CN103520613B - One treats anesthetis bowel syndrome capsule and preparation method thereof - Google Patents

Abstract

The invention discloses one and treat anesthetis bowel syndrome capsule and preparation method thereof, to solve the treatment problem of anesthetis bowel syndrome.It is characterized in that preparation method comprises: (1) by Alpinia japonica (Thunb.) Miq., Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae with vapor distillation extract volatile oil for subsequent use, medicinal residues are for subsequent use; (2) by Gecko, that Fructus Setariae Germinatus (parched to brown) is ground into fine powder is for subsequent use; (3) by gained medicinal residues mixing alcohol extraction 2 times in Aspongopus, Alga Sgrgassi Enerves, Flos jasmini, Bulbus Allii Victorialis, Herba Chlorophyti Laxi, Caulis Trachelospermi, Radix Ephedrae and step 1, merge twice alcohol extract, filter, reclaim ethanol and concentrating under reduced pressure becomes extractum; (4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.Clinical trial certificate: the present invention treats anesthetis bowel syndrome and has good effect and the higher feature of safety, clinic application, promotes.

Description

One treats anesthetis bowel syndrome capsule and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to one and treat anesthetis bowel syndrome capsule and preparation method thereof.

Background technology

Anesthetis bowel syndrome (narcotic bowel syndrome) refers to because anesthetic agents sexual factor causes intestinal smooth muscle motion function to lack of proper care or the nervous disorder such as myenteric nerve plexus, causes intestinal limited fine-motoric.Anesthetis bowel syndrome is different from common paralytic intestinal obstruction after operation.One is: this pathological changes can occur in the narcotic operation of any use, and clearly relevant to patient's body constitution, and this patient that has its source in of its generation is responsive to the height of anesthetis composition.It two is: anesthetis bowel syndrome can show as paralysis and spasm alternately outbreak, and symptom is unstable, and paralytic intestinal obstruction after operation is then benumbed to cause for intestinal and is short of power.

At present this pathological changes occur after process with paralytic intestinal obstruction after operation namely: the analgesic apparatus containing anaesthetic such as Postoperative Analgesia After pump of 1. stopping using; 2. the medicine promoting enterokinesia is used.But because the two pathologic basis is different, some cases is intestinal cramps state, uses the medicine of short enterokinesia to increase the weight of symptom on the contrary.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, provides a kind of curative effect certainly and little treatment anesthetis bowel syndrome capsule of side effect and preparation method thereof.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for the treatment of anesthetis bowel syndrome, it is characterized in that being prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, Alga Sgrgassi Enerves 3 ~ 10 parts, Flos jasmini 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, Alpinia japonica (Thunb.) Miq. 6 ~ 12 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Radix Ephedrae 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts.

Chinese medicine of the present invention can be prepared from by following method:

(1) Alpinia japonica (Thunb.) Miq., Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;

(3) by gained medicinal residues mixing in Aspongopus, Alga Sgrgassi Enerves, Flos jasmini, Bulbus Allii Victorialis, Herba Chlorophyti Laxi, Caulis Trachelospermi, Radix Ephedrae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;

(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.

Wherein said: Aspongopus is the dry body of Pentatomidae Insects Aspongopus Aspongopus chinensis Dallas.Nature and flavor are salty, temperature.Return liver,spleen,kidney warp.Merit can regulating QI to relieve pain, and warming middle-JIAO is supporing yang.

Herba Alyxiae Sinensis is herb and the root of apocynaceae plant chain pearl rattan.Toil, flat.Enter lung, liver, spleen three warp.Merit can expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.

Alga Sgrgassi Enerves is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Sargassum henslowianum Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.

Flos jasmini is Oleaceae plants Flos jasmini Jasminu, the dry flower of grandiflorum L..Property mildly bitter flavor; Property is put down.Return Liver Channel.Merit can soothing liver-QI for relieving depression, promoting the circulation of QI to relieve pain.

Cortex Seu Radix Wikstroemiae Micranthae is peel of stem and the root of Isolated From Thymelaeaceae Species little Huang structure Wikstroemia micrantha Hemsl..Sweet in the mouth; Property is put down.Return lung meridian.Merit can relieving cough and resolving phlegm; Heat reliving and toxin-eliminating.

Bulbus Allii Victorialis is the bulb of liliaceous plant Bulbus Allii Victorialis Allium victorialis L..Return lung meridian.Merit can dissipating blood stasis; Hemostasis; Removing toxic substances.

Alpinia japonica (Thunb.) Miq., is Zingiberaceae Alpinia plants Alpinia japonica (Thunb.) Miq. Alpinia japonica Miq., is used as medicine with root stock.Nature and flavor are pungent, warm.Return lung, spleen, Liver Channel.Merit can dispelling wind and removing obstruction in the collateral, regulating QI to relieve pain.

Herba Chlorophyti Laxi is herb or the root of feverfew Prenanthes henryi Dunn Prenanthes henryi Dunn.Bitter in the mouth; Cold in nature.Merit can heat-clearing and toxic substances removing; Dissipating blood stasis stops blooding.

Caulis Trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide Trachelospermum jasminoides (Lindl.) Lem..Hardship, is slightly cold.Return kidney, liver, kidney channel.Merit can dispelling wind and removing obstruction in the collateral, and removing heat from blood is subsided a swelling.

Gecko is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.Nature and flavor are salty, flat.Return lung, kidney channel.Merit can invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.

Radix Ephedrae is the dry root and rhizome of Ephedraceae plant plait Herba Ephedrae Ephedra sinica Stapf or epheday intermedia Ephedra intermedia Schrenk et C. A. Mey..Nature and flavor are sweet, flat.GUIXIN, lung meridian.Merit can hidroschesis.

Fructus Setariae Germinatus (parched to brown), for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv. is through drying of germinateing, fries to burnt brown according to frying method.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.

Compared with prior art, the present invention has following characteristics.

1, set forth one's views unique: start with from dredging collateral, to recover for the purpose of intestinal wall CO2 laser weld, avoid using purgatives medicine thing, although because purgatives medicine thing can solve abdominal distention for the moment, cause again new stimulation to intestinal wall, for a long time raw he become, protracted course of disease.

2, with Aspongopus, Herba Alyxiae Sinensis for monarch: inventor's clinical experience gained, anesthetis bowel syndrome is that the intestinal wall muscle that anesthetis causes shows with neural a kind of highly reflective, and Aspongopus regulating QI to relieve pain, Herba Alyxiae Sinensis promoting blood circulation to remove obstruction in the collateral, can reduce this zest and reflect the untoward reaction brought to intestinal.Basic pharmacology test confirms: anesthetis causes Partial small bowel obstruction rat model Aspongopus (20g crude drug/kg/d) and Herba Alyxiae Sinensis (10g crude drug/kg/d) mixing water decocting liquid gavage, can intestinal mucosa injury be reduced, to incomplete intestinal obstruction Intestinal Mucosa, there is protective effect; And the progradation of rat intestine wriggling is observed by charcoal end method, propelling rate (84.42 ± 13.24) % of Aspongopus, Herba Alyxiae Sinensis drug combination group is apparently higher than blank group of (59.33 ± 15.62) %.

3, monarch drug is assisted using Alga Sgrgassi Enerves hard masses softening and resolving, Cortex Seu Radix Wikstroemiae Micranthae digestion visible phlegm, Caulis Trachelospermi dispelling wind dredging collateral, Flos jasmini promoting the circulation of QI to relieve pain, Bulbus Allii Victorialis, Herba Chlorophyti Laxi dissipating blood stasis as ministerial drug: breath does not reach, of a specified duration then can block by accumulation of phlegm, so select the visible phlegm in Cortex Seu Radix Wikstroemiae Micranthae, Alga Sgrgassi Enerves removal intestinal venation, namely the intestinal wall muscle that alleviation anesthetis causes reacts with neural height, the ability of Flos jasmini, Caulis Trachelospermi increase medicine walking venation.Bulbus Allii Victorialis, Herba Chlorophyti Laxi have the advantages that dissipating blood stasis does not consume gas, are particularly suitable for Post operation simulataneous insufficiency and excessive and use.

4, with Gecko invigorating the lung and the kidney, the righting of Alpinia japonica (Thunb.) Miq. tonify deficiency subduing the wind syndrome, wherein the aminoacid that contains of Gecko and phospholipid composition can reduce the content of malonaldehyde in cell membrane (MDA), play the effect of stable intestinal cell cell membrane.

5, low dose of Radix Ephedrae is corrigent, and resist the anxiety that too much, the pungent loose medicine of this prescription invasion by pathogenic cold medicine of a cold nature thing too much has consumption impairment of QI the moon, one opens a conjunction, is more suitable for anesthetis bowel syndrome and uses.

6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, get protect sun defend in meaning, and contained coking composition has astriction, has the meaning of receipts in loose.

7, the homogeneous medicine multiple-effect of institute's thing of getting it filled in side, contributes to reducing medicament categories and consumption, does not increase Liver and kidney burden.

8, medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope.

9, adopt capsule formulation, taking convenience, compliance is good, is convenient to the consolidation of the course for the treatment of.

Detailed description of the invention

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, Alga Sgrgassi Enerves 6 parts, Flos jasmini 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, Alpinia japonica (Thunb.) Miq. 10 parts, Herba Chlorophyti Laxi 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Radix Ephedrae 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.

The preparation method of embodiment 1 is: Aspongopus, Herba Alyxiae Sinensis, Alga Sgrgassi Enerves, Flos jasmini, Cortex Seu Radix Wikstroemiae Micranthae, Bulbus Allii Victorialis, Alpinia japonica (Thunb.) Miq., Herba Chlorophyti Laxi, Caulis Trachelospermi, Gecko, Radix Ephedrae, Fructus Setariae Germinatus (parched to brown) mixing and water adding are decocted, filtrate is got after 30 minutes, medicinal residues add water continue decoction get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts of morning and evenings to take.

Embodiment 2, crude drug weight proportion: Aspongopus 10 parts, Herba Alyxiae Sinensis 6 parts, Alga Sgrgassi Enerves 3 parts, Flos jasmini 6 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 parts, Bulbus Allii Victorialis 6 parts, Alpinia japonica (Thunb.) Miq. 6 parts, Herba Chlorophyti Laxi 6 parts, Caulis Trachelospermi 6 parts, Gecko 1 part, Radix Ephedrae 3 parts, Fructus Setariae Germinatus (parched to brown) 10 parts.

Embodiment 3, crude drug weight proportion: Aspongopus 20 parts, Herba Alyxiae Sinensis 10 parts, Alga Sgrgassi Enerves 6 parts, Flos jasmini 10 parts, Cortex Seu Radix Wikstroemiae Micranthae 6 parts, Bulbus Allii Victorialis 10 parts, Alpinia japonica (Thunb.) Miq. 10 parts, Herba Chlorophyti Laxi 10 parts, Caulis Trachelospermi 10 parts, Gecko 2 parts, Radix Ephedrae 6 parts, Fructus Setariae Germinatus (parched to brown) 20 parts.

Embodiment 4, crude drug weight proportion: Aspongopus 30 parts, Herba Alyxiae Sinensis 12 parts, Alga Sgrgassi Enerves 10 parts, Flos jasmini 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 10 parts, Bulbus Allii Victorialis 12 parts, Alpinia japonica (Thunb.) Miq. 12 parts, Herba Chlorophyti Laxi 12 parts, Caulis Trachelospermi 12 parts, Gecko 5 parts, Radix Ephedrae 10 parts, Fructus Setariae Germinatus (parched to brown) 25 parts.

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) Alpinia japonica (Thunb.) Miq., Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;

(3) by gained medicinal residues mixing in Aspongopus, Alga Sgrgassi Enerves, Flos jasmini, Bulbus Allii Victorialis, Herba Chlorophyti Laxi, Caulis Trachelospermi, Radix Ephedrae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;

(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.

Can set every capsules is 0.5g.

The efficient combination of said medicine, coordinates mutually, effectively reach the object for the treatment of anesthetis bowel syndrome, and side effect is less.The above results is clinical data sufficient proof, and interrelated data is as follows.

1 object and method

1.1 object

1.1.1 case selection: case is selected from June, 2010 ~ 2013 are diagnosed as anesthetis bowel syndrome year June case 60 example after row epidural Anaesthesia.Wherein abdominal operation 31 example, limbs operation 22 example, craniocerebral operations 7 example.

1.1.2 anesthetis bowel syndrome diagnostic criteria: (1) anesthetis uses history; (2) bowel symptoms: paroxysmal abdominal pain; Vomiting; Abdominal distention; Aerofluxus and defecation stop; (3) sign: the intestinal tube of expansion has tenderness, rebound tenderness; Borborygmus is faint or disappear or gur gling; (4) mechanical intestinal obstruction is got rid of.

1.1.3 three groups are divided at random: matched group 20 example, decoction group 18 example, Capsules group 22 example.Compare in sex, age, art formula, postoperative use analgesia pump ratio before three groups of patient treatments, no significant difference (P>0.05), has comparability.

1.2 method.

1.2.1 Therapeutic Method: matched group takes gastrointestinal decompression, fluid infusion, correction acid base imbalance, anti-infective therapy, decoction group adds with embodiment 1 gained decoction on matched group medication basis, 2 times/d; Capsules group adds described embodiment 3 gained capsule 2g/ time on matched group medication basis, 2 times/d, altogether 5d.Three groups of patients are with analgesia pump, and after treatment 24h, symptom then removes Postoperative Analgesia After device without alleviation.

1.2.2 criterion of therapeutical effect: judge according to " new Chinese medicine guideline of clinical investigations ".Recovery from illness: Clinical symptom and sign disappears, normal passage of gas by anus defecation, borborygmus recovers, and X-ray of abdomen intestinal tube inflatable dilatation disappears, and can pull out gastrointestinal decompression tube.Effective: Clinical symptom and sign obviously alleviates, borborygmus recovers substantially, and X-ray of abdomen intestinal tube inflatable dilatation obviously alleviates, and can close gastrointestinal decompression tube and observe.Effective: abdominal part distending pain alleviates to some extent, aerofluxus, defecation are not smooth, and abdominal part auscultation borborygmus is weak, and X-ray of abdomen intestinal tube inflatable dilatation alleviates, and still needs indwelling gastrointestinal decompression tube.Invalid: still without aerofluxus, defecation after medication 72 h, Clinical symptom and sign is without alleviation or increase the weight of.

1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Measurement data t checks, enumeration data χ ²inspection.

2 results.

2.1 3 groups of Clinical efficacy comparisons: see the following form.Result shows: the cure rate of decoction group and Capsules group is apparently higher than matched group (decoction group P<0.01; Capsules group P<0.05); Total effective rate is apparently higher than matched group (P<0.05).

Group	Number of cases	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
							Matched group	20	1(5.00%)	6(30.00%)	6(30.00%)	7(35.00%)	65.00%
Decoction group	18	9(50.00%)	6(33.33%)	2(11.11%)	1(5.56%)	94.44%
							Capsules group	22	6(27.27%)	10(45.45%)	4(18.18%)	2(9.09%)	91.91%

2.2 3 groups of patient's analgesia pumps stop service conditions: matched group has 100%(15/15) patient 24h time stop to use analgesia pump, decoction group is 25%(4/16) and Capsules group be 33.33%(6/18), matched group termination of pumping rate is apparently higher than decoction group and Capsules group (P<0.05).

2.3 3 groups of adverse reactions of patients incidence rates compare: three groups all do not occur obvious adverse reaction record.

3. conclusion.

This result of study shows, after taking decoction of the present invention or capsule, anesthetis bowel syndrome patient cure rate, total effective rate are apparently higher than matched group, and termination of pumping rate is starkly lower than matched group, there is not obvious adverse reaction record, illustrate that pharmaceutical composition prepared by the inventive method has the lighter advantage of good effect, untoward reaction in treatment anesthetis bowel syndrome.

Claims (1)

1. treat the preparation method of anesthetis bowel syndrome capsule for one kind, it is characterized in that, be prepared from by the crude drug of following weight proportion: Aspongopus 10 ~ 30 parts, Herba Alyxiae Sinensis 6 ~ 12 parts, Alga Sgrgassi Enerves 3 ~ 10 parts, Flos jasmini 6 ~ 12 parts, Cortex Seu Radix Wikstroemiae Micranthae 3 ~ 10 parts, Bulbus Allii Victorialis 6 ~ 12 parts, Alpinia japonica (Thunb.) Miq. 6 ~ 12 parts, Herba Chlorophyti Laxi 6 ~ 12 parts, Caulis Trachelospermi 6 ~ 12 parts, Gecko 1 ~ 5 part, Radix Ephedrae 3 ~ 10 parts, Fructus Setariae Germinatus (parched to brown) 10 ~ 25 parts; Preparation method is made up of following steps:

(1) Alpinia japonica (Thunb.) Miq., Herba Alyxiae Sinensis, Cortex Seu Radix Wikstroemiae Micranthae coarse powder are extracted volatile oil 6 hours with vapor distillation after soaking 4 hours separately, and mixing for standby use after collecting, medicinal residues are for subsequent use;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) are pulverized 150 mesh sieves, and become fine powder for subsequent use;

(3) by gained medicinal residues mixing in Aspongopus, Alga Sgrgassi Enerves, Flos jasmini, Bulbus Allii Victorialis, Herba Chlorophyti Laxi, Caulis Trachelospermi, Radix Ephedrae and step 1 with 5 times amount 80% ethanol extraction 2 times, each 2 hours, merge twice ethanol extract, filter, reclaiming relative density when ethanol concentrating under reduced pressure become 60 DEG C is the extractum of 1.25 ~ 1.30;

(4) gained fine powder in step 2 is added gained extractum mixing in step 3,60 DEG C of oven dry, are ground into fine powder, add Tween-80 and make granule, and dry, granulate, sprays into gained volatile oil in step 1, and mixing, incapsulates, to obtain final product.