CN103055098A - Freeze-dried yam for preventing and treating cancer - Google Patents
Freeze-dried yam for preventing and treating cancer Download PDFInfo
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- CN103055098A CN103055098A CN2013100088982A CN201310008898A CN103055098A CN 103055098 A CN103055098 A CN 103055098A CN 2013100088982 A CN2013100088982 A CN 2013100088982A CN 201310008898 A CN201310008898 A CN 201310008898A CN 103055098 A CN103055098 A CN 103055098A
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Abstract
The invention relates to a medicine for preventing and treating tumors by regarding freeze-dried yam as a raw material. The medicine regards freeze-dried yam as the raw material and is prepared into powders, granules, pills, tablets and capsules. The freeze-dried yam has better curative effect for preventing and treating tumors than traditionally prepared yam.
Description
Technical field
The present invention relates to medicine, particularly the lyophilizing Rhizoma Dioscoreae of a kind of prevention and treatment cancer belongs to medical technical field.
Background technology
Rhizoma Dioscoreae original name Rhizoma Dioscoreae is the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.It is a kind of common vegetable, also is important simply Chinese medicine.Shennong's Herbal put down in writing its be medicine be again the tonic good merchantable brand, in the edible history in existing more than 2000 year of China.Compendium of Material Medica record Rhizoma Dioscoreae " tonify deficiency is thin, except cold and heat pathogen, invigorating middle warmer, and physical strength profiting, longue meat, reinforcing YIN-essence takes normal hearing and eyesight for a long time, makes light of one's life by commiting suicide and prolongs life." the modern study discovery; Rhizoma Dioscoreae is except containing the compositions such as crude fibre, pectin, amylase, phlegmatic temperament, glycoprotein, allantoin, saponin, batatasins, choline, dopamine, fatty acid, polysaccharide; also contain the indispensable trace element of human body such as iodine, calcium, ferrum and phosphorus; its nutritive value, medical value and disease-resistant mechanism just progressively are found and confirm, and more and more are subject to consumers in general's favor.
The processed product of tradition Rhizoma Dioscoreae has parched with bran, parching with earth, fries, Rhizoma Dioscoreae.The report that the freezing processing method of many Rhizoma Dioscoreaes is arranged in recent years, such as patent of invention 02148599.2, with Rhizoma Dioscoreae soaking sterilization in bactericidal liquid, then after peeling, the cutting Rhizoma Dioscoreae piece is soaked color fixative again with Rhizoma Dioscoreae piece soaking sterilization in bactericidal liquid in colour-keeping liquid, then through quick-freezing, plating water glaze freezes again, manufactured goods Rhizoma Dioscoreae piece.Patent of invention 95111876.5, with fresh Rhizoma dioscoreae through cleaning, peeling, sterilization, section, freezing vacuum dehydration, quality examination, pulverize, sieve, again sterilization treatment, metering pack, sampling chemical examination, vacuum seal, packing, finished product vanning warehouse-in.Prior art is not made targetedly the medicinal effects of lyophilizing Rhizoma Dioscoreae and being summed up.
We find that lyophilizing Rhizoma Dioscoreae processed product than traditional Rhizoma Dioscoreae in many tests shows better curative effect, show better curative effect the Rhizoma Dioscoreae of concocting than tradition aspect prevention and the treatment tumor especially.
Summary of the invention
The present invention is to be the medicine that raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae.
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is directly to pulverize with the lyophilizing Rhizoma Dioscoreae, is prepared into powder, pill.
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is take the lyophilizing Rhizoma Dioscoreae as raw material, through extract at low temperature, is prepared into powder, granule, pill, tablet, capsule with extract.
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is take the lyophilizing Rhizoma Dioscoreae as raw material, and other prepared slices of Chinese crude drugs of compatibility through extract at low temperature, are prepared into powder, granule, pill, tablet, capsule with extract.
A kind of preparation method of the lyophilizing Rhizoma Dioscoreae that the present invention is above-mentioned is: get fresh Rhizoma dioscoreae, clean roguing, be placed in the cryodesiccation chamber of freeze dryer, keeping being cryodesiccation chamber's evacuation under the prerequisite of freezing, make the ice distillation in the fresh Rhizoma dioscoreae, dehydrate.
A kind of preparation method of the lyophilizing Rhizoma Dioscoreae that the present invention is above-mentioned is: new fresh Rhizoma dioscoreae, clean roguing, and be cut into the Rhizoma Dioscoreae section of length 3～15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5-8Kg/ ㎡; Solidification point is controlled between-28～-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is to make oral formulations take the lyophilizing Rhizoma Dioscoreae as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 9-50g every day, divides and takes for 2-3 time.
Below by test example usefulness of the present invention is described.
1, preparation Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae
Get Rhizoma Dioscoreae and wash, with removing yam skin, 1. Rhizoma Dioscoreae is cut into the thin slice about 3mm, put and dry in the constant temperature oven to constant weight, get the Rhizoma Dioscoreae decoction pieces; 2. be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5-8Kg/ ㎡; Solidification point is controlled between-28～-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.
2, preparation Rhizoma Dioscoreae decoction pieces extract and lyophilizing Rhizoma Dioscoreae extract
Respectively Rhizoma Dioscoreae decoction pieces and lyophilizing Rhizoma Dioscoreae powder are broken to coarse powder.Add respectively 4 times of water gagings, stir at 10 ℃ and extracted 4 hours, extracting liquid filtering, centrifugal.Get the above-mentioned centrifugal liquid freeze drying box of packing into, lyophilizing.Vacuum is-35.0Pa, and pre-freeze temperature-40 ℃ is incubated 2 hours; 40 ℃/h of first phase programming rate heated up 0.5 hour, was incubated 0.5 hour; 20 ℃/h of second phase programming rate heated up 1 hour, was incubated 5 hours; 40 ℃/h of three phase programming rates heated up 0.5 hour, was incubated 8 hours; 40 ℃/h of fourth phase programming rate heated up 0.5 hour, was incubated 6 hours.When temperature of charge and heating-up temperature near the time dry the end, get Rhizoma Dioscoreae decoction pieces extract and lyophilizing Rhizoma Dioscoreae extract.
3, tumor cell line
People's lung source adenocarcinoma cell SPCA-1, human hepatoma cell line HepG2 and people's chronic myelogenous leukemia cell K562 all draw the cell bank from pharmacological room of Shandong Academy of Medical Sciences.Use the RPMI-1640 culture fluid, 37 ℃, 5% CO
2, relative humidity 100% is cultivated, and attached cell 0.25% trypsinization goes down to posterity.
4, MTT colorimetric method for determining extract is to the inhibitory action of growth of tumour cell
The trophophase cell of taking the logarithm is mixed with cell suspension with fresh RPMI-1640 culture fluid, 0.8 * 105/ml of 1 * 105/ml of suspension cell attached cell.Suspension cell is inoculated in 96 well culture plates after adding respectively the variable concentrations Experimental agents; Attached cell is inoculated in first in 96 well culture plates, and every hole 90 μ l add respectively the variable concentrations Experimental agents behind the 24h.Final volume is that every hole 100 μ l and every group are established 3 parallel holes, establishes altogether 5 groups: be subjected to reagent group T (culture fluid+cell suspension+variable concentrations is subjected to reagent), positive controls P (culture fluid+cell suspension+variable concentrations amycin), negative control group N (culture fluid+cell suspension), medicine color matched group TC (culture fluid+variable concentrations is subjected to reagent), blank group B (culture fluid+normal saline).Tested concentration is followed successively by 12.5 μ g/ml, 25 μ g/ml, 50 μ g/ml, 100 μ g/ml, 200 μ g/ml, 400 μ g/ml doxorubicin concentration are followed successively by 0.3125 μ g/ml, 0.625 μ g/ml, 1.25 μ g/ml, 2.5 μ g/ml, 5 μ g/ml, 10 μ g/ml.Put 37 ℃, 5%CO
2After cultivating 24h, 48h, 72h, 96h in the incubator, behind every hole adding MTT solution 10 μ l concussion mixing, continue to cultivate 4h, adding SDS90 μ l stops cultivating, 37 ℃ are spent the night, then shake 10min at micro oscillator under the room temperature, microplate reader is measured the absorbance (OD value) at 570nm wavelength place, and experiment repeats 3 times.The observation of cell growth inhibition ratio.
5, the statistical procedures experimental result is all parallel from 3 groups and through 3 repeated experiments, and all experimental datas are carried out the group difference of the multifactor analysis of variance relatively through the SPSS100 software processes.Difference between check matched group and each experimental group, with P＜0.01 or P＜0.05 for statistical significance is arranged.
6, result
Rhizoma Dioscoreae decoction pieces extract acts on different cell IC50 (table 1,2,3) with the lyophilizing Rhizoma Dioscoreae extract, the result shows, the lyophilizing Rhizoma Dioscoreae extract obviously is better than Rhizoma Dioscoreae decoction pieces extract for SPCA-1, HepG2, K 562 cells at the IC50 of 24h, 48h, 72h, 96h inhibited proliferation.
Table 1 Rhizoma Dioscoreae decoction pieces extract and lyophilizing Rhizoma Dioscoreae extract act on respectively the K56 cell at the IC50 of different time (mg/ml)
| Action time | 24h | 48h | 72h | 96 |
| The lyophilizing Rhizoma Dioscoreae extract | 65.6 | 56.2 | 32.7 | 21.16 |
| Rhizoma Dioscoreae decoction pieces extract | 446.8 | 435.7 | 417.5 | 387.8 |
Table 2 Rhizoma Dioscoreae decoction pieces extract and lyophilizing Rhizoma Dioscoreae extract act on respectively the HepG2 cell at the IC50 of different time (mg/ml)
| Action time | 24h | 48h | 72h | 96 |
| The lyophilizing Rhizoma Dioscoreae extract | 244.2 | 166.0 | 106.8 | 96.6 |
| Rhizoma Dioscoreae decoction pieces extract | 379.8 | 369.5 | 342.6 | 330.7 |
Table 3 Rhizoma Dioscoreae decoction pieces extract and lyophilizing Rhizoma Dioscoreae extract act on respectively the SPCA-1 cell at the IC50 of different time (mg/ml)
| Action time | 24h | 48h | 72h | 96 |
| The lyophilizing Rhizoma Dioscoreae extract | 334.2 | 321.3 | 244.6 | 225.1 |
| Rhizoma Dioscoreae decoction pieces extract | 434.0 | 410.8 | 317.4 | 300.5 |
The specific embodiment
The present invention is to be the medicine that raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae.
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is directly to pulverize with the lyophilizing Rhizoma Dioscoreae, is prepared into powder, pill.
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is take the lyophilizing Rhizoma Dioscoreae as raw material, through extract at low temperature, is prepared into powder, granule, pill, tablet, capsule with extract.
A kind of preparation method of the lyophilizing Rhizoma Dioscoreae that the present invention is above-mentioned is: get fresh Rhizoma dioscoreae, clean roguing, be placed in the cryodesiccation chamber of freeze dryer, keeping being cryodesiccation chamber's evacuation under the prerequisite of freezing, make the ice distillation in the fresh Rhizoma dioscoreae, dehydrate.
A kind of preparation method of the lyophilizing Rhizoma Dioscoreae that the present invention is above-mentioned is: new fresh Rhizoma dioscoreae, clean roguing, and be cut into the Rhizoma Dioscoreae section of length 3～15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5-8Kg/ ㎡; Solidification point is controlled between-28～-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.
The above-mentioned Rhizoma Dioscoreae of the present invention comprises tuber and the Bulbilus dioscoreae of Dioscoreaceae (Dioscoreaceae) plant Rhizoma Dioscoreae (DioscoreaoppositaThunb.).
What the present invention was above-mentioned is the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, is to make oral formulations take the lyophilizing Rhizoma Dioscoreae as raw material, takes the preparation that is equivalent to lyophilizing Rhizoma Dioscoreae 9-50g every day, divides and takes for 2-3 time.
Embodiment 1
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5Kg/ ㎡; Solidification point is controlled at-28 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae, be crushed to impalpable powder, be packed as the 3g/ bag, patients with lung cancer is oral, 3 bags of every days, minute 3 clothes.
Embodiment 2
Get new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is 8Kg/ ㎡; Solidification point is controlled between-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.Make the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae, be crushed to impalpable powder, be packed as the 10g/ bag, liver cancer patient is oral, 3 bags of every days, minute 3 clothes.
Embodiment 3
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 3cm, sabot, sabot weight is about 7kg/ ㎡, carries out pre-freeze to-28 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 40Pa of system, begin to be heated to 35 ℃, sublimation drying 15 hours; Keep again 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.
Get the lyophilizing Rhizoma Dioscoreae powder and be broken to coarse powder, add 4 times of water gagings, stir to extract 4 hours at 20 ℃, totally 2 times, merge extractive liquid, filters, and is centrifugal, the centrifugal liquid freeze drying box of packing into, lyophilizing.Get the lyophilizing Rhizoma Dioscoreae extract.
Get the lyophilizing Rhizoma Dioscoreae extract, add the lyophilizing Rhizoma Dioscoreae segmentation that embodiment 1 makes, granulate, reduced vacuum is dry, granulate, and the adding Pulvis Talci is an amount of, and tabletting gets the lyophilizing yam slice, and patients with renal cell carcinoma is oral, 18 of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 30g), minute 3 clothes.
Embodiment 4
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add an amount of dextrin, granulate, reduced vacuum is dry, and granulate is packed as the 10g/ bag, gets lyophilizing Rhizoma Dioscoreae granule, and patients with lung cancer is oral, 2 bags of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 50g), minute 2 clothes.
Embodiment 5
Get the lyophilizing Rhizoma Dioscoreae extract that embodiment 3 makes, add an amount of methylcellulose, granulate, reduced vacuum is dry, and granulate incapsulates, and gets lyophilizing Rhizoma Dioscoreae capsule, and patients with prostate cancer is oral, 15 of every days (being equivalent to lyophilizing Rhizoma Dioscoreae 15g), minute 3 clothes.
Embodiment 6
Get the lyophilizing Rhizoma Dioscoreae that embodiment 1 makes and divide, add an amount of differential silica gel, pill, reduced vacuum is dry, is packed as the 10g/ bag, and liver cancer patient is oral, 2 bags of every days, minute 2 clothes.
Embodiment 7
Adopt ZG-100 ㎡ type vacuum freeze drier, choose new fresh Rhizoma dioscoreae, clean roguing, be cut into the Rhizoma Dioscoreae section of length 10cm, sabot was carried out pre-freeze to-30 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 50Pa of system and begin to be heated to 40 ℃, sublimation drying 18 hours; Keep again temperature of charge at 45 ℃, make water content reach rear discharging below 2%.Get the lyophilizing Rhizoma Dioscoreae.
Get Poria 1kg, Rhizoma Atractylodis Macrocephalae 1k g, lyophilizing Rhizoma Dioscoreae 1kg, Radix Astragali 1.5kg, Radix Pseudostellariae 1.5kg, Herba Hedyotidis Diffusae 3kg, the water diafiltration is extracted, concentrating under reduced pressure, vacuum drying adds starch, and it is dry to granulate, and makes tablet, is used for the treatment of gastric cancer, takes in 100 days for the patient.
Embodiment 8
Adopt ZG-100 ㎡ type vacuum freeze drier.Choose new fresh Rhizoma dioscoreae Bulbilus dioscoreae, clean roguing, sabot, sabot weight is 7kg/ ㎡, carries out pre-freeze to-28 ℃ after lowering the temperature gradually 2 hours; Then be evacuated to the absolute pressure 40Pa of system, begin to be heated to 35 ℃, sublimation drying 15 hours; Keep again 35 ℃ of temperature of charge, when temperature of charge and heating-up temperature near the time dry the end, get the lyophilizing Rhizoma Dioscoreae.
Claims (6)
1. be the medicine that the raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae.
According to claim 1 be the medicine that raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, it is characterized in that directly pulverizing with the lyophilizing Rhizoma Dioscoreae, be prepared into powder, pill.
According to claim 1 be the medicine that raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, it is characterized in that take the lyophilizing Rhizoma Dioscoreae as raw material, through extract at low temperature, be prepared into powder, granule, pill, tablet, capsule with extract.
According to claim 1 be the medicine that raw material preparation has prevention and treatment tumor with the lyophilizing Rhizoma Dioscoreae, it is characterized in that take the lyophilizing Rhizoma Dioscoreae as raw material, other prepared slices of Chinese crude drugs of compatibility through extract at low temperature, are prepared into powder, granule, pill, tablet, capsule with extract.
5. a method for preparing the lyophilizing Rhizoma Dioscoreae is characterised in that and gets fresh Rhizoma dioscoreae, clean roguing, is placed in the cryodesiccation chamber of freeze dryer, is keeping being cryodesiccation chamber's evacuation under the prerequisite of freezing, and makes the ice distillation in the fresh Rhizoma dioscoreae, dehydrate.
6. according to claim 5 a kind of method for preparing the lyophilizing Rhizoma Dioscoreae is characterised in that new fresh Rhizoma dioscoreae, cleans roguing, is cut into the Rhizoma Dioscoreae section of length 3～15cm; To clean the Rhizoma Dioscoreae section sabot of roguing, loading amount is about 5-8Kg/ ㎡; Solidification point is controlled between-28～-32 ℃; After reaching the control temperature, open immediately vacuum pump and be evacuated to below the drying chamber pressure 50Pa, then start heater switch, promote distillation to rise; The temperature of China should be controlled at below 40 ℃; The temperature of resolution phase should be controlled at below 45 ℃.
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| CN103599322A (en) * | 2013-11-07 | 2014-02-26 | 培力(南宁)药业有限公司 | Preparation method of Chinese yam formula granules |
| CN104165497A (en) * | 2014-08-25 | 2014-11-26 | 济南康众医药科技开发有限公司 | Honeysuckle freeze-drying method |
| CN104197645A (en) * | 2014-08-25 | 2014-12-10 | 济南康众医药科技开发有限公司 | Gymnadenia conopsea freeze-drying method |
| CN110339276A (en) * | 2019-07-17 | 2019-10-18 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for treating digestive tract tumor and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599322A (en) * | 2013-11-07 | 2014-02-26 | 培力(南宁)药业有限公司 | Preparation method of Chinese yam formula granules |
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| CN104165497A (en) * | 2014-08-25 | 2014-11-26 | 济南康众医药科技开发有限公司 | Honeysuckle freeze-drying method |
| CN104197645A (en) * | 2014-08-25 | 2014-12-10 | 济南康众医药科技开发有限公司 | Gymnadenia conopsea freeze-drying method |
| CN110339276A (en) * | 2019-07-17 | 2019-10-18 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for treating digestive tract tumor and preparation method thereof |
| CN110339276B (en) * | 2019-07-17 | 2021-05-14 | 河南省中医院（河南中医药大学第二附属医院） | Traditional Chinese medicine for treating digestive tract tumor and preparation method thereof |
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Application publication date: 20130424 |