CN102988480B - Method for preparing bile and patchouli rhinitis tablets and application - Google Patents
Method for preparing bile and patchouli rhinitis tablets and application Download PDFInfo
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- CN102988480B CN102988480B CN201210378476.XA CN201210378476A CN102988480B CN 102988480 B CN102988480 B CN 102988480B CN 201210378476 A CN201210378476 A CN 201210378476A CN 102988480 B CN102988480 B CN 102988480B
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- gallbladder
- fragrant
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- 206010039083 rhinitis Diseases 0.000 title claims abstract description 40
- 210000000941 bile Anatomy 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title abstract description 11
- 235000011751 Pogostemon cablin Nutrition 0.000 title abstract 4
- 241000222666 Boerhavia diffusa Species 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims abstract description 25
- 239000003814 drug Substances 0.000 claims abstract description 24
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000000874 microwave-assisted extraction Methods 0.000 claims abstract description 11
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 210000000232 gallbladder Anatomy 0.000 claims description 33
- 241000628997 Flos Species 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 17
- 238000000605 extraction Methods 0.000 claims description 17
- 229940079593 drug Drugs 0.000 claims description 13
- 239000009670 cang er zi wan Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 9
- 230000004663 cell proliferation Effects 0.000 claims description 8
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
- 201000005202 lung cancer Diseases 0.000 claims description 7
- 208000020816 lung neoplasm Diseases 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 5
- 230000000274 adsorptive effect Effects 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 5
- 230000006837 decompression Effects 0.000 claims description 5
- 239000003480 eluent Substances 0.000 claims description 5
- 238000010828 elution Methods 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 238000004064 recycling Methods 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 240000002505 Pogostemon cablin Species 0.000 abstract 3
- 241001506766 Xanthium Species 0.000 abstract 2
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241001633683 Centipeda <firmicute> Species 0.000 abstract 1
- 244000035851 Chrysanthemum leucanthemum Species 0.000 abstract 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 abstract 1
- 206010023774 Large cell lung cancer Diseases 0.000 abstract 1
- 241000951473 Schizonepeta Species 0.000 abstract 1
- 201000009546 lung large cell carcinoma Diseases 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 21
- 238000002474 experimental method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000013558 reference substance Substances 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 201000009151 chronic rhinitis Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- JWHHANVGNNWIRI-UHFFFAOYSA-N methanol phosphoric acid hydrate Chemical compound O.OC.OP(O)(O)=O JWHHANVGNNWIRI-UHFFFAOYSA-N 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201210378476.XA CN102988480B (en) | 2012-10-08 | 2012-10-08 | Method for preparing bile and patchouli rhinitis tablets and application |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201210378476.XA CN102988480B (en) | 2012-10-08 | 2012-10-08 | Method for preparing bile and patchouli rhinitis tablets and application |
Publications (2)
Publication Number | Publication Date |
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CN102988480A CN102988480A (en) | 2013-03-27 |
CN102988480B true CN102988480B (en) | 2014-07-23 |
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CN201210378476.XA Active CN102988480B (en) | 2012-10-08 | 2012-10-08 | Method for preparing bile and patchouli rhinitis tablets and application |
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Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103623052A (en) * | 2013-09-30 | 2014-03-12 | 王洪珍 | Novel method for preparing danxiang (Chinese character) rhinitis tablet |
CN103566023B (en) * | 2013-10-29 | 2015-11-18 | 山东省立医院 | A kind of preparation method of toothache Pianomide and application |
CN103705683A (en) * | 2013-12-22 | 2014-04-09 | 青岛琴诚医药技术有限公司 | Preparation method and application of Sixiao pills |
CN104257752B (en) * | 2014-10-09 | 2018-03-20 | 成都市康飞药业有限公司 | A kind of medical composition and its use for treating rhinitis |
CN117599012A (en) * | 2023-12-08 | 2024-02-27 | 广西迪泰制药股份有限公司 | Preparation method of nose comfort tablet |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1803162A (en) * | 2005-01-12 | 2006-07-19 | 佛山德众药业有限公司 | Rhinological disease-treating pharmaceutical compositions and its preparing method |
CN101579186B (en) * | 2009-06-01 | 2010-11-03 | 赵青菊 | Pharmaceutical rhinitis pillow for external use and treating wind-heat rhinitis |
CN102258574B (en) * | 2011-07-13 | 2012-07-25 | 山东省立医院 | Chinese medicinal preparation for treating allergic rhinitis |
-
2012
- 2012-10-08 CN CN201210378476.XA patent/CN102988480B/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1803162A (en) * | 2005-01-12 | 2006-07-19 | 佛山德众药业有限公司 | Rhinological disease-treating pharmaceutical compositions and its preparing method |
CN101579186B (en) * | 2009-06-01 | 2010-11-03 | 赵青菊 | Pharmaceutical rhinitis pillow for external use and treating wind-heat rhinitis |
CN102258574B (en) * | 2011-07-13 | 2012-07-25 | 山东省立医院 | Chinese medicinal preparation for treating allergic rhinitis |
Non-Patent Citations (3)
Title |
---|
HPLC法测定胆香鼻炎片中绿原酸的含量;丁翔等;《陕西中医》;20041025;第25卷(第10期);全文 * |
丁翔等.HPLC法测定胆香鼻炎片中绿原酸的含量.《陕西中医》.2004,第25卷(第10期),全文. |
中华人民共和国***药典委员.胆香鼻炎片.《***颁药品标准 中药成方制剂第四册》.1991,第91页. * |
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CN102988480A (en) | 2013-03-27 |
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Effective date of registration: 20190212 Address after: 276600 Building No. 1, 59 Huanghai East Road, Junan County, Linyi City, Shandong Province, Unit 102 Patentee after: Li Jing Address before: 510000 Guangdong science and Technology Industrial Development Zone, Guangzhou, 231 and 233 podium B1B2 Building 1, two, three, four Patentee before: BOAO ZONGHENG NETWORK TECHNOLOGY Co.,Ltd. Effective date of registration: 20190212 Address after: 510000 Guangdong science and Technology Industrial Development Zone, Guangzhou, 231 and 233 podium B1B2 Building 1, two, three, four Patentee after: BOAO ZONGHENG NETWORK TECHNOLOGY Co.,Ltd. Address before: 226121 79 vegetable market road, three factory town, Haimen, Nantong, Jiangsu Patentee before: NANTONG SUNDAY TOURISM DEVELOPMENT CO.,LTD. |
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Effective date of registration: 20200312 Address after: 310000 no.41-19, Wujin Road, Wenyan street, Xiaoshan District, Hangzhou City, Zhejiang Province Patentee after: Zhejiang Yinzhi Acoustic Technology Co.,Ltd. Address before: 276600 Building No. 1, 59 Huanghai East Road, Junan County, Linyi City, Shandong Province, Unit 102 Patentee before: Li Jing |