CN103492412A - 分枝型peg修饰的glp-1类似物及其可药用盐 - Google Patents

分枝型peg修饰的glp-1类似物及其可药用盐 Download PDF

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Publication number
CN103492412A
CN103492412A CN201280018158.0A CN201280018158A CN103492412A CN 103492412 A CN103492412 A CN 103492412A CN 201280018158 A CN201280018158 A CN 201280018158A CN 103492412 A CN103492412 A CN 103492412A
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glp
pex
lys
analogs
peg
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CN201280018158.0A
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CN103492412B (zh
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王瑞军
赵军军
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Jiangsu Best Pharmaceutical Co ltd
Lianyungang Hongchuang Pharmaceutical Co ltd
Jiangsu Hansoh Pharmaceutical Group Co Ltd
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Jiangsu Hansen Pharmaceutical Co Ltd
Jiangsu Hansoh Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

提供了分枝型PEG修饰的GLP-1类似物及其可药用盐、其制备方法、含有治疗有效量的该类似物的药物组合物，及其制备治疗和/或预防Ⅱ型糖尿病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN201280018158.0A 2011-05-19 2012-04-26 分枝型peg修饰的glp-1类似物及其可药用盐 Active CN103492412B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201280018158.0A CN103492412B (zh) 2011-05-19 2012-04-26 分枝型peg修饰的glp-1类似物及其可药用盐

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2011101373301A CN102786590A (zh) 2011-05-19 2011-05-19 分枝型peg修饰的glp-1类似物及其可药用盐
CN201110137330.1 2011-05-19
PCT/CN2012/074706 WO2012155780A1 (zh) 2011-05-19 2012-04-26 分枝型peg修饰的glp-1类似物及其可药用盐
CN201280018158.0A CN103492412B (zh) 2011-05-19 2012-04-26 分枝型peg修饰的glp-1类似物及其可药用盐

Publications (2)

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CN103492412A true CN103492412A (zh) 2014-01-01
CN103492412B CN103492412B (zh) 2015-12-23

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CN2011101373301A Pending CN102786590A (zh) 2011-05-19 2011-05-19 分枝型peg修饰的glp-1类似物及其可药用盐
CN201280018158.0A Active CN103492412B (zh) 2011-05-19 2012-04-26 分枝型peg修饰的glp-1类似物及其可药用盐

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CN (2) CN102786590A (zh)
WO (1) WO2012155780A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX345226B (es) 2008-10-29 2017-01-20 Ablynx Nv Formulaciones de moleculas de union a antigeno de dominio sencillo.
CA2805572A1 (en) * 2010-07-16 2012-01-19 Martin Hegen Modified single domain antigen binding molecules and uses thereof
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
EP2976325B1 (en) 2013-03-21 2017-03-01 Sanofi-Aventis Deutschland GmbH Synthesis of cyclic imide containing peptide products
CN103724424B (zh) * 2013-12-27 2015-05-27 浙江省农业科学院 一种mPEG-SPA-pGLP-2复合物及其制备方法和应用
US10046058B2 (en) 2014-12-02 2018-08-14 Rezolute, Inc. Use of hydrophobic organic acids to increase hydrophobicity of proteins and protein conjugates
CN107708679A (zh) 2015-06-04 2018-02-16 安特里阿比奥有限公司 用于制备位点特异性蛋白质偶联物的胺聚乙二醇化方法
US11123405B2 (en) * 2015-12-23 2021-09-21 The Johns Hopkins University Long-acting GLP-1R agonist as a therapy of neurological and neurodegenerative conditions
CN107952064B (zh) 2016-10-14 2023-10-20 江苏豪森药业集团有限公司 含有聚乙二醇洛塞那肽的药物制剂及其制备方法
CN109929025A (zh) * 2017-12-18 2019-06-25 江苏豪森药业集团有限公司 一种基于反应动力学的聚乙二醇洛塞那肽的制备方法
CA3193453A1 (en) * 2020-09-30 2022-04-07 Beijing Ql Biopharmaceutical Co., Ltd. Polypeptide conjugates and methods of uses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006074600A1 (fr) * 2005-01-14 2006-07-20 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Exendines modifiees et utilisations correspondantes
CN1832959A (zh) * 2003-03-19 2006-09-13 伊莱利利公司 聚乙二醇连接的glp－1化合物
CN101868476A (zh) * 2007-09-05 2010-10-20 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100344323C (zh) * 2004-09-30 2007-10-24 华东师范大学 一种人胰高血糖素样肽－1的复合物及其制备方法
ES2350852T3 (es) * 2005-05-13 2011-01-27 Eli Lilly And Company Compuestos glp-1 pegilados.
US8293869B2 (en) * 2005-12-16 2012-10-23 Nektar Therapeutics Polymer conjugates of GLP-1
WO2007139941A2 (en) * 2006-05-26 2007-12-06 Amylin Pharmaceuticals, Inc. Composition and methods for treatment of congestive heart failure

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1832959A (zh) * 2003-03-19 2006-09-13 伊莱利利公司 聚乙二醇连接的glp－1化合物
WO2006074600A1 (fr) * 2005-01-14 2006-07-20 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Exendines modifiees et utilisations correspondantes
CN101868476A (zh) * 2007-09-05 2010-10-20 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途

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CN103492412B (zh) 2015-12-23
CN102786590A (zh) 2012-11-21

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Address after: 220047 Lianyungang economic and Technological Development Zone, Jiangsu

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Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu

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Patentee after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd.

Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu

Patentee before: Jiangsu best Pharmaceutical Co.,Ltd.

Patentee before: Lianyungang Hongchuang Pharmaceutical Co.,Ltd.

Address after: 222047 Lianyungang economic and Technological Development Zone, Jiangsu

Patentee after: Jiangsu best Pharmaceutical Co.,Ltd.

Patentee after: Lianyungang Hongchuang Pharmaceutical Co.,Ltd.

Address before: 222047 Lianyungang economic and Technological Development Zone, Jiangsu

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