CN103463439A - Chinese herbal preparation for treating severe acute pancreatitis - Google Patents
Chinese herbal preparation for treating severe acute pancreatitis Download PDFInfo
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- CN103463439A CN103463439A CN2013103773859A CN201310377385A CN103463439A CN 103463439 A CN103463439 A CN 103463439A CN 2013103773859 A CN2013103773859 A CN 2013103773859A CN 201310377385 A CN201310377385 A CN 201310377385A CN 103463439 A CN103463439 A CN 103463439A
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- 206010033645 Pancreatitis Diseases 0.000 title claims abstract description 16
- 206010033647 Pancreatitis acute Diseases 0.000 title claims abstract description 14
- 201000003229 acute pancreatitis Diseases 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 16
- 238000011282 treatment Methods 0.000 claims description 20
- 239000004575 stone Substances 0.000 claims description 9
- 241000736026 Sarcandra Species 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 12
- 210000004369 blood Anatomy 0.000 abstract description 12
- 241001517312 Calanthe Species 0.000 abstract description 6
- 230000008506 pathogenesis Effects 0.000 abstract description 4
- 210000004185 liver Anatomy 0.000 abstract description 3
- 238000009825 accumulation Methods 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 abstract description 2
- 210000003516 pericardium Anatomy 0.000 abstract description 2
- 241000411851 herbal medicine Species 0.000 abstract 2
- 244000135727 Abrus pulchellus subsp cantoniensis Species 0.000 abstract 1
- 235000017112 Abrus pulchellus subsp cantoniensis Nutrition 0.000 abstract 1
- 241000906564 Actaea vaginata Species 0.000 abstract 1
- 241001408213 Berberis wilsoniae Species 0.000 abstract 1
- 235000016514 Caesalpinia minax Nutrition 0.000 abstract 1
- 241001328994 Caesalpinia minax Species 0.000 abstract 1
- 244000025254 Cannabis sativa Species 0.000 abstract 1
- 244000227573 Desmodium styracifolium Species 0.000 abstract 1
- 240000001341 Reynoutria japonica Species 0.000 abstract 1
- 235000018167 Reynoutria japonica Nutrition 0.000 abstract 1
- 244000235293 Rubus alceifolius Species 0.000 abstract 1
- 240000004274 Sarcandra glabra Species 0.000 abstract 1
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- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
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- 239000004382 Amylase Substances 0.000 description 4
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- 235000019418 amylase Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
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- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
- 208000010718 Multiple Organ Failure Diseases 0.000 description 2
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- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 1
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- 210000000232 gallbladder Anatomy 0.000 description 1
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- 229960002700 octreotide Drugs 0.000 description 1
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Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a Chinese herbal preparation for treating severe acute pancreatitis. According to the traditional Chinese medicine, the pathogenesis of the severe acute pancreatitis is due to lacking of soothing of the liver and gall and accumulation of damp and hot, flaming heat toxin and blocking stagnant heat inside are further developed, then the lung is compressed, or the pericardium is invaginated, or the blood network vessel is thermally burnt to cause the severe acute pancreatitis. The key of the pathogenesis is excess heat and blood stasis. Therefore, the Chinese herbal medicines of caesalpinia minax hance, glabrous sarcandra herb, souliea vaginata, Wilson barberry, abrus cantoniensis hance, desmodium styracifolium, all grass or root of tricarinate calanthe, rubus alceaefolius poir, polygonum cuspidatum, root of procumbent urena, and pericarpium citri reticulatae viride are chosen and decocted with water to prepare a decoction of herbal medicine; the clinical test in the hospital shows that the total effective rate is up to 96.9%, and the occurrence rate of complications is remarkably lower than that of a contrast group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP.
Background technology
Acute pancreatitis is a kind of serious catabolism disease, PD is rapid, threat to life even, Severe Pancreatitis is because acutely systemic inflammatory response and systemic infection cause dyspnea, shock, multiple organ dysfunction, effectively treatment not in time, systemic inflammatory response syndrome can occur, its mortality rate is higher.In treatment, modus operandi also enlarges increasingly at present, even full pancreas excision.But this operative treatment side effect is larger, can produce exogenous infection after operation, and operation itself also increases the weight of the damage to body.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP.Chinese medicine is thought: severe pancreatitis is that the liver and gall mistake is dredged, and the pathogenesis of damp-heat accumulation, further develop into excessive noxious heat, retention of heat in the interior, or upper under the pressure of lung, or the pericardium that caves in, or due to injury of blood collaterals by heat.The key of its pathogenesis is " excess-heat blood stasis ".
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment Severe Acute Pancreatitis SAP is made by the Chinese medicine of following weight portion: bitter stone connects 9-13 parts, 10-15 parts of Herba Sarcandraes, 11-15 parts of Rhizoma soulieae vaginataes, 5-8 parts of Radix Berberidis wilsonae, 20-30 parts of Herba Abris, 12-16 parts of Herba Desmodii Styracifoliis, 15-25 parts of Herba seu Radix Calanthess, 8-14 parts of Radix seu Folium Rubi alceaefoliis, 30-35 parts of Rhizoma Polygoni Cuspidati, 12-18 parts of Radix urenae procumbentis, 13-15 parts, Pericarpium Citri Reticulatae Viride.
Preferably, bitter stone connects 11 parts, 12 parts of Herba Sarcandraes, 13 parts of Rhizoma soulieae vaginataes, 7 parts of Radix Berberidis wilsonae, 25 parts of Herba Abris, 14 parts of Herba Desmodii Styracifoliis, 20 parts of Herba seu Radix Calanthess, 11 parts of Radix seu Folium Rubi alceaefoliis, 32 parts of Rhizoma Polygoni Cuspidati, 15 parts of Radix urenae procumbentis, 14 parts, Pericarpium Citri Reticulatae Viride.
Preparation method: by traditional method decocting, make decoction.
In side: bitter stone company, Rhizoma soulieae vaginatae, Herba Desmodii Styracifolii pathogenic fire purging dampness, the relieving restlessness that clears away heart-fire, anti-inflammation, removing damp-heat, inducing diuresis for treating stranguria syndrome; Radix Berberidis wilsonae, Herba Abri heat-clearing and toxic substances removing, antiinflammatory, soothing the liver dissipating blood stasis; Herba seu Radix Calanthes, Radix seu Folium Rubi alceaefolii, Rhizoma Polygoni Cuspidati fall apart, the Radix urenae procumbentis removing toxic substances, blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons, clearing away heat to stop bleeding, promoting the function of the gallbladder to alleviate jaundice, invigorating the spleen to clear away damp pathogen; The Pericarpium Citri Reticulatae Viride depressed liver-energy dispersing and QI regulating, removing food stagnancyization is stagnant.
Clinical data
1, physical data: select in June, 2007～2010 year June my Out-patient Department and the 130 routine severe acute pancreatitis of accepting for medical treatment in hospital, all meet the Diagnosis in Severe Acute Pancreatitis standard.Be divided at random treatment group and matched group, treatment group 65 examples, male's 39 examples wherein, women's 26 examples, age average (45.3 ± 10.7) year, average (2.4 ± 1.2) d of the course of disease, pancreas balthazar ct scoring average (3.75 ± 1.34) minute.Matched group 65 examples, male's 36 examples wherein, women's 29 examples, age average (46.5 ± 11.3) year, average (2.5 ± 1.3) d of the course of disease, pancreas balthazar ct scoring average (3.86 ± 1.25) minute.Two groups of physical data such as age, the course of disease and the state of an illness, through difference not statistically significant relatively (p > 0.05), have comparability.
2, diagnostic criteria: with reference to the 6th pancreatic surgery academic conference " clinical diagnosis of acute pancreatitis and grade scale " in 1996.
3, Therapeutic Method: treatment group patient takes Chinese medicine preparation of the present invention, takes bitter stone and connects 11g, Herba Sarcandrae 12g, Rhizoma soulieae vaginatae 13g, Radix Berberidis wilsonae 7g, Herba Abri 25g, Herba Desmodii Styracifolii 14g, Herba seu Radix Calanthes 20g, Radix seu Folium Rubi alceaefolii 11g, Rhizoma Polygoni Cuspidati 32g, Radix urenae procumbentis 15g, Pericarpium Citri Reticulatae Viride 14g.Every day, potion, divided a secondary to take; Matched group octreotide 0.1～0.3mg adds in 5% Glucose Liquid 500m1 the speed intravenous drip with 25～50 μ g/h; Two groups equal seven days is a course for the treatment of.
4, the curative effect judging standard of formulating with reference to " the new Chinese medicine clinical guidance principle " of health ministry issue in 1993.In clinical recovery: 3d, symptom, sign are alleviated, and in 7d, disappear, and blood, amylase in urine recover normal; In produce effects: 7d, symptom, sign significantly take a turn for the better, and blood, amylase in urine recover normal; Effectively: in 7d, symptom, sign alleviate, and blood, amylase in urine have downward trend; Invalid: symptom in 7d, sign does not alleviate or worsen, and blood, amylase in urine do not reduce.
5, therapeutic outcome: after two groups of treatments two courses for the treatment of curative effect relatively, treatment group 65 examples, wherein clinical recovery 47 examples (72.3%), produce effects 9 examples (13.8%), effective 7 examples (10.8%), invalid 2 examples (3.1%), total effective rate is 96.9%; Matched group 65 examples, clinical recovery 26 examples (40.0%) wherein, produce effects 15 examples (23.1%), effective 10 examples (15.4%), invalid 14 examples (21.5%), total effective rate is 78.5%.Two groups relatively, and clinical recovery rate, the total effective rate for the treatment of group obviously are better than group, have comparability.P<0.05
6, the comparison of two groups of complication rates: treatment group generation respiratory distress syndrome 3 examples, renal failure 2 examples, deteriorated blood symptom 3 examples, multiple organ dysfunction syndrome 2 examples; Matched group generation respiratory distress syndrome 10 examples, renal failure 9 examples, multiple organ dysfunction syndrome 7 examples, deteriorated blood symptom 6 examples, treatment group complication rate (33.3%) is starkly lower than matched group (56.7%), and difference has statistical significance (p<0.01)
The specific embodiment
Embodiment mono-: bitter stone connects 11g, Herba Sarcandrae 12g, Rhizoma soulieae vaginatae 13g, Radix Berberidis wilsonae 7g, Herba Abri 25g, Herba Desmodii Styracifolii 14g, Herba seu Radix Calanthes 20g, Radix seu Folium Rubi alceaefolii 11g, Rhizoma Polygoni Cuspidati 32g, Radix urenae procumbentis 15g, Pericarpium Citri Reticulatae Viride 14g, and decocting is made decoction.
Embodiment bis-: bitter stone connects 13g, Herba Sarcandrae 15g, Rhizoma soulieae vaginatae 11, Radix Berberidis wilsonae 8g, Herba Abri 30g, Herba Desmodii Styracifolii 12g, Herba seu Radix Calanthes 25g, Radix seu Folium Rubi alceaefolii 8g, Rhizoma Polygoni Cuspidati 30g, Radix urenae procumbentis 12g, Pericarpium Citri Reticulatae Viride 13g, and decocting is made decoction.
Embodiment tri-: bitter stone connects 9g, Herba Sarcandrae 10g, Rhizoma soulieae vaginatae 15g, Radix Berberidis wilsonae 5g, Herba Abri 20g, Herba Desmodii Styracifolii 16g, Herba seu Radix Calanthes 15g, Radix seu Folium Rubi alceaefolii 14g, Rhizoma Polygoni Cuspidati 35g, Radix urenae procumbentis 18g, Pericarpium Citri Reticulatae Viride 15g, and decocting is made decoction.
Claims (2)
1. a Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: bitter stone connects 9-13 parts, 10-15 parts of Herba Sarcandraes, 11-15 parts of Rhizoma soulieae vaginataes, 5-8 parts of Radix Berberidis wilsonae, 20-30 parts of Herba Abris, 12-16 parts of Herba Desmodii Styracifoliis, 15-25 parts of Herba seu Radix Calanthess, 8-14 parts of Radix seu Folium Rubi alceaefoliis, 30-35 parts of Rhizoma Polygoni Cuspidati, 12-18 parts of Radix urenae procumbentis, 13-15 parts, Pericarpium Citri Reticulatae Viride.
2. a kind of Chinese medicine preparation for the treatment of Severe Acute Pancreatitis SAP according to claim 1 is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: bitter stone connects 11 parts, 12 parts of Herba Sarcandraes, 13 parts of Rhizoma soulieae vaginataes, 7 parts of Radix Berberidis wilsonae, 25 parts of Herba Abris, 14 parts of Herba Desmodii Styracifoliis, 20 parts of Herba seu Radix Calanthess, 11 parts of Radix seu Folium Rubi alceaefoliis, 32 parts of Rhizoma Polygoni Cuspidati, 15 parts of Radix urenae procumbentis, 14 parts, Pericarpium Citri Reticulatae Viride.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310377385.9A CN103463439B (en) | 2013-08-19 | 2013-08-19 | Chinese herbal preparation for treating severe acute pancreatitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310377385.9A CN103463439B (en) | 2013-08-19 | 2013-08-19 | Chinese herbal preparation for treating severe acute pancreatitis |
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| CN103463439A true CN103463439A (en) | 2013-12-25 |
| CN103463439B CN103463439B (en) | 2015-04-08 |
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| CN201310377385.9A Expired - Fee Related CN103463439B (en) | 2013-08-19 | 2013-08-19 | Chinese herbal preparation for treating severe acute pancreatitis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055979A (en) * | 2014-06-26 | 2014-09-24 | 沈彤 | Chinese herb preparation for treating liver and gall damp-heat type chronic pancreatitis |
| CN104383049A (en) * | 2014-12-03 | 2015-03-04 | 王玉春 | Traditional Chinese medicine formula for treating severe acute pancreatitis and preparation method thereof |
| CN106916168A (en) * | 2017-03-13 | 2017-07-04 | 牡丹江医学院 | It is a kind of to treat compound of severe pancreatitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103100063A (en) * | 2013-03-07 | 2013-05-15 | 马海全 | Traditional Chinese medicine for treating damp-heat type gallstone |
-
2013
- 2013-08-19 CN CN201310377385.9A patent/CN103463439B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103100063A (en) * | 2013-03-07 | 2013-05-15 | 马海全 | Traditional Chinese medicine for treating damp-heat type gallstone |
Non-Patent Citations (2)
| Title |
|---|
| 周建衡等: "粗叶悬钩子根部提取物对急性肝损伤的治疗作用研究", 《实用中西医结合临床》, vol. 7, no. 01, 28 February 2007 (2007-02-28) * |
| 洪振丰等: "粗叶悬钩子对实验性肝炎小鼠TNFα的影响", 《福建中医学院学报》, vol. 15, no. 02, 30 April 2005 (2005-04-30) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055979A (en) * | 2014-06-26 | 2014-09-24 | 沈彤 | Chinese herb preparation for treating liver and gall damp-heat type chronic pancreatitis |
| CN104383049A (en) * | 2014-12-03 | 2015-03-04 | 王玉春 | Traditional Chinese medicine formula for treating severe acute pancreatitis and preparation method thereof |
| CN106916168A (en) * | 2017-03-13 | 2017-07-04 | 牡丹江医学院 | It is a kind of to treat compound of severe pancreatitis and preparation method thereof |
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| CN103463439B (en) | 2015-04-08 |
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