CN102988614B - Preparation method and application of antiphlogosis tablet - Google Patents
Preparation method and application of antiphlogosis tablet Download PDFInfo
- Publication number
- CN102988614B CN102988614B CN201210378434.6A CN201210378434A CN102988614B CN 102988614 B CN102988614 B CN 102988614B CN 201210378434 A CN201210378434 A CN 201210378434A CN 102988614 B CN102988614 B CN 102988614B
- Authority
- CN
- China
- Prior art keywords
- preparation
- pianomide
- extraction
- ethanol
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 24
- 229940079593 drug Drugs 0.000 claims abstract description 14
- 238000000874 microwave-assisted extraction Methods 0.000 claims abstract description 11
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 10
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims abstract description 8
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 239000000284 extract Substances 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 17
- 241000628997 Flos Species 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 9
- 230000004663 cell proliferation Effects 0.000 claims description 8
- 229920002472 Starch Polymers 0.000 claims description 5
- 230000000274 adsorptive effect Effects 0.000 claims description 5
- 229940126678 chinese medicines Drugs 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 240000001949 Taraxacum officinale Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 abstract 1
- 229940015301 baicalein Drugs 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000000452 restraining effect Effects 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 21
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 description 10
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 description 10
- 229960003321 baicalin Drugs 0.000 description 10
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- JWHHANVGNNWIRI-UHFFFAOYSA-N methanol phosphoric acid hydrate Chemical compound O.OC.OP(O)(O)=O JWHHANVGNNWIRI-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210378434.6A CN102988614B (en) | 2012-10-08 | 2012-10-08 | Preparation method and application of antiphlogosis tablet |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210378434.6A CN102988614B (en) | 2012-10-08 | 2012-10-08 | Preparation method and application of antiphlogosis tablet |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102988614A CN102988614A (en) | 2013-03-27 |
CN102988614B true CN102988614B (en) | 2014-05-07 |
Family
ID=47918043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201210378434.6A Active CN102988614B (en) | 2012-10-08 | 2012-10-08 | Preparation method and application of antiphlogosis tablet |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102988614B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103566023B (en) * | 2013-10-29 | 2015-11-18 | 山东省立医院 | A kind of preparation method of toothache Pianomide and application |
CN105168624B (en) * | 2015-08-27 | 2019-11-29 | 韩志强 | A kind of sulfathiazole and preparation method thereof |
CN105911161B (en) * | 2016-04-12 | 2018-03-27 | 吉林修正药业新药开发有限公司 | A kind of sulfathiazole HPLC fingerprint map construction methods |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1733079A (en) * | 2005-09-05 | 2006-02-15 | 石洪波 | Pharmaceutical composition for treating and preventing respiratory tract viral infection, its preparation process and application |
-
2012
- 2012-10-08 CN CN201210378434.6A patent/CN102988614B/en active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1733079A (en) * | 2005-09-05 | 2006-02-15 | 石洪波 | Pharmaceutical composition for treating and preventing respiratory tract viral infection, its preparation process and application |
Non-Patent Citations (5)
Title |
---|
***药典委员会.消炎片.《***颁药品标准(中药成方制剂第四册)》.1991,152. * |
张继红等.紫花地丁有效成分的作用研究及临床应用.《药品评价》.2007,第04卷(第06期),434-436. |
紫花地丁有效成分的作用研究及临床应用;张继红等;《药品评价》;20071228;第04卷(第06期);434-436 * |
罗金岳等.超临界CO_2提取野菊花中的精油.《生物质化学工程》.2007,第41卷(第06期),11-14. |
超临界CO_2提取野菊花中的精油;罗金岳等;《生物质化学工程》;20071125;第41卷(第06期);11-14 * |
Also Published As
Publication number | Publication date |
---|---|
CN102988614A (en) | 2013-03-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102988723B (en) | Preparation method and application of traditional Chinese medicine | |
CN102973667B (en) | Preparation method and application of cold-fever tablet | |
CN102988526B (en) | Method for preparing Bailing tablets and application | |
CN102988480B (en) | Method for preparing bile and patchouli rhinitis tablets and application | |
CN102988612B (en) | Preparation method and application of tablet for clearing away heat | |
CN102988665B (en) | Method for preparing gynecological menstruation regulating tablets and application | |
CN102988489B (en) | Preparation method and application of nose comforting tablet | |
CN102988545B (en) | Preparation method and application of Yulian tablet | |
CN102988614B (en) | Preparation method and application of antiphlogosis tablet | |
CN103028005B (en) | Preparation method of anti-lumbago tablet and application thereof | |
CN102988502B (en) | Preparation method and application of Desheng tablet | |
CN102988479B (en) | Preparation method and application of anti-dazzling tablet | |
CN103656493B (en) | A kind of preparation method of blood stasis dispelling stomach reinforcing sheet and application | |
CN102836381B (en) | A kind of preparation method of regulating the spleen and stomach sheet and application | |
CN102973749B (en) | Preparation method and applications of divaricate saposhnikovia-angelica archang lica rhinitis tablets | |
CN102988550B (en) | Preparation method and application of qinlian tablet | |
CN102988611B (en) | Preparation method and application of antihypertension tablet | |
CN102988500B (en) | Method for preparing compound Dantong tablets and application | |
CN102988501B (en) | Preparation method and application of Libiling tablet | |
CN102988881B (en) | Preparation method and application of pulse unblocking tablet | |
CN104382871A (en) | Preparation method of dock root and hemerocallis fulva liver tonifying tablets and application of dock root and hemerocallis fulva liver tonifying tablets to preparation of medicines for inhibiting proliferation of lymphoid neoplasm cell P388D1 | |
CN102988522B (en) | Preparation method and application of naodesheng tablets | |
CN102988691B (en) | Preparation method and application of liver-strengthening tablet | |
CN103735960A (en) | Application of boenninghausenia sessilicarpa cough-asthma tablet to prepare medicaments for inhibiting lung cancer cell LLC proliferation | |
CN102988836B (en) | Preparation method and application of Fuganning tablets |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: FANG XINBING Effective date: 20140326 Owner name: ZHANG XIURONG Free format text: FORMER OWNER: BIAN YUPING Effective date: 20140326 |
|
C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Xiurong Inventor after: Fang Xinbing Inventor before: The inventor has waived the right to be mentioned |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: ZHANG XIURONG FANG XINBING Free format text: CORRECT: ADDRESS; FROM: 211224 NANJING, JIANGSU PROVINCE TO: 262100 WEIFANG, SHANDONG PROVINCE |
|
TA01 | Transfer of patent application right |
Effective date of registration: 20140326 Address after: 262100 obstetrics and Gynecology, Anqiu people's Hospital, 246 health Road, Shandong, Weifang, Anqiu Applicant after: Zhang Xiurong Applicant after: Fang Xinbing Address before: Lishui County of Nanjing City, Jiangsu province 211224 Jing Qiao Zhen Chen Biancun Applicant before: Bian Yuping |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Fang Xinbing Inventor before: Zhang Xiurong Inventor before: Fang Xinbing |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171108 Address after: 262100 obstetrics and Gynecology, Anqiu people's Hospital, 246 health Road, Shandong, Weifang, Anqiu Patentee after: Fang Xinbing Address before: 262100 obstetrics and Gynecology, Anqiu people's Hospital, 246 health Road, Shandong, Weifang, Anqiu Co-patentee before: Fang Xinbing Patentee before: Zhang Xiurong |