CN103181987B - Solanum septemlobum bunge fruit for treating cancers - Google Patents
Solanum septemlobum bunge fruit for treating cancers Download PDFInfo
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- CN103181987B CN103181987B CN201310065772.9A CN201310065772A CN103181987B CN 103181987 B CN103181987 B CN 103181987B CN 201310065772 A CN201310065772 A CN 201310065772A CN 103181987 B CN103181987 B CN 103181987B
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Abstract
The invention relates to a medicine for treating tumors, which is prepared by freeze-dried solanum septemlobum bunge fruit. The medicine is characterized by containing the freeze-dried solanum septemlobum bunge fruit, and the curative effect of the medicine is better than that of a medicine prepared by the whole herb of solanum septemlobum bunge and sundried solanum septemlobum bunge fruit.
Description
Technical field
The present invention relates to medicine, the medicine of particularly a kind of lyophilizing Herba Solani Lyrati fruit preparation of Therapeutic cancer, belongs to medical art.
Background technology
Herba Solani Lyrati is the dry aerial parts of the blue or green Qi (Solanum septemlobum Bunge) of plant of Solanaceae.Another name has: Yang Quan, blue or green Qi, Herba Saginae Japonicae, Herba Solani Septemlobi, wild Fructus Lycii, Radix solani coagulantis, child's fist, red ear pendant etc.Late summer taps, and removing impurity, dries.Property bitter, cold, return liver, stomach warp.Effect of tool heat-clearing and toxic substances removing.For hot carbuncle toxin, laryngopharynx swelling and pain, itchy skin eruption.
Respectfully under Herba Solani Lyrati item in Compendium of Material Medica to say: " flower purple, subclass Fructus Lycii, root, as Radix Polygalae, has not been in the mood for miserable for this careless popular name paint aunt, Ye Yiju." be Herba Solani Lyrati and bittersweet in " Chinese medicine voluminous dictionary ".Say that, in northern Shensi Herba Solani Lyrati, Shan Nan cries Herba Solani Lyrati in " Shaanxi Chinese herbal medicine ", the former plant of its base is Herba Solani Lyrati.In " Chinese Higher plant illustrated handbook ", under blue or green Qi item, another name has Herba Solani Lyrati.In " Chinese crude drug brief introduction ", Herba Solani Lyrati is blue or green cabinet.Under " national Chinese herbal medicine compilation " volume two Herba Solani Lyrati item, another name has blue or green handle.In " newly organized Chinese materia medica ", Herba Solani Lyrati is blue or green Qi.Herba Solani Lyrati of the present invention is the blue or green Qi (Solanum septemlobum Bunge) of plant of Solanaceae.Herba Solani Lyrati (Solanum lyratum Thunb) and bittersweet (So1num dnlcamars L), the Herba Solani Lyrati described in non-invention.
Herba Solani Lyrati fruit active anticancer is higher than Herba Solani Lyrati herb, and lyophilizing Herba Solani Lyrati fruit active anticancer is higher than the Herba Solani Lyrati fruit of drying.
Summary of the invention
The object of the invention is take Herba Solani Lyrati as the medicine that highly active treatment tumor prepared by raw material.The object of the present invention is achieved like this, with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor.
With the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be characterised in that described medicine contains lyophilizing Herba Solani Lyrati fruit.
Of the present invention with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be characterised in that described medicine is by the preparation of single taste lyophilizing Herba Solani Lyrati fruit.
Of the present invention with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be characterised in that lyophilizing Herba Solani Lyrati fruit directly takes.
Of the present invention with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be characterised in that lyophilizing Herba Solani Lyrati fruit is directly pulverized and make powder and take.
Lyophilizing Herba Solani Lyrati fruit of the present invention, is characterised in that with following technique lyophilizing: get Herba Solani Lyrati fruit and wash; Sabot, loading amount is 5-8Kg/ about ㎡; Solidification point controls between-28 ~-32 DEG C; After reaching control temperature, open vacuum pump evacuation immediately to drying chamber pressure 40-50Pa, then start heater switch, promote distillation; The temperature of distillation should control below 40 DEG C; The temperature of resolution phase should control below 45 DEG C, when temperature of charge and heating-up temperature close to time dryly to terminate, obtain lyophilizing Herba Solani Lyrati really.
The object of lyophilizing Herba Solani Lyrati fruit solves to dry loss of effective components comparatively greatly, the technical problems such as active anticancer is low.Directly prepare medicine of the present invention with fresh Herba Solani Lyrati fruit in the Herba Solani Lyrati fruit harvest season can reduce costs.Accordingly, lyophilizing Herba Solani Lyrati fruit of the present invention can replace with fresh Herba Solani Lyrati fruit Herba Solani Lyrati harvest season lyophilizing Herba Solani Lyrati fruit, and its consumption presses dry product conversion.
Of the present invention with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be on the basis of existing technology, adopt Chinese medicine preparation conventional method to be prepared into any pharmaceutically useful preparation.Such as, lyophilizing Herba Solani Lyrati is pulverized by fruit, makes powder and takes after mixing it with water; By lyophilizing Herba Solani Lyrati fruit by extracting further, extract adds adjuvant and makes tablet, capsule, granule, pill, but this does not limit the scope of the invention.
Extraction of the present invention is extract at low temperature; With water, ethanol, methanol or their solution return, dipping, seepage pressure effects.
Of the present invention with the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor, be with the medicine of Herba Solani Lyrati fruit for kinds cancers such as raw material preparation treatment pulmonary carcinoma, bladder cancer, cervical cancer, esophageal carcinoma, gastric cancer, hepatocarcinoma, cancer of pancreas, breast carcinomas.
Below by the inhibitory action test explanation usefulness of the present invention of drying Herba Solani Lyrati fruit and lyophilizing Herba Solani Lyrati fruit and breeding human hepatoma cell strain SMMC-7721, HepG2 and stomach cancer cell line MGC-803.
1, preparation is dried Herba Solani Lyrati fruit and lyophilizing Herba Solani Lyrati berry extract and is got respectively and dry Herba Solani Lyrati and lyophilizing Herba Solani Lyrati and pulverize, and respectively decocts with water twice, and first time adds water 8 times amount, decoct 2 hours, add water 8 times amount for the second time, decocts 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, being concentrated into relative density is 1.10(60 DEG C) time, add ethanol and make alcohol content reach 75%, precipitation, leave standstill 36 hours, Aspirate supernatant, reclaim ethanol, concentrated, dry, pulverize; Herba Solani Lyrati and lyophilizing Herba Solani Lyrati extract must be dried.
2, method mtt assay SMMC-7721, HepG2 and MGC-803 tri-kinds of cell strains are with containing 10% deactivation newborn calf serum, the penicillin of 100U/ml and the DMEM culture medium of 100 μ g/ml streptomycins are at 37 DEG C, cultivate under 5%CO2 condition, trophophase cell of taking the logarithm is for experiment.Getting concentration is respectively that SMMC-7721, HepG2 and MGC-803 cell strain 90 μ l of 2 × 106/ml cultivates in 96 orifice plates, blank group adds 10 μ lPBS, administration group adds the tested medicinal liquid of 10 μ l various dose respectively, medicine final concentration (calculating by crude drug).If negative control group, negative control group is the medicinal liquid adding various dose in not celliferous culture fluid.If 6 parallel holes, 24h is cultivated after cell administration, every hole adds 5.0 mg/mlMTT solution 20 μ l, after vibration mixing, be placed in incubator and continue to hatch 4h, discard the supernatant in each hole, add 100 μ lDMSO stopped reactions again, vibration mixing 10min, after the purple crystal in its each hole dissolves completely, measures its light absorption value (A490) by microplate reader at 490nm place.Press formulae discovery cell inhibitory rate below:
Growth inhibition ratio (%)=(N group OD average-B organizes OD average)-(T group OD average-TC organizes OD average)/N group OD average-B organizes OD average × 100%.
3, the results are shown in Table 1, table 2, table 3.
The suppression ratio result of table 1 couple SMMC-7721
| Suppression ratio (%) | 10（μg/ml） | 30（μg/ml） | 50（μg/ml） |
| Lyophilizing Herba Solani Lyrati fruit | 63.52 | 80.24 | 90.13 |
| Dry Herba Solani Lyrati fruit | 52.18 | 66.77 | 75.11 |
The suppression ratio result of table 2 couple HepG2
| Suppression ratio (%) | 10（μg/ml） | 30（μg/ml） | 50（μg/ml） |
| Lyophilizing Herba Solani Lyrati fruit | 68.22 | 75.41 | 89.20 |
| Dry Herba Solani Lyrati fruit | 55.40 | 66.28 | 77.11 |
The suppression ratio result of table 3 couple MGC-803
| Suppression ratio (%) | 10（μg/ml） | 30（μg/ml） | 50（μg/ml） |
| Lyophilizing Herba Solani Lyrati fruit | 74.95 | 86.28 | 93.01 |
| Dry Herba Solani Lyrati fruit | 50.75 | 74.46 | 84.46 |
Result shows, drying Herba Solani Lyrati fruit and lyophilizing Herba Solani Lyrati fruit all has human hepatoma cell strain SMMC-7721, HepG2 and stomach cancer cell line MGC-803 propagation and suppress to do, and lyophilizing Herba Solani Lyrati fruit curative effect is better than dries Herba Solani Lyrati really.
Detailed description of the invention
With the medicine of lyophilizing Herba Solani Lyrati fruit for raw material preparation treatment tumor.
Lyophilizing Herba Solani Lyrati fruit: get Herba Solani Lyrati fruit and wash; Sabot, loading amount is 5-8Kg/ about ㎡; Solidification point controls between-28 ~-32 DEG C; After reaching control temperature, open vacuum pump evacuation immediately to drying chamber pressure 40-50Pa, then start heater switch, promote distillation; The temperature of distillation should control below 40 DEG C; The temperature of resolution phase should control below 45 DEG C, when temperature of charge and heating-up temperature close to time dryly to terminate, obtain lyophilizing Herba Solani Lyrati really.
With lyophilizing Herba Solani Lyrati fruit for raw material, Chinese medicine preparation conventional method is adopted to be prepared into any pharmaceutically useful preparation.
Lyophilizing Herba Solani Lyrati fruit is pulverized, makes powder and take after mixing it with water.
By lyophilizing Herba Solani Lyrati fruit by extracting, extract adds adjuvant and makes tablet, capsule, granule, pill.
Lyophilizing Herba Solani Lyrati fruit is carried, the medicine of preparation treatment tumor with water low temperature.
Use water, ethanol, methanol or their solution return, dipping, seepage pressure effects lyophilizing Herba Solani Lyrati fruit respectively, the medicine of preparation treatment tumor.
With the medicine of lyophilizing Herba Solani Lyrati fruit for kinds cancers such as raw material preparation treatment pulmonary carcinoma, bladder cancer, cervical cancer, esophageal carcinoma, gastric cancer, hepatocarcinoma, cancer of pancreas, breast carcinomas.
embodiment 1
Get fresh maturescent Herba Solani Lyrati fruit, clean roguing; Sabot, sabot weight is 5 ㎏/㎡, is cooled to-20 DEG C DEG C gradually and carries out pre-freeze; It is 40Pa that sublimation drying is evacuated to system absolute pressure, starts to be heated to 30 DEG C, sublimation drying 20 hours; Parsing-desiccation keeps temperature of charge at 35 DEG C, makes water content reach 2 ~ 3%, obtains lyophilizing Herba Solani Lyrati fruit.
Get lyophilizing Herba Solani Lyrati fruit, be crushed to fine powder, be packed as 3g/ bag, obtain Herba Solani Lyrati powder.Patients with lung cancer is oral, every day 3 bags, point 3 clothes.
embodiment 2
Get fresh immature Herba Solani Lyrati fruit, clean roguing; Sabot, sabot weight is 8 ㎏/㎡, and Jiang Wen Zhi – 60 DEG C carries out pre-freeze gradually; It is 60Pa that sublimation drying is evacuated to system absolute pressure, starts to be heated to 60 DEG C, sublimation drying 24 hours; Parsing-desiccation keeps temperature of charge at 65 DEG C, makes water content reach 2 ~ 3%, obtains lyophilizing Herba Solani Lyrati fruit.
Get lyophilizing Herba Solani Lyrati fruit, be crushed to fine powder, be packed as 10g/ bag, obtain Herba Solani Lyrati powder, liver cancer patient is oral, every day 3 bags, point 3 clothes.
embodiment 3
Get the Herba Solani Lyrati fruit of fresh mature, sabot, sabot weight is 6 ㎏/㎡, is cooled to 30 DEG C gradually and carries out pre-freeze; It is 50Pa that sublimation drying is evacuated to system absolute pressure, starts to be heated to 50 DEG C, sublimation drying 20 hours; Parsing-desiccation keeps temperature of charge at 45 DEG C, makes water content reach 2 ~ 3%, obtains lyophilizing Herba Solani Lyrati fruit.
Get lyophilizing Herba Solani Lyrati fruit, be crushed to coarse powder, add 4 times of water gagings, stir extraction 4 hours, totally 2 times, merge extractive liquid, at 20 DEG C, filter, centrifugal, centrifugal liquid loads freeze drying box, lyophilizing.Obtain lyophilizing Herba Solani Lyrati extract.
Get extract, add appropriate dextrin, granulate, reduced vacuum is dry, and granulate, is packed as 10g/ bag, and obtain lyophilizing Herba Solani Lyrati granule, patients with gastric cancer is oral, every day 2 bags (being equivalent to lyophilizing Herba Solani Lyrati fruit 50g), point 2 clothes.
embodiment 4
Adopt ZG-100 ㎡ type vacuum freeze drier.Get Herba Solani Lyrati fruit (young fruit, crude fruit, mellow fruit mix) to wash; Sabot, loading amount is 7Kg/ about ㎡; Solidification point controls at-28 DEG C; After reaching control temperature, open vacuum pump evacuation immediately to below drying chamber pressure 45Pa, then start heater switch, promote distillation; The temperature of distillation should control below 40 DEG C; The temperature of resolution phase should control below 45 DEG C, when temperature of charge and heating-up temperature close to time dryly to terminate, obtain lyophilizing Herba Solani Lyrati really.
Get lyophilizing lyophilizing Herba Solani Lyrati fruit and be crushed to coarse powder, add 6 times of water gagings, stir extraction 4 hours, totally 2 times, merge extractive liquid, at 20 DEG C, filter, centrifugal, centrifugal liquid loads freeze drying box, lyophilizing.Obtain lyophilizing Herba Solani Lyrati berry extract.
Get lyophilizing Herba Solani Lyrati berry extract, pulverize, wet granulation, reduced vacuum is dry, granulate, and add Pulvis Talci in right amount, tabletting, obtain lyophilizing Herba Solani Lyrati chankings, cancer patient is oral, every day 18 (being equivalent to lyophilizing Herba Solani Lyrati fruit 40g), point 3 clothes.
embodiment 5
Lyophilizing Herba Solani Lyrati fruit prepared by Example 4, add 4 times of water gagings, stir extraction 4 hours, totally 2 times, merge extractive liquid, at 40 DEG C, filter, centrifugal, centrifugal liquid loads lyophilizing.Obtain lyophilizing Herba Solani Lyrati berry extract.
Get Herba Hedyotidis Diffusae, Radix Clematidis, each 600kg of Rhizoma Imperatae, with water extraction 2 times, first time adds 8 times of water gagings, extract 2 hours, second time adds 6 times amount water extraction 1 hour, merge extractive liquid, filter, concentrated, dry, obtain extract, add lyophilizing lyophilizing Herba Solani Lyrati berry extract 300kg, mixing, granulate, dry, granulate, add Pulvis Talci appropriate, tabletting, every sheet 0.4g.For treatment of esophagus cancer, every day 12, point 3 clothes.Effective percentage 80%.
embodiment 6
The lyophilizing Herba Solani Lyrati extract that Example 5 is obtained, add appropriate dextrin, granulate, reduced vacuum is dry, granulate, and be packed as 15g/ bag (being equivalent to Herba Solani Lyrati fruit 50g), obtain granule, be used for the treatment of pulmonary carcinoma and suffer from, every day 2 bags, point 2 clothes 1 month are a course for the treatment of.
embodiment 7
The lyophilizing Herba Solani Lyrati extract that Example 5 is obtained, add appropriate amount of starch, granulate, reduced vacuum is dry, and granulate, incapsulates, and obtain lyophilizing Herba Solani Lyrati capsule, prostatitis patient is oral, every day 15 (being equivalent to lyophilizing Herba Solani Nigri 30g), and point 3 clothes, cure for 7 days.
embodiment 8
Get lyophilizing Herba Solani Lyrati fruit, decoct with water twice, add water 8 times amount for the first time, decoct 2 hours, add water 8 times amount for the second time, decocts 1 hour, merge medicinal liquid, medicinal liquid filters, and gets filtrate, being concentrated into relative density is 1.10(60 DEG C) time, add ethanol and make alcohol content reach 75%, precipitation, leave standstill 36 hours, Aspirate supernatant, reclaim ethanol, concentrated, dry, pulverize; Obtain Herba Solani Lyrati berry extract.
Get Herba Solani Lyrati berry extract, add carboxymethyl starch sodium, gelatinized corn starch is granulated, dry, granulate, adds Pulvis Talci in right amount, mixing, tabletting.Every sheet is equivalent to Herba Solani Lyrati fruit 2g.Be used for the treatment of liver cancer patient, each 3, every day 3 times.Within 1 month, be 1 course for the treatment of, total effective rate is 70.88%.
Claims (1)
1. the method for the medicine of lyophilizing Herba Solani Lyrati fruit preparation treatment tumor, is characterized in that: prepared by the following method by single taste lyophilizing Herba Solani Lyrati fruit:
1) get fresh Herba Solani Lyrati fruit, sabot, sabot weight is 6 ㎏/㎡, is cooled to-30 DEG C gradually and carries out pre-freeze; It is 50Pa that sublimation drying is evacuated to system absolute pressure, starts to be heated to 50 DEG C, sublimation drying 20 hours; Parsing-desiccation keeps temperature of charge at 45 DEG C, makes water content reach 2 ~ 3%, obtains lyophilizing Herba Solani Lyrati fruit;
2) get lyophilizing Herba Solani Lyrati fruit, be crushed to coarse powder, add 4 times of water gagings, stir extraction 4 hours, totally 2 times, merge extractive liquid, at 20 DEG C, filter, centrifugal, centrifugal liquid loads freeze drying box, and lyophilizing, obtains lyophilizing Herba Solani Lyrati extract;
3) get extract, add appropriate dextrin, granulate, reduced vacuum is dry, and granulate, makes granule.
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| CN201310065772.9A CN103181987B (en) | 2013-03-03 | 2013-03-03 | Solanum septemlobum bunge fruit for treating cancers |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061531A (en) * | 1990-11-10 | 1992-06-03 | 蚌埠市雄蜂实业有限公司 | The new method that a kind of Chinese crude drug is concocted |
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| CN101607073A (en) * | 2008-06-20 | 2009-12-23 | 刘广伦 | A kind of traditional biological technology is cultivated the method for Chinese medicine health care product Herba Swertiae davidi and healthy liquid thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061531A (en) * | 1990-11-10 | 1992-06-03 | 蚌埠市雄蜂实业有限公司 | The new method that a kind of Chinese crude drug is concocted |
Non-Patent Citations (1)
| Title |
|---|
| 程超寰,杜汉阳编著.蜀羊泉.《本草药名汇考》.世界出版集团、上海古籍出版社出版,2004,第681页. * |
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Inventor after: Zhou Ran Inventor after: Li Shibiao Inventor after: Xu Cuiping Inventor after: Zhou Changzheng Inventor after: Su Jing Inventor before: Niu Fengju Inventor before: Li Shibiao Inventor before: Xu Cuiping Inventor before: Zhou Changzheng Inventor before: Su Jing |
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