CN109010558A - A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue - Google Patents
A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue Download PDFInfo
- Publication number
- CN109010558A CN109010558A CN201810970881.8A CN201810970881A CN109010558A CN 109010558 A CN109010558 A CN 109010558A CN 201810970881 A CN201810970881 A CN 201810970881A CN 109010558 A CN109010558 A CN 109010558A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- sterilizing
- preparation
- poria cocos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Toxicology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a kind of preparation methods of six drugs containing rehmanniae piece that kidney tonifying is antifatigue, and the method, steps are as follows: step 1. Rehmannia glutinosa, Chinese yam, and three kinds of medicinal materials of rhizoma alismatis add water to cook extraction, obtain extracting solution, extracting solution is concentrated to get clear cream；Step 2. cortex moutan, Fructus Corni, three kinds of pulverizing medicinal materials of Poria cocos carry out sterilization treatment after crushing；Step 3. particle preparation: the sterilizing medicinal powder of the clear cream of step 1 and step 2 being mixed, 18 mesh softwoods, dry, whole grain；Tabletting to obtain the final product, as needed, can be with film coating or sugar-coat.
Description
Technical field
The present invention relates to a kind of preparation methods of six drugs containing rehmanniae piece that kidney tonifying is antifatigue.Belong to pharmaceutical technology field.
Technical background
Formula for Liuwei Dihuang first appeared in Song Qian Yi key to Therapeutics of Children's Diseases, by groups such as Rehmannia glutinosa, cortex moutan, Fructus Cornis
At having effects that enriching yin and nourishing kidney, for dizziness and tinnitus caused by damage of kidney-YIN, osteopyrexia and fever, night sweat spermatorrhea.Six drugs containing rehmanniae piece
Pharmacological action is extensive, has the function of adjusting immune, anti-aging, antitumor, reducing blood sugar and blood lipid, liver protection, and to endocrine, painstaking effort
Guard system has an impact, adjustable alcium and phosphor metabolization, wherein it is most important to adjust immune, anti-aging, antitumor action.For many years,
Major colleges and universities, research institute, enterprise have carried out a variety of dosage form change researchs with formula for Liuwei Dihuang, form a variety of novel forms and produce
Product, including six drugs containing rehmanniae piece.
Existing six drugs containing rehmanniae piece is by 176 parts by weight of Rehmannia glutinosa, 66 parts by weight of cortex moutan, 88 parts by weight of Chinese yam, Fructus Corni 88
Parts by weight, 66 parts by weight of rhizoma alismatis, 66 parts by weight of Poria cocos are prepared.
Preparation method is as follows: the above Six-element, and cortex moutan, Fructus Corni, Poria cocos are ground into fine powder, is sieved, and mixes, remaining is ripe
Three taste such as glutinous rehmannia, adds water to cook three times, and it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, and filtrate is dense
It shortens cream into, is mixed with above-mentioned powder, low temperature drying, crush, add right amount of auxiliary materials, mix, particle is made, it is dry, it is pressed into 1000
Piece, sugar coating to get.
Monarch drug in a prescription is that Rehmannia glutinosa is sweet, slight bitter, tepor in side, return heart, liver and kidney channel；There are tonifying blood and regulating menstruation, the function of enriching yin and nourishing kidney
Effect.Ministerial drug is Fructus Corni, Chinese yam, and Fructus Corni slightly warm in nature is sour, puckery；It is included into liver, kidney channel；It tonifies the liver and kidney, the function of arresting seminal emission prevent prolapse
Effect；Chinese yam is mild-natured, sweet in flavor, returns spleen, lung, kidney, there is the effect of strengthening the spleen and tonifying the lung, beneficial stomach kidney tonifying, reinforce the kidney beneficial essence；Adjutant be cortex moutan,
Poria cocos, cortex moutan is bitter, pungent, slightly cold.Return heart, liver, stomach meridian；With clearing heat and cooling blood, promoting blood circulation to remove blood stasis moves back steaming effect, and Poria cocos is sweet, light,
It is flat.Return heart, spleen, kidney channel have clearing damp and promoting diuresis, invigorating the spleen, the effect of tranquilizing the mind.Keep medicine rhizoma alismatis sweet, light, trembles with fear.Return kidney, bladder meridian, has
The effect of having clearing damp and promoting diuresis, expelling the heat-evil.
Six drugs containing rehmanniae piece include flavonoids, Paeonol, vitamin, polysaccharide, a variety of amino acid and microelement etc. effectively at
Point, product is clinically widely used to treatment damage of kidney-YIN, dizziness and tinnitus, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat something lost
Essence is quenched one's thirst.Product is curative for effect, and quality is stablized, and safety is good.For many years, six drugs containing rehmanniae piece is with safe and reliable curative effect
The choice drug of traditional Chinese medical science field treatment kidney deficiency disease.
Existing six drugs containing rehmanniae piece is using traditional handicraft, and since the source of Chinese medicine is different, effective component Paeonol contains
It is larger to measure difference, often occurs detecting unqualified phenomenon, wastes medicinal material.In addition, the tablet shelf-life short is easy to appear discoloration, spot etc.
Phenomenon, the present invention improve to traditional handicraft on the basis of existing technology produces a kind of new six drugs containing rehmanniae piece.
Summary of the invention
The purpose of the present invention is to provide a kind of preparation method of six drugs containing rehmanniae piece that kidney is antifatigue, the six drugs containing rehmanniae pieces
It is made of the bulk pharmaceutical chemicals that following weight matches: 176 parts by weight of Rehmannia glutinosa, 66 parts by weight of cortex moutan, 88 parts by weight of Chinese yam, mountain
88 parts by weight of the fruit of medicinal cornel, 66 parts by weight of rhizoma alismatis, 66 parts by weight of Poria cocos can be made if the parts by weight use gram as measurement unit
Standby six drugs containing rehmanniae piece 1000.
The object of the present invention is achieved like this: the medicinal material in prescription being handled, optimization for the treatment of conditions and ginseng are passed through
Number removes harmful substance, and active component content increases, and preparation stability increases, and dissolution efficiency improves.
Preparation method of the invention, comprising the following steps:
1. Rehmannia glutinosa, Chinese yam, three kinds of medicinal materials of rhizoma alismatis add water to cook extraction, obtain extracting solution, extracting solution is concentrated to get clearly
Cream；
2. cortex moutan, Fructus Corni, three kinds of pulverizing medicinal materials of Poria cocos carry out sterilization treatment after crushing；
3. prepared by tablet: the sterilizing medicinal powder of the clear cream of step 1 and step 2 being mixed, freeze-drying, 18 mesh systems are soft
Material, dry, whole grain；Tabletting to obtain the final product, as needed, can be with film coating or sugar-coat.
Preferably, the preparation method is as follows:
1) by above-mentioned 176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis ratio by weight, added
8-20 times of amount of water decocts three times, and it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, and clear cream is relatively close
Degree is 1.30.12 times of amounts of water are added to decoct three times, it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, clearly
Cream relative density is 1.30.
2) 66 parts by weight of cortex moutan, 88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed, sterilizing, sterilization method point
Not are as follows: retorted, hot air sterilization, moist heat sterilization.Preferably, cortex moutan uses air-flow speed heat using retorted
Gas temperature is heated to 180 degree or more by sterilizer, is conveyed crude drug powder simultaneously by steam pressure, was completed within 4 seconds time
Sterilizing, then medicinal powder is segregated into cooling zone, complete out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Mountain Zhu
Cornel uses hot air sterilizer, and 160 degree of heated dry air is directly over heated object, drying, and disinfecting time 30-50 minutes；Fu
Siberian cocklebur Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, controls 103.4 kPas of vapour pressures, sterilizes
70 degree of drying afterwards.
3) crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.It is cold using vacuum
Freeze dry technology, control vacuum degree is in -1kPa, and at -20 DEG C -30 DEG C, preferable temperature is controlled at 0 DEG C -10 DEG C, dry for temperature control
14 mesh whole grain afterwards, tabletting.
The most preferred preparation method of the present invention, comprising the following steps:
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus 12 times of amounts of water decoct three times, first,
Secondary is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and clear cream relative density is 1.30.66 parts by weight of cortex moutan,
88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan is gone out using retorted using air-flow speed heat
Gas temperature is heated to 180 degree or more by bacterium machine, is conveyed crude drug powder simultaneously by steam pressure, was completed to go out within 4 seconds time
Bacterium, then medicinal powder is segregated into cooling zone, complete out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Fructus Corni
Using hot air sterilizer, 160 degree of heated dry air is directly over heated object, drying, disinfecting time 30-50 minutes；Poria cocos
Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, 103.4 kPas of vapour pressures is controlled, after sterilizing
70 degree of drying.Crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.Using vacuum refrigeration
Dry technology, controls vacuum degree -1kPa, and temperature controls 0 DEG C -10 DEG C, is drying to obtain, 14 mesh whole grains.Tabletting, sugar coating or film
Clothing, pressing plate, outsourcing to get.
The above-mentioned most preferred preparation method of the present invention, technical conditions therein and technical parameter are obtained by screening,
Screening process is as follows:
In order to improve the dissolution of the active principle in six drugs containing rehmanniae piece medicinal material, according to experiment parameter, optimize corresponding extract
Parameter.
Its preferred process of step 1 is as follows:
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out single factor exploration to amount of water, carry out
Experiment screening.It is shown in Table 1.
The extraction of step 1 carries out process optimization, presses 176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 weight of rhizoma alismatis respectively
Part, it is added water to cook three times, it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, and clear cream is relatively close
Degree is 1.30.Single factor exploration is carried out by inspection target of clear cream yield.
4 water-glass of single factor test of the influence clear cream yield of table 1
| Project | The rate of clear cream |
| Add 8 times of water amounts | 39.3% |
| Add 12 times of water amounts | 45.1% |
| Add 15 times of water amounts | 45.5% |
| Add 20 times of water amounts | 45.7% |
As can be seen from the above table: adding 12 times of water amounts, can achieve preferable paste volume, and with the rising of amount of water, clearly
Cream yield does not increase significantly, and therefore, from economical rationality on the basis of, it is best for adding 12 times of water amounts to extract.
Its preferred process of step 2 is as follows:
66 parts by weight of cortex moutan, 88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed, and to the sterilizing skill of crude drug powder
Art optimizes, and different sterilization methods is respectively adopted in three kinds of crude drug powders and is handled.Sterilization method is respectively as follows: superheated steam
Sterilizing, hot air sterilization, moist heat sterilization.
Retorted parameter are as follows: use gas velocity heat sterilization machine, gas temperature is heated to 180 degree or more, is passed through
Steam pressure conveys crude drug powder simultaneously, sterilizing was completed within 4 seconds time, then medicinal powder is segregated into cooling zone, completes out powder.
Hot air sterilization parameter are as follows: hot air sterilizer is used, 160 degree of heated dry air is directly over heated object, drying,
Disinfecting time 30-50 minutes.
Moist heat sterilization parameter are as follows: lead to steam sterilizing with Chinese patent drug sterilizing cabinet, control sterilizes 1 hour at 115-121 DEG C, controls
Make 103.4 kPas of vapour pressures.70 degree of drying after sterilizing.
Three kinds of medicinal material powders sterilize by above-mentioned three kinds of sterilization methods respectively, carry out the inspection of index of correlation respectively.
Cortex moutan is using the content of Paeonol as examination criteria, and Fructus Corni is using the content of loganin as Testing index.See Table 2 for details
The 2 preferred table of crude drug powder sterilization method of table
As can be seen from the above table: 1. cortex moutans are preferable using retorted effect, and content degradation rate is low.2. Fructus Corni
It is best using hot air sterilization using retorted and hot air sterilization effect, but from economic angle analysis.3. Poria cocos
Use 3 kinds of sterilizing methods can be with, but from economic angle analysis, it is best using moist heat sterilization.
It is therefore preferable that best sterilization process are as follows: cortex moutan uses retorted, and Fructus Corni uses hot air sterilization, Fu
Siberian cocklebur uses moist heat sterilization.
Its preferred process of step 3 is as follows:
Crude drug powder obtained by the obtained clear cream of step 1 and step 2 is mixed, 18 mesh softwoods.It is dry using vacuum refrigeration
Dry technology, controls vacuum degree -1kPa, and temperature controls -20 DEG C -30 DEG C, investigates to temperature, determine optimum drying temperature.With
The content of paeonol in Cortex Moutan is examination criteria.It is shown in Table 3.
3 vacuum freeze drying temperature investigation table of table
| Project | Paeonol content rate of descent |
| Temperature controls -20 DEG C -- and 10 DEG C | 0.87% |
| Temperature controls -10 DEG C -0 DEG C | 1.05% |
| Temperature controls 0 DEG C -10 DEG C | 4.58% |
| Temperature controls 10 DEG C -20 DEG C | 13.74% |
| Temperature controls 20 DEG C -30 DEG C | 17.01% |
As can be seen from the above table: constantly rising as temperature controls, the content rate of descent of Paeonol constantly rises.In conjunction with warp
The angle analysis of Ji is thought: at 0 DEG C -10 DEG C, it is best that content rate of descent, which controls within 5%, for temperature control.
In summary: optimised process is 176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus water
12 times of amounts decoct three times, and it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, and clear cream relative density is
1.30.66 parts by weight of cortex moutan, 88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan is steamed using overheat
Vapour sterilizing uses gas velocity heat sterilization machine, and gas temperature is heated to 180 degree or more, conveys crude drug simultaneously by steam pressure
Powder completed sterilizing within 4 seconds time, then medicinal powder is segregated into cooling zone, completed out powder.Fructus Corni uses hot air sterilization,
Poria cocos uses moist heat sterilization；Fructus Corni uses hot air sterilizer, and 160 degree of heated dry air is directly over heated object, drying,
Disinfecting time 30-50 minutes；Poria cocos Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, controls
103.4 kPas of vapour pressures, 70 degree of drying after sterilizing.Crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed,
18 mesh softwoods.Using Vacuum Freezing & Drying Technology, vacuum degree -1kPa is controlled, temperature controls 0 DEG C -10 DEG C, is drying to obtain, 14
Mesh whole grain.Tabletting, sugar coating or film-coating, pressing plate, outsourcing, i.e.,.
The sample for choosing optimised process preparation carries out accelerated stability investigation, investigates condition are as follows: 40 DEG C ± 2 DEG C of temperature, phase
It is placed 6 months under conditions of humidity 75% ± 5%.0th month during test, the 1st month, the 2nd month, the 3rd month, the
6 months separately sampled primary, is detected.Such as table 4
The accelerated stability data of 4 scheme of table
It is obtained from above-mentioned all data analyses: stability of the sample for using optimised process of the present invention to prepare than prior art
Good, products obtained therefrom stability is strong, long-term to place, and does not occur changing colour and spot, integrated artistic are easily operated, answers suitable for promoting
With.
The present invention on the basis of existing technology, improves the prior art, keeps the present invention excellent on many index
In the prior art:
The comparison of table 5 and the prior art
From above-mentioned data it can be seen that the paeonol content and Determination of Loganin of sample obtained by the technology of the present invention are due to it
Its prior art, medicinal material processing mode and other techniques are different, and particle drying mode uses vacuum freeze drying skill for the first time
Art.Therefore, the present invention has advanced and originality.
Specific embodiment
Present invention is further described in detail with reference to embodiments.
A kind of embodiment 1: preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus 12 times of amounts of water decoct three times, first,
Secondary is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and clear cream relative density is 1.30.66 parts by weight of cortex moutan,
88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan is gone out using retorted using air-flow speed heat
Gas temperature is heated to 180 degree or more by bacterium machine, is conveyed crude drug powder simultaneously by steam pressure, was completed to go out within 4 seconds time
Bacterium, then medicinal powder is segregated into cooling zone, complete out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Fructus Corni
Using hot air sterilizer, 160 degree of heated dry air is directly over heated object, drying, disinfecting time 30-50 minutes；Poria cocos
Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, 103.4 kPas of vapour pressures is controlled, after sterilizing
70 degree of drying.Crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.Using vacuum refrigeration
Dry technology, controls vacuum degree -1kPa, and temperature controls 0 DEG C -10 DEG C, is drying to obtain, 14 mesh whole grains.Tabletting, sugar coating or film
Clothing, pressing plate, outsourcing to get.
A kind of embodiment 2: preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus 15 times of amounts of water decoct three times, first,
Secondary is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and clear cream relative density is 1.30.66 parts by weight of cortex moutan,
88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan is gone out using retorted using air-flow speed heat
Gas temperature is heated to 180 degree or more by bacterium machine, is conveyed crude drug powder simultaneously by steam pressure, was completed to go out within 4 seconds time
Bacterium, then medicinal powder is segregated into cooling zone, complete out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Fructus Corni
Using hot air sterilizer, 160 degree of heated dry air is directly over heated object, drying, disinfecting time 30-50 minutes；Poria cocos
Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, 103.4 kPas of vapour pressures is controlled, after sterilizing
70 degree of drying.Crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.Using vacuum refrigeration
Dry technology controls vacuum degree -1kPa, and temperature controls -10 DEG C -- it 20 DEG C, is drying to obtain, 14 mesh whole grains.Tabletting, film coating,
Pressing plate, outsourcing to get.
A kind of embodiment 3: preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus 20 times of amounts of water decoct three times, first,
Secondary is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and clear cream relative density is 1.30.66 parts by weight of cortex moutan,
88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan is gone out using retorted using air-flow speed heat
Gas temperature is heated to 180 degree or more by bacterium machine, is conveyed crude drug powder simultaneously by steam pressure, was completed to go out within 4 seconds time
Bacterium, then medicinal powder is segregated into cooling zone, complete out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Fructus Corni
Using hot air sterilizer, 160 degree of heated dry air is directly over heated object, drying, disinfecting time 30-50 minutes；Poria cocos
Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, 103.4 kPas of vapour pressures is controlled, after sterilizing
70 degree of drying.Crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.Using vacuum refrigeration
Dry technology, controls vacuum degree -1kPa, and temperature controls 20 DEG C -30 DEG C, is drying to obtain, 14 mesh whole grains.Tabletting, sugar coating, pressure
Plate, outsourcing to get.
Claims (6)
1. a kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue, which is characterized in that the described method comprises the following steps:
1) Rehmannia glutinosa, Chinese yam, three kinds of medicinal materials of rhizoma alismatis add water to cook extraction, obtain extracting solution, extracting solution is concentrated to get clear cream；
2) cortex moutan, Fructus Corni, three kinds of pulverizing medicinal materials of Poria cocos carry out sterilization treatment after crushing；
3) prepared by tablet: the sterilizing medicinal powder of the clear cream of step 1 and step 2 being mixed, 18 mesh softwoods, dry, whole grain；Pressure
Piece to obtain the final product, as needed, can be with film coating or sugar-coat.
2. preparation method according to claim 1, which is characterized in that the preparation method is as follows:
1) it by 176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis ratio by weight, carries out adding 8-20 times of water
Amount decocts three times, and it is for the third time 1 hour that first and second time, which is respectively 2 hours, collecting decoction, filtration, and clear cream relative density is 1.30；
2) 66 parts by weight of cortex moutan, 88 parts by weight of Fructus Corni, 66 parts by weight of Poria cocos are crushed, and sterilizing, sterilization method is respectively as follows:
Retorted, hot air sterilization, moist heat sterilization；
3) crude drug powder after obtained clear cream and acquired three kinds of sterilizings is mixed, 18 mesh softwoods.It is dry using vacuum refrigeration
Dry technology, control vacuum degree is in -1kPa, and temperature is controlled at -20 DEG C -30 DEG C, 14 mesh whole grains after drying, tabletting.
3. preparation method according to claim 2, which is characterized in that wherein 12 times of amounts of step 1) plus water decoct three times, the
First and second is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and clear cream relative density is 1.30.
4. preparation method according to claim 2, which is characterized in that wherein step 2) cortex moutan uses retorted
Using gas velocity heat sterilization machine, gas temperature is heated to 180 degree or more, crude drug powder is conveyed simultaneously by steam pressure, at 4 seconds
Time in complete sterilizing, then medicinal powder is segregated into cooling zone, completes out powder.Fructus Corni uses hot air sterilization, and Poria cocos uses
Moist heat sterilization；Fructus Corni uses hot air sterilizer, and 160 degree of heated dry air is directly over heated object, drying, disinfecting time
30-50 minutes；Poria cocos Chinese patent drug sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, controls 103.4 kPas
Vapour pressure, 70 degree of drying after sterilizing.
5. preparation method according to claim 2, which is characterized in that wherein the control of step 3) temperature is at 0 DEG C -10 DEG C.
6. preparation method according to claim 2, which comprises the following steps:
176 parts by weight of Rehmannia glutinosa, 88 parts by weight of Chinese yam, 66 parts by weight of rhizoma alismatis carry out plus 12 times of amounts of water decoct three times, and first and second time
It is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, clear cream relative density is 1.30.66 parts by weight of cortex moutan, mountain Zhu
88 parts by weight of cornel, 66 parts by weight of Poria cocos are crushed respectively, and cortex moutan uses gas velocity heat sterilization machine using retorted,
Gas temperature is heated to 180 degree or more, crude drug powder is conveyed simultaneously by steam pressure, sterilizing was completed within 4 seconds time, then
Medicinal powder is segregated into cooling zone, completes out powder, Fructus Corni uses hot air sterilization, and Poria cocos uses moist heat sterilization；Fructus Corni uses
160 degree of heated dry air is directly over heated object, drying by hot air sterilizer, and disinfecting time 30-50 minutes；In Poria cocos at
Medicine sterilizing cabinet leads to steam sterilizing, and control sterilizes 1 hour at 115-121 DEG C, 103.4 kPas of vapour pressures is controlled, 70 degree after sterilizing
Drying mixes the crude drug powder after obtained clear cream and acquired three kinds of sterilizings, 18 mesh softwoods, using vacuum freeze drying
Technology, controls vacuum degree -1kPa, and temperature controls 0 DEG C -10 DEG C, is drying to obtain, 14 mesh whole grains, tabletting is coated to obtain the final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810970881.8A CN109010558A (en) | 2018-08-24 | 2018-08-24 | A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810970881.8A CN109010558A (en) | 2018-08-24 | 2018-08-24 | A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109010558A true CN109010558A (en) | 2018-12-18 |
Family
ID=64627351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810970881.8A Pending CN109010558A (en) | 2018-08-24 | 2018-08-24 | A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010558A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114699476A (en) * | 2022-04-11 | 2022-07-05 | 贵州中医药大学 | Medicine for treating fatigue and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565494A (en) * | 2003-06-25 | 2005-01-19 | 毛友昌 | Chewing tablet of |
-
2018
- 2018-08-24 CN CN201810970881.8A patent/CN109010558A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565494A (en) * | 2003-06-25 | 2005-01-19 | 毛友昌 | Chewing tablet of |
Non-Patent Citations (3)
| Title |
|---|
| 卢鹏伟等: "臭氧技术在制药行业中的应用", 《机电信息》 * |
| 郭奕等: "中药原生药粉的灭菌方法及其设备选型", 《机电信息》 * |
| 钟燕祥等: "《华夏医学论文集》", 30 June 1992, 中国科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114699476A (en) * | 2022-04-11 | 2022-07-05 | 贵州中医药大学 | Medicine for treating fatigue and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2005215225A1 (en) | Plant-based medicament for the treatment of Hepatitis C | |
| CN105250675B (en) | A kind of Chinese medicine composition for being used to prepare the medicine for the treatment of tumour | |
| CN102380061B (en) | A kind of eliminating the phlegm, dissolving phlegm, the Chinese medicine composition of cough-relieving and preparation method and application | |
| CN105831757A (en) | Preparation method of deer skin gelatin powder | |
| KR20130104692A (en) | Composition foranti-obesity using extract of crataegi fructus | |
| KR20110056905A (en) | Composition of mixed herb medicine for leached tea | |
| CN104222418A (en) | Rosebud beauty-maintaining tea and preparation method thereof | |
| CN109010558A (en) | A kind of preparation method for the six drugs containing rehmanniae piece that kidney tonifying is antifatigue | |
| CN103055098A (en) | Freeze-dried yam for preventing and treating cancer | |
| CN106579410A (en) | Maca, ginseng and Lycium ruthenicum Murr. tablet and preparation method thereof | |
| CN106177345A (en) | QIJU DIHUANG WAN and preparation method thereof | |
| CN106491678A (en) | A kind of processing method of cooked Radix Notoginseng and purposes | |
| CN104719534A (en) | Anti-aging tea bag and preparation method thereof | |
| CN106306959A (en) | Technology for preparing beverage containing honeysuckle extract | |
| KR101154031B1 (en) | Composition for Antifati gue containin g herbal mixture extract as in gredient compounds | |
| CN108704016A (en) | A kind of liver-protecting combination and preparation method thereof | |
| CN112914097A (en) | Health-care solid beverage for damp-heat constitution and preparation method thereof | |
| CN111165770A (en) | Four-tower Dai medicated soup for postpartum regulation and nourishing of women and preparation method thereof | |
| CN112914009A (en) | Health-care solid beverage for yang-deficiency constitution and preparation method thereof | |
| CN109464609A (en) | Composition and preparation method thereof with effect for reducing blood fat | |
| CN105267291B (en) | Compound composition for treating or protecting liver injury | |
| CN109223973B (en) | Radiation-proof composition and preparation method and application thereof | |
| CN107494630A (en) | A kind of composition for treating Fructus Akebiae anthracnose | |
| Carradori et al. | Patent survey on saffron and its multiple applications: an update | |
| TWI302442B (en) | Process methods and compositions to treat dysmenorrhea and premenstrual syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181218 |
|
| RJ01 | Rejection of invention patent application after publication |