CN104000196B - Compound tree peony seed oil formulation and preparation method and application - Google Patents
Compound tree peony seed oil formulation and preparation method and application Download PDFInfo
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- CN104000196B CN104000196B CN201410249654.8A CN201410249654A CN104000196B CN 104000196 B CN104000196 B CN 104000196B CN 201410249654 A CN201410249654 A CN 201410249654A CN 104000196 B CN104000196 B CN 104000196B
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- seed oil
- peony seed
- tree peony
- compound tree
- oil formulation
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- 229960004488 linolenic acid Drugs 0.000 description 1
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- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
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- 230000003000 nontoxic effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 244000144985 peep Species 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229940001083 tocotrienols 50 mg Drugs 0.000 description 1
- 230000005760 tumorsuppression Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000015099 wheat brans Nutrition 0.000 description 1
- 239000008802 xuezhikang Substances 0.000 description 1
- RZFHLOLGZPDCHJ-XZXLULOTSA-N α-Tocotrienol Chemical compound OC1=C(C)C(C)=C2O[C@@](CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1C RZFHLOLGZPDCHJ-XZXLULOTSA-N 0.000 description 1
- 235000019145 α-tocotrienol Nutrition 0.000 description 1
- 239000011730 α-tocotrienol Substances 0.000 description 1
- 235000019151 β-tocotrienol Nutrition 0.000 description 1
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- 235000019150 γ-tocotrienol Nutrition 0.000 description 1
- 150000003786 γ-tocotrienols Chemical class 0.000 description 1
- 235000019144 δ-tocotrienol Nutrition 0.000 description 1
- 150000003790 δ-tocotrienols Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention relates to a kind of with peony seed oil, tocotrienols and red colouring agent for food, also used as a Chinese medicine for raw material prepares the method for compound tree peony seed oil formulation and the compound tree peony seed oil formulation that the method is prepared, and the application of this compound tree peony seed oil formulation.This compound tree peony seed oil formulation can be liquid state, powder or be processed into the forms such as particle electuary, tablet, capsule, oral liquid further, have safe and efficient, bioavilability is high, steady quality, can the feature of industrialization, and have significant reducing blood lipid, hypotensive, reduce cholesterol, improve cardiovascular and cerebrovascular disease, the effect of antitumor, antifatigue.
Description
Technical field
The invention belongs to health medicine field of food, be specifically related to the application of a kind of compound tree peony seed oil formulation and preparation method thereof, this compound tree peony seed oil formulation.
Background technology
Natural VE is the compound of natural tocopherol, comprises tocopherol and tocotrienols, is the fat-soluble vitamin of a class.Tocotrienols comprises alpha-tocotrienol, β-tocotrienols, γ-tocotrienols and δ-tocotrienols 4 kinds of isomers, tocotrienols is mainly present in the minority such as barley, wheat cereal, and especially in rice bran oil, palm oil, wheat bran, Arnotto seed, content is more.Tocotrienols and the structural main distinction of tocopherol are; tocotrienols has unsaturated terminal chain; this oxidation resistance making tocotrienols is stronger, is about 40 ~ 60 times of tocopherol, and has and reduce cholesterol, anticancer, the physiological function of protecting cardiovascular and neuroprotective etc. unique.Tocotrienols by inhibition tumor cell propagation, inducing apoptosis of tumour cell, induced tumor cell cycle arrest, suppress HMG-CoA reductase activity, Tumor suppression new vascular generation, reduction telomerase activation etc., play the physiological function that it is better than tocopherol.
Red colouring agent for food, also used as a Chinese medicine, claims red bent ancient times, is inoculated on rice is prepared from through fermentation with Monascus fungus.Red colouring agent for food, also used as a Chinese medicine is as traditional Chinese medicine, and Ming Dynasty's Li Shizhen (1518-1593 A.D.) is evaluated in Compendium of Material Medica: " help digestion and invigorate blood circulation, the dry stomach of invigorating the spleen; Sweet, warm, nontoxic; This is that people peeps the skilful person of good fortune also! ".Modern study confirms, red colouring agent for food, also used as a Chinese medicine has the multiple efficacies such as reducing blood lipid, hypotensive, hypoglycemic, antitumor, antifatigue.Red colouring agent for food, also used as a Chinese medicine can suppress atherosclerotic development, improves function of vascular endothelium, reduces the generation of adhesion molecule.Have modern Chinese herbal medicine Effects of Xuezhikang and the Zhibituo of China's independent intellectual property right, main component is red colouring agent for food, also used as a Chinese medicine.
Peony seed oil was approved as new resource food in 2011 by the Ministry of Public Health, detect through internal authority testing agency PONY, unrighted acid contained by peony seed oil is up to more than 92%, wherein alpha-linolenic acid accounts for 42%, linoleic acid accounts for 28%, and oleic acid accounts for 22%, also containing tens kinds of bioactivators such as paeonol, tree peony saponin, nutritive value is very abundant, is a kind of fabulous natural health care source.But, unrighted acid in peony seed oil, very easily be subject to the impact of the physics such as ambient light photograph, air, temperature, metal ion and chemical factor and change, produce the chemical substances such as peroxide, hydroxide, aldehyde, ketone, low-molecular-weight fatty acid, trans-fatty acid, not only reduce nutritive value of food and digestive utilization ratio, and the material produced is to human health.
Summary of the invention
The object of this invention is to provide a kind of preparation of compound tree peony seed oil, and preparation method and related application.
The invention provides a kind of compound tree peony seed oil formulation, it is characterized in that, described compound tree peony seed oil formulation comprises peony seed oil and tocotrienols, and preferably, described preparation comprises red colouring agent for food, also used as a Chinese medicine further.
Preferably, described preparation is liquid compound tree peony seed oil formulation, or by microcapsules technology, will be dissolved with the peony seed oil parcel of tocotrienols or tocotrienols and red colouring agent for food, also used as a Chinese medicine, the Powdered compound tree peony seed oil formulation be prepared into.
Further, described compound tree peony seed oil formulation, includes following component by weight: tocotrienols 0.1% ~ 60%, peony seed oil 40% ~ 99.9%.Or tocotrienols 0.1% ~ 50%, red colouring agent for food, also used as a Chinese medicine 1% ~ 20%, peony seed oil 30% ~ 98.9%.
The present invention also provides a kind of preparation method of compound tree peony seed oil formulation, it is characterized in that, the peony seed oil of proper proportion is heated to 50 ~ 80 DEG C, add the tocotrienols of aforementioned proportion or tocotrienols and red colouring agent for food, also used as a Chinese medicine, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Further, the present invention also provides a kind of preparation method of Powdered compound tree peony seed oil formulation, described method comprises with above-mentioned liquid compound tree peony seed oil formulation for core, and one of following component is wall material, prepares Powdered compound tree peony seed oil formulation by microcapsules technology:
(1) yeast;
(2) soybean protein isolate and sodium alginate;
(3) peony meal albumen and sodium alginate; Or
(4) one or more in cyclodextrin, maltodextrin, starch octenyl succinate anhydride, shitosan, lactose, xanthans, guar gum, Arabic gum.
Preferred version (1), described wall material is yeast, and further, described yeast is the waste yeast liquid of wine brewing or antibiotics plant, or food grade dry ferment.
Preferably, described method comprises the steps (1) yeast purifying or deactivation, (2) yeast autolysis, (3) packing.
Preferably, in described encapsulating step, core: wall material mass ratio is 1:2 ~ 3:1.
Preferably, described yeast purifying or inactivation step, for getting wine brewing or antibiotics plant waste yeast liquid, by the sterile water wash of 2 ~ 3 times of volumes, sieve 2 times with 80 orders, 100 object sieves respectively, removing hop resin and other larger impurity, under 3000 ~ 5000r/min normal temperature, centrifugal 5 ~ 10min, abandons supernatant, then uses sterile water wash 1 ~ 2 time, to supernatant colorless and odorless, centrifugally obtain milky yeast milk, through vacuum drying or spraying dry, obtained dry ferment.The food grade dry ferment of living, 65 ~ 70 DEG C of deactivation 20 ~ 30min, or ultra violet lamp deactivation.
Preferably, described yeast autolysis step is the dry ferment after getting purifying or deactivation, the water adding 4 ~ 10 times makes suspension (i.e. yeast: water is 1:4 ~ 1:10), add autolysis promoter ethanol 0.5 ~ 5% again, and to adjust initial ph value be 5 ~ 7, changing temperature autolysis 12 ~ 48h within the scope of 40 ~ 60 DEG C, at 80 ~ 95 DEG C, go out after enzyme l0 ~ 15min, 3000 ~ 5000r/min centrifugation 30 ~ 40min, it is for subsequent use that 30 ~ 50 DEG C of vacuum drying or freeze drying obtain yeast cell wall.
Preferably, described encapsulating step is for core with liquid compound tree peony seed oil formulation, yeast after process is wall material, liquid compound tree peony seed oil formulation and yeast sealing is added in core wall material mass ratio 1:2 ~ 3:1 ratio, put into 50 ~ 80 DEG C of water bath with thermostatic control oscillators, frequency of oscillation 80 ~ 160r/min, vibration 6 ~ 12h, namely liquid compound tree peony seed oil formulation enters yeast cells inside by diffusion effect, form microcapsules, vacuum filtration reclaims the liquid compound tree peony seed oil formulation do not wrapped into, use absolute ethanol washing 2 ~ 3 yeast surface raffinates again, 30 ~ 50 DEG C of vacuum drying 20 ~ 30min or freeze drying, obtain Powdered compound tree peony seed oil formulation.
Preferred version (2), described wall material is soybean protein isolate and sodium alginate, and further, the mass ratio of described soybean protein isolate and sodium alginate is 2:1 ~ 5:1.
Preferably, described method comprises with liquid compound tree peony seed oil formulation for core, and soybean protein isolate and sodium alginate are wall material, prepares through following steps (1) emulsification, (2) packing, (3) solidification, drying and obtains.
Preferably, described core and wall material mass ratio are 1:2 ~ 2:1.
Preferably, described emulsifying step is, by soybean protein isolate and distilled water 1:20 ~ 1:30 mixing in mass ratio, to add certain emulsifying agent 60 ~ 80 DEG C of stirring and dissolving, regulate solution ph to 7 ~ 9, make solution and sodium alginate have identical electric charge with alkali.
Preferably, described emulsifying agent be citric acid monoglyceride, sucrose ester, lecithin, soybean lecithin, glycerine monofatty ester one or more, emulsifying agent addition is 0.1 ~ 0.3% of microcapsules gross mass.
Preferably, described encapsulating step is temperature 40 ~ 80 DEG C, add a certain proportion of liquid compound tree peony seed oil formulation, homogeneous 5 ~ the 10min of 3000 ~ 6000r/min high speed forms homogeneous emulsion, be 4.1 with acid for adjusting pH value to the isoelectric point of 3 ~ 4(soybean protein isolate), make soybean protein isolate and sodium alginate with opposite charges, and stirring at low speed 20 ~ 25min, the multiple condensed phase that wall material generation complex coacervation produces is wrapped in liquid compound tree peony seed oil formulation surface, form microcapsule suspensions, be diluted with water and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Preferably, described solidification, drying steps, be to add curing agent, stirring at low speed solidification 1 ~ 2h, stratification, filters, washes the wet capsule of rear collection, obtain Powdered compound tree peony seed oil formulation through 30 ~ 50 DEG C of vacuum freeze dryings.
Preferably, described curing agent be glucono-δ-lactone, glucose, pectin, tannic acid one or more, the addition of curing agent is 0.8 ~ 2% of microcapsules gross mass.
Preferred version (3), described wall material is peony meal albumen and sodium alginate, and further, the mass ratio of described peony meal albumen and sodium alginate is 2:1 ~ 5:1.
Preferably, described method comprises with liquid compound tree peony seed oil formulation for core, and peony meal albumen and sodium alginate are wall material, prepares through following steps (1) emulsification, (2) packing, (3) solidification, drying and obtains.
Preferably, described core and wall material mass ratio are 1:2 ~ 2:1.
Preferably, described emulsifying step is, by peony meal albumen and distilled water 1:20 ~ 1:30 mixing in mass ratio, to add certain emulsifying agent 60 ~ 80 DEG C of stirring and dissolving, regulate solution ph to 7 ~ 9, make solution and sodium alginate have identical electric charge with alkali.
Preferably, described emulsifying agent be citric acid monoglyceride, sucrose ester, lecithin, soybean lecithin, glycerine monofatty ester one or more, emulsifying agent addition is 0.1 ~ 0.3% of microcapsules gross mass.
Preferably, described encapsulating step is temperature 40 ~ 80 DEG C, add a certain proportion of liquid compound tree peony seed oil formulation, homogeneous 5 ~ the 10min of 3000 ~ 6000r/min high speed forms homogeneous emulsion, be 4.5 with acid for adjusting pH value to the isoelectric point of 3.2 ~ 4.2(peony meal albumen), make peony meal albumen and sodium alginate with opposite charges, and stirring at low speed 20 ~ 25min, the multiple condensed phase that wall material generation complex coacervation produces is wrapped in liquid compound tree peony seed oil formulation surface, form microcapsule suspensions, be diluted with water and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Preferably, described solidification, drying steps, be to add curing agent, stirring at low speed solidification 1 ~ 2h, stratification, filters, washes the wet capsule of rear collection, obtain Powdered compound tree peony seed oil formulation through 30 ~ 50 DEG C of vacuum freeze dryings.
Preferably, described curing agent be glucono-δ-lactone, glucose, pectin, tannic acid one or more, the addition of curing agent is 0.8 ~ 2% of microcapsules gross mass.
Preferred version (4), described wall material is one or more in cyclodextrin, maltodextrin, starch octenyl succinate anhydride, shitosan, lactose, converted starch, xanthans, guar gum, Arabic gum, lactalbumin, alcohol soluble protein, casein, soybean protein isolate.
Preferred, described wall material is converted starch, Arabic gum and maltodextrin, and further, the mass ratio of converted starch, Arabic gum and maltodextrin is 1:0.8 ~ 1.2:0.8 ~ 1.2, and core and wall material mass ratio are 2 ~ 4:1.
Preferably, described method comprises with liquid compound tree peony seed oil formulation for core, and above-mentioned material is wall material, through the preparation of following steps (1) wall material, (2) emulsification, (3) spraying dry preparation and obtaining.
Preferably, the preparation process of described wall material is converted starch, Arabic gum, maltodextrin to be dissolved in the hot water of 60 ~ 65 DEG C, adds liquid compound tree peony seed oil formulation while stirring.
Preferred, in above-mentioned solution, total solids content is 30%.
Preferably, described emulsifying step is to continue stirring 10 ~ 15min, by colloid mill homogeneous 2 ~ 3 times or homogenization pressure 20 ~ 50Mpa, 30 ~ 50 DEG C carry out high-pressure homogeneous obtained emulsion.
Preferably, described spray drying step is EAT 140 ~ 180 DEG C, and leaving air temp 80 ~ 100 DEG C, enters spray dryer drying by emulsion with flow 20ml/min, obtains Powdered compound tree peony seed oil formulation.
The present invention also provides a kind of compound tree peony seed oil formulation, is prepared from by above-mentioned arbitrary method.
Preferably, described compound tree peony seed oil formulation can be liquid state, powder or be processed into the forms such as particle electuary, tablet, capsule, oral liquid further.
The present invention also provides a kind of application of above-mentioned compound tree peony seed oil formulation, described in be applied as health-care oil food, health-care oil or food additives etc.
Preferably, described health food have significant reducing blood lipid, hypotensive, reduce cholesterol, improve cardiovascular and cerebrovascular disease, the effect of antitumor, antifatigue.。
Compound tree peony seed oil formulation prepared by the present invention, is conducive to tocotrienols and red colouring agent for food, also used as a Chinese medicine absorbs effectively, is also beneficial to peony seed oil simultaneously and preserves for a long time, plays the physiological function that three works in coordination with.This compound tree peony seed oil formulation, particle electuary type or soft capsule dosage form or Tabules or oral liquid formulation can be adopted, have safe and efficient, bioavilability is high, steady quality, can the feature of industrialization, and have significant reducing blood lipid, hypotensive, reduce cholesterol, improve cardiovascular and cerebrovascular disease, the effect of antitumor, antifatigue.
Detailed description of the invention
Further illustrate the present invention below in conjunction with embodiment, should be appreciated that these examples can not as restriction of the present invention, without departing from the spirit and substance of the case in the present invention, the amendment done or replacement all belong to scope of the present invention.If do not specialize, the means in following embodiment are conventional means known in the art.
Prepared by embodiment 1 liquid compound tree peony seed oil formulation
The peony seed oil of 85 parts is heated to 60 DEG C, adds the tocotrienols of 5 parts and the red colouring agent for food, also used as a Chinese medicine of 10 parts, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Prepared by embodiment 2 liquid compound tree peony seed oil formulation
The peony seed oil of 55 parts is heated to 70 DEG C, adds the tocotrienols of 40 parts and the red colouring agent for food, also used as a Chinese medicine of 5 parts, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Prepared by embodiment 3 liquid compound tree peony seed oil formulation
The peony seed oil of 30 parts is heated to 80 DEG C, adds the tocotrienols of 50 parts and the red colouring agent for food, also used as a Chinese medicine of 20 parts, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Prepared by embodiment 4 liquid compound tree peony seed oil formulation
The peony seed oil of 98.9 parts is heated to 60 DEG C, adds the tocotrienols of 0.1 part and the red colouring agent for food, also used as a Chinese medicine of 1 part, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Prepared by embodiment 5 liquid compound tree peony seed oil formulation
The peony seed oil of 40 parts is heated to 80 DEG C, adds the tocotrienols of 60 parts, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Prepared by embodiment 6 liquid compound tree peony seed oil formulation
The peony seed oil of 99.9 parts is heated to 70 DEG C, adds the tocotrienols of 0.1 part, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
Embodiment 7 yeast microcapsule method prepares Powdered compound tree peony seed oil formulation
Step one waste yeast liquid purifying
Get wine brewing or antibiotics plant waste yeast liquid, by the sterile water wash of 2 times of volumes, 2 times are sieved respectively, removing hop resin and other larger impurity, centrifugal 5min under 5000r/min normal temperature with 80 orders, 100 object sieves, abandon supernatant, use sterile water wash again 1 ~ 2 time, to supernatant colorless and odorless, centrifugally obtain milky yeast milk, through vacuum drying or spraying dry, obtained dry ferment particle.
Step 2 yeast autolysis prepares wall material
Get the yeast after purifying, the water adding 4 times makes suspension, add autolysis promoter 0.5% ethanol again, and adjust initial ph value 6, changing temperature autolysis 48h within the scope of 40 ~ 60 DEG C, at 80 DEG C, go out enzyme l5min, after 3000r/min centrifugation 40min, it is for subsequent use that 30 DEG C of vacuum drying or freeze drying obtain yeast cell wall.
Prepared by step 3 Powdered compound tree peony seed oil formulation
With the arbitrary liquid compound tree peony seed oil formulation of embodiment 1-4 for core, yeast after process is wall material, in core: wall material mass ratio 1:2 ratio adds liquid compound tree peony seed oil formulation and yeast sealing, put into 50 DEG C of water bath with thermostatic control oscillators, frequency of oscillation 80r/min, vibration 12h, namely compound tree peony seed oil formulation enters yeast cells inside by diffusion effect, form microcapsules, vacuum filtration reclaims the compound tree peony seed oil formulation do not wrapped into, use absolute ethanol washing 2 yeast surface raffinates again, 30 DEG C of vacuum drying 30min or freeze drying, obtain Powdered compound tree peony seed oil formulation.
Embodiment 8 yeast microcapsule method prepares Powdered compound tree peony seed oil formulation
The deactivation of step one dry ferment
By food grade dry ferment 65 DEG C of deactivation 30min, or ultra violet lamp deactivation.
Step 2 yeast autolysis prepares wall material
Get the yeast after purifying, the water adding 10 times makes suspension, add autolysis promoter 5% ethanol again, and adjust initial ph value 7, changing temperature autolysis 12h within the scope of 40 ~ 60 DEG C, at 95 DEG C, go out enzyme l0min, after 5000r/min centrifugation 30min, it is for subsequent use that 50 DEG C of vacuum drying or freeze drying obtain yeast cell wall.
Prepared by step 3 Powdered compound tree peony seed oil formulation
With the arbitrary liquid compound tree peony seed oil formulation of embodiment 1-4 for core, yeast after process is wall material, in core: wall material mass ratio 3:1 ratio adds liquid compound tree peony seed oil formulation and yeast sealing, put into 50 DEG C of water bath with thermostatic control oscillators, frequency of oscillation 160r/min, vibration 6h, namely compound tree peony seed oil formulation enters yeast cells inside by diffusion effect, form microcapsules, vacuum filtration reclaims the compound tree peony seed oil formulation do not wrapped into, use absolute ethanol washing 2 yeast surface raffinates again, 50 DEG C of vacuum drying 20min or freeze drying, obtain Powdered compound tree peony seed oil formulation.
Embodiment 9 yeast microcapsule method prepares Powdered compound tree peony seed oil formulation
Step one waste yeast liquid purifying
Get wine brewing or antibiotics plant waste yeast liquid, by the sterile water wash of 3 times of volumes, 2 times are sieved respectively, removing hop resin and other larger impurity, centrifugal 10min under 5000r/min normal temperature with 80 orders, 100 object sieves, abandon supernatant, use sterile water wash again 1 ~ 2 time, to supernatant colorless and odorless, centrifugally obtain milky yeast milk, through vacuum drying or spraying dry, obtained dry ferment particle.
Step 2 yeast autolysis prepares wall material
Get the yeast after purifying, the water adding 6 times makes suspension, add autolysis promoter 1% ethanol again, and adjust initial ph value 6, changing temperature autolysis 36h within the scope of 40 ~ 60 DEG C, at 90 DEG C, go out enzyme l2min, after 4000r/min centrifugation 35min, it is for subsequent use that 30 DEG C of vacuum drying or freeze drying obtain yeast cell wall.
Prepared by step 3 Powdered compound tree peony seed oil formulation
With the arbitrary liquid compound tree peony seed oil formulation of embodiment 5-6 for core, yeast after process is wall material, in core: wall material mass ratio 1:1 ratio adds liquid compound tree peony seed oil formulation and yeast sealing, put into 50 DEG C of water bath with thermostatic control oscillators, frequency of oscillation 100r/min, vibration 10h, namely compound tree peony seed oil formulation enters yeast cells inside by diffusion effect, form microcapsules, vacuum filtration reclaims the compound tree peony seed oil formulation do not wrapped into, use absolute ethanol washing 2 yeast surface raffinates again, 40 DEG C of vacuum drying 25min or freeze drying, obtain Powdered compound tree peony seed oil formulation.
Embodiment 10 yeast microcapsule method prepares Powdered compound tree peony seed oil formulation
The deactivation of step one dry ferment
By food grade dry ferment 65 DEG C of deactivation 30min, or ultra violet lamp deactivation.
Step 2 yeast autolysis prepares wall material
Get the yeast after purifying, the water adding 8 times makes suspension, add autolysis promoter 3% ethanol again, and adjust initial ph value 5, changing temperature autolysis 24h within the scope of 40 ~ 60 DEG C, at 95 DEG C, go out enzyme l0min, after 5000r/min centrifugation 30min, it is for subsequent use that 50 DEG C of vacuum drying or freeze drying obtain yeast cell wall.
Prepared by step 3 Powdered compound tree peony seed oil formulation
With the arbitrary liquid compound tree peony seed oil formulation of embodiment 5-6 for core, yeast after process is wall material, in core: wall material mass ratio 2:1 ratio adds liquid compound tree peony seed oil formulation and yeast sealing, put into 50 DEG C of water bath with thermostatic control oscillators, frequency of oscillation 120r/min, vibration 8h, namely compound tree peony seed oil formulation enters yeast cells inside by diffusion effect, form microcapsules, vacuum filtration reclaims the compound tree peony seed oil formulation do not wrapped into, use absolute ethanol washing 2 yeast surface raffinates again, 50 DEG C of vacuum drying 20min or freeze drying, obtain Powdered compound tree peony seed oil formulation.
Embodiment 11 soybean protein isolate and sodium alginate complex coacervation prepare Powdered compound tree peony seed oil formulation
Step one, be wall material with soybean protein isolate and sodium alginate, mass ratio is 2:1, adds the water of 30 times respectively, soybean protein isolate and sodium alginate is configured to the solution of about 3.33%.
Step 2, in soybean protein isolate solution, add emulsifying agent citric acid monoglyceride, addition is 0.1% of microcapsules gross mass, stirring and dissolving at 60 DEG C, regulates the pH value to 9 of solution with alkali.
Step 3, the liquid compound tree peony seed oil formulation adding embodiment 1-4 arbitrary in above-mentioned solution are core, core and wall material mass ratio are 1:2, at 40 DEG C of temperature, the emulsion of stable homogeneous is obtained with the speed high-speed stirred 5min of 6000r/min, and with acid for adjusting pH value to 4, add sodium alginate soln to above-mentioned emulsion droplet again and stir, water bath heat preservation reaction 25min, forms complex coacervation thing in system.The water dilution cooling of the amount of doubling, and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Step 4, add the glucono-δ-lactone of microcapsules gross mass 0.8% to above-mentioned system, solidify 2h at water-bath 40 DEG C, filtration washing precipitates, and 30 DEG C of vacuum freeze dryings obtain Powdered compound tree peony seed oil formulation.
Embodiment 12 soybean protein isolate and sodium alginate complex coacervation prepare Powdered compound tree peony seed oil formulation
Step one, be wall material with soybean protein isolate and sodium alginate, mass ratio is 5:1, adds the water of 20 times respectively, soybean protein isolate and sodium alginate is configured to the solution of about 5%.
Step 2, in soybean protein isolate solution, add emulsifier lecithin and soybean lecithin, addition is 0.3% of microcapsules gross mass, lecithin: soybean lecithin mass ratio is 1:1, stirring and dissolving at 80 DEG C, regulates the pH value to 7 of solution with alkali.
Step 3, the liquid compound tree peony seed oil formulation adding embodiment 5-6 arbitrary in above-mentioned solution are core, core and wall material mass ratio are 2:1, at 80 DEG C of temperature, the emulsion of stable homogeneous is obtained with the speed high-speed stirred 10min of 3000r/min, and with acid for adjusting pH value to 3, add sodium alginate soln to above-mentioned emulsion droplet again and stir, water bath heat preservation reaction 20min, forms complex coacervation thing in system.The water dilution cooling of the amount of doubling, and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Step 4, add the glucose of microcapsules gross mass 2% to above-mentioned system, solidify 1h at water-bath 80 DEG C, filtration washing precipitates, and 50 DEG C of vacuum freeze dryings obtain Powdered compound tree peony seed oil formulation.
Embodiment 13 peony meal albumen and sodium alginate complex coacervation prepare Powdered compound tree peony seed oil formulation
Step one, be wall material with peony meal albumen and sodium alginate, mass ratio is 3:1, adds the water of 25 times respectively, peony meal albumen and sodium alginate is configured to the solution of about 4%.
Step 2, in peony meal protein solution, add emulsifying agent sucrose ester, addition is 0.2% of microcapsules gross mass, stirring and dissolving at 70 DEG C, regulates the pH value to 8 of solution with alkali.
Step 3, the liquid compound tree peony seed oil formulation adding embodiment 1-4 arbitrary in above-mentioned solution are core, core and wall material mass ratio are 1:1, at 60 DEG C of temperature, the emulsion of stable homogeneous is obtained with the speed high-speed stirred 8min of 4500r/min, and with acid for adjusting pH value to 3.2, add sodium alginate soln to above-mentioned emulsion droplet again and stir, water bath heat preservation reaction 20min, forms complex coacervation thing in system.The water dilution cooling of the amount of doubling, and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Step 4, add the pectin of microcapsules gross mass 1.5% to above-mentioned system, solidify 1.5h at water-bath 60 DEG C, filtration washing precipitates, and 30 DEG C of vacuum freeze dryings obtain Powdered compound tree peony seed oil formulation.
Embodiment 14 peony meal albumen and sodium alginate complex coacervation prepare Powdered compound tree peony seed oil formulation
Step one, be wall material with peony meal albumen and sodium alginate, mass ratio is 4:1, adds the water of 20 times respectively, peony meal albumen and sodium alginate is configured to the solution of about 5%.
Step 2, in peony meal protein solution, add emulsifying agent citric acid monoglyceride and glycerine monofatty ester, addition is 0.15% of microcapsules gross mass, citric acid monoglyceride and glycerine monofatty ester mass ratio are 2:1, stirring and dissolving at 60 DEG C, regulate the pH value to 7 of solution with alkali.
Step 3, the liquid compound tree peony seed oil formulation adding embodiment 5-6 arbitrary in above-mentioned solution are core, core and wall material mass ratio are 1:2, at 40 DEG C of temperature, the emulsion of stable homogeneous is obtained with the speed high-speed stirred 10min of 6000r/min, and with acid for adjusting pH value to 4.2, add sodium alginate soln to above-mentioned emulsion droplet again and stir, water bath heat preservation reaction 20min, forms complex coacervation thing in system.The water dilution cooling of the amount of doubling, and be placed in ice bath and continue to be stirred to less than 10 DEG C, make the gelation of gained complex coacervation thing.
Step 4, add glucose and the tannic acid of microcapsules gross mass 1.5% to above-mentioned system, glucose: tannic acid mass ratio is 1:1, solidifies 1h at water-bath 70 DEG C, and filtration washing precipitates, and 30 DEG C of vacuum freeze dryings obtain Powdered compound tree peony seed oil formulation.
Embodiment 15 spraying dry microcapsule method prepares Powdered compound tree peony seed oil formulation
Step one, converted starch, Arabic gum, maltodextrin are dissolved in the hot water of 60 DEG C by the mass ratio of 1:1:1, add the liquid compound tree peony seed oil formulation that embodiment 1-4 is arbitrary while stirring.Wherein, in above-mentioned solution, total solids content is 30%.
Step 2, continue to stir 15min, by colloid mill homogeneous 2 ~ 3 times or homogenization pressure 40Mpa, 40 DEG C carry out high-pressure homogeneous obtained emulsion.
Step 3, at EAT 160 DEG C, leaving air temp 90 DEG C, emulsion is entered spray dryer drying with flow 20ml/min, obtain Powdered compound tree peony seed oil formulation.
Embodiment 16 spraying dry microcapsule method prepares Powdered compound tree peony seed oil formulation
Step one, converted starch, Arabic gum, maltodextrin are dissolved in the hot water of 65 DEG C by the mass ratio of 1:0.8:1.2, add the liquid compound tree peony seed oil formulation that embodiment 5-6 is arbitrary while stirring.Wherein, in above-mentioned solution, total solids content is 30%.
Step 2, continue to stir 10min, by colloid mill homogeneous 2 ~ 3 times or homogenization pressure 50Mpa, 30 DEG C carry out high-pressure homogeneous obtained emulsion.
Step 3, at EAT 140 DEG C, leaving air temp 100 DEG C, emulsion is entered spray dryer drying with flow 20ml/min, obtain Powdered compound tree peony seed oil formulation.
The preparation of embodiment 17 compound tree peony seed oil soft capsule
Step one, take each component according to following weight percents: gelatin 36.0%, glycerine 18.0%, methyl p-hydroxybenzoate 0.06%, water 45.94%.After taking above-mentioned raw materials by formula ratio, in inputization glue tank, change glue; By the solution of gained by being transferred to after colloid mill in the bucket of band attemperator, be connected on soft capsule pellet press, for the preparation of soft capsule peel.
Step 2, take each component according to following weight percents: compound tree peony seed oil formulation 98%, ditert-butylhydro quinone 0.2% that embodiment 1-6 is arbitrary.Take the arbitrary compound tree peony seed oil formulation of embodiment 1-6 and ditert-butylhydro quinone by formula ratio, be heated dissolving, stir.Above-mentioned solution is put into reservoir, is injected in soft capsule peel by soft capsule pellet press, suppresses; The soft capsule pressed is cleaned, and is cured by drying equipment; Last packing, i.e. obtained compound tree peony seed oil soft capsule of the present invention.
The preparation of embodiment 18 compound tree peony seed oil oral liquid
Each component is taken: liquid compound tree peony seed oil formulation 89.6%, honey 10.0%, stevioside 0.2%, acesulfame potassium 0.2% that embodiment 1-6 is arbitrary according to following weight percents.Take above-mentioned each material by formula ratio, fully dissolve; Then gained solution is transferred in oral liquid filling machine, injects in container; Sterilizing, i.e. compound tree peony seed oil oral liquid obtained of the present invention.
The preparation of embodiment 19 compound tree peony seed oil electuary
Each component is taken: Powdered compound tree peony seed oil formulation 35.0%, cane sugar powder 45.0%, converted starch 16.0%, citric acid 2.0%, malic acid 2.0% that embodiment 7-16 is arbitrary according to following weight percents.
First above-mentioned each material is carried out pulverizing or sieving; The material pulverized or after sieving is taken successively by formula ratio; Load weighted material is dropped into mixer, mixes; Add the edible ethanol (volume fraction is 70%) of above-mentioned raw materials gross mass 10 ~ 20% again as wetting agent, granulated by granulator; The particle drying equipment made is carried out drying, carries out whole grain by pelletizing machine subsequently; Last packing, i.e. obtained compound tree peony seed oil particles electuary of the present invention.
The preparation of embodiment 20 compound tree peony seed oil sheet agent
Each component is taken: Powdered compound tree peony seed oil formulation 35.0%, sucrose 28.5%, starch 10.0%, coated vitamin C 1.5%, microcrystalline cellulose 15.0%, dextrin 8.0%, film coating agent 1.0%, dolomol 0.6%, silica 0.4% that embodiment 7-16 is arbitrary according to following weight percents.
First above-mentioned each material is carried out pulverizing or sieving; The material pulverized or after sieving is taken successively by formula ratio; Load weighted Powdered compound tree peony seed oil formulation, starch, coated vitamin C, sucrose, microcrystalline cellulose and dextrin are dropped into mixer, mixes; The edible ethanol (volume fraction is 70%) adding above-mentioned raw materials gross mass 10 ~ 20% again, as wetting agent, is granulated by granulator; The particle drying equipment made is carried out drying, carries out whole grain by pelletizing machine subsequently; Add dolomol, silica always mix, by be always mixed even after material carry out compressing tablet by tablet press machine, plain sheet keep in, for subsequent use; Film coating agent is added in suitable quantity of water, stir, be mixed with the coating solution that concentration is 5.0 ~ 15.0%, by seed-coating machine, Cotton seeds is carried out to the plain sheet pressed; Last packing, i.e. obtained compound tree peony seed oil formulation tablet of the present invention.
The preparation of embodiment 21 compound tree peony seed oil capsule
Each component is taken: Powdered compound tree peony seed oil formulation 54.0%, coated vitamin C 9.0%, microcrystalline cellulose 36.0%, dolomol 0.6%, silica 0.4% that embodiment 7-16 is arbitrary according to following weight percents.
First above-mentioned each material is carried out pulverizing, sieving; Take pulverizing successively by formula ratio, sieve after material; Load weighted material is dropped into mixer, mixes; Then by capsule filler, capsule is filled; Last packing, i.e. obtained compound tree peony seed oil formulation capsule of the present invention.
The preparation of embodiment 22 compound tree peony seed oil oral liquid
Each component is taken: Powdered compound tree peony seed oil formulation 30.0%, honey 10.0%, fructose 20.0%, vitamin C sodium salt 5%, malic acid 2.0%, citric acid 1.6%, carragheen 1.0%, stevioside 0.2%, the pure water of acesulfame potassium 0.2%, 30% that embodiment 7-16 is arbitrary according to following weight percents.
Take above-mentioned each material by formula ratio, drop in water, fully dissolve; Then gained solution is transferred in oral liquid filling machine, injects in container; Sterilizing, i.e. obtained compound tree peony seed oil formulation oral liquid of the present invention.
One, in order to evaluate the compound tree peony seed oil formulation product that the present invention obtains, at room temperature, we, from the acid value of product and peroxide value two data, evaluate the stability of compound tree peony seed oil formulation.Each sample is chosen 10 samples and is measured, and following list data is mean value.
Index illustrates:
1, the KOH milligram number that contained free fatty needs during acid value refers to and in 1g grease, unit mg/g.Useful acid value carrys out the freshness of measure oil.National standard " family's standard " the fresh food vegetable oil sanitary standard of measure oil " acid value≤3mg/g.
2, peroxide value refers to the amount of peroxides percentage composition produced in Oxidation of Fat and Oils process, unit g/100g.Assay method is that I is separated out in ROOH and KI effect in acid condition
2, then use Na
2s
2o
3titration, mM number calculated, is mM number of ROOH.Its size reflects degree spoiled by rancid oil or fat, and in general higher its of peroxide value becomes sour more severe.National standard " family's standard " in general degree crosses edible vegetable oil sanitary standard " peroxide value≤0.25g/100g.
3, the Powdered compound tree peony seed oil formulation of embodiment 7,8,11,13,15 with the liquid compound tree peony seed of embodiment 4 oil for raw material illustrates, the Powdered compound tree peony seed oil formulation of embodiment 9,10,12,14,16 with the liquid compound tree peony seed oil of embodiment 6 for raw material illustrates.
4, because the Powdered compound tree peony seed oil formulation of embodiment 7-16 contains wall material, the mensuration of acid value and peroxide value can be disturbed, need to carry out pretreatment to sample.Processing method: take benzinum as solvent, the liquid compound tree peony seed oil of sonic oscillation extraction.In 50mL hard glass test tube, the Powdered compound tree peony seed oil formulation sample accurately adding embodiment 7-16 is about 5g, pours 25mL benzinum into, is placed in ultrasonic cleaner tank, sonic oscillation 30min; Take out, filter, and fully wash with benzinum, merging filtrate, Rotary Evaporators reclaims benzinum, heating water bath, and fully volatilization benzinum is placed in vacuum drying chamber, 50 DEG C remove benzinum further, obtain liquid compound tree peony seed oil, and then measure acid value and peroxide value.
Result shows, embodiment 6 is the compound preparation that tocotrienols is minimum, embodiment 5 is the compound preparation that tocotrienols content is the highest, the acid value coming into effect example 5 and 6 from three month demonstrates the difference (p<0.05) of conspicuousness, compare with single peony seed oil, acid value and peroxide value all demonstrate the difference (p<0.05) of conspicuousness simultaneously.From 6th month, the peroxide value of embodiment 5 and 6 demonstrated the difference (p<0.05) of conspicuousness.The above results illustrates, relative to single peony seed oil, adds the freshness that can extend peony seed oil after tocotrienols, reduces the degree of spoilage of grease, and increases along with the concentration of tocotrienols, and its above-mentioned effect also increases, one-tenth positive correlation.
Result shows, embodiment 4 is the compound preparation that tocotrienols and red colouring agent for food, also used as a Chinese medicine content are minimum, embodiment 3 is the compound preparation that tocotrienols and red colouring agent for food, also used as a Chinese medicine content are the highest, the acid value coming into effect example 3 and 4 from three month demonstrates the difference (p<0.05) of conspicuousness, compare with single peony seed oil, acid value and peroxide value all demonstrate the difference (p<0.05) of conspicuousness simultaneously.From 6th month, the peroxide value of embodiment 3 and 4 demonstrated the difference (p<0.05) of conspicuousness.The above results illustrates, relative to single peony seed oil, can extend the freshness of peony seed oil after adding tocotrienols and red colouring agent for food, also used as a Chinese medicine, reduce the degree of spoilage of grease, and increases along with the concentration of tocotrienols and red colouring agent for food, also used as a Chinese medicine, and its above-mentioned effect also increases, and becomes positive correlation.
The Powdered compound tree peony seed oil formulation of embodiment 7,8,11,13,15 with the liquid compound tree peony seed oil of tocotrienols and the minimum embodiment 4 of red colouring agent for food, also used as a Chinese medicine content for raw material illustrates, the Powdered compound tree peony seed oil formulation of embodiment 9,10,12,14,16 with the liquid compound tree peony seed oil of the minimum embodiment of tocotrienols content 6 for raw material illustrates, above-described embodiment was from three month, compared with single peony seed oil, acid value and peroxide value all demonstrate the difference (p<0.05) of conspicuousness.The above results explanation, Powdered compound tree peony seed oil formulation can extend the freshness of peony seed oil, reduces the degree of spoilage of grease, and, those skilled in the art can know by inference when tocotrienols content or tocotrienols and red colouring agent for food, also used as a Chinese medicine content increase, and its effect can be better.
Result confirms simultaneously, the Powdered compound tree peony seed oil formulation of embodiment 7,8,11,13,15 also demonstrates the difference (p<0.05) of conspicuousness relative to liquid compound tree peony seed oil acid value from three month of embodiment 4, and peroxide value demonstrated the difference (p<0.05) of conspicuousness from 9th month.Identical result also appears in the contrast of the Powdered compound tree peony seed oil formulation of embodiment 9,10,12,14,16 and the liquid compound tree peony seed oil of embodiment 6, the above results explanation, micro-embedded technology can extend the freshness of peony seed oil further, reduces the degree of spoilage of grease.
Two, we also measured were the bioavilability of tocotrienols or red colouring agent for food, also used as a Chinese medicine in each embodiment.Each sample is chosen 10 samples and is measured, and following list data is mean value.
Index illustrates:
1, with the dosage gastric infusion of purifying tocotrienols 50mg/kg to mouse, measure the concentration of tocotrienols in vein, in contrast, the bioavailability setting this numerical value is 100%, other embodiments are with the preparation of Isodose tocotrienols (50mg/kg) correspondence, gastric infusion, to mouse, measures the relative bioavailability of this embodiment under the same conditions.Embodiment 1,2,3,4,5,6 is followed successively by 1g/kg, 125mg/kg, 100mg/kg, 50g/kg, 83.3mg/kg, 50g/kg to the amount of formulation of mouse.
2, with the dosage gastric infusion of red colouring agent for food, also used as a Chinese medicine 50mg/kg to mouse, measure the concentration of red colouring agent for food, also used as a Chinese medicine in vein, in contrast, the bioavailability setting this numerical value is 100%, other embodiments are with the preparation of Isodose red colouring agent for food, also used as a Chinese medicine (50mg/kg) correspondence, gastric infusion, to mouse, measures the relative bioavailability of this embodiment under the same conditions.Embodiment 1,2,3,4 is followed successively by 500mg/kg, 1g/kg, 250mg/kg, 5g/kg to the amount of formulation of mouse.
Result shows, embodiment 4 and 6 is the compound preparation that tocotrienol concentration is minimum, embodiment 5 is the compound preparation that tocotrienol concentration is the highest, compared with embodiment 5, the tocotrienols bioavailability of embodiment 4 and 6 demonstrates the difference (p < 0.05) of conspicuousness, compare with single tocotrienols, bioavailability also demonstrates the difference of conspicuousness simultaneously
Different (p < 0.05).The above results illustrates, relative to single tocotrienols, can improve fertility triolefin after adding peony seed oil
The bioavailability of phenol, and reduce along with the concentration of tocotrienols, its above-mentioned effect also increases, and becomes negative correlation.
Result shows, embodiment 4 is the compound preparation that red colouring agent for food, also used as a Chinese medicine concentration is minimum, embodiment 3 is the compound preparation that red colouring agent for food, also used as a Chinese medicine concentration is the highest, compared with embodiment 4, the red colouring agent for food, also used as a Chinese medicine bioavailability of embodiment 3 demonstrates the difference (p < 0.05) of conspicuousness, compare with single red colouring agent for food, also used as a Chinese medicine, bioavailability also demonstrates the difference (p < 0.05) of conspicuousness simultaneously.The above results illustrates, relative to single red colouring agent for food, also used as a Chinese medicine, adds the bioavailability that can improve red colouring agent for food, also used as a Chinese medicine after peony seed oil, and reduces along with the concentration of red colouring agent for food, also used as a Chinese medicine, and its above-mentioned effect also increases, one-tenth negative correlation.
Claims (8)
1. a compound tree peony seed oil formulation, is characterized in that, described compound tree peony seed oil formulation comprises peony seed oil, tocotrienols and red colouring agent for food, also used as a Chinese medicine.
2. compound tree peony seed oil formulation as claimed in claim 1, it is characterized in that, described preparation includes following component by weight: tocotrienols 0.1% ~ 50%, red colouring agent for food, also used as a Chinese medicine 1% ~ 20%, peony seed oil 30% ~ 98.9%.
3. compound tree peony seed oil formulation as arbitrary in claim 1-2, it is characterized in that, described preparation is liquid compound tree peony seed oil formulation, or pass through microcapsules technology, to the peony seed oil parcel of tocotrienols and red colouring agent for food, also used as a Chinese medicine be dissolved with, and be prepared into Powdered compound tree peony seed oil formulation or further above-mentioned liquid compound tree peony seed oil formulation or Powdered compound tree peony seed oil formulation be processed into particle electuary, tablet, capsule, drink form.
4. the preparation method of the compound tree peony seed oil formulation that claim 1-3 is arbitrary, described method comprises peony seed oil is heated to 50 ~ 80 DEG C, add tocotrienols and the red colouring agent for food, also used as a Chinese medicine of corresponding proportion, stir, homogeneous preparation becomes the liquid compound tree peony seed oil formulation of stable homogeneous.
5. preparation method as claimed in claim 4, it is characterized in that, comprising liquid compound tree peony seed oil formulation is further core, and one of following component is wall material, prepares Powdered compound tree peony seed oil formulation by microcapsules technology:
(1) yeast;
(2) soybean protein isolate and sodium alginate;
(3) peony meal albumen and sodium alginate; Or
(4) one or more in cyclodextrin, maltodextrin, starch octenyl succinate anhydride, shitosan, lactose, xanthans, guar gum, Arabic gum.
6. the preparation method as described in claim 4 or 5, it is characterized in that, the liquid compound tree peony seed oil formulation of described claim 4 or the Powdered compound tree peony seed oil formulation of claim 5 can be processed into particle electuary, tablet, capsule, drink form further.
7. the application of the compound tree peony seed oil formulation that claim 1-3 is arbitrary, is characterized in that, described in be applied as health food or food additives.
8. apply as claimed in claim 7, it is characterized in that, described health food is health-care oil.
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