CN103463439B - Chinese herbal preparation for treating severe acute pancreatitis - Google Patents
Chinese herbal preparation for treating severe acute pancreatitis Download PDFInfo
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- CN103463439B CN103463439B CN201310377385.9A CN201310377385A CN103463439B CN 103463439 B CN103463439 B CN 103463439B CN 201310377385 A CN201310377385 A CN 201310377385A CN 103463439 B CN103463439 B CN 103463439B
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Abstract
The invention discloses a Chinese herbal preparation for treating severe acute pancreatitis. According to the traditional Chinese medicine, the pathogenesis of the severe acute pancreatitis is due to lacking of soothing of the liver and gall and accumulation of damp and hot, flaming heat toxin and blocking stagnant heat inside are further developed, then the lung is compressed, or the pericardium is invaginated, or the blood network vessel is thermally burnt to cause the severe acute pancreatitis. The key of the pathogenesis is excess heat and blood stasis. Therefore, the Chinese herbal medicines of caesalpinia minax hance, glabrous sarcandra herb, souliea vaginata, Wilson barberry, abrus cantoniensis hance, desmodium styracifolium, all grass or root of tricarinate calanthe, rubus alceaefolius poir, polygonum cuspidatum, root of procumbent urena, and pericarpium citri reticulatae viride are chosen and decocted with water to prepare a decoction of herbal medicine; the clinical test in the hospital shows that the total effective rate is up to 96.9%, and the occurrence rate of complications is remarkably lower than that of a contrast group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP.
Background technology
Acute pancreatitis is a kind of serious catabolism disease, PD is rapid, even threat to life, Severe Pancreatitis causes dyspnea, shock, multiple organ dysfunction due to violent systemic inflammatory response and systemic infection, effectively treat not in time, can occur systemic inflammatory response syndrome, its mortality rate is higher.In treatment, modus operandi also expands increasingly at present, even full pancreas excision.But this operative treatment side effect is comparatively large, can produce exogenous infection after surgery, and operation itself also increases the weight of the damage to body.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP.Chinese medicine is thought: severe pancreatitis is that liver and gall are lost and dredged, and the pathogenesis of damp-heat accumulation, develops into excessive noxious heat further, retention of heat in the interior, or under the pressure of lung, or the pericardium that caves in, or caused by injury of blood collaterals by heat.The key of its pathogenesis is " excess-heat blood stasis ".
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment Severe Acute Pancreatitis SAP is made up of the Chinese medicine of following weight portion: bitter stone connect 9-13 parts, Herba Sarcandrae 10-15 parts, Rhizoma soulieae vaginatae 11-15 parts, Radix Berberidis wilsonae 5-8 parts, Herba Abri 20-30 parts, Herba Desmodii Styracifolii 12-16 parts, Herba seu Radix Calanthes 15-25 parts, Radix seu Folium Rubi alceaefolii 8-14 parts, Rhizoma Polygoni Cuspidati 30-35 parts, Radix urenae procumbentis 12-18 parts, 13-15 parts, Pericarpium Citri Reticulatae Viride.
Preferably, bitter stone connect 11 parts, Herba Sarcandrae 12 parts, Rhizoma soulieae vaginatae 13 parts, Radix Berberidis wilsonae 7 parts, Herba Abri 25 parts, Herba Desmodii Styracifolii 14 parts, Herba seu Radix Calanthes 20 parts, Radix seu Folium Rubi alceaefolii 11 parts, Rhizoma Polygoni Cuspidati 32 parts, Radix urenae procumbentis 15 parts, 14 parts, Pericarpium Citri Reticulatae Viride.
Preparation method: make decoction by traditional method decocting.
Fang Zhong: bitter stone company, Rhizoma soulieae vaginatae, Herba Desmodii Styracifolii pathogenic fire purging dampness, clear away heart-fire relieving restlessness, anti-inflammation, removing damp-heat, inducing diuresis for treating stranguria syndrome; Radix Berberidis wilsonae, Herba Abri heat-clearing and toxic substances removing, antiinflammatory, soothing the liver dissipating blood stasis; Herba seu Radix Calanthes, Radix seu Folium Rubi alceaefolii, Rhizoma Polygoni Cuspidati are loose, Radix urenae procumbentis removing toxic substances, blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons, clearing away heat to stop bleeding, promoting the function of the gallbladder to alleviate jaundice, invigorating the spleen to clear away damp pathogen; Pericarpium Citri Reticulatae Viride depressed liver-energy dispersing and QI regulating, removing food stagnancyization is stagnant.
Clinical data
1, physical data: select in June, 2007 ~ 2010 year June my Out-patient Department and the 130 routine severe acute pancreatitis of accepting for medical treatment in hospital, all meet Diagnosis in Severe Acute Pancreatitis standard.Be divided into treatment group and matched group at random, treatment group 65 example, wherein male 39 example, women 26 example, age average (45.3 ± 10.7) year, average (2.4 ± 1.2) d, the pancreas balthazar ct of the course of disease marks average (3.75 ± 1.34) point.Matched group 65 example, wherein male 36 example, women 29 example, the age average (46.5 ± 11.3) year, average (2.5 ± 1.3) d, the pancreas balthazar ct of the course of disease marks average (3.86 ± 1.25) point.The physical data such as two groups of ages, the course of disease and state of an illness, through comparing difference not statistically significant (p>0.05), have comparability.
2, diagnostic criteria: with reference to the 6th pancreatic surgery academic conference " clinical diagnosis of acute pancreatitis and grade scale " in 1996.
3, Therapeutic Method: treatment group patient takes Chinese medicine preparation of the present invention, takes bitter stone and connects 11g, Herba Sarcandrae 12g, Rhizoma soulieae vaginatae 13g, Radix Berberidis wilsonae 7g, Herba Abri 25g, Herba Desmodii Styracifolii 14g, Herba seu Radix Calanthes 20g, Radix seu Folium Rubi alceaefolii 11g, Rhizoma Polygoni Cuspidati 32g, Radix urenae procumbentis 15g, Pericarpium Citri Reticulatae Viride 14g.Every day, potion, divided a secondary to take; Matched group octreotide 0.1 ~ 0.3mg adds in 5% Glucose Liquid 500m1 with the speed intravenous drip of 25 ~ 50 μ g/h; Two groups equal seven days is a course for the treatment of.
4, with reference to the curative effect judging standard that " the new Chinese medicine clinical guidance principle " of health ministry issue in 1993 is formulated.Clinical recovery: in 3d, symptom, sign are alleviated, and disappear in 7d, blood, amylase in urine recover normal; Effective: in 7d, symptom, sign significantly take a turn for the better, blood, amylase in urine recover normal; Effective: in 7d, symptom, sign alleviate, blood, amylase in urine have downward trend; Invalid: in 7d, symptom, sign do not alleviate or worsen, and blood, amylase in urine do not reduce.
5, therapeutic outcome: treat comparitive study after two courses for the treatment of for two groups, treatment group 65 example, wherein clinical recovery 47 example (72.3%), effective 9 examples (13.8%), effective 7 examples (10.8%), invalid 2 examples (3.1%), total effective rate is 96.9%; Matched group 65 example, wherein clinical recovery 26 example (40.0%), effective 15 examples (23.1%), effective 10 examples (15.4%), invalid 14 examples (21.5%), total effective rate is 78.5%.Two groups are compared, and clinical recovery rate, the total effective rate for the treatment of group are obviously better than group, have comparability.P<0.05
6, the comparison of two groups of complication rates: treatment group generation respiratory distress syndrome 3 example, renal failure 2 example, deteriorated blood symptom 3 example, multiple organ dysfunction syndrome 2 example; Matched group generation respiratory distress syndrome 10 example, renal failure 9 example, multiple organ dysfunction syndrome 7 example, deteriorated blood symptom 6 example, treatment group complication rate (33.3%) is starkly lower than matched group (56.7%), and difference has statistical significance (p<0.01)
Detailed description of the invention
Embodiment one: bitter stone connects 11g, Herba Sarcandrae 12g, Rhizoma soulieae vaginatae 13g, Radix Berberidis wilsonae 7g, Herba Abri 25g, Herba Desmodii Styracifolii 14g, Herba seu Radix Calanthes 20g, Radix seu Folium Rubi alceaefolii 11g, Rhizoma Polygoni Cuspidati 32g, Radix urenae procumbentis 15g, Pericarpium Citri Reticulatae Viride 14g, and decocting makes decoction.
Embodiment two: bitter stone connects 13g, Herba Sarcandrae 15g, Rhizoma soulieae vaginatae 11, Radix Berberidis wilsonae 8g, Herba Abri 30g, Herba Desmodii Styracifolii 12g, Herba seu Radix Calanthes 25g, Radix seu Folium Rubi alceaefolii 8g, Rhizoma Polygoni Cuspidati 30g, Radix urenae procumbentis 12g, Pericarpium Citri Reticulatae Viride 13g, and decocting makes decoction.
Embodiment three: bitter stone connects 9g, Herba Sarcandrae 10g, Rhizoma soulieae vaginatae 15g, Radix Berberidis wilsonae 5g, Herba Abri 20g, Herba Desmodii Styracifolii 16g, Herba seu Radix Calanthes 15g, Radix seu Folium Rubi alceaefolii 14g, Rhizoma Polygoni Cuspidati 35g, Radix urenae procumbentis 18g, Pericarpium Citri Reticulatae Viride 15g, and decocting makes decoction.
Claims (1)
1. treat the Chinese medicine preparation of Severe Acute Pancreatitis SAP for one kind, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight: bitter stone connects 11g, Herba Sarcandrae 12g, Rhizoma soulieae vaginatae 13g, Radix Berberidis wilsonae 7g, Herba Abri 25g, Herba Desmodii Styracifolii 14g, Herba seu Radix Calanthes 20g, Radix seu Folium Rubi alceaefolii 11g, Rhizoma Polygoni Cuspidati 32g, Radix urenae procumbentis 15g, Pericarpium Citri Reticulatae Viride 14g, and decocting makes decoction.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104055979A (en) * | 2014-06-26 | 2014-09-24 | 沈彤 | Chinese herb preparation for treating liver and gall damp-heat type chronic pancreatitis |
| CN104383049A (en) * | 2014-12-03 | 2015-03-04 | 王玉春 | Traditional Chinese medicine formula for treating severe acute pancreatitis and preparation method thereof |
| CN106916168B (en) * | 2017-03-13 | 2019-08-27 | 牡丹江医学院 | A kind of compound and preparation method thereof for treating severe pancreatitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103100063A (en) * | 2013-03-07 | 2013-05-15 | 马海全 | Traditional Chinese medicine for treating damp-heat type gallstone |
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| CN103100063A (en) * | 2013-03-07 | 2013-05-15 | 马海全 | Traditional Chinese medicine for treating damp-heat type gallstone |
Non-Patent Citations (2)
| Title |
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| 粗叶悬钩子对实验性肝炎小鼠TNFα的影响;洪振丰等;《福建中医学院学报》;20050430;第15卷(第02期);24-26 * |
| 粗叶悬钩子根部提取物对急性肝损伤的治疗作用研究;周建衡等;《实用中西医结合临床》;20070228;第7卷(第01期);78-79 * |
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