HRP20181039T1 - Cjepiva koja sadrže kolesterol i cpg kao jedine molekule koje nose adjuvans - Google Patents
Cjepiva koja sadrže kolesterol i cpg kao jedine molekule koje nose adjuvans Download PDFInfo
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- HRP20181039T1 HRP20181039T1 HRP20181039TT HRP20181039T HRP20181039T1 HR P20181039 T1 HRP20181039 T1 HR P20181039T1 HR P20181039T T HRP20181039T T HR P20181039TT HR P20181039 T HRP20181039 T HR P20181039T HR P20181039 T1 HRP20181039 T1 HR P20181039T1
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- 229960005486 vaccine Drugs 0.000 title claims 13
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title claims 6
- 239000002671 adjuvant Substances 0.000 title claims 3
- 235000012000 cholesterol Nutrition 0.000 title claims 3
- 239000000427 antigen Substances 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 230000001580 bacterial effect Effects 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 229960002715 nicotine Drugs 0.000 claims 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 229960003983 diphtheria toxoid Drugs 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 claims 1
- 108091027075 5S-rRNA precursor Proteins 0.000 claims 1
- 108010077805 Bacterial Proteins Proteins 0.000 claims 1
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 claims 1
- 101710132601 Capsid protein Proteins 0.000 claims 1
- -1 EFGRvIII Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241001534160 Escherichia virus Qbeta Species 0.000 claims 1
- 241000714209 Norwalk virus Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 102000000763 Survivin Human genes 0.000 claims 1
- 108010002687 Survivin Proteins 0.000 claims 1
- 108010067390 Viral Proteins Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000013566 allergen Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002095 exotoxin Substances 0.000 claims 1
- 231100000776 exotoxin Toxicity 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- JFINOWIINSTUNY-UHFFFAOYSA-N pyrrolidin-3-ylmethanesulfonamide Chemical compound NS(=O)(=O)CC1CCNC1 JFINOWIINSTUNY-UHFFFAOYSA-N 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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Claims (11)
1. Cjepivo, naznačeno time što sadrži jedan ili više antigena i adjuvans, gdje je svaki od jednog ili više antigena neovisno mikrobni antigen, autoantigen, tumorski antigen, alergen, ili tvar koja izaziva ovisnost, a adjuvans se sastoji od jednog ili više izoliranih oligonukleotida CpG ili agonista TLR koji je oligoribonukleotid, te kolesterola.
2. Cjepivo u skladu s patentnim zahtjevom 1, naznačeno time što je svaki od jednog ili više antigena neovisno peptid, peptid konjugiran s proteinskim nosačem, peptid konjugiran s virusu sličnom česticom, polipeptid, recombinant protein, pročišćeni protein, cijeli ubijeni patogen, živi oslabljeni virus ili virusni vektor koji eksprimira antigen, žive oslabljene bakterije ili bakterijski vektor koji eksprimira antigen, polisaharid, polisaharid konjugiran s proteinskim nosačem, hapten, hapten konjugiran s proteinskim nosačem ili mala molekula.
3. Cjepivo u skladu s patentnim zahtjevom 2, naznačeno time što je antigen bakterijskog podrijetla, virusnog podrijetla ili parazitnog poidrijetla.
4. Cjepivo u skladu s patentnim zahtjevom 3, naznačeno time što
a) bakterijski antigen su cijele ubijene bakterije, žive oslabljene bakterije ili pročišćeni bakterijski proteini; ili
b) virusni antigen su cijeli ubijeni virus, živi oslabljeni virus ili pročišćeni virusni proteini.
5. Cjepivo u skladu s patentnim zahtjevom 2, naznačeno time što je proteinski nosač bakterijski toksoid ili njegov derivat, egzotoksin iz bakterije Pseudomonas, KLH ili virusu slična čestica.
6. Cjepivo u skladu s patentnim zahtjevom 5, naznačeno time što
a) bakterijski toksoid je difterijski toksoid, ili njegov derivat; ili
b) virusu slična čestica je HBsAg, HBcAg, E. coli bakteriofag Qβ, virus Norwalk ili influenca HA.
7. Cjepivo u skladu s patentnim zahtjevom 1, naznačeno time što
a) tvar koja izaziva ovisnost je nikotin ili nikotinu slična molekula; ili
b) tumorski antigen je jedan ili više od survivina, Her-2, EFGRvIII, PSA, PAP ili PMSA.
8. Cjepivo u skladu s patentnim zahtjevom 2, naznačeno time što je hapten konjugiran s proteinskim nosačem nikotin ili nikotinu slična molekula, konjugirana s difterijskim toksoidom ili njegovim derivatom.
9. Cjepivo u skladu s patentnim zahtjevom 1, naznačeno time što je količina kolesterola u odnosu na količinu antigena 0,1 do 50 puta veća, težinski, 1 do 10 puta veća, težinski, ili jednaka težini antigena.
10. Cjepivo u skladu s patentnim zahtjevom 1, naznačeno time što dodatno sadrži farmaceutski nosač.
11. Cjepivo u skladu s bilo kojim od patentnih zahtjeva 1 do 10, naznačeno time što je namijenjeno upotrebi u postupku izazivanja antigenski specifičnog imunosnog odgovora kod subjekta kojem je to potrebno, gdje se cjepivo primijenjuje u količini koja djelotvorno izaziva antigenski specifičan imunosni odgovor kod subjekta.
Applications Claiming Priority (3)
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US34924410P | 2010-05-28 | 2010-05-28 | |
PCT/IB2011/052347 WO2011148356A1 (en) | 2010-05-28 | 2011-05-27 | Vaccines comprising cholesterol and cpg as sole adjuvant - carrier molecules |
EP11727536.2A EP2575878B1 (en) | 2010-05-28 | 2011-05-27 | Vaccines comprising cholesterol and cpg as sole adjuvant-carrier molecules |
Publications (1)
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HRP20181039T1 true HRP20181039T1 (hr) | 2018-08-24 |
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HRP20181039TT HRP20181039T1 (hr) | 2010-05-28 | 2018-07-05 | Cjepiva koja sadrže kolesterol i cpg kao jedine molekule koje nose adjuvans |
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US (1) | US10456463B2 (hr) |
EP (1) | EP2575878B1 (hr) |
JP (3) | JP6034285B2 (hr) |
KR (1) | KR101528021B1 (hr) |
CN (1) | CN103025351B (hr) |
AU (2) | AU2011259718B2 (hr) |
BR (1) | BR112012030337B1 (hr) |
CA (1) | CA2800158C (hr) |
CL (1) | CL2012003299A1 (hr) |
DK (1) | DK2575878T3 (hr) |
ES (1) | ES2683316T3 (hr) |
HR (1) | HRP20181039T1 (hr) |
HU (1) | HUE038894T2 (hr) |
LT (1) | LT2575878T (hr) |
MX (1) | MX347471B (hr) |
NZ (1) | NZ603527A (hr) |
PL (1) | PL2575878T3 (hr) |
PT (1) | PT2575878T (hr) |
RS (1) | RS57428B1 (hr) |
SI (1) | SI2575878T1 (hr) |
WO (1) | WO2011148356A1 (hr) |
ZA (1) | ZA201208837B (hr) |
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