CN101804135A - Compound combined drug for treating poultry coccidiosis and preparation method thereof - Google Patents
Compound combined drug for treating poultry coccidiosis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound combined drug for treating poultry coccidiosis and a preparation method thereof. The compound combined drug comprises the following bulk drugs in parts by weight: 6-9 parts of rangooncreeper fruit, 3-6 parts of chinaberry bark, 6-9 parts of areca seed, 10-15 parts of hawthorn fruit, 3-6 parts of costustoot, 4.5-9 parts of Chinese dwarf cherry seed, 5-9 parts of perilla seed, 16-20 parts of Chinese rhubarb, 3-5 parts of golden thread, 10-20 parts of Japanese thistle herb root, 3-6 parts of Chinese pulsatilla root and 3-6 parts of honeysuckle flower. The implementation steps are detailed as follows: (1) weighing according to weight parts; (2) rinsing and drying; (3) crushing and sieving; (4) infiltrating and extracting; (5) pressurizing, impregnating and extracting; (6) carrying out flocculate sedimentation; (7) filtering and removing impurities; and (8) concentrating, adding purified water and preparing the compound combined drug. The effective ingredients in the drug have obvious effect of repelling insects, can effectively repel and kill roundworm and pinworm of the intestinal canal, have the effect of regulating vital energy and stopping pain, and also have the effects of killing and inhibiting bacterium and the effect of repairing the damaged intestinal mucosa, thus quickly eliminating intestinal parasites and inflammation. Simultaneously, the effective ingredients in the drug have the functions of astringing to stop bleeding and diarrhea.
Description
Technical field
The present invention relates to Chinese medicine for the treatment of the birds disease and preparation method thereof, particularly a kind of compound composite medicament for the treatment of avian coccidiosis and preparation method thereof.
Background technology
At present, chicken coccidiosis is to support modal a kind of disease in the fowl production, and clinical manifestation is mainly with hemorrhagic enteritis, dysentery, and the height M ﹠ M of chickling is a feature.The coccidiosis that parasitizes chicken is a lot, and what pathogenicity was the strongest is tender eimeria tenella and murder by poisoning eimeria tenella, very big to poultry husbandry harm.Thereby coccidiosis damages intestinal tissue and causes ingesting and the disorder of digestion process or alimentation, dewatering, lose blood etc. descends the birds Abwehrkraft des Koepers, other bacterial diseasees of easy infection by colonizing in the intestinal.Primary disease mainly betides the chickling in 3 monthly ages, easy infection in the 15-45 age in days, and the chickling mortality rate can reach 50%, even 100%.The present medicine multiselect ion carrier antibiotic of treatment coccidiosis, as very can mycete, horse shut out mycete, Salinomycin and chemical synthetic drug, as Robenidine, diclazuril etc.; But because above drug residue problem more and more causes people's attention; Therefore, providing a kind of Chinese medicine preparation of noresidue, effectively prevent and treat avian coccidiosis, is present urgent problem.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, a kind of compound composite medicament for the treatment of avian coccidiosis and preparation method thereof is provided.
Implementation of the present invention is as follows for achieving the above object: a kind of compound composite medicament for the treatment of avian coccidiosis is characterized in that being prepared from by following crude drug by weight: Fructus Quisqualis 6-9 part, Cortex Meliae 3-6 part, Semen Arecae 6-9 part, Fructus Crataegi 10-15 part, Radix Aucklandiae 3-6 part, Semen Pruni 4.5-9 part, Fructus Perillae 5-9 part, Radix Et Rhizoma Rhei 16-20 part, Rhizoma Coptidis 3-5 part, Radix Cirsii Japonici 10-20 part, Radix Pulsatillae 3-6 part, Flos Lonicerae 3-6 part.
A kind of preparation method for the treatment of the compound composite medicament of avian coccidiosis, concrete implementation step is as follows:
(1) takes by weighing by weight: Fructus Quisqualis 6-9 part, Cortex Meliae 3-6 part, Semen Arecae 6-9 part, Fructus Crataegi 10-15 part, Radix Aucklandiae 3-6 part, Semen Pruni 4.5-9 part, Fructus Perillae 5-9 part, Radix Et Rhizoma Rhei 16-20 part, Rhizoma Coptidis 3-5 part, Radix Cirsii Japonici 10-20 part, Radix Pulsatillae 3-6 part, Flos Lonicerae 3-6 part;
(2) rinsing drying: routinely that above-mentioned various crude drug rinsings are clean, make it at 60 ℃-100 ℃ of temperature, time 1-2 hour inner drying;
(3) crushing screening: adopt pulverizer that crude drug is pulverized, cross sieve No. 2;
(4) soak into extraction: the crude drug after the pulverizing soaked in purified water 3-4 hour, and quantity of solvent is 2-4 a times of crude drug total amount;
(5) pressurization is oozed: adopt pressurization infiltration method extraction fast, 1.5 hours time, pressure is 200Pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1+1 natural clarifying agent, and the ratio of flocculating setting agent is 1% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 350 purpose films, remove impurity such as destarching, resin, tannin;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution, the purified water that adds the 3-4 times of weight is again made.
Composition principle: this product prescription compiles monarch, minister, helps, makes, and according to the principle of traditional Chinese medical science organic conception and determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, has brought into play Chinese medicine and has distinguished a double function of controlling, and its concrete function is summarized as follows with curing mainly:
1, anthelmintic, anti-inflammation: Fructus Quisqualis has the effect of expelling and killing ascarid, removing food stagnancy spleen invigorating.Cortex Meliae has parasite killing, regulates the flow of vital energy, the analgesic effect.Semen Arecae has that parasite killing, row stagnate, the effect of diuretic.Flos Lonicerae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Pulsatillae all have the effect of heat-clearing and toxic substances removing, the diffusing poison of detumescence, eliminating pathogenic heat from blood to cure dysentery.Therefore the effective ingredient in this product has stronger anthelmintic action, can effectively kill bellyworm, pinworm, and has an effect of regulating QI to relieve pain, effective ingredient in the Chinese medicine has the bactericidal effect simultaneously, and to the damage intestinal mucosa have repair, thereby eliminate Enterozoa and inflammation fast.
2, the function that has astringing to arrest bleeding, antidiarrheal: Fructus Crataegi has the effect of dyspepsia and intestinal stasis relieving, dispelling the stagnated QI dissipating blood stasis.The Radix Aucklandiae has promoting the circulation of QI to relieve pain, the effect of stomach function regulating antidiarrheal.Radix Cirsii Japonici has removing heat from blood, hemostatic effect.Semen Pruni has the effect of loosening bowel to relieve constipation, inducing diuresis to remove edema.Fructus Perillae has the effect of intestine moistening, relieving constipation.Therefore the effective ingredient among this side can be treated the various hemorrhages that bleeding due to blood-heat causes effectively, and the performance anastalsis suppresses intestinal bleeding, adds the QI invigorating medicine simultaneously, can effectively treat because the deficiency of vital energy can not be taken the photograph the intestinal bleeding that blood causes.
The invention has the beneficial effects as follows: the effective ingredient in this medicine has significant anthelmintic action, can effectively kill bellyworm, pinworm, and has an effect of regulating QI to relieve pain, and the effective ingredient in the Chinese medicine has sterilization and presses down all effects, intestinal mucosa to damage has repair, thereby eliminates Enterozoa and inflammation fast.The function that has astringing to arrest bleeding, antidiarrheal simultaneously.
In a word, reasonable recipe of the present invention, preparation technology is simple, and outstanding effect is the triple function with expelling and killing ascarid, dyspepsia and intestinal stasis relieving and cooling blood for hemostasis, and is widely used.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1 (every weight portion is by 1kg)
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 8kg, Cortex Meliae 4kg, Semen Arecae 7kg, Fructus Crataegi 13kg, Radix Aucklandiae 6kg, Semen Pruni 6kg, Fructus Perillae 6kg, Radix Et Rhizoma Rhei 20kg, Rhizoma Coptidis 5kg, Radix Cirsii Japonici 20kg, Radix Pulsatillae 5kg, Flos Lonicerae 5kg.
The concrete implementation step of this composition of medicine is as follows:
(1) takes by weighing by weight: Fructus Quisqualis 8kg, Cortex Meliae 4kg, Semen Arecae 7kg, Fructus Crataegi 13kg, Radix Aucklandiae 6kg, Semen Pruni 6kg, Fructus Perillae 6kg, Radix Et Rhizoma Rhei 20kg, Rhizoma Coptidis 5kg, Radix Cirsii Japonici 20kg, Radix Pulsatillae 5kg, Flos Lonicerae 5kg;
(2) rinsing drying: routinely that above-mentioned various crude drug rinsings are clean, make it at 60 ℃-100 ℃ of temperature, time 1-2 hour inner drying;
(3) crushing screening: adopt pulverizer that crude drug is pulverized, cross sieve No. 2;
(4) soak into extraction: the crude drug after the pulverizing soaked in purified water 3-4 hour, and quantity of solvent is 2-4 a times of crude drug total amount;
(5) pressurization is oozed: adopt pressurization infiltration method extraction fast, 1.5 hours time, pressure is 200Pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1+1 natural clarifying agent, and the ratio of flocculating setting agent is 1% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 350 purpose films, remove impurity such as destarching, resin, tannin;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution, the purified water that adds the 3-4 times of weight is again made.
Embodiment 2
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 6kg, Cortex Meliae 4kg, Semen Arecae 5kg, Fructus Crataegi 10kg, Radix Aucklandiae 4kg, Semen Pruni 4kg, Radix Cirsii Japonici 10kg, Fructus Perillae 5kg, Radix Et Rhizoma Rhei 16kg, Rhizoma Coptidis 3kg, Radix Pulsatillae 3kg, Flos Lonicerae 5kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 3
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 7kg, Cortex Meliae 3kg, Semen Arecae 6kg part, Fructus Crataegi 13kg, Radix Aucklandiae 3kg, Semen Pruni 5kg, Radix Cirsii Japonici 13kg, Fructus Perillae 5kg, Radix Et Rhizoma Rhei 17kg part, Rhizoma Coptidis 4kg, Radix Pulsatillae 6kg, Flos Lonicerae 3kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 4
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 8kg, Cortex Meliae 4kg, Semen Arecae 7kg, Fructus Crataegi 13kg, Radix Aucklandiae 6kg, Semen Pruni 7kg, Radix Cirsii Japonici 15kg, Fructus Perillae 6kg, Radix Et Rhizoma Rhei 18kg part, Rhizoma Coptidis 5kg, Radix Pulsatillae 4kg, Flos Lonicerae 3kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 5
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 7kg, Cortex Meliae 5kg, Semen Arecae 6kg, Fructus Crataegi 15kg, Radix Aucklandiae 5kg, Semen Pruni 7kg, Radix Cirsii Japonici 16kg, Fructus Perillae 8kg, Radix Et Rhizoma Rhei 19kg part, Rhizoma Coptidis 4kg, Radix Pulsatillae 4kg, Flos Lonicerae 6kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 6
A kind of compound composite medicament for the treatment of avian coccidiosis, comprise Fructus Quisqualis 9kg, Cortex Meliae 6kg, Semen Arecae 8kg, Fructus Crataegi 13kg, Radix Aucklandiae 6kg, Semen Pruni 9kg, Radix Cirsii Japonici 14kg, Fructus Perillae 8kg, Radix Et Rhizoma Rhei 17kg part, Rhizoma Coptidis 3kg, Radix Pulsatillae 3kg, Flos Lonicerae 3kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 7
A kind of compound composite medicament for the treatment of avian coccidiosis, comprise Fructus Quisqualis 8kg, Cortex Meliae 5kg, Semen Arecae 7kg, Fructus Crataegi 13kg, Radix Aucklandiae 5kg, Semen Pruni 7kg, Radix Cirsii Japonici 20kg, Fructus Perillae 7kg, Radix Et Rhizoma Rhei 17kg part, Rhizoma Coptidis 3kg, Radix Pulsatillae 3kg, Flos Lonicerae 3kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 8
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 6kg, Cortex Meliae 6kg, Semen Arecae 9kg, Fructus Crataegi 15kg, Radix Aucklandiae 6kg, Semen Pruni 9kg, Radix Cirsii Japonici 16kg, Fructus Perillae 9kg, Radix Et Rhizoma Rhei 16kg part, Rhizoma Coptidis 3kg, Radix Pulsatillae 5kg, Flos Lonicerae 3kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 9
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 9kg, Cortex Meliae 6kg, Semen Arecae 9kg, Fructus Crataegi 10kg, Radix Aucklandiae 3kg, Semen Pruni 4.5kg, Radix Cirsii Japonici 15kg, Fructus Perillae 10kg, Radix Et Rhizoma Rhei 18kg part, Rhizoma Coptidis 4kg, Radix Pulsatillae 3kg, Flos Lonicerae 5kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Embodiment 10
A kind of compound composite medicament for the treatment of avian coccidiosis comprises Fructus Quisqualis 6kg, Cortex Meliae 3kg, Semen Arecae 6kg, Fructus Crataegi 10kg, Radix Aucklandiae 6kg, Semen Pruni 9kg, Radix Cirsii Japonici 17kg, Fructus Perillae 9kg, Radix Et Rhizoma Rhei 19kg part, Rhizoma Coptidis 4kg, Radix Pulsatillae 4kg, Flos Lonicerae 4kg.
Take by weighing the preparation method behind the above various crude drug and other is with embodiment 1.
Clinical trial:
AA chickling artificial vaccination coccidiosis worm's ovum with the 12-15 age in days, adopt respectively in the invention process 1 preparation this treatment avian coccidiosis compound composite medicament height (1.0ml/kg mixes drink), in (0.5ml/kg mixes drink), low dosage (0.25ml/kg mixes drink), ball peaceful (0.3mkg/kg mixes and drinks the medicine matched group) treat according to the amount of the regulation in the experimental program.Clinical efficacy experiment through this experiment shows, mortality rate, the medicine of this medicine group chickling of the embodiment of the invention 1 preparation wanted the poor heteropole of efficient and cure rate and infected group significantly (P＜0.01), and this compound recipe combined traditional Chinese medicine that shows this treatment avian coccidiosis has better curative effect to avian coccidiosis.
Table 1 test method:
| Numbering | Group | Quantity/only | Usage and consumption | Drug treatment |
| ??A | The normal healthy controls group | ??60 | Do not infect, not administration, sufficient drinking-water | ??- |
| ??B | Infect matched group | ??60 | Do not infect, not administration, sufficient drinking-water | ??- |
| ??C | Embodiment 1 high dose group | ??60 | 1.0ml/kg/24h mix drink | 6 days |
| ??D | Dosage group among the embodiment 1 | ??60 | 0.5kg/24h mix drink | 6 days |
| ??E | Embodiment 1 low dose group | ??60 | 0.25/24h mix drink | 6 days |
| ??F | Ball is rather organized (medicine matched group) | ??60 | 0.3ml/kg/24h mix drink | 6 days |
Table 2 experimental result
| Numbering | Group | Mortality rate/% | Inefficiency/% | Effective percentage/% | Cure rate/% | The relative weight gain rate % |
| ??A | The normal healthy controls group | ??0 | ??0 | ??0 | ??0 | ??100 |
| Numbering | Group | Mortality rate/% | Inefficiency/% | Effective percentage/% | Cure rate/% | The relative weight gain rate % |
| ??B | Infect matched group | ??37.5 | ??37.5 | ??62.5 | ??62.5 | ??62.5 |
| ??C | Embodiment 1 high dose group | ??7.9 | ??4.2 | ??95.8 | ??95.8 | ??95 |
| ??D | Dosage group among the embodiment 1 | ??9.2 | ??9.6 | ??90.4 | ??90.4 | ??87.2 |
| ??E | Embodiment 1 low dose group | ??13.5 | ??15.4 | ??81.5 | ??80.1 | ??80.5 |
| ??F | Ball is rather organized (medicine matched group) | ??20.5 | ??22.2 | ??76 | ??66.5 | ??84.5 |
This result of the test shows that medicine of the present invention is used for the treatment of the birds coccidiosis very obvious effects.Curative effect statistics and X2 assay show that the therapeutic effect difference of the peaceful group of this medicine height, middle low dose group and ball is (P＜0.01) extremely significantly.
Application example:
The application of medicine of the present invention aspect chicken coccidiosis and the treatment of escherichia coli mixed infection case.
2000 of area, Shandong one raiser AA broiler chicken, in the morbidity of 25 ages in days, it is depressed, slow-witted upright that spirit appears in the initial stage, and fertilizer just is with blood, and sick chicken outward appearance feather pine is disorderly.
Cut open inspection: dissect 10 chickens, sick chicken is found heart, the cheesy thing of liver outer wrapping, and caecum is hemorrhage, and according to disease symptom, pathological change, to be coccidiosis combine infection with escherichia coli are mixed in tentative diagnosis.
Drug therapy:
(1) strengthens feeding and management, add in the drinking-water in " multidimensional electrolyte ".
(2) medicine 400ml/1000 every day of the present invention, concentrate and once drink the morning.
Medication 4 days was paid a return visit on the 5th day, and chicken mines massively to eat to be increased, and is almost recovered.
Above-mentioned detailed description of compound composite medicament of this treatment avian coccidiosis and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can exemplify out several embodiment according to limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (2)
1. a compound composite medicament for the treatment of avian coccidiosis is characterized in that being prepared from by following crude drug by weight: Fructus Quisqualis 6-9 part, Cortex Meliae 3-6 part, Semen Arecae 6-9 part, Fructus Crataegi 10-15 part, Radix Aucklandiae 3-6 part, Semen Pruni 4.5-9 part, Fructus Perillae 5-9 part, Radix Et Rhizoma Rhei 16-20 part, Rhizoma Coptidis 3-5 part, Radix Cirsii Japonici 10-20 part, Radix Pulsatillae 3-6 part, Flos Lonicerae 3-6 part.
2. the preparation method of the compound composite medicament of a treatment avian coccidiosis according to claim 1 is characterized in that concrete implementation step is as follows:
(1) takes by weighing by weight: Fructus Quisqualis 6-9 part, Cortex Meliae 3-6 part, Semen Arecae 6-9 part, Fructus Crataegi 10-15 part, Radix Aucklandiae 3-6 part, Semen Pruni 4.5-9 part, Fructus Perillae 5-9 part, Radix Et Rhizoma Rhei 16-20 part, Rhizoma Coptidis 3-5 part, Radix Cirsii Japonici 10-20 part, Radix Pulsatillae 3-6 part, Flos Lonicerae 3-6 part;
(2) rinsing drying: routinely that above-mentioned various crude drug rinsings are clean, make it at 60 ℃-100 ℃ of temperature, time 1-2 hour inner drying;
(3) crushing screening: adopt pulverizer that crude drug is pulverized, cross sieve No. 2;
(4) soak into extraction: the crude drug after the pulverizing soaked in purified water 3-4 hour, and quantity of solvent is 2-4 a times of crude drug total amount;
(5) pressurization is oozed: adopt pressurization infiltration method extraction fast, 1.5 hours time, pressure is 200Pa;
(6) flocculating sedimentation: the flocculating setting agent of employing is the ZTC1+1 natural clarifying agent, and the ratio of flocculating setting agent is 1% of an extract total amount;
(7) filter: adopt ultrafiltration membrance filter, cross 350 purpose films, remove destarching, resin, tannin impurity;
(8) concentrate: be concentrated into relative density and be 1.05 concentrated solution, the purified water that adds the 3-4 times of weight is again made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201010158856A CN101804135A (en) | 2010-04-28 | 2010-04-28 | Compound combined drug for treating poultry coccidiosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010158856A CN101804135A (en) | 2010-04-28 | 2010-04-28 | Compound combined drug for treating poultry coccidiosis and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293225A (en) * | 2011-06-30 | 2011-12-28 | 徐建明 | Environment-friendly household Chinese herbal medicine insect repellent pesticide |
| CN103055075A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating nematodosis and taeniasis of fish and preparation method of pure Chinese medicinal composition |
| CN105797048A (en) * | 2016-04-21 | 2016-07-27 | 颍上县中军农业科技开发有限公司 | Drug for controlling coccidiosis in pigeons |
-
2010
- 2010-04-28 CN CN201010158856A patent/CN101804135A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102293225A (en) * | 2011-06-30 | 2011-12-28 | 徐建明 | Environment-friendly household Chinese herbal medicine insect repellent pesticide |
| CN103055075A (en) * | 2012-12-04 | 2013-04-24 | 青岛绿曼生物工程有限公司 | Pure Chinese medicinal composition for treating nematodosis and taeniasis of fish and preparation method of pure Chinese medicinal composition |
| CN103055075B (en) * | 2012-12-04 | 2015-07-29 | 青岛绿曼生物工程有限公司 | Pure Chinese medicine composition for the treatment of fishing line parasitosis and taeniasis and preparation method thereof |
| CN105797048A (en) * | 2016-04-21 | 2016-07-27 | 颍上县中军农业科技开发有限公司 | Drug for controlling coccidiosis in pigeons |
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Application publication date: 20100818 |