the extract by applying ultrasonic waves.

The ultrasound extraction conditions are 160 to 200 minutes at a temperature of 60 to 70 ° C, preferably 180 minutes at a temperature of 65 ° C. If the temperature and time are out of the range, the yield of the active ingredient is poor and the active ingredient is destroyed .

The hot water extraction method has a drawback in that the extraction efficiency is low and energy consumption is higher than that of the ultrasonic extraction method, the useful component is destroyed due to heat, the protein is mutated, the component is lost, and only the soluble component is extracted. desirable.

The skin moisturizing adjuvant composition using the natural material manufactured by the above method is mixed with cosmetic (body wash, body lotion, skin, lotion, moisturizing article, etc.) (mixing of 0.05 to 20 parts by weight with respect to 100 parts by weight of cosmetic raw material, And the skin moisturizing adjuvant composition using natural materials may be directly used or diluted with water or the like.

Meanwhile, in the present embodiment, the ultrasonic extraction may be performed by ultrasonic extraction after mixing all the natural materials, mixing the natural materials one by one with the above-mentioned materials (water, butylene glycol), ultrasonic extraction followed by mixing . Of course, the herbal extracts prepared through the respective ultrasonic extraction are mixed at the same ratio as the mixing ratio of the above-mentioned medicinal materials.

1: 0.9 ~ 1.1: 0.9 ~ 1.1: 0.9 ~ 1.1: 0.9 ~ 1.1: 0.4 ~ 0.6: 0.4 The ratio of the extracts of Angelica keiskei 1: 0.5: 0.5: 0.5: 0.5: 0.6: 0.4 to 0.6: 0.4 to 0.6, which is an optimal ratio for reducing heat or cooling the skin, 0.5: 0.5.

Even when the whole of natural materials are mixed, it is used in the same weight ratio as each of the natural material extracts described above, such as gold, phthalocyanine, yellow white, gardenia, licorice,

1. Test characteristics of this embodiment

end. material

250g, 250g, 250g, 250g, 250g, 500g, 500g, 500g, 150g, 250g, 250g,

I. Produce

Five times the amount of the natural material mixture (3,250 g) was extracted with water (water 5: butylene glycol 3), and the mixture was ultrasonically extracted at 65 ° C for 180 minutes.

When the final extract was calculated to be 100%, it was extracted so that a mixture of natural materials was 20%, water was 50%, and butylene glycol was 30%. After extraction, it was filtered using 0.5μ filter.

&Lt; Example 2 >

The skin moisturizing adjuvant composition using the natural material according to the present invention is characterized in that it helps to moisturize the skin. Thus, the mixture of natural materials has a ratio of 1: 0.4 by weight in terms of weight ratio of toadaceae: Hwangjeong: 0.5 to 0.5: 0.5 to 0.25: 0.125, in a mixing ratio of from about 0.6: 0.4 to 0.6: 0.4 to 0.6: 0.4 to 0.6: 0.2 to 0.3: 0.12 to 0.13,

In this embodiment, 45 to 55% by weight of water, 25 to 35% by weight of water, and 18 to 22% by weight of a natural material mixture are prepared by mixing and ultrasonic extraction as in the case of the above-mentioned Example 1.

Water and butylene glycol were the same as in Example 1.

The tossa is well-tempered, flavorful, sweet and poisonous. He also writes his appetite, his mouth dry and thirsty. Helps the semen and gives the bone marrow.

Hwang Jeong has a good temperament, a good taste, and no poison. (5) to 7 (7), to strengthen the tendons and bones, to see the stomach, and to grasp the heart (Jung).

Chunghwa is cold, flavorless, poisonous. It makes the small intestine go well, sucking the pus, killing the poison, and treating the pussy. It is a very good medicine to heal bleeding.

Hwanggi is slightly warm in temperament, sweet in taste and not poisonous. Helps and fatigues the stomach, removes the butler, sucks the pus from the old booth, and stops the sick. I am depressed and sweating, and by itself I stop sweating, which acts on the surface of the skin.

Hwang Baek is cold and tasteless and poisonous. 5 chapters, jaundice and jaundice (intestinal hemorrhoids: one of the hemorrhoids) in the forehead. Diarrhea and dysentery, red blood cells, heal the food window, killing the insecticide, scurvy, burning, fever and sickness in the eyes, and healing the inside of the mouth to eliminate osteoporosis.

Machi-hyun is tasty and has a temperamental character. It works on heart and colon. It lowers fever, solves poisons, eliminates ejaculation, kills insects, and makes them pee. In pharmacological experiments, it was found that the action of arteriosclerosis, the action of increasing the blood pressure, the act of suppressing the uterus, and the action of stopping the blood.

This embodiment is manufactured in the same manner as in Embodiment 1. [

Also in this embodiment, as in the case of Example 1, it is also possible to perform ultrasonic extraction of all the natural materials and to produce all of the medicinal materials separately by ultrasonically extracting them and then mixing all the medicinal material extracts. In this case, (Root) Extract: Chrysanthemum (root) Extract: Chrysanthemum (root) Extract: Angelica (root) Extract: ) Extract in a weight ratio of 1: 0.4-0.6: 0.4-0.6: 0.4-0.6: 0.4-0.6: 0.2-0.3: 0.12-0.13.

2. Test characteristics of this embodiment

end. material

480g, 480g, 480g, 480g, 480g, 240g, and 120g, respectively.

I. Produce

Five times as much as the natural material mixture (3,240 g) was extracted with water (water 5: butylene glycol 3) and ultrasonically extracted at 65 ° C for 180 minutes.

3. Test results according to Examples 1 and 2 are as follows.

end. Subject selection criteria.

1) A person who does not have any symptoms of irritation on the skin due to the examination of the dermatologist and physical examination.

2) Those who understood the purpose and content of the examination and expressed willingness to participate voluntarily.

3) Understand possible side effects and sign a written agreement.

4) Volunteers who can follow up during the test.

Twenty subjects were selected according to the selection criteria.

I. Test products.

Example 1 (Chelating solution: prescription to cool the skin, and it plays a role of heat in skin erythema and severe itching in the local area) or Example 2 (limbus solution: skin moisturizing formula to dry skin and help skin itching) (9% by weight of cyanotic solution), Clance SMA Clinic Infusion Mist (0.09% by weight of cyanogen solution), Clance SMA Clinic Intensive Cream containing 9% by weight of a skin moisturizing adjuvant composition using natural materials A clinic bodywash (0.07% by weight of limbal fluids) and 4 kinds of Clance SML clinic lotions (7% by weight of limbal fluids).

The Clance SML Clinic Intensive Cream is a product mixed with a purified water humectant (glycerin), a surfactant, an emulsifying aid, a surfactant, a solvent, an antioxidant, an increasing agent, a sequestering agent, The material is a known cream material, and since the present invention does not derive an effect by a material other than the cyanotic liquid, the materials used in the four kinds of products are not specifically limited. That is, it is only an example of a product for this test because the pharmaceutical composition of the present invention can be used in various product forms such as the use of a stock solution, the use of a dilution liquid with water, and the like.

All. Testing agency.

Sookmyung University Oriental medicine bio industry clinical support center.

la. Test Methods.

Patch test for 4 days on the subject's back, Immediately before application, Immediately after application, 6 hours after application, and 12 hours after application.

hemp. result

The results of the human skin application tests of three types of skin patches including Clance SMA Clinic Body Lotion and the others were found to belong to the unstimulated product group according to the evaluation of the mean score.

There was no skin abnormality during the test period.

FIG. 1 shows data of a comparative example showing a change in water under a condition where the embodiment of the present invention is not used, and FIGS. 2 and 3 show changes in water after using the embodiment (cream, lotion) of the present invention.

As can be seen from the results of the moisture changes of FIGS. 1 to 3, it was confirmed that most of the subjects using the present example exhibited higher moisture than when the present example was not used, and as a result, skin moisturizing effect was excellent. It was also confirmed that the same moisture change was observed in the other two species except cream and lotion (Fig. 1 shows a state in which the moisturizing agent is not applied. However, for the purpose of comparison with this embodiment, immediately after application, 6 hours after application, 12 hours after application ).

It was confirmed that the results obtained by using only the cyanotic fluid and the limbal fluid of Examples 1 and 2 of the present invention also improved the moisturizing effect as compared with the case where the present invention was not used,

Claims

45 to 55% by weight of water, 25 to 35% by weight of butylene glycol as a solvent, and 18 to 22% by weight of a mixture of a natural material consisting of gold, rhodochrosite, yellowish white, gardenia, licorice,
Wherein the mixture of natural materials has a weight ratio of 1: 0.9 to 1.1: 0.9 to 1.1: 0.9 to 1.1: 0.9 to 1.1: 0.4 to 0.6: 0.4 to 0.6 : 0.4 to 0.6: 0.4 to 0.6, and the mixture is extracted through ultrasonic extraction or ultrasonically extracted and mixed.

45 to 55% by weight of water, 25 to 35% by weight of butylene glycol as a solvent, and 18 to 22% by weight of a mixture of natural materials consisting of a mixture of a silicate, a horseradish, a silkworm, Angelica gigas,
0.4 to 0.6: 0.4 to 0.6: 0.4 to 0.6: 0.4 to 0.6: 0.2 to 0.3: 0.12 to 0.13 in terms of weight ratio in a weight ratio of 1: 0.4 to 0.6: 0.4 Wherein the skin moisturizing adjuvant composition is obtained by ultrasonic extraction or ultrasonic extraction.

The method according to claim 1 or 2, wherein the natural materials of the natural material mixture are each 80 to 120 mesh in size, and are ultrasonically extracted at a temperature of 60 to 70 ° C for 160 to 200 minutes. Adjuvant composition.