CN103191293B - Sub-health-preventive drug composition and preparation method thereof - Google Patents
Sub-health-preventive drug composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to medical supplies, and particularly relates to a sub-health-preventive drug composition. The drug comprises effective components and pharmaceutically acceptable auxiliary materials, and is characterized in that the effective components are water extract prepared by the following ingredients in percentage by weight: 18-23% of gensing, 13-18% of radix rehmanniae preparata, 9-16% of radix bupleuri, 8-13% of rhizome dioscoreae, 8-10% of prepared fructus corni, 6-9% of radix scutellariae, 5-8% of fructus schizandrae, 6-9% of cortex moutan radicis, and 3-4% of prepared radix licorice. The drug composition has the advantages of tonifying kidney and regulating the liver, tonifying qi and yin, being simple in drugs and specific in power, and obvious in sub-health prevention effect.
Description
Invention field
The present invention relates to a kind of medical configuration product, specifically a kind ofly take the medical configuration product that plant is raw material.
Background technology
Subhealth state refers to the intermediateness of human body between health and disease, shows as degradation under the reduction of body vigor, hypofunction, adaptive capacity.According to statistics, in China, there is 60～70% crowd in sub-health state.The ubiquity of subhealth state, serious harm people's health, affected national economy and social harmonious development.Fatigue is the combined reaction that in body, multiple Physiology and biochemistry changes, and can affect to some extent people's quality of life.Previously document shows that tired incidence rate in sub-health population is higher, and fatigue is one of main clinic symptoms of subhealth state, is to cause subhealth state that a key factor of development occurs, and correcting fatigue is early the measure of effective intervening sub-health.At present, not yet completely clear and definite for the mechanism of sub-health state, modern medicine to it also without good prevention and treatment method.Chinese Traditional Medicine has mass foundation widely in China, the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science, "prevention first" and focus on health preserving shown sufficient advantage in the prevention of subhealth state and treatment.Because the incidence rate of sub-health state is very high, this just requires must be popular to its means of prevention and method, to meet numerous sub-health population demand.And traditional differentiation of tcm must complete under Chinese physician's guidance, this has brought many difficulties for the control of subhealth state.Therefore, seek a kind of can bring into play tcm characteristic again the popular subhealth state method of preventing and treating be desirability.
Why the medicine of preventing and treating subhealth state is not easy to succeed in developing, and main reason is to cause the cause of disease of subhealth state also cannot be identified.Modern medicine adopts anti symptom treatment more, and tired Therapeutic Method is mainly contained: 1. cognitive-behavioral therapy; 2. the symptomatic therapy of applying hormone, antidepressants, somnifacient, analgesics etc. alleviates clinical symptoms; 3. give vitamin and coenzyme Q10 etc. with supporting treatment.But above method clinical data is less, concrete curative effect still can not be completely clear and definite, and side effect is larger.
The paper of Lian Donghui (Lian Donghui. Liu Wei Di Huang Wan with Plus o n treatment subhealth state syndrome of deficiency of kidney yin 60 routine .[J]. the Henan traditional Chinese medical science, 2011, 31 (8): 930-931.) mention subhealth state syndrome of deficiency of kidney yin patient is adopted to Radix Rehmanniae Preparata, Fructus Corni (formal name used at school is Fructus Corni), Rhizoma Dioscoreae, Cortex Moutan, Rhizoma Alismatis, Poria, the Rhizoma Anemarrhenae, Cortex Phellodendri, Semen Ziziphi Spinosae, Radix Codonopsis, Radix Angelicae Sinensis compatibility treatment is (according to drug ratios Radix Rehmanniae Preparata: Fructus Corni: Rhizoma Dioscoreae: Cortex Moutan: Rhizoma Alismatis: Poria: the Rhizoma Anemarrhenae: Cortex Phellodendri: Semen Ziziphi Spinosae: Radix Codonopsis: Radix Angelicae Sinensis takes with 8:4:4:3:3:3:3:3:4:4:4 ratio) receive good efficacy, test group deficiency of the kidney yin symptom is obviously improved.But the inclined to one side tonifying kidney-yin of the party, the power of QI invigorating a little less than, without soothing the liver effect, the stagnation of liver-QI and fatigability subhealth state is suffered from a deficiency of the kidney, QI and blood is not normal is its basic pathogenesis, therefore the medicine of the soothing the liver QI invigorating of the kidney invigorating seems particularly important.
The patent of invention (publication number is CN101181514) of a kind of " improving the Chinese medicine health care product that sub-health status promotes immunologic function " that innings Granted publication has been known by state, these health product by Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Radix Bupleuri, Rhizoma Atractylodis, Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Fructus Corni (formal name used at school is Fructus Corni), Fructus Schisandrae Chinensis, Fructus Crataegi, the Cortex Eucommiae, Radix Ophiopogonis, Radix Platycodonis, Fructus Aurantii Immaturus totally 15 kinds of Chinese medicines form.Above-mentioned Chinese medicine health care product has the effect of element culturing fixed folder, beneficial heart the kidney invigorating, soothing the liver smooth will.Treat clinically sub-health status crowd 260 examples, total effective rate 98%.But in this Chinese medicine health care product, the raw material such as Radix Ginseng is comparatively famous and precious, and kidney-reinforcing drug is less, the power of the kidney invigorating a little less than, and medicine is more, is unfavorable for applying.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition of preventing and treating subhealth state, and liver is adjusted in this pharmaceutical composition the kidney invigorating, supplementing QI and nourishing YIN, and medicine letter power is special, and the effect for the treatment of subhealth state is remarkable.
The technical scheme that the present invention addresses the above problem is:
Prevent and treat a pharmaceutical composition for subhealth state, this medicine is comprised of effective ingredient and pharmaceutically acceptable adjuvant, it is characterized in that, described effective ingredient is the water extract that following percentage by weight crude drug is made: Radix Codonopsis 18%～23%, Radix Rehmanniae Preparata 13～18%, Radix Bupleuri 9～16%, Rhizoma Dioscoreae 8～13%, Fructus Corni (processed) 8～10%, Radix Ophiopogonis 6～9%, Radix Scutellariae 6～9%, Fructus Schisandrae Chinensis 5～8%, Cortex Moutan 6～9%, Radix Glycyrrhizae Preparata 3～4%.
The best proportioning of crude drug described in aforementioned pharmaceutical compositions is: Radix Codonopsis 20%, Radix Rehmanniae Preparata 15%, Radix Bupleuri 10%, Rhizoma Dioscoreae 10%, Fructus Corni (processed) 10%, Radix Ophiopogonis 8%, Radix Scutellariae 8%, Fructus Schisandrae Chinensis 7%, Cortex Moutan 8%, Radix Glycyrrhizae Preparata 4%.
Pharmaceutical composition of the present invention, wherein said effective ingredient is made by following methods:
By proportioning, get water extraction 2～4 times for crude drug, add 8～12 times of decoctings at every turn and boil 1～3h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.10～1.50 extractum.
Above-mentioned extractum adds pharmaceutically acceptable adjuvant method routinely can cause various solid orally ingestibles, as granule, tablet or capsule.
Pharmaceutical composition of the present invention is total to Ten Herbs by Radix Codonopsis, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Fructus Corni (processed), Radix Bupleuri, Radix Scutellariae, Radix Ophiopogonis, Cortex Moutan, Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata and forms, Radix Codonopsis spleen reinforcing lung qi wherein, promote the production of body fluid, Radix Rehmanniae Preparata enriching yin and nourishing kidney, life essence-filling, marrow-benefitting, Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, three share, liver is adjusted in the kidney invigorating, and supplementing QI and nourishing YIN, is monarch drug; Rhizoma Dioscoreae reinforcing both QI and YIN, the flat three warmers of mending, Fructus Corni (processed) liver and kidney tonifying, restrains astringent or styptic treatment for spontaneous sweating, with Radix Rehmanniae Preparata compatibility, be the meaning of " three mend ", replenishing YIN and removing heat Radix Ophiopogonis, trimethyl gallic acid temperature yin fluid astringing, the two and Radix Codonopsis share the meaning into " SHENGMAI SAN ", supplementing QI for promoting the production of body fluid, and this five medicines compatibility is ministerial drug; Assistant, with Cortex Moutan, Radix Scutellariae clearing away heat and cooling blood, dampness, is removed hot and suffocating, deficiency-heat, not only Radix Scutellariae and Radix Bupleuri but also be the meaning of " little Radix Bupleuri "; The spleen reinforcing of Radix Glycyrrhizae Preparata QI invigorating, coordinating the actions of various ingredients in a prescription is for making medicine.Ten taste medicines cooperations play altogether the kidney invigorating and adjust liver, supplementing QI and nourishing YIN.The inventor is through years of researches and practice summary, find that subhealth state fatigue symptom and traditional Chinese medical science QI and blood are not normal, the symptom of the stagnation of liver-QI of suffering from a deficiency of the kidney is similar, therefore, this pharmaceutical composition is according to the pathogeny of the pathogenesis of subhealth state fatigue and modern medicine, according to the dialectical of the traditional Chinese medical science and logos prescription, by modern pharmaceutical technique, make the medicine that effectively prevents subhealth state fatigue, through zoopery and clinical case contrast proof, can effectively improve the tired spiritlessness and weakness occurring of subhealth state, the lazyness of breathing hard speech, poor appetite abdominal distention, soreness of the waist and knees, dribbling urination, impotence and premature ejaculation, the symptom such as defecate uncomfortable.Prepare pharmaceutical composition of the present invention medical material used and be common medical material, moderate cost, material is easy to get, and preparation technology is simple, is suitable for industrialization and produces.
To prove the technique effect that the present invention has by zoopery and clinical trial below.
1, pharmacodynamic experiment
For checking medicine of the present invention is in the pharmacological action preventing and treating aspect subhealth state, for its clinical use provides scientific basis, spy carries out following pharmacodynamic experiment.This experiment adopts the tired rat model of the subhealth state of this seminar invention, according to the main fatigue symptom of subhealth state, mobility, declines and the Evaluation of blood test of being correlated with.
1.1 experiment material
1.1.1 experimental subject
4 week age male SPF level kunming mice (medical animal experiment center, Guangdong Province provides, the quality certification number: Guangdong probatio inspectionem pecuoarem word 2008th～0002) 130, body weight 18～22g.
1.1.2 experiment condition
Clean level Animal House, temperature is (22～26 ℃), relative humidity 40～60%, light and shade replaces 12h.Before experiment, all mice adaptability is fed 7d, all mice sub-cage rearings, and 5/cage, freely drink water, standard feed free choice feeding.
1.1.3 main experimental instrument and equipment
1,120cm * 60cm * 60cm swimming trunk; 2, stopwatch; 3, eppendorf micropipettor; 4, Sigma freezing centrifuge; 5, Olympas AU800 automatic clinical chemistry analyzer.
1.1.4 tested medicine
Prepared scattered seed agent (by embodiment 1 prescription and method preparation) is made into desired concn with distilled water, shakes all and use afterwards.
1.2 experimental technique
1.2.1 experiment grouping
Experiment starts preposition mice in swimming trunk adaptability swimming instruction 4d, 5min/d, 24 ± 2 ℃ of water temperatures.Before experiment, 1d fasting is weighed, and mice bear to 7% body constitution and measures one's own ability and exhaust swimming, records swimming time, the mice that rejecting swimming time and weight differ greatly.Finally filter out 100 kunming mices and test, get wherein 50 mices and carry out degree of fatigue mensuration, remaining 50 mouse assay blood urea nitrogen and lactic acid.Experiment is divided into 5 groups: Normal group, the tired model group of subhealth state, experimental group 1, experimental group 2, experimental group 3,10 every group.
Experimental group 1: take off the granule of stating embodiment 1, add with distilled water, shake up, be made into and be equivalent to 1ml containing the aqueous solution of the prepared extractum 130mg of crude drug.
Experimental group 2: take off the granule of stating embodiment 4, add with distilled water, shake up, be made into and be equivalent to 1ml containing the aqueous solution of the prepared extractum 130mg of crude drug.
Experimental group 3: take off the granule of stating embodiment 5, add with distilled water, shake up, be made into and be equivalent to 1ml containing the aqueous solution of the prepared extractum 130mg of crude drug.
Except Normal group is left intact, all the other each group adopts forces the 8h that stands in the every sky and water of mice, 9d continuously, preparation fatigability subhealth state model.Concrete grammar: the morning every day 9:00, it is that the mice of 0.8cm is raised box modeling that each group mice is put into the depth of water, that afternoon, 17:00 took out it from water box, normally raised.
Normal group and model group normal diet, do not give pharmaceutical intervention.Experimental group 1, experimental group 2, experimental group 3: every day, gavage was 1 time, and gavage dosage is 1g/Kg.9d surveys mice swimming time.
1.2.3 observation index mice swimming time; Serum ALT, AST, BUN.Power exhausts swimming standard: mice nose does not have the continuous 10s of upstream face.
1.2.4 data statistics utilizes SPSS13.0 software to carry out data statistic analysis, and result is with mean ± standard deviation
represent, result is carried out significance analysis, significant difference P<0.05 with independent sample t check.
1.3 result
1.3.1 mice general status
Normal group mice is vivaciously active, and fur is bright and clean neat, and eyes have god, and responsive to food, escape reaction is fast.
Model group mice expression is cold, has a weary expression, and expression in the eyes is intense darkness without light, hypotrichosis, and build is thin and weak, and escape reaction ability obviously reduces, insensitive to food.
Medicine group expression of the present invention is quiet, and more active, build is moderate, and fur is bright and clean, and escape reaction is very fast, more responsive to food.Each organizes the improvement of mice fatigue symptom dose-effect relationship, is specially dosage group < high dose group in low dose group <.
1.3.2 the attitude of swimming
Model group mice strokes is inharmonious, and rectilinear motion is less, floating more, easily drowned.Medicine group mice strokes of the present invention is coordinated, and rectilinear motion is many, is difficult for drowned.
1.3.3 mice swimming time result
Compare with model group, medicine group swimming time significant prolongation (P<0.05), points out medicine of the present invention can significantly improve the swimming time of mice.Mice swimming time odds ratio, drug study group 1 of the present invention, experimental group 2, experimental group 3 no difference of science of statistics (P>0.05).(in Table 2～1) prompting medicine of the present invention can prevent the generation of mice fatigue type sub-health.
Table 2～1 9d mice swimming time
Note: P<0.05
1.3.4 Mouse Blood blood urea nitrogen and lactate level are respectively organized in experiment
Compare with Normal group, model group Mouse Blood lactic acid and urea nitrogen levels, without significantly changing (P>0.05), point out this modeling method to have no significant effect Mouse Blood lactic acid and urea nitrogen levels.With model group comparison, after drug study group 1 of the present invention, experimental group 2, experimental group 3 mice swimming, blood urea nitrogen and lactate level significantly reduce (P<0.05).(in Table 2～2)
Mice lactic acid and urea nitrogen levels are respectively organized in table 2～2 experiment
Note: P<0.05
1.4 conclusion
The demonstration of this experimental result, medicine of the present invention can significantly improve the fatigue symptom of the tired mice of subhealth state and reduce the removing of the tired metabolite of blood, has the effect of good anti-subhealth state.
2 clinical trials
2.1 case selection
Selected case derives from Guangzhou Nanfang Hospital and is in hospital and outpatient.Meet subhealth state Chinese and western medicine diagnosis and differential diagnosis in tcm standard, the age was the patient of 18～60 years old.There are no significant (P ﹥ 0.05) for difference at aspects such as sex, age, Pathogenesis, TCM Syndrome Type distribution, the distributions of traditional Chinese medical science disease before patient, shows that balance between the two groups is better, has comparability.And meet following condition: (1) sanity, can partner treatment; (2) without serious organic disease and spiritual, nervous system disease; (3) without infectious disease psychosis and poisoning disease.Biometrics system of Nanfang Medical Univ bears center at random and data management.According to include in/exclusion standard, according to patient's Principles in Informed Consent, 150 routine patients are divided into 5 groups at random, each group is observed 30 examples.
The diagnostic criteria of 2.2 sub-health states:
According to the conversion of questionnaire " subhealth state rating scale " score, divide evaluation:
In man's <40 year, 54 minutes≤transform minute < 79 minutes, be judged to be sub-health state;
Man >=40 years old, 55 minutes≤transform minute < 80 minutes, is judged to be sub-health state;
Female, 54 minutes≤transform minute < 78 minutes, is judged to be sub-health state.
2.3 Therapeutic Method
Matched group 1: the disclosed Chinese medicine health care product of application for a patent for invention that is CN101181514 by publication number, concrete prescription is: Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 20g, Poria 15g, Radix Bupleuri 15g, Rhizoma Atractylodis 10g, Radix Ginseng 12g, Radix Astragali 15g, Rhizoma Dioscoreae 25g, Fructus Corni 15g, Fructus Schisandrae Chinensis 12g, Fructus Crataegi 20g, Cortex Eucommiae 15g, Radix Ophiopogonis 15g, Radix Platycodonis 12g, Fructus Aurantii Immaturus 12g.Concrete preparation method is the method for the 7th page of 11-12 of this patent application specification described in capable.Instructions of taking: every day 3 times, each 10g.
Matched group 2: by drafting prescription described in the eastern brightness paper of company be: Radix Rehmanniae Preparata 24g, Fructus Corni 12g, Rhizoma Dioscoreae 12g, Cortex Moutan 9g, Rhizoma Alismatis 9g, Poria 9g, Rhizoma Anemarrhenae 9g, Cortex Phellodendri 9g, Semen Ziziphi Spinosae 12g, Radix Codonopsis 12g, Radix Angelicae Sinensis 12g.Preparation method is identical with following embodiment 1.Warm boiled water, every day 2 times, respectively took 10g(1 parcel 7,19 o'clock every days).
Treatment group 1: the oral medicine of preparing according to the method for embodiment 1, warm boiled water, every day 2 times, respectively took 10g(1 parcel 7,19 o'clock every days).
Treatment group 2: the oral medicine of preparing according to the method for embodiment 4, warm boiled water, every day 2 times, respectively took 10g(1 parcel 7,19 o'clock every days).
Treatment group 3: the oral medicine of preparing according to the method for embodiment 5, warm boiled water, every day 2 times, respectively took 10g(1 parcel 7,19 o'clock every days).
5 groups of treatments are 3 months the course for the treatment of.
2.3 evaluation index
1. clinical efficacy evaluation criteria
Recovery from illness: cardinal symptom disappears, it is normal that sexual life recovers, and symptom improvement rate is more than 95%; Effective: cardinal symptom significantly alleviates, symptom improvement rate is between 94%～60%, and sign is obviously improved; Effective: cardinal symptom and minor symptom and sign make moderate progress, symptom improvement rate is between 59%～30%; Invalid: before and after medication, symptom is not improved, symptom improvement rate less than 30%, every index is all without improving.
2. fatigue assessment scale score
2.4 result
(1) respectively organize Clinical efficacy comparison
Compare with matched group 2, the clinical efficacy effective percentage of each treatment group all has significant difference.Compare with treatment group 1, the clinical efficacy effective percentage for the treatment of group 3 is less than treatment group 1, and difference has statistical significance.Clinical trial shows, medicine of the present invention is effectively tired to subhealth state, and curative effect is better than matched group.(in Table 1)
Table 1 treatment group and the comparison of matched group curative effect
Note: learn and process by statistics, treatment group curative effect is better than matched group (P<0.05)
(2) two groups of fatigue assessment scale integral contrasts
Treat front 5 groups of fatigue assessment scale integral contrasts without significant difference (P>0.05), after treatment, each treatment group fatigue assessment scale integration decline degree is compared with matched group 2, and difference has significant difference (P<0.01); Compare with treatment group 1, treatment group 3 integration decline degree are less than treatment group 1, and difference has significant difference (P<0.05).Prompting your pupil hexamer can improve the fatigue state of sub-health population.
Table 2 treatment group and matched group fatigue assessment scale integral contrast
Note: learn and process by statistics, treatment group curative effect is better than matched group (P<0.05)
2.5 conclusion
Medicine of the present invention has the kidney invigorating and adjusts liver, the effect of supplementing QI and nourishing YIN, the clinical common liver energy stagnation type subhealth state of suffering from a deficiency of the kidney is had to good therapeutic effect, visible Drug therapy subhealth state determined curative effect, and do not find that this product has obvious toxic-side effects to heart, liver and gastrointestinal tract, use safety, taking convenience.
The specific embodiment
Example 1: granule
Prescription: Radix Codonopsis 30g, Radix Rehmanniae Preparata 20g, Radix Bupleuri 15g, Rhizoma Dioscoreae 15g, Fructus Corni (processed) 15g, Radix Ophiopogonis 12g, Radix Scutellariae 12g, Fructus Schisandrae Chinensis 10g, Cortex Moutan 12g, Radix Glycyrrhizae Preparata 5g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 3h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.50 extractum, first add by weight the dextrin of 4 times, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and obtained dry powder, then added by weight the Icing Sugar of 2 times, with 95% ethanol, made wetting agent soft material processed, crossing 16 mesh sieves granulates, dry, granulate, is distributed into 10 gram of one bag.
Instructions of taking: each 10g, every day 2 times, warm boiled water.
Example 2: tablet
Prescription: Radix Codonopsis 25g, Radix Rehmanniae Preparata 21g, Radix Bupleuri 22g, Rhizoma Dioscoreae 21g, Fructus Corni (processed) 17g, Radix Ophiopogonis 11g, Radix Scutellariae 9g, Fructus Schisandrae Chinensis 6g, Cortex Moutan 9g, Radix Glycyrrhizae Preparata 5g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 12 times of decoctings at every turn and boil 1h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.49 extractum, add by weight the dextrin of 4 times, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and obtained dry powder, then added by weight the Icing Sugar of 2 times, with 95% ethanol, made wetting agent soft material processed, crossing 16 mesh sieves granulates, dry, conventional method tabletting, makes tablet.
Instructions of taking: each 2, every day 2 times, warm water delivery service.
Example 3: capsule
Prescription: Radix Codonopsis 24g, Radix Rehmanniae Preparata 17g, Radix Bupleuri 17g, Rhizoma Dioscoreae 17g, Fructus Corni (processed) 21g, Radix Ophiopogonis 12g, Radix Scutellariae 14g, Fructus Schisandrae Chinensis 10g, Cortex Moutan 10g, Radix Glycyrrhizae Preparata 4g.
Preparation method: get crude drug water extraction 2 times by said ratio, add 8 times of decoctings at every turn and boil 3h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.12 extractum, first add by weight the dextrin of 4 times, 80 ℃ of vacuum dryings, pulverized 65 mesh sieves and obtained dry powder, then added by weight the Icing Sugar of 2 times, with 95% ethanol, make wetting agent soft material processed, cross 16 mesh sieves and granulate, dry, granulate, pack gelatine capsule into, make capsule.
Instructions of taking: each 3, every day 2 times, warm water delivery service.
Example 4: granule
Prescription: Radix Codonopsis 37g, Radix Rehmanniae Preparata 26g, Radix Bupleuri 18g, Rhizoma Dioscoreae 11g, Fructus Corni (processed) 13g, Radix Ophiopogonis 9g, Radix Scutellariae g, Fructus Schisandrae Chinensis 8g, Cortex Moutan 11g, Radix Glycyrrhizae Preparata 6g
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 2h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.38 extractum, first add by weight the dextrin of 4 times, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and obtained dry powder, then added by weight the Icing Sugar of 2 times, with 95% ethanol, made wetting agent soft material processed, crossing 16 mesh sieves granulates, dry, granulate, is distributed into 10 gram of one bag.
Instructions of taking: each 10g, every day 2 times, warm boiled water.
Example 5: granule
Prescription: Radix Codonopsis 22g, Radix Rehmanniae Preparata 18g, Radix Bupleuri 26g, Rhizoma Dioscoreae 11g, Fructus Corni (processed) 15g, Radix Ophiopogonis 13g, Radix Scutellariae 15g, Fructus Schisandrae Chinensis 11g, Cortex Moutan 11g, Radix Glycyrrhizae Preparata 4g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 2h, then merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.38 extractum, first add by weight the dextrin of 4 times, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and obtained dry powder, then added by weight the Icing Sugar of 2 times, with 95% ethanol, made wetting agent soft material processed, crossing 16 mesh sieves granulates, dry, granulate, is distributed into 10 gram of one bag.Instructions of taking: each 10g, every day 3 times, warm boiled water.
Claims (4)
1. treat a pharmaceutical composition for subhealth state, this medicine is comprised of effective ingredient and pharmaceutically acceptable adjuvant, it is characterized in that, described effective ingredient is the water extract that following percentage by weight crude drug is made: Radix Codonopsis 18%～23%, Radix Rehmanniae Preparata 13～18%, Radix Bupleuri 9～16%, Rhizoma Dioscoreae 8～13%, Fructus Corni (processed) 8～10%, Radix Ophiopogonis 6～9%, Radix Scutellariae 6～9%, Fructus Schisandrae Chinensis 5～8%, Cortex Moutan 6～9%, Radix Glycyrrhizae Preparata 3～4%.
2. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 1, is characterized in that, the proportioning of described crude drug is: Radix Codonopsis 20%, Radix Rehmanniae Preparata 15%, Radix Bupleuri 10%, Rhizoma Dioscoreae 10%, Fructus Corni (processed) 10%, Radix Ophiopogonis 8%, Radix Scutellariae 8%, Fructus Schisandrae Chinensis 7%, Cortex Moutan 8%, Radix Glycyrrhizae Preparata 4%.
3. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 1 and 2, is characterized in that, described effective ingredient is made by following methods:
By proportioning, get water extraction 2～4 times for crude drug, add 8～12 times of water at every turn, decoct 1～3h, then, merge decoction liquor, filter, finally filtrate is concentrated into relative density and is 1.10～1.50 extractum.
4. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 3, is characterized in that, described pharmaceutical composition is granule, tablet or capsule.
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