CN102988612B - Preparation method and application of tablet for clearing away heat - Google Patents
Preparation method and application of tablet for clearing away heat Download PDFInfo
- Publication number
- CN102988612B CN102988612B CN201210390073.7A CN201210390073A CN102988612B CN 102988612 B CN102988612 B CN 102988612B CN 201210390073 A CN201210390073 A CN 201210390073A CN 102988612 B CN102988612 B CN 102988612B
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- preparation
- tablet
- qinghuo
- extraction
- ethanol
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- 238000000874 microwave-assisted extraction Methods 0.000 claims abstract description 11
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 10
- 230000004663 cell proliferation Effects 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 239000000284 extract Substances 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 9
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
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- 229940126678 chinese medicines Drugs 0.000 claims description 5
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- 239000010282 Emodin Substances 0.000 abstract description 11
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 10
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- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
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- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 10
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 10
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- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 10
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
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- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
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- 206010040943 Skin Ulcer Diseases 0.000 description 1
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- 230000010165 autogamy Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
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- 239000000470 constituent Substances 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- JWHHANVGNNWIRI-UHFFFAOYSA-N methanol phosphoric acid hydrate Chemical compound O.OC.OP(O)(O)=O JWHHANVGNNWIRI-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210390073.7A CN102988612B (en) | 2012-10-15 | 2012-10-15 | Preparation method and application of tablet for clearing away heat |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210390073.7A CN102988612B (en) | 2012-10-15 | 2012-10-15 | Preparation method and application of tablet for clearing away heat |
Publications (2)
Publication Number | Publication Date |
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CN102988612A CN102988612A (en) | 2013-03-27 |
CN102988612B true CN102988612B (en) | 2014-05-07 |
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CN201210390073.7A Expired - Fee Related CN102988612B (en) | 2012-10-15 | 2012-10-15 | Preparation method and application of tablet for clearing away heat |
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CN (1) | CN102988612B (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104306830A (en) * | 2014-11-13 | 2015-01-28 | 山东中大药业有限公司 | Preparing method of rhubarb and day lily liver tonifying tablet and application thereof in preparation of drugs for inhibiting cell proliferation of myeloma cells P3X63Ag8 |
CN104434827A (en) * | 2014-11-13 | 2015-03-25 | 山东中大药业有限公司 | Preparation method of rumex nepalensis and hemerocallis tablet for benefiting liver and application of rumex nepalensis and hemerocallis tablet to preparation of drug for inhibiting proliferation of teratocarcinoma cell P19 |
CN104306822A (en) * | 2014-11-13 | 2015-01-28 | 山东中大药业有限公司 | Preparation method of liver benefiting tablet containing nepal dock root and day lily and application of liver benefiting tablet to preparation of drug for restraining multiplication of liver tumor cell H22 cell |
CN105748615A (en) * | 2016-02-28 | 2016-07-13 | 南京正亮医药科技有限公司 | Method for preparing tablet containing rheum officinale, berberine hydrochloride and scutellaria baicalensis and application thereof |
CN111494507B (en) * | 2020-06-18 | 2022-01-18 | 海南葫芦娃药业集团股份有限公司 | Preparation method of internal heat clearing tablets |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
CN102614242A (en) * | 2012-04-13 | 2012-08-01 | 孙长海 | Dropping pill of isatis root and folium isatidis and preparing method thereof |
-
2012
- 2012-10-15 CN CN201210390073.7A patent/CN102988612B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102397451A (en) * | 2011-11-26 | 2012-04-04 | 苏州派腾生物医药科技有限公司 | Preparation method of cholagogic tablet |
CN102614242A (en) * | 2012-04-13 | 2012-08-01 | 孙长海 | Dropping pill of isatis root and folium isatidis and preparing method thereof |
Non-Patent Citations (5)
Title |
---|
中华人民共和国药典委员会.清火片.《***颁药品标准(中药成方制剂第二册)》.1990,244. * |
大黄及其成分的抗炎作用.《国外医学.中医中药分册》.2003,第25卷(第01期),54. |
大黄及其成分的抗炎作用;《国外医学.中医中药分册》;20030130;第25卷(第01期);54 * |
林小燕等.清火片生产工艺优选.《海峡药学》.2009,第21卷(第10期),18-20. |
清火片生产工艺优选;林小燕等;《海峡药学》;20091015;第21卷(第10期);18-20 * |
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CN102988612A (en) | 2013-03-27 |
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PB01 | Publication | ||
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ASS | Succession or assignment of patent right |
Owner name: UNIVERSITY OF SCIENCE AND TECHNOLOGY OF INNER MONG Free format text: FORMER OWNER: LI ZHENGMEI Effective date: 20140319 |
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C41 | Transfer of patent application or patent right or utility model | ||
C53 | Correction of patent for invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Yali Inventor after: Bao Jinlong Inventor after: Dong Yanshan Inventor before: The inventor has waived the right to be mentioned |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: REQUEST NOT TO RELEASE THE NAME TO: LI YALI BAO JINLONG DONG YANSHAN Free format text: CORRECT: ADDRESS; FROM: 211200 NANJING, JIANGSU PROVINCE TO: 014010 BAOTOU, INNER MONGOLIA AUTONOMOUS REGION |
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TA01 | Transfer of patent application right |
Effective date of registration: 20140319 Address after: 014010 the Inner Mongolia Autonomous Region Baotou Kunqu Arden Street No. 7 Applicant after: University of Science and Technology of Inner Mongolia Address before: 211200, No. 1, Shandong Road, Lishui Economic Development Zone, Nanjing, Jiangsu Applicant before: Li Zhengmei |
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C14 | Grant of patent or utility model | ||
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140507 Termination date: 20161015 |
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CF01 | Termination of patent right due to non-payment of annual fee |