CN103025351B - 包含胆固醇和作为唯一的佐剂-载剂分子的cpg的疫苗 - Google Patents
包含胆固醇和作为唯一的佐剂-载剂分子的cpg的疫苗 Download PDFInfo
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- CN103025351B CN103025351B CN201180036906.3A CN201180036906A CN103025351B CN 103025351 B CN103025351 B CN 103025351B CN 201180036906 A CN201180036906 A CN 201180036906A CN 103025351 B CN103025351 B CN 103025351B
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Abstract
Description
疫苗组 | 佐剂(剂量) | 载剂 |
T01 | 无 | 无 |
T02 | CpG23878(250μg) | QCDCR |
T03 | CpG23877(1:10) | 胆固醇 |
T04 | CpG23878(1:10) | 胆固醇 |
T05 | 铝胶 | 无 |
Claims (27)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34924410P | 2010-05-28 | 2010-05-28 | |
US61/349,244 | 2010-05-28 | ||
PCT/IB2011/052347 WO2011148356A1 (en) | 2010-05-28 | 2011-05-27 | Vaccines comprising cholesterol and cpg as sole adjuvant - carrier molecules |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103025351A CN103025351A (zh) | 2013-04-03 |
CN103025351B true CN103025351B (zh) | 2016-08-24 |
Family
ID=44626939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180036906.3A Active CN103025351B (zh) | 2010-05-28 | 2011-05-27 | 包含胆固醇和作为唯一的佐剂-载剂分子的cpg的疫苗 |
Country Status (22)
Country | Link |
---|---|
US (1) | US10456463B2 (zh) |
EP (1) | EP2575878B1 (zh) |
JP (3) | JP6034285B2 (zh) |
KR (1) | KR101528021B1 (zh) |
CN (1) | CN103025351B (zh) |
AU (2) | AU2011259718B2 (zh) |
BR (1) | BR112012030337B1 (zh) |
CA (1) | CA2800158C (zh) |
CL (1) | CL2012003299A1 (zh) |
DK (1) | DK2575878T3 (zh) |
ES (1) | ES2683316T3 (zh) |
HR (1) | HRP20181039T1 (zh) |
HU (1) | HUE038894T2 (zh) |
LT (1) | LT2575878T (zh) |
MX (1) | MX347471B (zh) |
NZ (1) | NZ603527A (zh) |
PL (1) | PL2575878T3 (zh) |
PT (1) | PT2575878T (zh) |
RS (1) | RS57428B1 (zh) |
SI (1) | SI2575878T1 (zh) |
WO (1) | WO2011148356A1 (zh) |
ZA (1) | ZA201208837B (zh) |
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PL2376107T3 (pl) * | 2008-12-09 | 2014-09-30 | Coley Pharm Group Inc | Oligonukleotydy immunostymulujące |
US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
US9314519B2 (en) * | 2012-08-21 | 2016-04-19 | Intervet Inc. | Liquid stable virus vaccines |
ES2894138T3 (es) * | 2013-05-14 | 2022-02-11 | Zoetis Services Llc | Composiciones de vacuna novedosas que comprenden oligonucleótidos inmunoestimulantes |
ES2750608T3 (es) | 2013-07-25 | 2020-03-26 | Exicure Inc | Construcciones esféricas a base de ácido nucleico como agentes inmunoestimulantes para uso profiláctico y terapéutico |
AU2014321369B2 (en) * | 2013-09-19 | 2020-04-16 | Zoetis Services Llc | Oil-based adjuvants |
MX2016004961A (es) | 2013-10-17 | 2016-06-28 | Zoetis Services Llc | Procedimientos y composiciones para el tratamiento de infecciones por s. equi. |
US11318200B2 (en) * | 2013-11-26 | 2022-05-03 | Zoetis Services Llc | Methods and compositions for induction of immune response |
TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
US10456459B2 (en) * | 2015-07-20 | 2019-10-29 | Zoetis Services Llc | Liposomal adjuvant compositions |
RS62015B1 (sr) * | 2015-07-20 | 2021-07-30 | Zoetis Services Llc | Kompozicije lipozomalnog adjuvansa |
CN114848656A (zh) | 2015-09-09 | 2022-08-05 | 清华大学 | 作为高效的疫苗佐剂的甲羟戊酸通路的抑制剂 |
CN107149671B (zh) * | 2016-03-03 | 2021-02-05 | 郭文江 | 一种药物组合物及其应用 |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
WO2019115385A1 (en) * | 2017-12-15 | 2019-06-20 | Bayer Animal Health Gmbh | Immunostimulatory compositions |
BR112022000347A2 (pt) * | 2019-07-12 | 2022-04-12 | Res Found Dev | Vacinas de ehrlichia e composições imunogênicas |
IT202100014747A1 (it) * | 2021-06-07 | 2022-12-07 | Consiglio Nazionale Ricerche | Derivati sterolici come nuovi ligandi del recettore dectina-1 nel trattamento terapeutico di patologie correlate a tale recettore |
CN115645417A (zh) * | 2022-10-17 | 2023-01-31 | 武汉轻工大学 | 鹅去氧胆酸在制备治疗或预防猪病毒性腹泻的药物或饲料添加剂中的应用 |
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WO2009156960A2 (en) * | 2008-06-27 | 2009-12-30 | Pfizer Inc. | Novel adjuvant compositions |
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KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 T 유사체를 함유하는 CpG 올리고뉴클레오티드 유사체 |
EP2160199A2 (en) * | 2007-05-17 | 2010-03-10 | Coley Pharmaceutical Group, Inc. | Class a oligonucleotides with immunostimulatory potency |
WO2009120247A2 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
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CN1889977A (zh) * | 2003-10-13 | 2007-01-03 | 葛兰素史密丝克莱恩生物有限公司 | 含白介素18和皂苷佐剂***的疫苗组合物 |
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