CN103191293A - Sub-health-preventive drug composition and preparation method thereof - Google Patents
Sub-health-preventive drug composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to medical supplies, and particularly relates to a sub-health-preventive drug composition. The drug comprises effective components and pharmaceutically acceptable auxiliary materials, and is characterized in that the effective components are water extract prepared by the following ingredients in percentage by weight: 18-23% of gensing, 13-18% of radix rehmanniae preparata, 9-16% of radix bupleuri, 8-13% of rhizome dioscoreae, 8-10% of prepared fructus corni, 6-9% of radix scutellariae, 5-8% of fructus schizandrae, 6-9% of cortex moutan radicis, and 3-4% of prepared radix licorice. The drug composition has the advantages of tonifying kidney and regulating the liver, tonifying qi and yin, being simple in drugs and specific in power, and obvious in sub-health prevention effect.
Description
Invention field
The present invention relates to a kind of medical configuration product, specifically be a kind of be the medical configuration product of raw material with the plant.
Background technology
Subhealth state refers to that human body is in the intermediateness between health and the disease, shows as degradation under the reduction of body vigor, hypofunction, the adaptive capacity.According to statistics, there is 60～70% crowd to be in sub-health state in China.The ubiquity of subhealth state, serious harm people's health, influenced the harmonious development of national economy and society.Fatigue is the combined reaction that multiple Physiology and biochemistry changes in the body, can influence people's quality of life to some extent.Previously document shows that tired incidence rate in sub-health population is higher, and fatigue is one of main clinic symptoms of subhealth state, is to cause subhealth state that a key factor of development takes place, and correcting fatigue early is the measure of effective intervening sub-health.At present, not clear and definite fully as yet for the mechanism of sub-health state, modern medicine does not also have the better prevention way to it.The tradition Chinese medicine has mass foundation widely in China, the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science, preventive treatment of disease thought and pay attention to health preserving shown sufficient advantage in the prevention of subhealth state and treatment.Because the incidence rate of sub-health state is very high, this just requires must be popular to its means of prevention and method, to satisfy numerous sub-health population demand.And traditional differentiation of tcm must be finished under Chinese physician's guidance, and this has brought many difficulties for the control of subhealth state.Therefore, seek a kind of can bring into play tcm characteristic again the popular subhealth state method of preventing and treating be desirability.
Why the medicine of preventing and treating subhealth state is not easy to succeed in developing, and main reason is to cause the cause of disease of subhealth state also can't be identified.Modern medicine adopts anti symptom treatment more, and the Therapeutic Method of fatigue is mainly contained: 1. cognitive-behavioral therapy; 2. the symptomatic therapy of using hormone, antidepressants, somnifacient, analgesics etc. alleviates clinical symptoms; 3. give vitamin and coenzyme Q10 etc. with supporting treatment.But above method clinical data is less, and concrete curative effect still can not be clear and definite fully, and side effect is bigger.
The paper of Lian Donghui (Lian Donghui. LIUWEI DIHUANG WAN adds flavor treatment subhealth state syndrome of deficiency of kidney yin 60 routine .[J]. the Henan traditional Chinese medical science, 2011,31 (8): 930-931.) mention subhealth state syndrome of deficiency of kidney yin patient is adopted Radix Rehmanniae Preparata, Fructus Corni (formal name used at school is Fructus Corni), Rhizoma Dioscoreae, Cortex Moutan, Rhizoma Alismatis, Poria, the Rhizoma Anemarrhenae, Cortex Phellodendri, Semen Ziziphi Spinosae, Radix Codonopsis, good efficacy is received in Radix Angelicae Sinensis compatibility treatment (according to the drug ratios Radix Rehmanniae Preparata: Fructus Corni: Rhizoma Dioscoreae: Cortex Moutan: Rhizoma Alismatis: Poria: the Rhizoma Anemarrhenae: Cortex Phellodendri: Semen Ziziphi Spinosae: Radix Codonopsis: Radix Angelicae Sinensis takes by weighing with the 8:4:4:3:3:3:3:3:4:4:4 ratio), and test group deficiency of the kidney yin symptom is obviously improved.But should the side tonifying kidney-yin partially, the power of QI invigorating a little less than, no soothing the liver effect, and the fatigability subhealth state stagnation of liver-QI of suffering from a deficiency of the kidney, QI and blood is not normal to be its basic pathogenesis, so the medicine of the soothing the liver QI invigorating of the kidney invigorating seems particularly important.
The patent of invention (publication number is CN101181514) of a kind of " improving the Chinese medicine health care product that sub-health status promotes immunologic function " that innings Granted publication has been known by state, these health product by Radix Angelicae Sinensis, the Radix Paeoniae Alba, Poria, Radix Bupleuri, Rhizoma Atractylodis, Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae, Fructus Corni (formal name used at school is Fructus Corni), Fructus Schisandrae Chinensis, Fructus Crataegi, the Cortex Eucommiae, Radix Ophiopogonis, Radix Platycodonis, Fructus Aurantii Immaturus totally 15 kinds of Chinese medicines form.Above-mentioned Chinese medicine health care product has the effect of element culturing fixed folder, beneficial heart the kidney invigorating, soothing the liver smooth will.Treat sub-health status crowd 260 examples clinically, total effective rate 98%.But raw material such as Radix Ginseng is comparatively famous and precious in this Chinese medicine health care product, and kidney-reinforcing drug is less, the power of the kidney invigorating a little less than, and medicine is more, is unfavorable for applying.
Summary of the invention
Technical problem to be solved by this invention provides a kind of pharmaceutical composition of preventing and treating subhealth state, and liver is transferred in this pharmaceutical composition the kidney invigorating, supplementing QI and nourishing YIN, and medicine letter power is special, and the effect for the treatment of subhealth state is remarkable.
The technical scheme that the present invention addresses the above problem is:
A kind of pharmaceutical composition of preventing and treating subhealth state, this medicine is made up of effective ingredient and acceptable accessories, it is characterized in that, described effective ingredient is the water extract that following percentage by weight crude drug is made: Radix Codonopsis 18%～23%, Radix Rehmanniae Preparata 13～18%, Radix Bupleuri 9～16%, Rhizoma Dioscoreae 8～13%, Fructus Corni (processed) 8～10%, Radix Ophiopogonis 6～9%, Radix Scutellariae 6～9%, Fructus Schisandrae Chinensis 5～8%, Cortex Moutan 6～9%, Radix Glycyrrhizae Preparata 3～4%.
The best proportioning of crude drug described in the aforementioned pharmaceutical compositions is: Radix Codonopsis 20%, Radix Rehmanniae Preparata 15%, Radix Bupleuri 10%, Rhizoma Dioscoreae 10%, Fructus Corni (processed) 10%, Radix Ophiopogonis 8%, Radix Scutellariae 8%, Fructus Schisandrae Chinensis 7%, Cortex Moutan 8%, Radix Glycyrrhizae Preparata 4%.
Pharmaceutical composition of the present invention, wherein said effective ingredient is made by following method:
Get crude drug with water extraction 2～4 times by proportioning, add 8～12 times of decoctings at every turn and boil 1～3h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.10～1.50 extractum and get final product.
Above-mentioned extractum adds acceptable accessories method routinely can cause various solid orally ingestibles, as granule, tablet or capsule.
Pharmaceutical composition of the present invention by Radix Codonopsis, Rhizoma Dioscoreae, Radix Rehmanniae Preparata, Fructus Corni (processed), Radix Bupleuri, Radix Scutellariae, Radix Ophiopogonis, Cortex Moutan, Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata totally ten the flavor Chinese medicines form, Radix Codonopsis spleen reinforcing lung qi wherein, promote the production of body fluid, the Radix Rehmanniae Preparata enriching yin and nourishing kidney, life essence-filling, marrow-benefitting, Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, the three share, liver is transferred in the kidney invigorating, and supplementing QI and nourishing YIN is monarch drug; The Rhizoma Dioscoreae reinforcing both QI and YIN, the flat three warmers of mending, the Fructus Corni (processed) liver and kidney tonifying is restrained astringent or styptic treatment for spontaneous sweating, with the Radix Rehmanniae Preparata compatibility, be the meaning of " three mend ", replenishing YIN and removing heat Radix Ophiopogonis, trimethyl gallic acid temperature yin fluid astringing, the two and Radix Codonopsis share the meaning into " SHENGMAI SAN ", supplementing QI for promoting the production of body fluid, and this five medicines compatibility is ministerial drug; Assistant is removed hot and suffocating, deficiency-heat with Cortex Moutan, Radix Scutellariae clearing away heat and cooling blood, dampness, not only Radix Scutellariae and Radix Bupleuri but also be the meaning of " little Radix Bupleuri "; The spleen reinforcing of Radix Glycyrrhizae Preparata QI invigorating, coordinating the actions of various ingredients in a prescription is for making medicine.Ten flavor medicines cooperations play the kidney invigorating altogether and transfer liver, supplementing QI and nourishing YIN.The inventor is through years of researches and practice summary, find that subhealth state fatigue symptom and traditional Chinese medical science QI and blood are not normal, the symptom of the stagnation of liver-QI of suffering from a deficiency of the kidney is similar, therefore, this pharmaceutical composition is the pathogeny according to pathogenesis and the modern medicine of subhealth state fatigue, according to the dialectical of the traditional Chinese medical science and logos prescription, make the medicine that effectively prevents subhealth state fatigue with modern pharmaceutical technology, can effectively improve the tired spiritlessness and weakness that occurs of subhealth state through zoopery and clinical case contrast proof, the lazyness of breathing hard speech, poor appetite abdominal distention, soreness of the waist and knees; dribbling urination; impotence and premature ejaculation; symptoms such as it is uncomfortable to defecate.Prepare the used medical material of pharmaceutical composition of the present invention and be common medical material, moderate cost, material is easy to get, and preparation technology is simple, is suitable for industrialization production.
To prove the technique effect that the present invention has by zoopery and clinical trial below.
1, pharmacodynamic experiment
For checking medicine of the present invention in the pharmacological action that prevents and treats aspect the subhealth state, for its clinical use provides scientific basis, the spy carries out following pharmacodynamic experiment.The tired rat model of the subhealth state of this seminar invention is adopted in this experiment, detects according to the main fatigue symptom of subhealth state, mobility decline and relevant physiochemical indice.
1.1 experiment material
1.1.1 experimental subject
4 age in week male SPF level kunming mice (medical animal experiment center, Guangdong Province provides, the quality certification number: Guangdong probatio inspectionem pecuoarem word the 2008th～0002) 130, body weight 18～22g.
1.1.2 experiment condition
Cleaning level Animal House, temperature is (22～26 ℃), relative humidity 40～60%, light and shade replaces 12h.Whole mice adaptabilities are fed 7d before the experiment, and all mice sub-cage rearings, are freely drunk water the standard feed free choice feeding by 5/cage.
1.1.3 main experimental instrument and equipment
1,120cm * 60cm * 60cm case of swimming; 2, stopwatch; 3, eppendorf micropipettor; 4, Sigma freezing centrifuge; 5, Olympas AU800 automatic clinical chemistry analyzer.
1.1.4 be subjected to the reagent product
Prepared scattered seed agent (by embodiment 1 prescription and method preparation) is made into desired concn with distilled water, shakes all back uses.
1.2 experimental technique
1.2.1 experiment grouping
The preposition mice of experiment beginning is in swimming case adaptability swimming instruction 4d, 5min/d, 24 ± 2 ℃ of water temperatures.The 1d fasting is weighed before the experiment, and mice bear 7% body constitution measures one's own ability and exhaust swimming, records swimming time, and rejecting power exhausts the mice that swimming time and body constitution amount differ greatly.Filter out 100 kunming mices at last and experimentize, getting wherein, 50 mices carry out degree of fatigue mensuration, remaining 50 mouse assay blood urea nitrogen and lactic acid.Experiment is divided into 5 groups: normal control group, the tired model group of subhealth state, experimental group 1, experimental group 2, experimental group 3,10 every group.
Experimental group 1: take off the granule of stating embodiment 1, distilled water is used in adding, shakes up, and is made into to be equivalent to the aqueous solution that 1ml contains the prepared extractum 130mg of crude drug.
Experimental group 2: take off the granule of stating embodiment 4, distilled water is used in adding, shakes up, and is made into to be equivalent to the aqueous solution that 1ml contains the prepared extractum 130mg of crude drug.
Experimental group 3: take off the granule of stating embodiment 5, distilled water is used in adding, shakes up, and is made into to be equivalent to the aqueous solution that 1ml contains the prepared extractum 130mg of crude drug.
Except the normal control group was left intact, all the other each groups adopt forced the 8h that stands in mice water every day, and 9d prepares fatigability subhealth state model continuously.Concrete grammar: the morning every day 9:00, it is that the mice of 0.8cm is raised the box modeling that each group mice is put into the depth of water, that afternoon, 17:00 took out it from the water box, the normal raising.
Normal control group and model group normal diet do not give pharmaceutical intervention.Experimental group 1, experimental group 2, experimental group 3: irritate stomach every day 1 time, irritating stomach dosage is 1g/Kg.9d surveys mice power and exhausts swimming time.
1.2.3 observation index mice power exhausts swimming time; Serum ALT, AST, BUN.Power exhausts the swimming standard: the mice nose does not have the continuous 10s of upstream face.
1.2.4 data statistics utilizes SPSS13.0 software to carry out data statistic analysis, the result is with mean ± standard deviation
Expression, the result carries out significance analysis, significant difference P＜0.05 with the independent sample t check.
1.3 result
1.3.1 the general situation of mice
Normal control group mice is vivaciously active, and fur is bright and clean neat, and eyes have god, and to the food sensitivity, escape reaction is fast.
Model group mice expression is cold, has a weary expression, and expression in the eyes is intense darkness without light, hypotrichosis, and build is thin and weak, and the escape reaction ability obviously reduces, and is insensitive to food.
Medicine group expression of the present invention peace and quiet, more active, build is moderate, and fur is bright and clean, and escape reaction is very fast, and is responsive to food.Each organizes the improvement of mice fatigue symptom dose-effect relationship, is specially low dose group＜middle dosage group＜high dose group.
1.3.2 swimming attitude
Model group mice strokes is inharmonious, and rectilinear motion is less, and is floating more, easily drowned.Medicine group mice strokes of the present invention is coordinated, and rectilinear motion is many, is difficult for drowned.
1.3.3 mice power exhausts the swimming time result
Compare with model group, medicine group power exhausts swimming time significant prolongation (P＜0.05), and the power of pointing out medicine of the present invention can significantly improve mice exhausts swimming time.Mice power exhausts the swimming time odds ratio, drug study group 1 of the present invention, experimental group 2, experimental group 3 no difference of science of statistics (P〉0.05).(seeing Table 2～1) prompting medicine of the present invention can prevent the generation of mice fatigue type sub-health.
Table 2～1 9d mice power exhausts swimming time
Annotate: P＜0.05
1.3.4 mice blood urea nitrogen and lactate level are respectively organized in experiment
Compare with the normal control group, model group mice blood lactic acid and urea nitrogen levels do not have remarkable change (P〉0.05), point out this modeling method that mice blood lactic acid and urea nitrogen levels are not had obvious influence.Compare with model group, drug study group 1 of the present invention, experimental group 2, experimental group 3 mices swimming back blood urea nitrogen and lactate level significantly reduce (P＜0.05).(seeing Table 2～2)
Mice lactic acid and urea nitrogen levels are respectively organized in table 2～2 experiments
Annotate: P＜0.05
1.4 conclusion
This experimental result shows that medicine of the present invention can significantly improve the fatigue symptom of the tired mice of subhealth state and reduce the removing of the tired metabolite of blood, and the effect of anti-subhealth state is preferably arranged.
2 clinical trials
2.1 case is selected
Selected case derives from Guangzhou Nanfang Hospital and is in hospital and the outpatient.Meet subhealth state Chinese and western medicine diagnosis and differential diagnosis in tcm standard, the age was 18～60 years old patient.There are no significant (P ﹥ 0.05) for difference at aspects such as sex, age, cause of disease formation, TCM Syndrome Type distribution, the distributions of traditional Chinese medical science disease before the patient, shows that harmony better has comparability between group.And meet following condition: (1) sanity, can partner treatment; (2) no serious organic disease and spirit, nervous system disease; (3) without infectious disease psychosis and poisoning disease.Biometrics system of Nanfang Medical Univ bears the center at random and data management.According to including in/exclusion standard, according to patient's informed consent principle, 150 routine patients are divided into 5 groups at random, each group is observed 30 examples.
2.2 the diagnostic criteria of sub-health state:
Conversion according to questionnaire " subhealth state rating scale " score divides evaluation:
Man＜40 years old 54 minutes≤transform and divided＜79 fens, is judged to be sub-health state;
Man 〉=40 years old 55 minutes≤transform and divided＜80 fens, is judged to be sub-health state;
The woman 54 minutes≤transform and divided＜78 fens, is judged to be sub-health state.
2.3 Therapeutic Method
Matched group 1: be the disclosed Chinese medicine health care product of application for a patent for invention of CN101181514 by publication number, concrete prescription is: Radix Angelicae Sinensis 15g, Radix Paeoniae Alba 20g, Poria 15g, Radix Bupleuri 15g, Rhizoma Atractylodis 10g, Radix Ginseng 12g, Radix Astragali 15g, Rhizoma Dioscoreae 25g, Fructus Corni 15g, Fructus Schisandrae Chinensis 12g, Fructus Crataegi 20g, Cortex Eucommiae 15g, Radix Ophiopogonis 15g, Radix Platycodonis 12g, Fructus Aurantii Immaturus 12g.Concrete preparation method is the 7th page of capable described method of 11-12 of this patent application specification.Instructions of taking: every day 3 times, each 10g.
Matched group 2: by connecting the described prescription of drafting of eastern brightness paper be: Radix Rehmanniae Preparata 24g, Fructus Corni 12g, Rhizoma Dioscoreae 12g, Cortex Moutan 9g, Rhizoma Alismatis 9g, Poria 9g, Rhizoma Anemarrhenae 9g, Cortex Phellodendri 9g, Semen Ziziphi Spinosae 12g, Radix Codonopsis 12g, Radix Angelicae Sinensis 12g.Preparation method is identical with following embodiment 1.Warm boiled water, is respectively obeyed the 10g(1 parcel at 19 o'clock at every day 2 times every day 7).
Treatment group 1: the oral medicine for preparing according to the method for embodiment 1, warm boiled water, is respectively obeyed the 10g(1 parcel at 19 o'clock at every day 2 times every day 7).
Treatment group 2: the oral medicine for preparing according to the method for embodiment 4, warm boiled water, is respectively obeyed the 10g(1 parcel at 19 o'clock at every day 2 times every day 7).
Treatment group 3: the oral medicine for preparing according to the method for embodiment 5, warm boiled water, is respectively obeyed the 10g(1 parcel at 19 o'clock at every day 2 times every day 7).
5 groups of treatments are 3 months the course for the treatment of.
2.3 evaluation index
1. clinical efficacy evaluation criteria
Recovery from illness: cardinal symptom disappears, and it is normal that sexual life recovers, and the doing well,improving rate is more than 95%; Produce effects: cardinal symptom significantly alleviates, and the doing well,improving rate is between 94%～60%, and sign is obviously improved; Effectively: cardinal symptom and minor symptom and sign make moderate progress, and the doing well,improving rate is between 59%～30%; Invalid: symptom does not have obvious improvement before and after the medication, doing well,improving rate less than 30%, and every index does not all have improvement.
2. fatigue assessment scale score
2.4 result
(1) respectively organizes clinical efficacy relatively
Compare with matched group 2, the clinical efficacy effective percentage of each treatment group all has significant difference.Compare with treatment group 1, the clinical efficacy effective percentage for the treatment of group 3 is less than treatment group 1, and difference has statistical significance.Clinical trial shows that medicine of the present invention is effectively tired to subhealth state, and curative effect is better than matched group.(seeing Table 1)
Table 1 treatment group and matched group curative effect are relatively
Annotate: learn by statistics and handle, treatment group curative effect is better than matched group (P＜0.05)
(2) two groups of fatigue assessment scale integrations relatively
Treating preceding 5 groups of fatigue assessment scale integrations does not relatively have significant difference (P〉0.05), and each treatment group fatigue assessment scale integration decline degree for the treatment of back is compared with matched group 2, and difference has significant difference (P＜0.01); Compare with treatment group 1, treatment is organized 3 integration decline degree less than treatment group 1, and difference has significant difference (P＜0.05).Prompting your pupil hexamer can improve the fatigue state of sub-health population.
Table 2 treatment group and matched group fatigue assessment scale integration are relatively
Annotate: learn by statistics and handle, treatment group curative effect is better than matched group (P＜0.05)
2.5 conclusion
Medicine of the present invention has the kidney invigorating and transfers liver, the effect of supplementing QI and nourishing YIN, the clinical common liver energy stagnation type subhealth state of suffering from a deficiency of the kidney had good therapeutic effect, as seen this Drug therapy subhealth state determined curative effect, and do not find that this product has obvious toxic-side effects to heart, liver and gastrointestinal tract, use safety, taking convenience.
The specific embodiment
Example 1: granule
The prescription: Radix Codonopsis 30g, Radix Rehmanniae Preparata 20g, Radix Bupleuri 15g, Rhizoma Dioscoreae 15g, Fructus Corni (processed) 15g, Radix Ophiopogonis 12g, Radix Scutellariae 12g, Fructus Schisandrae Chinensis 10g, Cortex Moutan 12g, Radix Glycyrrhizae Preparata 5g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 3h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.50 extractum, add earlier 4 times dextrin by weight, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and got dry powder, added 2 times Icing Sugar more by weight, made wetting agent soft material processed with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.
Instructions of taking: each 10g, every day 2 times, warm boiled water.
Example 2: tablet
The prescription: Radix Codonopsis 25g, Radix Rehmanniae Preparata 21g, Radix Bupleuri 22g, Rhizoma Dioscoreae 21g, Fructus Corni (processed) 17g, Radix Ophiopogonis 11g, Radix Scutellariae 9g, Fructus Schisandrae Chinensis 6g, Cortex Moutan 9g, Radix Glycyrrhizae Preparata 5g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 12 times of decoctings at every turn and boil 1h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.49 extractum, add 4 times dextrin by weight, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and got dry powder, added 2 times Icing Sugar more by weight, made wetting agent soft material processed with 95% ethanol, crossing 16 mesh sieves granulates, drying, the conventional method tabletting is made tablet.
Instructions of taking: each 2, every day 2 times, warm water delivery service.
Example 3: capsule
The prescription: Radix Codonopsis 24g, Radix Rehmanniae Preparata 17g, Radix Bupleuri 17g, Rhizoma Dioscoreae 17g, Fructus Corni (processed) 21g, Radix Ophiopogonis 12g, Radix Scutellariae 14g, Fructus Schisandrae Chinensis 10g, Cortex Moutan 10g, Radix Glycyrrhizae Preparata 4g.
Preparation method: get crude drug water extraction 2 times by said ratio, add 8 times of decoctings at every turn and boil 3h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.12 extractum, add earlier 4 times dextrin by weight, 80 ℃ of vacuum dryings were pulverized 65 mesh sieves and were got dry powder, added 2 times Icing Sugar more by weight, make wetting agent soft material processed with 95% ethanol, cross 16 mesh sieves and granulate drying, granulate, the gelatine capsule of packing into is made capsule.
Instructions of taking: each 3, every day 2 times, warm water delivery service.
Example 4: granule
The prescription: Radix Codonopsis 37g, Radix Rehmanniae Preparata 26g, Radix Bupleuri 18g, Rhizoma Dioscoreae 11g, Fructus Corni (processed) 13g, Radix Ophiopogonis 9g, Radix Scutellariae g, Fructus Schisandrae Chinensis 8g, Cortex Moutan 11g, Radix Glycyrrhizae Preparata 6g
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.38 extractum, add earlier 4 times dextrin by weight, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and got dry powder, added 2 times Icing Sugar more by weight, made wetting agent soft material processed with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.
Instructions of taking: each 10g, every day 2 times, warm boiled water.
Example 5: granule
The prescription: Radix Codonopsis 22g, Radix Rehmanniae Preparata 18g, Radix Bupleuri 26g, Rhizoma Dioscoreae 11g, Fructus Corni (processed) 15g, Radix Ophiopogonis 13g, Radix Scutellariae 15g, Fructus Schisandrae Chinensis 11g, Cortex Moutan 11g, Radix Glycyrrhizae Preparata 4g.
Preparation method: get crude drug water extraction 3 times by said ratio, add 10 times of decoctings at every turn and boil 2h, merge decoction liquor then, filter, at last filtrate is concentrated into relative density and is 1.38 extractum, add earlier 4 times dextrin by weight, 80 ℃ of vacuum dryings, pulverize 65 mesh sieves and got dry powder, added 2 times Icing Sugar more by weight, made wetting agent soft material processed with 95% ethanol, crossing 16 mesh sieves granulates, drying, granulate is distributed into 10 grams, one bag.Instructions of taking: each 10g, every day 3 times, warm boiled water.
Claims (4)
1. pharmaceutical composition for the treatment of subhealth state, this medicine is made up of effective ingredient and acceptable accessories, it is characterized in that, described effective ingredient is the water extract that following percentage by weight crude drug is made: Radix Codonopsis 18%～23%, Radix Rehmanniae Preparata 13～18%, Radix Bupleuri 9～16%, Rhizoma Dioscoreae 8～13%, Fructus Corni (processed) 8～10%, Radix Ophiopogonis 6～9%, Radix Scutellariae 6～9%, Fructus Schisandrae Chinensis 5～8%, Cortex Moutan 6～9%, Radix Glycyrrhizae Preparata 3～4%.
2. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 1 is characterized in that the proportioning of described crude drug is: Radix Codonopsis 20%, Radix Rehmanniae Preparata 15%, Radix Bupleuri 10%, Rhizoma Dioscoreae 10%, Fructus Corni (processed) 10%, Radix Ophiopogonis 8%, Radix Scutellariae 8%, Fructus Schisandrae Chinensis 7%, Cortex Moutan 8%, Radix Glycyrrhizae Preparata 4%.
3. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 1 and 2 is characterized in that described effective ingredient is made by following method:
Get crude drug with water extraction 2～4 times by proportioning, add 8～12 times of water at every turn, decoct 1～3h, then, merge decoction liquor, filter, at last filtrate is concentrated into relative density and is 1.10～1.50 extractum, get final product.
4. a kind of pharmaceutical composition for the treatment of subhealth state according to claim 3 is characterized in that, described pharmaceutical composition is granule, tablet or capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177208A (en) * | 2016-08-31 | 2016-12-07 | 周毅 | A kind of subhealth state that regulates causes the Chinese herbal and crude drugs preparations of insomnia agitation |
| CN106266951A (en) * | 2016-08-31 | 2017-01-04 | 周毅 | A kind of subhealth state of alleviating causes the Chinese herbal and crude drugs preparations of insomnia and dreamful sleep |
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| CN106177208A (en) * | 2016-08-31 | 2016-12-07 | 周毅 | A kind of subhealth state that regulates causes the Chinese herbal and crude drugs preparations of insomnia agitation |
| CN106266951A (en) * | 2016-08-31 | 2017-01-04 | 周毅 | A kind of subhealth state of alleviating causes the Chinese herbal and crude drugs preparations of insomnia and dreamful sleep |
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| CN103191293B (en) | 2014-12-10 |
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