CN101757540A - Traditional Chinese medicine composition for treating nephrotic syndrome and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating nephrotic syndrome and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a new traditional Chinese medicine composition for treating nephrotic syndrome and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the following Chinese medicinal herbs such as American ginseng, ginseng, codonopsis pilosula, unprocessed astragalus mongholicus, Chinese yam, turtle shell, tortoise plastron, cornu cervi degelatinatum, fruit of Chinese wolfberry, root of Chinese trichosanthes, fruit of Chinese magnoliavine, seed of Chinese dodder, herba cistanche, Chinese caterpillar fungus, prepared rehmannia root, polygonum multiflorum, fructus ligustri lucidi, dried orange peel, myristica fragrans, fructus amomi, semen euryales, mangnolia officinalis, fructus chebulae, fructus rosae laevigatae, fructus alpiniae oxyphyllae, oyster, drynaria rhizome, dogwood, root-bark of Chinese wolfberry, phellodendron, fructus gardenia, white atractylodes rhizome, lucid asparagus, ophiopogon japonicus, herba epimedii, rhizoma anemarrhenae, root of kudzu vine and the like. The traditional Chinese medicine composition can be prepared into any one common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can remarkably improve symptoms of proteinuria, hypoalbuminemia, hematuresis, generaldropsy, listlessness, poor physical strength, inappetence, insomnia and amnesia, hypomnesis and the like of the patients suffering from the nephrotic syndrome and has accurate clinical treatment effect, remarkable treatment effect and rapid effect taking. Because of being combined by basically adopting medicinal and edible medicines specified in National Formulary, the invention has the advantages of low cost, basically no toxic and side effects and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of nephrotic syndrome.Relating in particular to a kind of is the Chinese medicine composition and preparation method thereof of the treatment nephrotic syndrome of crude drug with the Chinese herbal medicine.
Background technology
Nephrotic syndrome is not a kind of independence disease, but one group of clinical syndrome in the renal glomerular disease.Disease causes that damage, infection, medicine, tumor and the diabetes etc. of glomerular capillary filter membrane all can cause the generation of nephrotic syndrome.Clinical manifestation is symptoms such as a large amount of albuminuria, hypoalbuminemia, edema companion, treat timely and effectively as not taking, normal easily the initiation sends out sore infection, hypercoagulability and venous thrombosis, acute renal failure, renal tubular function go down, bone and the multiple diseases that have a strong impact on Health and Living such as abnormal calcium metabolism, endocrine and Developmental and Metabolic Disorder, and the clinical onset rate has the trend of continuous rising in recent years.
There is not the specific treatment method at present, the symptom that is primarily aimed at clinical manifestation adopts symptomatic treatments such as hormone, immunosuppressant, anticoagulant, often fall flat, and side effect is big, in order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment nephrotic syndrome, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical the accent, emergency is taken in concurrently, filters out the natural plant of eliminating toxic substances to remove stasis, inducing diuresis to remove edema, nourishing the liver and kidney, according to the theory of Chinese medical science prescription, be prepared from according to certain weight proportion.A kind of Chinese medicine composition of evident in efficacy, with low cost, treatment nephrotic syndrome that toxic and side effects is minimum is provided.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be: pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is assorted to overcome above-described shortcoming, and a kind of Chinese medicine composition of treatment nephrotic syndrome of evident in efficacy, with low cost, almost non-toxic side effect is provided.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of Chinese medicine composition for the treatment of nephrotic syndrome of the present invention, the component of main following weight portion is formed:
Radix Panacis Quinquefolii 1～20 gram, the person 1～30 gram, Radix Codonopsis 1～50 gram, Radix Astragali 1～50 gram, Ganoderma 1～30 gram, Radix Angelicae Sinensis 1～50 gram, the Radix Paeoniae Alba 1～50 gram, RHIIZOMA DIOSCOREAE frOm Henan of China 1～50 gram, Carapax Trionycis 1～30 gram, Carapax et Plastrum Testudinis～30 grams, Cornu Cervi Degelatinatum 1～30 gram, Radix Rehmanniae 1～40 gram, Fructus Lycii 1～40 gram, Radix Trichosanthis 1～40 gram, Fructus Schisandrae Chinensis 1～40 gram, Semen Cuscutae 1～30 gram, Herba Cistanches 1～40 gram, Cordyceps 1～30 gram, Radix Rehmanniae Preparata 1～40 gram, Radix Polygoni Multiflori 1～40 gram, Massa Medicata Fermentata 1～50 gram, Fructus Hordei Germinatus 1～40 gram, Semen Arecae 1～40 gram, Fructus Ligustri Lucidi 1～30 gram, Pericarpium Citri Reticulatae 1～50 gram, Rhizoma Cyperi 1～40 gram, Semen Myristicae 1～30 gram, Fructus Amomi 1～30 gram, Endothelium Corneum Gigeriae Galli 1～30 gram, Semen Euryales 1～40 gram.
Be preferably:
Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Radix Rehmanniae Preparata 15 grams, Radix Polygoni Multiflori 20 grams, Massa Medicata Fermentata 30 grams, Fructus Hordei Germinatus 20 grams, Semen Arecae 15 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Rhizoma Cyperi 30 grams, Semen Myristicae 20 grams, Fructus Amomi 15 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams.
The weight portion consumption of each component of Chinese medicine composition of the present invention can also be:
Semen Ziziphi Spinosae 1～30 gram, Semen Raphani 1～30 gram, Fructus Crataegi 1～30 gram, Cortex Magnoliae Officinalis 1～30 gram, Fructus Chebulae's 1～30 gram, Fructus Mume 1～40 gram, Fructus Rosae Laevigatae 1～30 gram, Fructus Alpiniae Oxyphyllae 1～30 gram, Ootheca Mantidis 1～30 gram, Endoconcha Sepiae 1～30 gram, Concha Ostreae 1～30 gram, Rhizoma Drynariae 1～30 gram, Fructus Corni 1～40 gram, Cortex Lycii 1～50 gram, Cortex Phellodendri 1～40 gram, Fructus Gardeniae 1～30 gram, Radix Adenophorae (Radix Glehniae) 1～40 gram, Herba Dendrobii 1～40 gram, Rhizoma Polygonati Odorati 1～40 gram, the Rhizoma Atractylodis Macrocephalae 1～40 gram, Radix Asparagi 1～40 gram, Radix Ophiopogonis 1～40 gram, Herba Epimedii 1～30 gram, Radix Morindae Officinalis 1～30 gram, the Rhizoma Anemarrhenae 1～30 gram, Radix Puerariae 1～50 gram.
Be preferably:
Semen Ziziphi Spinosae 12 gram, Semen Raphani 20 grams, Fructus Crataegi 15 grams, Cortex Magnoliae Officinalis 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Adenophorae (Radix Glehniae) 15 grams, Herba Dendrobii 15 grams, Rhizoma Polygonati Odorati 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 gram.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese medicine composition of the present invention is opened one's minds based on traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, in conjunction with safe one and Pu innovation theory system " ten thousand diseases ascent theory ", " the five internal organs differentiation of syndromes of YIN and YANG guiding principle ", " three-dimensional conservation regulation and control rule " and clinical treatment " pairing principle " are as instructing, take place in conjunction with disease, development and the rule that changes, classify according to the original new drug system, formation is monarch with " the five internal organs basic function is adjusted; equilibrium between yin and yang coordination side ", " the main pathogenesis of the five internal organs adjustment side " is minister, " therapy of serious disease side " is assistant, " clinical fundamental symptoms symptomatic treatment side " Chinese medicine patent medicine " original new drug system " for making.This is the important content of Thailand one and Pu (Beijing) Chinese medicine academy patent strategy.
The structure of Thailand one and Pu patent strategy is convenient to Chinese medicine and is realized standardization, scale, industrialization, modernization and industrialization.For traditional Chinese medicine development has been opened up a road that meets the Chinese medicine self-law with innovation.The used herbal raw material medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: for oral administration: 1) capsule: obey 2～5 every day three times at every turn, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The treatment that the present invention is directed to the nephrotic syndrome patient is very effective, various crude drug are coordinated mutually can play together and are at utmost brought into play drug effect, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never are limited to the present invention.
The preparation of [embodiment 1] capsule
Take by weighing each raw material by following weight portion: Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 grams.
Grind into after each component mixing with above-mentioned weight and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each raw material by following weight portion: Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 grams.
Each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
The preparation of [embodiment 3] tablet
Take by weighing each raw material according to following weight portion: Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 grams.
Each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
The preparation of [embodiment 4] pill
Take by weighing each raw material according to following weight portion: Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 grams.
Each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material according to following weight portion: Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 grams.
Each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into rule
Fixed concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
[experimental example] traditional Chinese medicine composition for treating nephrotic syndrome of the present invention patient's clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 139 routine patients altogether, wherein male 83 examples, women 56 examples; The oldest person 77 years old, the age reckling has only 5 years old.
Therapeutic Method:
Usage and dosage: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: obey 2～5 every day three times at every turn, and every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats for 9 courses of treatment altogether.
The therapeutic evaluation standard
Cure: on inspection: albuminuria, hypoalbuminemia, hematuria are normal fully, and edema disappears, and is in high spirits, antisecosis, and the normal or significantly increase of appetite, symptoms such as insomnia forgetfulness, hypomnesis are normal substantially.
Produce effects: on inspection: albuminuria, hypoalbuminemia, hematuria are near normal, and edema disappears, and is in high spirits, antisecosis, and appetite increases, and symptoms such as insomnia forgetfulness, hypomnesis are significantly recovered.
Effectively: on inspection: albuminuria, hypoalbuminemia, hematuria are obviously improved, and edema disappears substantially, and spirit takes a turn for the better, and health is stronger, and appetite increases, doing well,improvings such as insomnia forgetfulness, hypomnesis.
Invalid: index no change or change not obviously, sign does not have change substantially, symptom basic as before.
Model case:
1, Wu, man, 27 years old, workman.
It is surplus to suffer from nephrotic syndrome 4 years, through the treatment stable disease.Flu back recurrence before half a year, urine protein (++ ++) at that time, the height edema is in hospital with Drug therapys such as prednisones, and the state of an illness takes a turn for the better gradually, and urine protein is turned out cloudy, and edema fades.But knock-on appears in 15 milligram hours next day that prednisone reduces to, urine protein (++ ++), ask tcm diagnosis and treatment then.It is red and impractical to examine meeting, and the whole body is weak, the soreness of waist, yellowish urine.Tongue is dark red, and tongue is greasy in vain, stringy and rolling pulse.Routine urinalysis: albumen (+++), 5～7 of leukocyte.Took Chinese medicine composition of the present invention 1 month, during flu 1 time, stable disease is withdrawn prednisone, it is surplus March to take Chinese medicine composition of the present invention again, above-mentioned symptom disappears, urine examination feminine gender, stable disease.
2, congratulate certain, man, 18 years old, student.
Began to suffer from nephrotic syndrome in 2 years old.Each flu then disease recurs and increases the weight of, and very then the whole body serious edema must increase the weight of hormone dosage, takes the Chinese medicine of relieving the exterior syndrome by diaphoresis simultaneously orally, and the state of an illness could be alleviated.When the state of an illness is steady, then take LIUWEI DIHUANG WAN and JINGUI SHENQI WAN Zhi Qiben.Can be still poor because of child's resistance, only obey coldrex, be difficult to adhere to, so that the state of an illness is touching does not heal, not the clothes coldrexs for many years, promptly be the clothes prednisones.Take Chinese medicine composition of the present invention after 1 month, symptom is significantly improved, and it is surplus May to take Chinese medicine composition of the present invention again, and above-mentioned symptom disappears, during catch a cold 3 times, stable disease is followed up a case by regular visits to and is not had recurrence so far.
3, fur coat, man, 7 years old.
Intend examining nephrotic syndrome companion chronic renal insufficiency through certain hospital, the February of being in hospital is surplus, repeatedly through various western medicines, fail to produce effects, school has fallen ill to endanger and has notified patient's pale complexion when examining, the manner rope that disappears, anasarca, enlarged abdomen such as drum, breast is born high prominent, and the scrotum enlargement is bright, under the stool drop difficulty, faint and thready pulse wild, corpulent tongue, pale tongue, greasy fur neatly.Take Chinese medicine composition of the present invention after 15 days, hydrouria, edema subtracts greatly, and scrotum is swollen to move back to the greatest extent substantially, and expression is active, and thready pulse has god, and it is surplus March to take Chinese medicine composition of the present invention again, and all diseases disappear entirely, and health check-up is chemically examined all in normal range, follows up a case by regular visits to not recurrence in 2 years.
4, poplar, woman, 21 years old, student.
No obvious inducement before 2 years, and eyelid and edema of pair of lower extremities occur, and albuminuria http://www.sjzsbyy.com/danbain fourth, low molecular heparin calcium occur " etc. behind the symptomatic treatment, remission.But before one month, do not have obvious inducement, and eyes eyelid moderate edema appears once more, two lower limb refer to the concavity edema, lassitude, diet, the sleep inequality.Take Chinese medicine composition of the present invention after 20 days, symptom is significantly improved, and it is surplus March to take Chinese medicine composition of the present invention again, and above-mentioned symptom all disappears, stable disease.
5, the week certain, man, 5 years old.
Anasarca appears in patient's no obvious inducement before 1 year, does albumen 2+ have urine examined? +, be diagnosed as " acute nephritis ", mainly use the hormone symptomatic treatment, edema disappears after 10 days, and urine protein is turned out cloudy.But after going home three days, because anasarca appears again in hyperkinesia.So father and mother are sent to hospital again, the albumen 3+ that has urine examined is diagnosed as " nephrotic syndrome " specifically, and hospital gives him oral prednisone sheet, and urine protein is turned out cloudy after ten days, leaves hospital after 20 days.Soon, not only the state of an illness is offended again, and edema increases the weight of after taking hormone after leaving hospital, and flu is generated heat always, behind examination in hospital, show, urine protein (+++).Take Chinese medicine composition of the present invention after 20 days, the state of an illness takes a favorable turn, and it is surplus March to take Chinese medicine composition of the present invention again, and the infant mental status is good, urine protein (-), and above-mentioned symptom all disappears, stable disease, not recurrence.
6, Wang, woman, 60 years old, retired cadre.
The patient is after once " flu http://www.aliyiyao.com/topic/nkjb/hxxtjb/gm/ " before half a year, facial area and electrograph inspection occurring shows no obvious abnormalities, the bat rabat shows: both sides hydrothorax http://www.aliyiyao.com/topic/nkjb/hxxtjb/xq changes the place of examination in Urology Department, albumen (++ ++) has urine examined, albumin 13g/l, triglyceride and T-CHOL raise, give 50 milliliters of hormones, day once, play decoction being taken at a draught morning, and cooperate symptomatic treatment such as infection anticoagulant, the edema degree alleviates, but do not disappear fully, and patient's ascites is obvious.Take Chinese medicine composition of the present invention after 20 days, face and edema of pair of lower extremities disappear, and nervous sense uncomfortable in chest disappears, and it is surplus February to take Chinese medicine composition of the present invention again, and it is normal that every index is all recovered.
7, Lee, woman, 40 years old, cadre.
The patient in calendar year 2001 because upper respiratory tract infection causes morbidity, and beginning is malaise, the soreness of waist, face and edema of pair of lower extremities, edema was very serious from head to foot afterwards, also edema of eyes macular area when the most serious, urine protein (++ ++).Hospital is diagnosed as the refractory type nephrotic syndrome of healing, and is in hospital and does not feel any better half a year.The back is with the treatment of a large amount of hormones and cyclophosphamide, and albumen drops to (++), but side effect is big, after change and register the department of Chinese medicine, remove hormone while taking traditional Chinese medicine, it is many to treat half a year, albumen is (++) all the time.Take Chinese medicine composition of the present invention after 1 month, albumen begins to descend, stable disease, and take a turn for the better gradually, it is surplus April to take Chinese medicine composition of the present invention again, and thoroughly recovery from illness is resumed work, and is fine always so far.
8, Zhang, man, 24 years old, driver.
Patient 2000 is because of eyelid and facial little edema, to the chemical examination of local hospital, routine urinalysis albumen (++ ++), granular cast (++) is not felt any better behind the symptomatic treatment, for a long time and ascites is even more serious, after used a large amount of prednisones, urine routine test albumen (++ ++), granular cast (+++), after use cyclophosphamide again, still be not clearly better.Examine constantly that patient's hair almost takes off light, " moon face ", " buffalo hump " abdominal tympanites.Take Chinese medicine composition of the present invention after 1 month, edema disappears entirely, takes Chinese medicine composition of the present invention again 2 months, patient has changed a people, and symptom greatly takes a turn for the better, continuous clothes Chinese medicine composition of the present invention 6 months, every laboratory indexes all recovers normally now to marry, still in further paying a return visit.
Five, therapeutic outcome:
In the 139 routine cases of being accepted for medical treatment,, wherein cure 72 examples through treatment in 9 months, produce effects 38 examples, effective 25 examples, invalid 4 examples, total effective rate reaches 97%.The result shows that Chinese medicine composition of the present invention has extremely significant curative effect to treatment nephrotic syndrome patient.
Claims (7)
1. Chinese medicine composition for the treatment of nephrotic syndrome is characterized in that: mainly contain following bulk drugs and form:
Radix Panacis Quinquefolii 1～20 gram, the person 1～30 gram, Radix Codonopsis 1～50 gram, Radix Astragali 1～50 gram, Ganoderma 1～30 gram, Radix Angelicae Sinensis 1～50 gram, the Radix Paeoniae Alba 1～50 gram, RHIIZOMA DIOSCOREAE frOm Henan of China 1～50 gram, Carapax Trionycis 1～30 gram, Carapax et Plastrum Testudinis～30 grams, Cornu Cervi Degelatinatum 1～30 gram, Radix Rehmanniae 1～40 gram, Fructus Lycii 1～40 gram, Radix Trichosanthis 1～40 gram, Fructus Schisandrae Chinensis 1～40 gram, Semen Cuscutae 1～30 gram, Herba Cistanches 1～40 gram, Cordyceps 1～30 gram, Radix Rehmanniae Preparata 1～40 gram, Radix Polygoni Multiflori 1～40 gram, Massa Medicata Fermentata 1～50 gram, Fructus Hordei Germinatus 1～40 gram, Semen Arecae 1～40 gram, Fructus Ligustri Lucidi 1～30 gram, Pericarpium Citri Reticulatae 1～50 gram, Rhizoma Cyperi 1～40 gram, Semen Myristicae 1～30 gram, Fructus Amomi 1～30 gram, Endothelium Corneum Gigeriae Galli 1～30 gram, Semen Euryales 1～40 gram.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that: the weight portion of each crude drug is:
Radix Panacis Quinquefolii 6 grams, the person 10 grams, Radix Codonopsis 20 grams, Radix Astragali 30 grams, Ganoderma 10 grams, Radix Angelicae Sinensis 30 grams, the Radix Paeoniae Alba 30 grams, RHIIZOMA DIOSCOREAE frOm Henan of China 30 grams, Carapax Trionycis 10 grams, Carapax et Plastrum Testudinis 10 grams, Cornu Cervi Degelatinatum 10 grams, Radix Rehmanniae 15 grams, Fructus Lycii 20 grams, Radix Trichosanthis 20 grams, Fructus Schisandrae Chinensis 20 grams, Semen Cuscutae 15 grams, Herba Cistanches 10 grams, Cordyceps 10 grams, Radix Rehmanniae Preparata 15 grams, Radix Polygoni Multiflori 20 grams, Massa Medicata Fermentata 30 grams, Fructus Hordei Germinatus 20 grams, Semen Arecae 15 grams, Fructus Ligustri Lucidi 15 grams, Pericarpium Citri Reticulatae 30 grams, Rhizoma Cyperi 30 grams, Semen Myristicae 20 grams, Fructus Amomi 15 grams, Endothelium Corneum Gigeriae Galli 15 grams, Semen Euryales 20 grams.
3. according to the described Chinese medicine composition of claim 1, wherein crude drug also has:
Semen Ziziphi Spinosae 1～30 gram, Semen Raphani 1～30 gram, Fructus Crataegi 1～30 gram, Cortex Magnoliae Officinalis 1～30 gram, Fructus Chebulae's 1～30 gram, Fructus Mume 1～40 gram, Fructus Rosae Laevigatae 1～30 gram, Fructus Alpiniae Oxyphyllae 1～30 gram, Ootheca Mantidis 1～30 gram, Endoconcha Sepiae 1～30 gram, Concha Ostreae 1～30 gram, Rhizoma Drynariae 1～30 gram, Fructus Corni 1～40 gram, Cortex Lycii 1～50 gram, Cortex Phellodendri 1～40 gram, Fructus Gardeniae 1～30 gram, Radix Adenophorae (Radix Glehniae) 1～40 gram, Herba Dendrobii 1～40 gram, Rhizoma Polygonati Odorati 1～40 gram, the Rhizoma Atractylodis Macrocephalae 1～40 gram, Radix Asparagi 1～40 gram, Radix Ophiopogonis 1～40 gram, Herba Epimedii 1～30 gram, Radix Morindae Officinalis 1～30 gram, the Rhizoma Anemarrhenae 1～30 gram, Radix Puerariae 1～50 gram.
4. according to the described Chinese medicine composition of claim 3, wherein the weight portion of each component is:
Semen Ziziphi Spinosae 12 gram, Semen Raphani 20 grams, Fructus Crataegi 15 grams, Cortex Magnoliae Officinalis 20 grams, Fructus Chebulae's 15 grams, Fructus Mume 20 grams, Fructus Rosae Laevigatae 15 grams, Fructus Alpiniae Oxyphyllae 20 grams, Ootheca Mantidis 15 grams, Endoconcha Sepiae 15 grams, Concha Ostreae 15 grams, Rhizoma Drynariae 15 grams, Fructus Corni 15 grams, Cortex Lycii 30 grams, Cortex Phellodendri 20 grams, Fructus Gardeniae 20 grams, Radix Adenophorae (Radix Glehniae) 15 grams, Herba Dendrobii 15 grams, Rhizoma Polygonati Odorati 15 grams, the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Herba Epimedii 15 grams, Radix Morindae Officinalis 15 grams, the Rhizoma Anemarrhenae 15 grams, Radix Puerariae 30 gram.
5. according to claim 1,2,3 or 4 described any Chinese medicine compositions, it is characterized in that: can be prepared into any oral formulations commonly used according to the method for Chinese medicinal of routine.
6. according to the described Chinese medicine composition of claim 5, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
7. the application of the described any Chinese medicine composition of claim 1～6 in preparation treatment nephrotic syndrome medicine.
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