CN103549219B - Drug feed additive for promoting skin health of aquatic animals and preparation method thereof - Google Patents
Drug feed additive for promoting skin health of aquatic animals and preparation method thereof Download PDFInfo
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- CN103549219B CN103549219B CN201310577759.1A CN201310577759A CN103549219B CN 103549219 B CN103549219 B CN 103549219B CN 201310577759 A CN201310577759 A CN 201310577759A CN 103549219 B CN103549219 B CN 103549219B
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Abstract
The invention discloses a drug feed additive for promoting skin health of aquatic animals. The drug feed additive comprises the following components in parts by weight: 2 parts of Chinese herbal medicines, 7 parts of a carrier and 1 part of vitamins, wherein the Chinese herbal medicines comprise the following components in weight percentage: 8%-15% of angelica, 5%-10% of salvia miltiorrhiza, 18%-25% of liquorice, 25%-30% of frankincense, 25%-30% of myrrh and 5%-10% of borneol; the carrier is starch; the vitamins comprise vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B12 and vitamin C in a weight ratio of 12:12:64:26:6:1:26. The invention also discloses a preparation method of the drug feed additive. The preparation method comprises the following steps: crushing the Chinese herbal medicines at low temperature; and three-dimensionally mixing the vitamins and the Chinese herbal medicines. The drug feed additive prepared by the method is capable of alleviating ulcer symptoms of aquatic animal skins, alleviating bacterial infection, promoting wound healing, improving the feed intake of the aquatic animals and reducing the feed conversion ratio of the aquatic animals.
Description
Technical field
The present invention relates to the technical field of feed addictive, particularly relate to and a kind ofly promote medicated feed additive of aquatic livestock skin health and preparation method thereof.
Background technology
Along with the development of aquaculture of aquatic animal science and technology, modern breeding enterprise more and more trends towards the management method of science, at present, in aquaculture industry, often occur that aquatic livestock baits mutually, collide and the symptom such as skin infection, ulcer that the factor such as bacteriological infection causes, be unfavorable for the health of aquatic livestock body, extend feeding time, increase cost of feeding, also affect the transaction value of aquatic livestock dealing simultaneously.Therefore, for aquaculture enterprise, improving the body health of aquatic livestock, reduce cost of feeding, is the important method improving aquaculture economic benefit.
With regard to whole cultivation overall situation, abuse of antibiotics causes disaster, make the drug resistance of aquatic livestock more obvious, also can suppress the immunity function of aquiculture animal, and once virulent bacterium obtains drug resistance to the antibiotic that people, aquatic livestock share, after human infection, it is even invalid that original effective antibiotic curative effect can reduce; Meanwhile, can cause medicament residue, those are for the antibiotic of aquiculture animal, harmful, can enter human body by food chain, damage the health of the mankind.
Feed addictive refers to the mixture of a kind of raw material or several raw material added in basic forage mixture or in a part of feed for certain special requirement, and feed addictive can improve aquaculture of aquatic animal economic benefit preferably.The present inventor is through a large amount of practical experiences with after groping, think that the component of feed addictive and the skin health of the difference of content on aquatic livestock have larger impact, therefore, how the component of formula feed additive and corresponding content thereof are the emphasis of the aquatic livestock scientific research personnel research and development of this area.In view of this, the present invention's research and devise and a kind ofly promote feed addictive of aquatic livestock skin health and preparation method thereof, this case produces thus.
Summary of the invention
The object of the present invention is to provide a kind of feed addictive promoting aquatic livestock skin health, with alleviate aquatic livestock skin ulcer symptoms, reduce bacteriological infection and accelerating wound healing, and improve the feed intake of aquatic livestock and reduce its feedstuff-meat ratio.
Another object of the present invention is to provide a kind of preparation method promoting the feed addictive of aquatic livestock skin health, by steps such as low-temperature grinding and 3 D stereo mixing, to prepare above-mentioned feed addictive.
The technical scheme adopted that the present invention solves its technical problem is:
Promote a medicated feed additive for aquatic livestock skin health, comprise the component of following portions by weight: 2 parts, Chinese herbal medicine, 7 parts, carrier and vitamin 1 part; Wherein, described Chinese herbal medicine is made up of the component of following mass percent: Radix Angelicae Sinensis 8-15%, red sage root 5-10%, Radix Glycyrrhizae 18-25%, frankincense 25-30%, myrrh 25-30% and borneol 5-10%; Described carrier is starch; Described vitamin is by Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, by weight 12:12:64:26:6:1:26 composition.
As the preferred embodiment of embodiment, described Chinese herbal medicine is made up of by weight 1:1:2.5:3:3:1 Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae, frankincense, myrrh and borneol.
Promote a preparation method for the medicated feed additive of aquatic livestock skin health, comprise the steps:
Step one, the Radix Angelicae Sinensis taking above-mentioned parts by weight, the red sage root and Radix Glycyrrhizae, Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae to be cut off or after inclined tab process, the cut-out of Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae or inclined tab material are carried out co-grinding by micronizer, final pulverizing order number is more than or equal to 300 orders, obtained raw material one;
Step 2, the frankincense taking above-mentioned parts by weight and myrrh, adopt Universalpulverizer to pulverize, pulverizing temperature is 45-50 DEG C, obtained raw material two;
Step 3, take the borneol of above-mentioned parts by weight, low-temperature grinding borneol, low-temperature grinding temperature is 30 DEG C, obtained raw material three;
Step 4, raw material one described above, described raw material two and described raw material three are carried out co-grinding again together, obtained herbal raw material;
Step 5, take the Cobastab of above-mentioned parts by weight
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, in three-dimensional stereo mixing machines, the herbal raw material obtained with step 4 fully mixes 15-20 minute, obtained mixed product;
Step 6, packing is carried out to the mixed product obtained by step 5, obtained feed addictive.
As the preferred embodiment of embodiment, in described step one, before being also included in raw material one co-grinding, dry pretreated step is carried out to described Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae cut-out or inclined tab material, dry 4 hours of the described red sage root and Radix Glycyrrhizae, described Radix Angelicae Sinensis is dry 2-3 hour under cryogenic.
As the preferred embodiment of embodiment, in described step 2, described pulverizing carries out low-temperature grinding under cooling system, and described low-temperature grinding temperature is 45-50 DEG C.
Adopt the medicated feed additive that above-mentioned preparation method obtains, combine the feature of the cooperative compensating of vitamin and Chinese herbal medicine drug effect, B family vitamin can help to maintain heart on the one hand, nervous function, maintain the health of digestive system and skin, participate in energetic supersession, muscle power can be strengthened, nourishing and fit keeping function, vitamin C can promote the biosynthesis of ossein, be conducive to healing sooner of tissue injury mouth, iron can be improved simultaneously, the utilization of calcium and folic acid, alleviate plumbous, cadmium, the heavy metals such as arsenic are to the toxic action of body, strengthen the body anti-stress ability of environment and immunity to external world, on the other hand, in Chinese herbal medicine, frankincense, myrrh have promoting blood circulation and stopping pain, effect of detumescence and promoting granulation, borneol swells and ache for sore, and the symptom of not holding back after bursting has astriction, the red sage root, promoting blood circulation to disperse blood clots and relieves pain, the carbuncle that disappears nourishes blood, Radix Angelicae Sinensis, can enrich blood and invigorate blood circulation, and can treat damage again, Radix Glycyrrhizae, separates hundred poison, hard muscles and bones, longue meat.In a word, product of the present invention, by aquatic livestock of feeding, effectively can improve reparation speed, the Healing Rate of aquatic livestock wound, be conducive to the rehabilitation of skin; Use antibiotic can be reduced simultaneously, reduce medicament residue, green non-pollution.And, add this product and also can reduce feedstuff-meat ratio, reduce input and increase income.
Below in conjunction with detailed description of the invention, the present invention will be further described.
Detailed description of the invention
Embodiment 1
Promote a medicated feed additive for aquatic livestock skin health, comprise the component of following portions by weight: 2 parts, Chinese herbal medicine, 7 parts, carrier and vitamin 1 part; Wherein, described Chinese herbal medicine is made up of the component of following mass percent: Radix Angelicae Sinensis 8-15%, red sage root 5-10%, Radix Glycyrrhizae 18-25%, frankincense 25-30%, myrrh 25-30% and borneol 5-10%; Described carrier is starch; Described vitamin is by Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, by weight 12:12:64:26:6:1:26 composition.
As the preferred embodiment of embodiment, described Chinese herbal medicine is made up of by weight 1:1:2.5:3:3:1 Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae, frankincense, myrrh and borneol.
Embodiment 2
Promote a preparation method for the medicated feed additive of aquatic livestock skin health, comprise the steps:
Step one, the Radix Angelicae Sinensis taking embodiment 1 parts by weight, the red sage root and Radix Glycyrrhizae, Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae to be cut off or after inclined tab process, the cut-out of Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae or inclined tab material are carried out co-grinding by micronizer, the medicinal part of Chinese herbal medicine is different, be ground into the time that Ultramicro-powder consumes also different, final pulverizing order number is more than or equal to 300 orders, obtained raw material one;
Step 2, the frankincense taking embodiment 1 parts by weight and myrrh, adopt Universalpulverizer to pulverize, pulverizing temperature is 45-50 DEG C, obtained raw material two;
Step 3, take the borneol of embodiment 1 parts by weight, low-temperature grinding borneol, low-temperature grinding temperature is 30 DEG C, obtained raw material three;
Step 4, raw material one described above, described raw material two and described raw material three are carried out co-grinding again together, obtained herbal raw material;
Step 5, take the Cobastab of embodiment 1 parts by weight
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, in three-dimensional stereo mixing machines, the herbal raw material obtained with step 4 fully mixes 15-20 minute, obtained mixed product;
Step 6, packing is carried out to the mixed product obtained by step 5, this medicated feed additive obtained.
As the preferred embodiment of embodiment, in described step one, before being also included in raw material one co-grinding, dry pretreated step is carried out to described Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae cut-out or inclined tab material, dry 4 hours of the described red sage root and Radix Glycyrrhizae, described Radix Angelicae Sinensis is dry 2-3 hour under cryogenic.
As the preferred embodiment of embodiment, in described step 2, described pulverizing carries out low-temperature grinding under cooling system, and described low-temperature grinding temperature is 45-50 DEG C.
This medicated feed additive contains multivitamin, Chinese medicine powder and carrier, and by the pulverizing of different conditions, then mixing manufacture forms.Because borneol is containing a large amount of volatile ingredient, so must pulverize under the state of low temperature, and its thick taste, therefore to pulverize separately; And frankincense, myrrh are resinaes, temperature is higher softening more severe, and sticky stickiness is also higher, and board can be caused to work, and therefore also will separate with other Chinese medicines under the condition of low temperature and pulverize; All the other Chinese medicines, Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae are then by normal Crushing of Ultrafine broken wall treatment, and the powder obtained after above Crushing of Ultrafine, through three-dimensional stereo mixing machines mixing, the product mix finally obtained is this product.
Embodiment 3
This product (wherein Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae, frankincense, myrrh and borneol are by weight 1:1:2.5:3:3:1), can take 2 kinds of modes, and one is external application, and one is for oral administration, experiment in continuous ten days.
The outer used time, adopt the mode of dipping, point experimental group and control group.Wherein, experimental group is thrown in by the addition of 20ppm and is added to the water (water temperature controls within 40 DEG C), within about 5 minutes, will the grouper of exanthemv symptom be had to pour in experimental group again, soaks about 1 hour, then make into manage with circulating water; And control group does not add product, keep the cultivation state of circulating water.
Time for oral administration, experimental group adds in feed by the addition of 0.5%, put-on method with normally cultivate identical, but require first making pharmaceutical chemistry time stop a hello meal, and medicine addition to be reduced by half.This product and control group is not is not thrown something and fed.
After experiment terminates, the wound healing at the grouper exanthemv place of experimental group rapidly, receipts scar is effective, skin recovery is rapid, and fish vitality of subject is strong, does not have the phenomena of mortality.Although in certain minimizing of searching for food of front grouper of throwing something and feeding several times, after transition, it is searched for food and has recovered normal, and increases.And the grouper exanthemv of control group does not improve significantly, having notably festers increases the weight of, even dead.Find when weighing in, the summary of the weightening finish ratio control group of experimental group grouper is high, and this health of grouper body recovery due to experimental group speed is fast and cause that search for food than blank group more.Therefore, this product can alleviate aquatic livestock skin ulcer symptoms, reduce bacteriological infection and accelerating wound healing, and improve the feed intake of aquatic livestock and reduce its feedstuff-meat ratio.
The above, be only present pre-ferred embodiments, therefore can not limit scope of the invention process successively, the equivalence change namely done according to the scope of the claims of the present invention and description with modify, all should still belong in scope that the present invention contains.
Claims (4)
1. promote a medicated feed additive for aquatic livestock skin health, it is characterized in that: the component comprising following portions by weight: 2 parts, Chinese herbal medicine, 7 parts, carrier and vitamin 1 part; Wherein, described carrier is starch; Described vitamin is by Cobastab
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, by weight 12:12:64:26:6:1:26 composition; Described Chinese herbal medicine is made up of by weight 1:1:2.5:3:3:1 Radix Angelicae Sinensis, the red sage root, Radix Glycyrrhizae, frankincense, myrrh and borneol.
2. promote a preparation method for the medicated feed additive of aquatic livestock skin health, it is characterized in that: comprise the steps:
Step one, the Radix Angelicae Sinensis taking parts by weight as claimed in claim 1, the red sage root and Radix Glycyrrhizae, Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae to be cut off or after inclined tab process, the cut-out of Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae or inclined tab material are carried out co-grinding by micronizer, final pulverizing order number is more than or equal to 300 orders, obtained raw material one;
Step 2, the frankincense taking parts by weight as claimed in claim 1 and myrrh, adopt Universalpulverizer to pulverize, pulverizing temperature is 45-50 DEG C, obtained raw material two;
Step 3, take the borneol of parts by weight as claimed in claim 1, low-temperature grinding borneol, low-temperature grinding temperature is 30 DEG C, obtained raw material three; Step 4, raw material one described above, described raw material two and described raw material three are carried out co-grinding again together, obtained herbal raw material;
Step 5, take the Cobastab of parts by weight as claimed in claim 1
1, Cobastab
2, Cobastab
3, Cobastab
5, Cobastab
6, Cobastab
12and vitamin C, in three-dimensional stereo mixing machines, the herbal raw material obtained with step 4 fully mixes 15-20 minute, obtained mixed product;
Step 6, packing is carried out to the mixed product obtained by step 5, obtained medicated feed additive.
3. a kind of preparation method promoting the medicated feed additive of aquatic livestock skin health as claimed in claim 2, it is characterized in that: in described step one, before being also included in raw material one co-grinding, dry pretreated step is carried out to described Radix Angelicae Sinensis, the red sage root and Radix Glycyrrhizae cut-out or inclined tab material, dry 4 hours of the described red sage root and Radix Glycyrrhizae, described Radix Angelicae Sinensis is dry 2-3 hour under cryogenic.
4. a kind of preparation method promoting the medicated feed additive of aquatic livestock skin health as claimed in claim 2, it is characterized in that: in described step 2, described pulverizing carries out low-temperature grinding under cooling system, and described low-temperature grinding temperature is 45-50 DEG C.
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| CN104686793B (en) * | 2015-03-20 | 2018-06-26 | 清远海贝生物技术有限公司 | A kind of Chinese herbal composite feed additive for preventing snakehead skin-ulcer |
| CN108077915A (en) * | 2018-01-15 | 2018-05-29 | 蚌埠自愈力道田科技有限公司 | A kind of fruit plain nutritional powder formula and its production technology entirely |
| CN110521881A (en) * | 2019-09-11 | 2019-12-03 | 铜仁市万山区水产站 | A kind of yellow eel disease resistance nutritional agents and preparation method thereof |
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| CN102845596A (en) * | 2012-09-03 | 2013-01-02 | 杨高林 | Omnivorous fish feed and preparation method thereof |
| CN103263669A (en) * | 2013-05-23 | 2013-08-28 | 金红叶纸业集团有限公司 | Skin care composition and facial tissue with same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102845596A (en) * | 2012-09-03 | 2013-01-02 | 杨高林 | Omnivorous fish feed and preparation method thereof |
| CN103263669A (en) * | 2013-05-23 | 2013-08-28 | 金红叶纸业集团有限公司 | Skin care composition and facial tissue with same |
Non-Patent Citations (1)
| Title |
|---|
| 斑马鱼模型在中医药研究中的应用现状;王佑华;《中西医结合学报》;20121130;第10卷(第11期);第1189-1197页 * |
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Address after: The new road in Haicang District of Xiamen city of Fujian Province, No. 36 of 361026 Patentee after: ZHONG SHA ANIMAL HEALTH PRODUCT (XIAMEN) CO.,LTD. Address before: The new road in Haicang District of Xiamen city of Fujian Province, No. 36 of 361026 Patentee before: XIAMEN XINGSHA ANIMAL HEALTH PRODUCTS FACTORY |
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Denomination of invention: Pharmaceutical feed additive for promoting skin health of aquatic animals and its preparation method Effective date of registration: 20200805 Granted publication date: 20150304 Pledgee: Bank of China Limited Xiamen Kaiyuan sub branch Pledgor: ZHONG SHA ANIMAL HEALTH PRODUCT (XIAMEN) Co.,Ltd. Registration number: Y2020980004714 |
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Date of cancellation: 20230913 Granted publication date: 20150304 Pledgee: Bank of China Limited Xiamen Kaiyuan sub branch Pledgor: ZHONG SHA ANIMAL HEALTH PRODUCT (XIAMEN) CO.,LTD. Registration number: Y2020980004714 |