CN103055075A - Pure Chinese medicinal composition for treating nematodosis and taeniasis of fish and preparation method of pure Chinese medicinal composition - Google Patents
Pure Chinese medicinal composition for treating nematodosis and taeniasis of fish and preparation method of pure Chinese medicinal composition Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating the nematodosis and taeniasis of fish and a preparation method of the pure Chinese medicinal composition. The pure Chinese medicinal composition for treating the nematodosis and taeniasis of the fish is prepared by mixing the following components in part by weight: 25 to 45 parts of quisqualis indica, 25 to 45 parts of rhubarb, 20 to 40 parts of salt, 20 to 40 parts of fineleaf schizonepeta herb, 15 to 35 parts of caulis perillae, 15 to 35 parts of chinaberry bark and root-bark, 20 to 40 parts of costus root, 20 to 40 parts of dandelion, 25 to 45 parts of cyrtomium rhizome and 25 to 45 parts of areca catechu. The pure Chinese medicinal composition and the preparation method have the advantages that the pure Chinese medicinal composition is rational in formula, easy to prepare, free of toxic or side effects, medicament residues and medicament resistance and high in superfine grinding degree and bioavailability, can treat both symptoms and root causes and has remarkable curative effects, and clinical results prove that the pure Chinese medicinal composition has a special effect of treating the nematodosis and taeniasis of the fish.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment fishing line parasitosis and taeniasis and preparation method thereof.
Background technology
Fishing line parasitosis a kind of parasitic disease that to be nematosis cause at the intestinal wall of fish shows as the fish body and becomes thin, the body surface blackout, and inappetence, intestinal wall inflammation etc., a large amount of parasitisms can cause the fish kills such as Mylopharyngodon piceus, Ctenopharyngodon idellus.The fish tapeworm disease is that cestode is invaded the parasitic disease that the fish intestinal causes, sick fish peels off solely to swim in the water surface and do not eat food, and health is black and thin; Cutting open has parasitic white banded polypide in the visible intestinal of fish belly, when parasite is more, fish intestinal front end is expanded, and causes intestinal obstructions, inflammation occurs.The Fish such as this worm can parasitic grass, silver carp, flathead, dace with the Ctenopharyngodon idellus especially severe of being injured, can make the large quantities of death of Ctenopharyngodon idellus.
This disease almost spreads all over all fish culture countries of the world, is widely distributed.The primary disease western medicine mainly uses antiparasitic and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis, micronizing, bioavailability are high, the specific medicament for the treatment of both the principal and secondary aspects of a disease be this field scientific research technical staff new problem anxious to be resolved it
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, micronizing, bioavailability are high, treating both the principal and secondary aspects of a disease, effective treatment fishing line parasitosis of successful and pure Chinese medicine composition of taeniasis and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis, by following component by weight mixed preparing form: Fructus Quisqualis 25-45 part, Radix Et Rhizoma Rhei 25-45 part, Sal 20-40 part, Herba Schizonepetae 20-40 part, Caulis Perillae 15-35 part, Cortex Meliae 15-35 part, Radix Aucklandiae 20-40 part, Herba Taraxaci 20-40 part, Rhizoma Osmundae 25-45 part, Semen Arecae 25-45 part.
Described various component optimum ratio amount is: 35 parts of Fructus Quisqualis, 35 parts of Radix Et Rhizoma Rhei, 30 parts of Sal, 30 parts of Herba Schizonepetae, 25 parts of Caulis Perillaes, 25 parts of Cortex Meliaees, 30 parts of the Radix Aucklandiae, 30 parts of Herba Taraxacis, 35 parts of Rhizoma Osmundae, 35 parts of Semen Arecaes.
A kind of preparation method for the treatment of the pure Chinese medicine composition of fishing line parasitosis and taeniasis, carry out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Fructus Quisqualis 25-45 part, Radix Et Rhizoma Rhei 25-45 part, Sal 20-40 part, Herba Schizonepetae 20-40 part, Caulis Perillae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight Cortex Meliae 15-35 part, Radix Aucklandiae 20-40 part, Herba Taraxaci 20-40 part, Rhizoma Osmundae 25-45 part, Semen Arecae 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Fructus Quisqualis: sweet, warm, return stomach, spleen channel, have the function of killing insect and eliminating accumulation; Cure mainly ascariasis, abdominal pain due to worm stagnation, enterobiasis etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Sal: cold, salty, return stomach, kidney, lung, liver, large intestine, small intestine meridian, have heat-clearing and toxic substances removing, removing heat from blood, softening the hard mass, parasite killing, antipruritic function; Cure mainly trusted subordinate's distension syndrome, constipation and anuresis, hemorrhage, skin infection etc.
Herba Schizonepetae: hot, warm, return liver, lung meridian, have the function of the loose wind that induces sweat, rash, the skin ulcer that disappears; Cure mainly flu, rubella, skin infection from the beginning of etc.
Caulis Perillae: hot, warm, return spleen, lung meridian, have regulating the flow of QI to ease the stomach, pain relieving, antiabortive function; Cure mainly that the chest and diaphragm painful abdominal mass is vexed, gastralgia, belch vomiting, frequent fetal movement etc.
Cortex Meliae: bitter, cold, return stomach, spleen, Liver Channel, have the function of parasite killing, treatment tinea; Cure mainly abdominal pain due to worm stagnation, scabies etc.
The Radix Aucklandiae: hot, bitter, warm, return spleen, stomach, large intestine, three warmers, gallbladder meridian, have the function of promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cure mainly that the gastrointestinal stagnation of QI, food stagnation tripe are swollen, weight, stomachache etc. behind the dysentery.
Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp, have the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Cure mainly sore, lung abscess, pharyngalgia, jaundice due to damp-heat, pyretic stranguria etc.
Rhizoma Osmundae: bitter, cold, return liver, stomach warp, have the function of heat-clearing and toxic substances removing, cooling blood for hemostasis, anthelmintic; Cure mainly epidemic disease flu, maculae caused by violent heat pathogen, sore swollen toxin, abdominal pain due to worm stagnation etc.
Semen Arecae: bitter, hot, warm, return stomach, large intestine channel, have the function of anthelmintic, removing food stagnancy, circulation of qi promoting, diuretic; Cure mainly taeniasis, the impaction of rumen, dyspeptic abdominal distention, constipation, edema etc.
Above all herbal medicines for paathogenic factor and the clinical symptoms of fishing line parasitosis and taeniasis, are brought into play the effect for the treatment of both the principal and secondary aspects of a disease according to the theoretical compatible combination of Chinese veterinarian.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, draws materials wide, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this ten herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment fishing line parasitosis and taeniasis are had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 250 parts of Fructus Quisqualis, 250 parts of Radix Et Rhizoma Rhei, 200 parts of Sal, 200 parts of Herba Schizonepetae, 150 parts of Caulis Perillaes, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Cortex Meliaees, 200 parts of the Radix Aucklandiae, 200 parts of Herba Taraxacis, 250 parts of Rhizoma Osmundae, 250 parts of Semen Arecaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 350 parts of Fructus Quisqualis, 350 parts of Radix Et Rhizoma Rhei, 300 parts of Sal, 300 parts of Herba Schizonepetae, 250 parts of Caulis Perillaes, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Cortex Meliaees, 300 parts of the Radix Aucklandiae, 300 parts of Herba Taraxacis, 350 parts of Rhizoma Osmundae, 350 parts of Semen Arecaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight 450 parts of Fructus Quisqualis, 450 parts of Radix Et Rhizoma Rhei, 400 parts of Sal, 400 parts of Herba Schizonepetae, 350 parts of Caulis Perillaes, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Cortex Meliaees, 400 parts of the Radix Aucklandiae, 400 parts of Herba Taraxacis, 450 parts of Rhizoma Osmundae, 450 parts of Semen Arecaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
The clinical experiment animal selects 200 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus nematicide.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 60 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " fish is precious loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 3% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 1 is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus nematicide:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 25 | 45 | 30 |
| II | The precious loose group of fish | 10.0 | 73.3 | 16.7 |
| III | Present composition group | 5.0 | 83.3 | 11.7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the precious loose group of fish aspect the cure rate.
The clinical experiment animal selects 300 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus taeniasis.Ill fish isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 100 tails, 3 groups of feeding environments are identical, and experiment was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " fish is precious loose " by specification; Present composition group can be for oral administration with product of the present invention (embodiment of the invention 1 prepared compositions), admixes bait feeding in 3% ratio, every day 2-3 time, is used in conjunction 3-5 days; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table 2 is field applicable cases contrasts of the present invention and other medicines treatment Ctenopharyngodon idellus taeniasis:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 23 | 42 | 35 |
| II | The precious loose group of fish | 10 | 80 | 10 |
| III | Present composition group | 5 | 88 | 7 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared significant difference (P＜0.05) with the precious loose group of fish aspect the cure rate.
Safety testing:
Choose 80 age in days healthy grass carp, 30 tails, 5 times according to the embodiment of the invention 1 made compositions recommended dose took orally 10 days, during the medication, any bad or Deviant Behavior performance does not appear in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment fishing line parasitosis and taeniasis and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis, it is characterized in that by following component by weight mixed preparing form: Fructus Quisqualis 25-45 part, Radix Et Rhizoma Rhei 25-45 part, Sal 20-40 part, Herba Schizonepetae 20-40 part, Caulis Perillae 15-35 part, Cortex Meliae 15-35 part, Radix Aucklandiae 20-40 part, Herba Taraxaci 20-40 part, Rhizoma Osmundae 25-45 part, Semen Arecae 25-45 part.
2. the pure Chinese medicine composition for the treatment of fishing line parasitosis according to claim 1 and taeniasis, it is characterized in that by following component by weight mixed preparing form: 35 parts of Fructus Quisqualis, 35 parts of Radix Et Rhizoma Rhei, 30 parts of Sal, 30 parts of Herba Schizonepetae, 25 parts of Caulis Perillaes, 25 parts of Cortex Meliaees, 30 parts of the Radix Aucklandiae, 30 parts of Herba Taraxacis, 35 parts of Rhizoma Osmundae, 35 parts of Semen Arecaes.
3. the preparation method of the pure Chinese medicine composition of a treatment fishing line parasitosis according to claim 1 and 2 and taeniasis is characterized in that carrying out as follows:
(1) each composition in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing by weight Fructus Quisqualis 25-45 part, Radix Et Rhizoma Rhei 25-45 part, Sal 20-40 part, Herba Schizonepetae 20-40 part, Caulis Perillae 15-35 part, mix 5-10 minute to even;
(3) take by weighing by weight 35 parts of Cortex Meliae 15-35 parts, Radix Aucklandiae 20-40 part, Herba Taraxaci 20-40 part, Rhizoma Osmundae 25-45 part, Semen Arecae, mix 5-10 minute to evenly;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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Cited By (3)
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| CN106577378A (en) * | 2016-11-25 | 2017-04-26 | 蓝明 | Cultivation method of selenium-enriched fish |
| CN106577379A (en) * | 2016-11-25 | 2017-04-26 | 蓝明 | Culture method of selenium-rich weevers |
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| CN105031128A (en) * | 2015-09-18 | 2015-11-11 | 武汉华扬动物药业有限责任公司 | Traditional Chinese medicine composition for preventing or treating ectoparasite of aquatic culture animals and preparation method and application thereof |
| CN106577378A (en) * | 2016-11-25 | 2017-04-26 | 蓝明 | Cultivation method of selenium-enriched fish |
| CN106577379A (en) * | 2016-11-25 | 2017-04-26 | 蓝明 | Culture method of selenium-rich weevers |
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