CN103732240A - G-csf二聚体在制备治疗神经退行性疾病药物中的应用 - Google Patents

G-csf二聚体在制备治疗神经退行性疾病药物中的应用 Download PDF

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Publication number
CN103732240A
CN103732240A CN201280036654.9A CN201280036654A CN103732240A CN 103732240 A CN103732240 A CN 103732240A CN 201280036654 A CN201280036654 A CN 201280036654A CN 103732240 A CN103732240 A CN 103732240A
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China
Prior art keywords
csf
dimers
colony stimulating
stimulating factor
dimer
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CN201280036654.9A
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CN103732240B (zh
Inventor
武栋栋
黄智华
黄予良
严孝强
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Yiyi biopharmaceutical (Beijing) Co.,Ltd.
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Generon Shanghai Corp Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

本发明公开了G-CSF二聚体在制备治疗神经退行性疾病药物中的应用。本发明使用G-CSF二聚体分子，能够显著增加PD模型动物黑质多巴胺能神经元的数量，提高多巴胺能神经元的功能。此外，G-CSF二聚体分子能够显著减少海马区神经元细胞的凋亡，改善AD模型大鼠学习记忆能力。本发明的二聚体G-CSF的血清半衰期延长，有效阻止神经元的丢失，从而能够更有效地治疗神经退行性疾病。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201280036654.9A 2011-07-25 2012-07-24 G-csf二聚体在制备治疗神经退行性疾病药物中的应用 Active CN103732240B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280036654.9A CN103732240B (zh) 2011-07-25 2012-07-24 G-csf二聚体在制备治疗神经退行性疾病药物中的应用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN201110209712.0 2011-07-25
CN201110209712 2011-07-25
PCT/CN2012/079106 WO2013013613A1 (zh) 2011-07-25 2012-07-24 G-csf二聚体在制备治疗神经退行性疾病药物中的应用
CN201280036654.9A CN103732240B (zh) 2011-07-25 2012-07-24 G-csf二聚体在制备治疗神经退行性疾病药物中的应用

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CN103732240A true CN103732240A (zh) 2014-04-16
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US (1) US9642917B2 (zh)
EP (1) EP2737905B1 (zh)
JP (1) JP5947891B2 (zh)
CN (1) CN103732240B (zh)
AU (1) AU2012289433B2 (zh)
CA (1) CA2842969C (zh)
WO (1) WO2013013613A1 (zh)

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CN113166219A (zh) * 2018-09-28 2021-07-23 纪念斯隆-凯特琳癌症中心 干细胞衍生的人小神经胶质细胞、制备方法及使用方法

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CN102260343A (zh) 2010-05-25 2011-11-30 健能隆医药技术（上海）有限公司 重组人g-csf二聚体在治疗神经损伤疾病中的用途
EP3050570A1 (en) * 2015-01-31 2016-08-03 Neurovision Pharma GmbH Pharmaceutical composition consisting of a combination of G-CSF with GM-CSF
US9876264B2 (en) 2015-10-02 2018-01-23 At&T Intellectual Property I, Lp Communication system, guided wave switch and methods for use therewith
WO2024037633A2 (en) 2022-08-19 2024-02-22 Evive Biotechnology (Shanghai) Ltd Formulations comprising g-csf and uses thereof

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JP5947891B2 (ja) 2016-07-06
EP2737905A4 (en) 2015-03-18
WO2013013613A1 (zh) 2013-01-31
CA2842969C (en) 2018-03-27
AU2012289433A1 (en) 2014-03-13
AU2012289433B2 (en) 2017-07-27
US20140248234A1 (en) 2014-09-04
CA2842969A1 (en) 2013-01-31
CN103732240B (zh) 2015-12-09
JP2014521612A (ja) 2014-08-28
EP2737905A1 (en) 2014-06-04
EP2737905B1 (en) 2019-09-11
US9642917B2 (en) 2017-05-09

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Address after: 101111 1st, 2nd and 3rd floors, 3rd floor, 99 Kechuang 14th Street, Daxing District, Beijing Economic and Technological Development Zone

Patentee after: Beijing Jiannenglong Biopharmaceutical Co.,Ltd.

Address before: 201203 Shanghai City, Pudong New Area Road No. 1011, room 307, Zhangjiang hi tech Haley

Patentee before: GENERON (SHANGHAI) Corp.,Ltd.

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Address after: 101111 1st, 2nd and 3rd floors, 3rd floor, 99 Kechuang 14th Street, Daxing District, Beijing Economic and Technological Development Zone

Patentee after: Yiyi biopharmaceutical (Beijing) Co.,Ltd.

Address before: 101111 1st, 2nd and 3rd floors, 3rd floor, 99 Kechuang 14th Street, Daxing District, Beijing Economic and Technological Development Zone

Patentee before: Beijing Jiannenglong Biopharmaceutical Co.,Ltd.

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Application publication date: 20140416

Assignee: NANJING SHUNXIN PHARMACEUTICALS CO., LTD. OF CHIATAI TIANQING PHARMACEUTICAL Group

Assignor: Yiyi biopharmaceutical (Beijing) Co.,Ltd.

Contract record no.: X2022990000878

Denomination of invention: Application of G-CSF Dimer in Preparation of Drugs for Neurodegenerative Diseases

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