CN103494199B - Peony seed oil soft capsule with lipid-lowering effect and preparation method thereof - Google Patents
Peony seed oil soft capsule with lipid-lowering effect and preparation method thereof Download PDFInfo
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- CN103494199B CN103494199B CN201310474119.8A CN201310474119A CN103494199B CN 103494199 B CN103494199 B CN 103494199B CN 201310474119 A CN201310474119 A CN 201310474119A CN 103494199 B CN103494199 B CN 103494199B
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- peony
- extract
- soft capsule
- seed oil
- edible alcohol
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 74
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 38
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- 239000000312 peanut oil Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
- A23P20/25—Filling or stuffing cored food pieces, e.g. combined with coring or making cavities
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention mainly relates to a peony seed oil soft capsule with a lipid-lowering effect. The filling of the soft capsule is prepared from the following ingredients in parts by weight: 30-40 parts of peony seed oil, 30-40 parts of linseed oil, 10-20 parts of grape seed oil, 10-20 parts of safflower oil, 0.5-0.8 parts of vitamin E, 0.2-0.5 parts of peony flower extract, 0.1-0.3 parts of peony root extract and 0.1-0.3 parts of peony seed skin extract, wherein the peony flower extract, the peony root extract and the peony seed skin extract are obtained by extracting the peony flower, the peony root and the peony seed skin by using edible alcohol respectively, concentrating the resulting extracts, dissolving the extracts by using anhydrous edible alcohol, and filtering the resulting solutions to obtain the filtrates. The contents of various essential unsaturated fatty acids for a human body in the soft capsule provided by the invention are proper; the defect that the content of the linolenic acid in the daily diet is less is fully improved; the specific peony flower extract, peony root extract and peony seed skin extract contained in the soft capsule have good effects in lowering lipid, promoting blood circulation and removing stasis; the soft capsule is obvious and lasting in healthcare effect.
Description
Technical field
The invention belongs to tree peony deep process technology field, relate generally to a kind of peony seed oil soft capsule with effect for reducing fat and preparation method thereof.
Background technology
Tree peony originates in the western part of China Qinling Mountains and Daba Mountain one band mountain area, is perennial machaka, poor growth, and plant type is little.Tree peony is the distinctive woody rare flower of China, has the artificial cultivation of the self-sow of thousands of years and more than 2,000 year historical.Tree peony have " aromatic ", " king's in spending " laudatory title.Tree peony whole body is precious, and peony can be for viewing and admiring, and peony can also be made peony flower tea, peony essential oil; Moutan root bark is traditional Chinese medicine " root bark of tree peony "; Tree peony leaf can extract flavones; Peony seeds can extract oil, and oil contains multiple unrighted acid, and especially rare odd-numbered fatty acid is a kind of edible oil and fat source that important exploitation is worth that has.
Paeonia suffruticosa seed is the nut that is subject to shell and plants shell double shielding, has natural " longevity " gene.Peony seed oil shows through grease authoritative department Southern Yangtze University and the test of Chinese grain and oil quality Supervision Test Center Deng Duojia professional institution, peony seed oil unsaturated fatty acid content reaches more than 90%, especially estimable is that wherein polyunsaturated fatty acid-leukotrienes (belonging to w-3 series) content surpasses 40%, is 140 times of olive oil.The vegetable oil being extracted by peony seeds is the distinctive woody macadamia nut oil of China, nutritious and unique because of it, there is again medical care effect, by relevant expert, be called " best oil in the world ", be the treasure in vegetable oil, and obtain new resource food approval on March 22nd, 2011.
High nutritive value due to peony seed oil, its unsaturated fatty acid content is greater than 90%, wherein three kinds of important unrighted acids: leukotrienes, and linoleic acid (belonging to w-6 series) and the content of oleic acid (monounsaturated fatty acids) are respectively: 43%, 20%, 25%.Similar with linseed oil, the linolenic acid content of peony seed oil is also higher.In peony seed oil, still containing in addition the odd-numbered fatty acid with better active anticancer, is a kind of important oily resource that has exploitation future.
Grape-kernel oil, is a kind of conventional base oil, contains more linoleic acid (content is greater than 70%), and grape-kernel oil key property is the materials such as its aliphatic acid that contains abundant vitamin, trace mineral, needed by human, fructose.The OPC that grape-kernel oil also contains can be protected the elasticity of human vas, and protection human skin is avoided ultraviolet injury etc.Therefore make it have anti-oxidantly, desalination color spot, reduces melanin deposition, skin whitening, removal spot, activating human body skin cells of superficial layer, reduces the appearance of wrinkle, and the effect such as delay senility.Grape-kernel oil no side effects, adapt to applicable crowd comprise children, the elderly, pregnant woman or sportsman all can, accommodation is very wide.
The content of Linoleic Acid in Safflower Oil is greater than 80%, is that in known plants, content is the highest, is therefore described as " king of linoleic acid ".Safflower seed oil can maintain cell softness, strengthens elasticity and activity, and the softness that skin is become is fine and smooth, and can promote hair growth.In addition, another feature of safflower seed oil is in oil, to be rich in natural VE, and average content, in 800mgDL left and right, be that in all plants, content is the highest, so safflower is described as " hat of vitamin E ".Vitamin E in safflower seed oil is pure natural, the natural VE with vital activity.Vitamin E is a kind of very strong reducing agent, has extremely strong antioxidation.It also has antidotal effect, and aging, old and feeble cell and tissue are got increasingly vigorous.Vitamin E is a kind ofly can improve body immunity, eliminates free radical, the nutriment of pre-anti-cancer.
In linseed oil, alpha-linolenic acid content is 53%, and alpha-linolenic acid is essential fatty acid, in human body, can be converted into eicosapentaenoic acid and DHA, and they are the effective active composition in fish oil.The effects such as that alpha-linolenic acid has is antitumor, antithrombotic, reducing blood lipid, nourishing brain cell, regulating plant nerve, receive more concern.In linseed, contain a large amount of polysaccharide, that polysaccharide has is antitumor, antiviral, the effect of antithrombotic, reducing blood lipid.But linseed oil also has a weak point, compare with other vegetable oil exactly, again relatively less, therefore the most handy linseed oil and other edible oils converge the nutritional labeling of other of linseed oil, make ready-mixed oil, various like this nutritional labelings are just reached equilibrium.
In unrighted acid, having some is that mankind itself can not synthesize, must be from food, draw, and be called must unrighted acid.Must in unrighted acid, there be several unrighted acids extremely important, as linoleic acid, leukotrienes, arachidonic acid etc.Alpha-linolenic acid has extremely important effect for the mankind's health.Alpha-linolenic acid is a kind of polyunsaturated fatty acid, is a kind of essential fatty acid.Alpha-linolenic acid is a kind of life core substance, is to form human body brain cell and histiocytic important component, and be a kind of nutrient that the mankind need in life every day.Alpha-linolenic acid has very strong growth intelligence, and vision protection reduces blood fat, cholesterol, delay senility, and antiallergy, the effects such as the generation of inhibition cancer and transfer.Once human body long-term lacking alpha-linolenic acid, will cause the deterioration of brain organ, the organs of vision and senile dementia to occur, and can cause that the incidence of the modern diseases such as hypertension, cancer rises.
Human body only otherwise lack linoleic acid, just can synthesize other two kinds necessary unrighted acids in vivo.Therefore, linoleic acid is most important unrighted acid in human body, is the basic substance of life.
Needed by human body oleic acid, linoleic acid, linolenic amount are to have a certain proportion ofly, and not more high better, too high all have harm to human body.In the aliphatic acid needing at human body, the ratio of monounsaturated fatty acids maximum (as oleic acid).The China expert of NNFA recommends the ratio of the aliphatic acid of definite human body needs to be: saturated fatty acid: monounsaturated fatty acids: polyunsaturated fatty acid=1:6:1.The content of w-6 series (as linoleic acid) and w-3 series (as alpha-linolenic acid) is also had to requirement abroad simultaneously, for adult, preferably ratio is 4:1-10:1[king Hua Zhi, kingly way ripple, Li Qiulin, Wang Fengling, Xiong Sumin. fatty acid composition and health in grease, oil engineering, 2010,6:16-19].But, there are some researches show again, too much linoleic acid is also disadvantageous to human body, Chinese scholar's research thinks relatively good when the ratio of w-6 series (as linoleic acid)/w-3 series (as alpha-linolenic acid) is 1:1, in view of alpha-linolenic acid content in current our edible grease lower, therefore, the two ratio of the present invention is 1.5 left and right.
Distinctive tree peony polyphenol and tree peony flavones in peony and root extract, be very strong antioxidant and effect for reducing fat, can also extend other antioxidants (as vitamin C vitamin E) time in vivo, delay skin aging.Suppress color spot, senile plaque expelling, prevents and treats acne simultaneously, bright and clean skin quality.
In daily edible grease, soya-bean oil: linoleic acid content is 55%, oleic acid content is 30%; Peanut oil: oleic acid content 41%, linoleic acid content 37%; Sunflower oil: oleic acid 15% left and right, linoleic acid 70%.In these oil, oleic acid and linoleic acid content are high, and another aliphatic acid a-linolenic acid content of needed by human seldom.Therefore, by suitable cooperation, suitably reduce the content of oleic acid, increase the content of a-linolenic and linoleic, make a-leukotrienes/linoleic content ratio is 1.5 left and right simultaneously, fully adjusts due to the less deficiency of a-linolenic acid content in diet.
Summary of the invention
The object of this invention is to provide a kind of peony seed oil soft capsule with effect for reducing fat and preparation method thereof, in this soft capsule, the content of various needed by human unrighted acids is suitable, substantially improved due to the less deficiency of bringing of linolenic acid content in diet, the extract that contains distinctive peony and root, there is good lipopenicillinase and function of promoting blood circulation to disperse blood clots, obvious health-care efficacy and lasting.
The technical scheme that the present invention realizes above-mentioned purpose employing is: a kind of peony seed oil soft capsule with effect for reducing fat, the filler of described soft capsule is made by following component according to parts by weight: peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part, safflower seed oil 10-20 part, vitamin E 0.5-0.8 part, peony extract 0.2-0.5 part, tree peony root extract 0.1-0.3 part and peony seeds bark extract 0.1-0.3 part;
Described peony extract is that peony is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 2-4 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining;
Described tree peony root extract is that tree peony root is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 3-5 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining;
Described peony seeds bark extract be peony seeds skin through 50-70% edible alcohol extract, concentrated making after solvent-free medicinal extract, add its weight 2-4 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining.
Described peony seed oil is that the seed benevolence of the red tree peony of phoenix or Paeonia papaveracea presses through colding pressing.
Described peony seeds skin is the peony seeds shell that the peony seeds of the red tree peony of phoenix or Paeonia papaveracea obtains through shelling.
The raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
A preparation method with the peony seed oil soft capsule of effect for reducing fat, comprises the following steps:
Step 1, according to parts by weight, get peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part and safflower seed oil 10-20 part, add in agitator, in 30min, be warming up to 40-50 ℃, then under the condition that low whipping speed is 60-120r/min, stir 1-5h, standing being cooled to after 20-30 ℃, adopt former mixing speed to stir 20-60min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add peony petal raw material weight 15-20 ethyl acetate doubly to soak 8-10d, taking out baking oven that peony petal is placed in 60-80 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; In dry peony petal, add its weight 8-12 edible alcohol doubly, the mass concentration of edible alcohol is 95 %, after soaking 8-12d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain tree peony root powder; Then add tree peony root grain weight amount 10-16 edible alcohol doubly, the mass concentration of edible alcohol is 95%, after soaking 4-6d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 3-5 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get peony seeds skin raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain peony seeds skin powder; Then add peony seeds skin grain weight amount 8-14 edible alcohol doubly, the mass concentration of edible alcohol is 60-70%, after soaking 6-10d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to parts by weight, get peony extract 0.2-0.5 part that step 2 obtains, peony seeds bark extract 0.1-0.3 part that tree peony root extract 0.1-0.3 part that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 2-4h under the condition of 60-80r/min, then add vitamin E 0.5-0.8 part, and be warming up to 45 ℃, low whipping speed is to stir 1-3 h under the condition of 90-120 r/min, stirring finishes rear standing 36-48 h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
Beneficial effect of the present invention
One, soft capsule provided by the invention are by suitably coordinating several plant oils, effectively adjusted the content of oleic acid, linoleic acid plus linolenic acid, the content of oleic acid suitably reduces, the content of a-linolenic and linoleic increases, make a-leukotrienes/linoleic content ratio be greater than 1.5 simultaneously, can substantially improve due to the less deficiency of bringing of linolenic acid content in diet, promote base oil to give full play to feature separately, make peony seed oil soft capsule obvious health-care efficacy, peony seed oil mixes with other plant oil simultaneously, effectively reduces the cost of raw material.
Two, the present invention is by the mixing of several plant oils, effectively changed the content of various needed by human unrighted acids in capsule, especially improve content and the ratio of a-linolenic and linoleic, make Contents of Main Components remain on good level, allomeric function is improved.Adopt this good formulation packing of soft capsule, can effectively avoid the oxidation deterioration of unrighted acid, there is again advantage easy to carry and use simultaneously.
Three, in peony seed oil, contain abundant leukotrienes, but oleic acid wherein and linoleic acid content are lower, unrighted acid is easy to again oxidation deterioration, therefore to higher grape-kernel oil and the safflower seed oil of compound linoleic acid content in peony seed oil, in safflower seed oil, not only contain abundant natural VE, and can effectively suppress the rotten of peony seed oil and grape-kernel oil.
The extract that four, has added peony, root and seed skin in capsule of the present invention, active ingredient is tree peony polyphenol and flavone compound, has very strong antioxidant and effect for reducing blood fat.Can extend other antioxidants time of onset in vivo, as vitamin C and vitamin E, delay skin aging suppresses color spot, senile plaque expelling simultaneously, prevents and treats acne, bright and clean skin quality, and effect is remarkable, also can use for lipopenicillinase or fat-reducing.
The specific embodiment
A kind of peony seed oil soft capsule with effect for reducing fat, the filler of described soft capsule is made by following component according to parts by weight: peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part, safflower seed oil 10-20 part, vitamin E 0.5-0.8 part, peony extract 0.2-0.5 part, tree peony root extract 0.1-0.3 part and peony seeds bark extract 0.1-0.3 part;
Described peony extract is that peony is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 2-4 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining;
Described tree peony root extract is that tree peony root is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 3-5 filtrate that doubly anhydrous edible alcohol dissolves, filtration obtains;
Described peony seeds bark extract be peony seeds skin through 50-70% edible alcohol extract, concentrated making after solvent-free medicinal extract, add its weight 2-4 doubly anhydrous edible alcohol dissolve, filter the filtrate obtaining.
Described peony seed oil is that the seed benevolence of the red tree peony of phoenix or Paeonia papaveracea presses through colding pressing.
Described peony seeds skin is the peony seeds shell that the peony seeds of the red tree peony of phoenix or Paeonia papaveracea obtains through shelling.
The raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
A preparation method with the peony seed oil soft capsule of effect for reducing fat, comprises the following steps:
Step 1, according to parts by weight, get peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part and safflower seed oil 10-20 part, add in agitator, in 30min, be warming up to 40-50 ℃, then under the condition that low whipping speed is 60-120r/min, stir 1-5h, standing being cooled to after 20-30 ℃, adopt former mixing speed to stir 20-60min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add peony petal raw material weight 15-20 ethyl acetate doubly to soak 8-10d, taking out baking oven that peony petal is placed in 60-80 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; In dry peony petal, add its weight 8-12 edible alcohol doubly, the mass concentration of edible alcohol is 95 %, after soaking 8-12d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain tree peony root powder; Then add tree peony root grain weight amount 10-16 edible alcohol doubly, the mass concentration of edible alcohol is 95%, after soaking 4-6d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 3-5 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get peony seeds skin raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain peony seeds skin powder; Then add peony seeds skin grain weight amount 8-14 edible alcohol doubly, the mass concentration of edible alcohol is 60-70%, after soaking 6-10d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to parts by weight, get peony extract 0.2-0.5 part that step 2 obtains, peony seeds bark extract 0.1-0.3 part that tree peony root extract 0.1-0.3 part that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 2-4h under the condition of 60-80r/min, then add vitamin E 0.5-0.8 part, and be warming up to 45 ℃, low whipping speed is to stir 1-3 h under the condition of 90-120 r/min, stirring finishes rear standing 36-48 h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
Below in conjunction with specific embodiment, the present invention will be further described:
Embodiment 1:
A kind of peony seed oil soft capsule with effect for reducing fat, the filler of described soft capsule is made by following component according to parts by weight: 30 parts of peony seed oils, 30 parts of linseed oil, 10 parts of grape-kernel oils, 10 parts of safflower seed oils, 0.5 part of vitamin E, 0.1 part of the red peony seeds bark extract of 0.2 part of peony extract, 0.1 part of tree peony root extract and phoenix;
Described peony seed oil is that the seed benevolence of the red tree peony of phoenix presses through colding pressing.
The raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
A preparation method with the peony seed oil soft capsule of effect for reducing fat, comprises the following steps:
Step 1, according to the parts by weight in above-mentioned formula, get the red peony seed oil of phoenix, linseed oil, grape-kernel oil and safflower seed oil, add in agitator, in 30min, be warming up to 40 ℃, then under the condition that low whipping speed is 60r/min, stir 1h, standing being cooled to after 20 ℃, adopt former mixing speed to stir 20min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add the ethyl acetate of 15 times of peony petal raw material weights to soak 8d, taking out baking oven that peony petal is placed in 60 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; To the edible alcohol that adds 8 times of its weight in dry peony petal, the mass concentration of edible alcohol is 95%, after soaking 8d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 50 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60 orders, obtain tree peony root powder; Then the edible alcohol that adds 10 times of tree peony root grain weight amounts, the mass concentration of edible alcohol is 95%, after soaking 4d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 3 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get the red peony seeds skin of phoenix raw material, with clear water, clean, under 50 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60 orders, obtain peony seeds skin powder; Then the edible alcohol that adds 8 times of peony seeds skin grain weight amounts, the mass concentration of edible alcohol is 60%, after soaking 6d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 2 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to the parts by weight in above-mentioned formula, get the peony extract that step 2 obtains, the peony seeds bark extract that the tree peony root extract that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 2h under the condition of 60r/min, then according to the amount in formula, add vitamin E, and be warming up to 45 ℃, low whipping speed is to stir 1 h under the condition of 90 r/min, stirring finishes rear standing 36h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
Embodiment 2:
A kind of peony seed oil soft capsule with effect for reducing fat, the filler of described soft capsule is made by following component according to parts by weight: 40 parts of peony seed oils, 40 parts of linseed oil, 20 parts of grape-kernel oils, 20 parts of safflower seed oils, 0.8 part of vitamin E, 0.3 part of 0.5 part of peony extract, 0.3 part of tree peony root extract and paeonia rockii seed bark extract;
Described peony seed oil is that the seed benevolence of Paeonia papaveracea presses through colding pressing.
The raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
A preparation method with the peony seed oil soft capsule of effect for reducing fat, comprises the following steps:
Step 1, according to the parts by weight in above-mentioned formula, get paeonia rockii seed oil, flax oil content, grape-kernel oil and safflower seed oil, add in agitator, in 30min, be warming up to 50 ℃, then under the condition that low whipping speed is 120r/min, stir 5h, standing being cooled to after 30 ℃, adopt former mixing speed to stir 60min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add the ethyl acetate of 20 times of peony petal raw material weights to soak 10d, taking out baking oven that peony petal is placed in 80 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; To the edible alcohol that adds 12 times of its weight in dry peony petal, the mass concentration of edible alcohol is 95 %, after soaking 12d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add the anhydrous edible alcohol of 4 times of medicinal extract weight to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 60 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 80 orders, obtain tree peony root powder; Then the edible alcohol that adds 16 times of peony seeds skin grain weight amounts, the mass concentration of edible alcohol is 95%, after soaking 6d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 5 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get paeonia rockii seed skin raw material, with clear water, clean, under 60 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 80 orders, obtain peony seeds skin powder; Then the edible alcohol that adds 14 times of tree peony root grain weight amounts, the mass concentration of edible alcohol is 70%, after soaking 10d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 4 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to the parts by weight in above-mentioned formula, get the peony extract that step 2 obtains, the peony seeds bark extract that the tree peony root extract that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 4h under the condition of 80r/min, then the vitamin E that adds above-mentioned formula ratio, and be warming up to 45 ℃, low whipping speed is to stir 3 h under the condition of 120 r/min, stirring finishes rear standing 48 h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
Embodiment 3:
A kind of peony seed oil soft capsule with effect for reducing fat, the filler of described soft capsule is made by following component according to parts by weight: 35 parts of peony seed oils, 35 parts of linseed oil, 15 parts of grape-kernel oils, 15 parts of safflower seed oils, 0.7 part of vitamin E, 0.2 part of the red peony seeds bark extract of 0.4 part of peony extract, 0.2 part of tree peony root extract and phoenix;
Described peony seed oil is that the young benevolence of phoenix tree peony and Paeonia papaveracea is that 1:1 mixes according to mass ratio, through colding pressing squeezing, obtains.
The raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
A preparation method with the peony seed oil soft capsule of effect for reducing fat, comprises the following steps:
Step 1, according to the parts by weight in above-mentioned formula, get peony seed oil, linseed oil, grape-kernel oil and safflower seed oil, add in agitator, in 30min, be warming up to 45 ℃, then under the condition that low whipping speed is 90r/min, stir 3h, standing being cooled to after 25 ℃, adopt former mixing speed to stir 40min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add the ethyl acetate of 18 times of peony petal raw material weights to soak 9d, taking out baking oven that peony petal is placed in 70 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; To the edible alcohol that adds 10 times of its weight in dry peony petal, the mass concentration of edible alcohol is 95 %, after soaking 10d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add the anhydrous edible alcohol of 3 times of medicinal extract weight to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 55 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60 orders, obtain tree peony root powder; Then the edible alcohol that adds 13 times of tree peony root grain weight amounts, the mass concentration of edible alcohol is 95%, after soaking 5d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 4 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get the red peony seeds skin of phoenix raw material, with clear water, clean, under 55 ℃ of conditions, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 80 orders, obtain peony seeds skin powder; Then the edible alcohol that adds 11 times of peony seeds skin grain weight amounts, the mass concentration of edible alcohol is 65%, after soaking 8d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add the anhydrous edible alcohol of 3 times of medicinal extract weight to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to the parts by weight in above-mentioned formula, get the peony extract that step 2 obtains, the peony seeds bark extract that the tree peony root extract that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 3h under the condition of 70r/min, then the vitamin E that adds above-mentioned formula ratio, and be warming up to 45 ℃, low whipping speed is to stir 2 h under the condition of 105 r/min, stirring finishes rear standing 42 h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
lipopenicillinase experimental study
1. given the test agent
The resulting soft capsule sample of embodiment 3.
animal subject and raising condition
Male mouse of kunming, 30, clean level, body weight 22 ± 2 g, are provided by University Of Science and Technology Of He'nan's Experimental Animal Center.
Experimental animal feeding condition: barrier system Animal House, 22 ± 2 ℃ of temperature, relative humidity 40% ~ 60%, controlling lighting hours is 14 h, sub-cage rearing, every group of 2 cages, ad lib and drinking-water, change bedding and padding in time, fixed time cleaning mouse cage and water bottle etc.Mouse starts experiment after adapting to one week.
feed
Basal feed, high lipid food (85% basal feed+4% cholesterol+10% lard+1% sodium taurocholate), is provided by University Of Science and Technology Of He'nan's Experimental Animal Center preparation.
reagent
T-CHOL (TC) kit, triglycerides (TG) kit, HDL-C (HDL-C) kit, LDL-C (LDL-C) kit.
instrument
Kjeldahl apparatus, ELIASA, Laser Scanning Confocal Microscope, ultraviolet-uisible spectrophotometer, Rotary Evaporators, electronic analytical balance.
reducing blood lipid weight-reducing experiment
30 mouse are divided into six groups at random, 10 every group; Be respectively Normal group, hyperlipidemia model group, administration group.Normal group feeding basal feed, all the other respectively organize feeding high lipid food; Normal group and hyperlipidemia model group every day early 9 fill with and feed physiological saline, administration group every day early 9 with 15 mg/ dosage only, fill with and feed soft capsule respectively.
reducing blood lipid weight-reducing experiment detects index
(1) changes of weight trend
Each organizes mouse all with basal feed feeding one week, adapts to laboratory environment.Start afterwards according to drug dosage schedule, each organizes feeding corresponding feed.Test eight weeks by a definite date, on every Mondays, weigh Mouse Weight Thursday.Record and analyze weight data.
(2) serum TC, TG, HDL-C, LDL-C content
Mouse, raised for the 8th weekend, water 12 h are can't help in fasting, and eyeball is got blood, 4 ℃ of standing 1.5 h of whole blood, low-temperature centrifugation 15 min, separation of serum, enzymatic assays serum TC, TG, HDL-C and LDL-C.
(3) liver weight and liver index, the total fat in abdominal cavity weigh and fat index
After getting blood, the dislocation of mouse cervical vertebra is put to death, and takes out liver, and with physiological saline washing, filter paper blots the physiological saline of remained on surface, weighs immediately, records the liver weight of every mouse.Before killing mouse, claim to obtain Mouse Weight, with liver anharmonic ratio body weight, calculate Mouse Liver index.
Take out after liver, the abdominal cavity fat of mouse is carefully peeled off out, comprise all fat of stomach fat, perirenal fat and epididymis.With physiological saline washing filter paper, blot, accurately weigh immediately.With abdominal cavity total fat anharmonic ratio body weight, calculate the fat index of every mouse.
. statistical procedures
All data acquisitions are analyzed with SAS, and result represents with (x ± s), compares group difference.
experimental result
(1) changes of weight
Before and after table 1 experiment, Mouse Weight changes
(2) serum TC, TG, HDL-C, LDL-C content
Table 2 is respectively organized mouse mouse blood lipid level
#P<0.01, model group and normal group comparison; * P<0.01, administration group and model group comparison.
(3) liver weight and liver index, the total fat in abdominal cavity weigh and fat index
Table 3 is respectively organized mouse liver exponential sum fat index
#P<0.01, model group and normal group comparison; * P<0.05, administration group and model group comparison.
By research, can find out, by being administered systemically, peony seed oil soft capsule has obvious effect for reducing fat.
Claims (6)
1. a peony seed oil soft capsule with effect for reducing fat, it is characterized in that: the filler of described soft capsule is made by following component according to parts by weight: peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part, safflower seed oil 10-20 part, vitamin E 0.5-0.8 part, peony extract 0.2-0.5 part, tree peony root extract 0.1-0.3 part and peony seeds bark extract 0.1-0.3 part;
Described peony extract is that peony is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 2-4 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining;
Described tree peony root extract is that tree peony root is that 95% edible alcohol extracts, concentrated making after solvent-free medicinal extract through mass concentration, adds its weight 3-5 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining;
Described peony seeds bark extract be peony seeds skin through 50-70% edible alcohol extract, concentrated making after solvent-free medicinal extract, add its weight 2-4 anhydrous edible alcohol doubly to dissolve, filter the filtrate obtaining.
2. a kind of peony seed oil soft capsule with effect for reducing fat as described in claim 1, is characterized in that: described peony seed oil is that the seed benevolence of the red tree peony of phoenix or Paeonia papaveracea presses through colding pressing.
3. a kind of peony seed oil soft capsule with effect for reducing fat as claimed in claim 1, is characterized in that: described peony seeds skin is the peony seeds shell that the peony seeds of the red tree peony of phoenix or Paeonia papaveracea obtains through shelling.
4. a kind of peony seed oil soft capsule with effect for reducing fat as claimed in claim 1, is characterized in that: the raw material of the tree peony root extract that preparation is described is the root of tree peony belt leather.
5. a kind of preparation method with the peony seed oil soft capsule of effect for reducing fat as described in claim 1, is characterized in that: comprise the following steps:
Step 1, according to parts by weight, get peony seed oil 30-40 part, linseed oil 30-40 part, grape-kernel oil 10-20 part and safflower seed oil 10-20 part, add in agitator, in 30min, be warming up to 40-50 ℃, then under the condition that low whipping speed is 60-120r/min, stir 1-5h, standing being cooled to after 20-30 ℃, adopt former mixing speed to stir 20-60min, after stirring finishes, obtain mixing peony seed oil, standby;
Step 2, take fresh peony, removal of impurities, retain petal and pistil, by petal and pistil place at room temperature dry in the shade to moisture be 10-15%, then add peony petal raw material weight 15-20 ethyl acetate doubly to soak 8-10d, taking out baking oven that peony petal is placed in 60-80 ℃, to be dried to moisture be 5-8%, obtains dry peony petal, standby; In dry peony petal, add its weight 8-12 edible alcohol doubly, the mass concentration of edible alcohol is 95 %, after soaking 8-12d, filter, it is decompression distillation under 0.1Mpa condition that the filtrate that filtration obtains is less than 60 ℃, vacuum in temperature, be concentrated into solvent-freely, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter and obtain filtrate, be peony extract, standby;
Step 3, get tree peony root raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain tree peony root powder; Then add tree peony root grain weight amount 10-16 edible alcohol doubly, the mass concentration of edible alcohol is 95%, after soaking 4-6d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 3-5 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain tree peony root extract, standby;
Step 4, get peony seeds skin raw material, with clear water, clean, under 50-60 ℃ of condition, dry to moisture and be less than 10%, be placed in pulverizer and be crushed to 60-80 order, obtain peony seeds skin powder; Then add peony seeds skin grain weight amount 8-14 edible alcohol doubly, the mass concentration of edible alcohol is 60-70%, after soaking 6-10d, filter, filtering the filtrate that obtains, in temperature, to be less than 60 ℃, vacuum be decompression distillation under 0.1Mpa condition, is concentrated into solvent-free, obtain medicinal extract, then add medicinal extract weight 2-4 anhydrous edible alcohol doubly to dissolve, filter, collect filtrate, obtain peony seeds bark extract, standby;
Step 5, according to parts by weight, get peony extract 0.2-0.5 part that step 2 obtains, peony seeds bark extract 0.1-0.3 part that tree peony root extract 0.1-0.3 part that step 3 obtains and step 4 obtain mixes, filter, filtrate joins in the mixing peony seed oil that step 1 obtains, in temperature for being no more than 35 ℃, mixing speed is to stir 2-4h under the condition of 60-80r/min, then add vitamin E 0.5-0.8 part, and be warming up to 45 ℃, low whipping speed is to stir 1-3 h under the condition of 90-120 r/min, stirring finishes rear standing 36-48 h, with 200 mesh sieves, remove by filter precipitation again, obtain the filler of soft capsule, standby,
Step 6, according to gelatin, the G & W for conventional process of preparing soft capsule, prepare soft capsule shell, the filler of the soft capsule that soft capsule shell after having prepared has obtained step 5 carries out capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
6. a kind of preparation method with the peony seed oil soft capsule of effect for reducing fat as claimed in claim 5, is characterized in that: the clean production area that each component of the filler of described soft capsule is all 100,000 grades at cleanliness factor prepares.
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