BR112022000347A2 - Vacinas de ehrlichia e composições imunogênicas - Google Patents

Vacinas de ehrlichia e composições imunogênicas

Info

Publication number
BR112022000347A2
BR112022000347A2 BR112022000347A BR112022000347A BR112022000347A2 BR 112022000347 A2 BR112022000347 A2 BR 112022000347A2 BR 112022000347 A BR112022000347 A BR 112022000347A BR 112022000347 A BR112022000347 A BR 112022000347A BR 112022000347 A2 BR112022000347 A2 BR 112022000347A2
Authority
BR
Brazil
Prior art keywords
ehrlichia
immunogenic compositions
vaccines
canis
adjuvant
Prior art date
Application number
BR112022000347A
Other languages
English (en)
Inventor
M Mwangi Duncan
J Millership Jason
W Mcbride Jere
Joseph Dominowski Paul
Sharath Rai
M Wappel Sharon
Suman Mahan
Original Assignee
Res Found Dev
Zoetis Services Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Found Dev, Zoetis Services Llc filed Critical Res Found Dev
Publication of BR112022000347A2 publication Critical patent/BR112022000347A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1246—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Rickettsiales (O)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0233—Rickettsiales, e.g. Anaplasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/29—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Richettsiales (O)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

vacinas de ehrlichia e composições imunogênicas. a presente invenção refere-se a composições imunogênicas que podem ser usadas, em alguns aspectos, para induzir uma resposta imunológica contra um ehrlichia como o ehrlichia canis. em algumas concretizações, a composição imunogênica compreende uma bacterina e. canis e/ou adjuvante, como por exemplo, uma emulsão ou um adjuvante lipossomal. métodos relacionados, como para diagnóstico ou vacinação contra ehrlichiosis, também são fornecidos.
BR112022000347A 2019-07-12 2020-07-13 Vacinas de ehrlichia e composições imunogênicas BR112022000347A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962873843P 2019-07-12 2019-07-12
US201962879762P 2019-07-29 2019-07-29
US202063049476P 2020-07-08 2020-07-08
PCT/US2020/041779 WO2021011456A1 (en) 2019-07-12 2020-07-13 Ehrlichia vaccines and immunogenic compositions

Publications (1)

Publication Number Publication Date
BR112022000347A2 true BR112022000347A2 (pt) 2022-04-12

Family

ID=71948757

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022000347A BR112022000347A2 (pt) 2019-07-12 2020-07-13 Vacinas de ehrlichia e composições imunogênicas

Country Status (10)

Country Link
US (1) US20220356231A1 (pt)
EP (1) EP3996741A1 (pt)
JP (1) JP2022540197A (pt)
CN (1) CN114514238A (pt)
AU (1) AU2020314625A1 (pt)
BR (1) BR112022000347A2 (pt)
CA (1) CA3146842A1 (pt)
CL (1) CL2022000086A1 (pt)
MX (1) MX2022000525A (pt)
WO (1) WO2021011456A1 (pt)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043085A (en) * 1998-08-27 2000-03-28 Research Development Foundation Ehrlichia canis 120-kDa immunodominant antigenic protein and gene
JP4494974B2 (ja) * 2002-11-04 2010-06-30 リサーチ ディベロップメント ファウンデーション イヌおよびヒトエールリヒア症の免疫診断のためのｐ１５３およびｐ１５６抗原ならびにその使用
US20050202046A1 (en) * 2004-03-11 2005-09-15 Wyeth Canine vaccine for protection against ehrlichiosis
EP2439210B1 (en) * 2005-04-04 2018-12-26 Idexx Laboratories, Inc. Ehrlichia Canis DIVA (Differentiation of Infected from Vaccinated Animals)
US7842474B2 (en) * 2005-04-04 2010-11-30 Idexx Laboratories, Inc. Ehrlichia canis DIVA (differentiate infected from vaccinated animals)
US8591906B2 (en) * 2005-06-16 2013-11-26 Research Development Foundation Immunoreactive protein orthologs of Ehrlichia canis and E. chaffeensis
WO2008000070A1 (en) * 2006-06-27 2008-01-03 Wellington Laboratories Inc. Glycyrrhetinic acid derivatives
WO2008112007A1 (en) * 2006-08-31 2008-09-18 Research Development Foundation Immunoreactive glycoprotein gp19 of ehrlichia canis
CN104758929B (zh) * 2008-06-27 2018-05-25 硕腾有限责任公司 新颖的佐剂组合物
US8329189B2 (en) * 2009-04-28 2012-12-11 Research Development Foundation Immunoreactive Ehrlichia p120/p140 epitopes and uses thereof
RS57428B1 (sr) * 2010-05-28 2018-09-28 Zoetis Belgium S A Vakcine koje sadrže holesterol i cpg kao jedine molekule nosače ađuvansa
EP2433646A1 (en) * 2010-09-22 2012-03-28 Intervet International BV Vaccine against Ehrlichia canis and associated methods
JP6313752B2 (ja) * 2012-05-31 2018-04-18 ゾエティス・エルエルシー Ｂ．ブロンキセプチカ（Ｂ．Ｂｒｏｎｃｈｉｓｅｐｔｉｃａ）感染から保護するためのイヌ呼吸器コロナウイルスでのワクチン接種
CN109675026A (zh) * 2013-09-19 2019-04-26 硕腾服务有限责任公司 油基佐剂
AU2019311181A1 (en) * 2018-07-27 2021-02-18 Research Development Foundation Chimeric immunogenic polypeptides

Also Published As

Publication number Publication date
CL2022000086A1 (es) 2022-09-30
US20220356231A1 (en) 2022-11-10
WO2021011456A1 (en) 2021-01-21
JP2022540197A (ja) 2022-09-14
CN114514238A (zh) 2022-05-17
EP3996741A1 (en) 2022-05-18
CA3146842A1 (en) 2021-01-21
MX2022000525A (es) 2022-04-20
AU2020314625A1 (en) 2022-02-03

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