CN103501798A - 抗新型流感病毒剂 - Google Patents
抗新型流感病毒剂 Download PDFInfo
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- CN103501798A CN103501798A CN201280020117.5A CN201280020117A CN103501798A CN 103501798 A CN103501798 A CN 103501798A CN 201280020117 A CN201280020117 A CN 201280020117A CN 103501798 A CN103501798 A CN 103501798A
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- influenza virus
- fructus chaenomelis
- type influenza
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Images
Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011098230A JP2012229178A (ja) | 2011-04-26 | 2011-04-26 | 抗新型インフルエンザウイルス剤 |
JP2011-098230 | 2011-04-26 | ||
PCT/JP2012/002772 WO2012147327A1 (ja) | 2011-04-26 | 2012-04-23 | 抗新型インフルエンザウイルス剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103501798A true CN103501798A (zh) | 2014-01-08 |
Family
ID=47071858
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201280020117.5A Pending CN103501798A (zh) | 2011-04-26 | 2012-04-23 | 抗新型流感病毒剂 |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2012229178A (ja) |
KR (1) | KR20140023357A (ja) |
CN (1) | CN103501798A (ja) |
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WO (1) | WO2012147327A1 (ja) |
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Citations (3)
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JP2005343836A (ja) * | 2004-06-04 | 2005-12-15 | Lotte Co Ltd | 抗インフルエンザウイルス剤及びこれを含有する感染抑制用品及び飲食物 |
CN1931320A (zh) * | 2006-10-13 | 2007-03-21 | 解会元 | 药酒组合物及其制备方法 |
WO2011036883A1 (ja) * | 2009-09-24 | 2011-03-31 | 株式会社ロッテ | 抗インフルエンザウイルス剤 |
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JP5117644B2 (ja) * | 2000-11-06 | 2013-01-16 | 丸善製薬株式会社 | インフルエンザウィルス感染に対する予防剤 |
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2011
- 2011-04-26 JP JP2011098230A patent/JP2012229178A/ja not_active Withdrawn
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2012
- 2012-04-23 WO PCT/JP2012/002772 patent/WO2012147327A1/ja active Application Filing
- 2012-04-23 CN CN201280020117.5A patent/CN103501798A/zh active Pending
- 2012-04-23 KR KR1020137030181A patent/KR20140023357A/ko not_active Application Discontinuation
- 2012-04-26 TW TW101114914A patent/TW201304797A/zh unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005343836A (ja) * | 2004-06-04 | 2005-12-15 | Lotte Co Ltd | 抗インフルエンザウイルス剤及びこれを含有する感染抑制用品及び飲食物 |
CN1931320A (zh) * | 2006-10-13 | 2007-03-21 | 解会元 | 药酒组合物及其制备方法 |
WO2011036883A1 (ja) * | 2009-09-24 | 2011-03-31 | 株式会社ロッテ | 抗インフルエンザウイルス剤 |
Non-Patent Citations (1)
Title |
---|
REIKO SAWAI, ET AL.: "Anti-influenza virus activity of Chaenomeles sinensis", 《JOURNAL OF ETHNOPHARMACOLOGY》 * |
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KR20140023357A (ko) | 2014-02-26 |
JP2012229178A (ja) | 2012-11-22 |
WO2012147327A1 (ja) | 2012-11-01 |
TW201304797A (zh) | 2013-02-01 |
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