CN102688379A

CN102688379A - Chinese herbal medicine pill for treating constipation

Info

Publication number: CN102688379A
Application number: CN2012101830617A
Authority: CN
Inventors: 李珍华; 张西菊
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-05-31
Filing date: 2012-05-31
Publication date: 2012-09-26
Anticipated expiration: 2032-05-31
Also published as: CN102688379B

Abstract

The invention discloses a Chinese herbal medicine pill for treating constipation. The preparation method for the pills comprises the following steps: (1) taking fructus cannabis, Chinese dwarf cherry seed, astragalus mongholicus, largehead atractylodes rhizome, dried radix rehmanniae and radix scrophulariae, crushing by a material string method and screening by a 100-mesh screen for later use; crushing cistanche and codonopsis pilosula to fine powder and screening the 100-mesh screen for later use; crushing rhubarb to fine powder and screening by the 100-mesh screen for later use; soaking costustoot for 1 hour with proper amount of water, extracting volatile oil by a volatile oil extractor and preparing volatile oil beta- cyclodextrin inclusion compound for later use by using a saturated solution; decocting rhizoma cyperi, semen cassiae, stir-fried radish seed, radix ophiopogonis and costustoot dreg twice with water and concentrating into a mixture with the ratio of decoction and raw medicine material being 1 to 1 for later use; (2) taking rhubarb powder in step (1) and a part of water decoction for stripping and pilling the inner layers; drying the inner layers at temperature of below 40 DEG C; pilling the middle layer by using cistanche, codonopsis pilosula, beta-cyclodextrin inclusion compound of costus root essential oils, and part of decoction, and drying at the temperature of below 40DEG C; and pilling the outer layers by using fructus cannabis, Chinese dwarf cherry seed, astragalus mongholicus, largehead atractylodes rhizome, dried radix rehmanniae, radix scrophulariae and the rest of water decoction, and drying the obtained product at 50 DEG C to obtain the Chinese herbal medicine pills.

Description

A kind of Chinese herbal medicine pill of treating constipation

Technical field:

The invention belongs to technical field of Chinese medicines, particularly a kind of Chinese herbal medicine pill of treating constipation

Background technology:

Feces was detained of a specified duration at enteric cavity, surpass 48 hours, and large quantity of moisture is absorbed by intestinal wall, and dry, hard, the difficult discharge of the feces that causes death named constipation.The reason of the generation of constipation is many-sided; Functional constipation, organic constipation are arranged; Degenerate with improper dietary habit and life style, psychentonia, spleen and stomach function, functional activities of the body fluid loses void, birth defect, inflammatory stimulus, abuse cathartic reach and suppresses defecation for a long time consciously, also has many medicines possibly cause or increase the weight of constipation.These common medicines comprise the antacid that contains aluminum or calcium, antihistaminic, anti-Parkinson medicine, calcareous complementary goods, diuretic, anesthetis, phenothiazine, tranquillizer, three ring analeptic etc.In general, the short-term constipation is little to the influence of human body, but constipation can not get correction for a long time, and intrarectal harmful substance can not in time be got rid of, and can produce harmful effect to human body, like recial disease hemorrhoid complicated by anal fistula, anal fissure, rectal cancer, even brings out sudden death.

Summary of the invention:

The present invention provides a kind of Chinese herbal medicine pill of treating constipation, and the present invention is achieved in that pharmaceutical formulation of the present invention is: the Rhizoma Atractylodis Macrocephalae 30 restrains, Semen Cassiae 20 restrains, the Radix Astragali 20 restrains, Herba Cistanches 20 restrains, Radix Codonopsis 15 restrains, Semen Raphani (parched) 15 restrains, Rhizoma Cyperi 15 restrains, Fructus Cannabis 15 restrains, the Radix Aucklandiae 10 restrains, Radix Et Rhizoma Rhei 10 restrains, Semen Pruni 12 restrains, the Radix Rehmanniae 12 restrains, restrain Radix Ophiopogonis 9 and Radix Scrophulariae 9 restrains.

Its method for making is: Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae that get in the said medicine (1) are pulverized with " flushing method ", and it is subsequent use to cross 100 mesh sieves; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, and it is subsequent use to cross 100 mesh sieves; Radix Et Rhizoma Rhei powder is broken into fine powder, and it is subsequent use to cross 100 mesh sieves; The Radix Aucklandiae adds an amount of immersion of water 1 hour, extracts volatile oil with volatile oil extractor, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, and is subsequent use; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and the decocte with water of Radix Aucklandiae medicinal residues 2 times merge 2 times fried liquid, and be concentrated into-decocting liquid: crude drug is 1: 1 mixture, and is subsequent use; (2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer; In oven dry below 40 ℃; The Benexate Hydrochloride of reuse Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae and part decocting liquid flooding ball middle level; In oven dry below 40 ℃, the general ball of reuse Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and surplus water decocting liquid is outer, is drying to obtain at 50 ℃.

Method for making explanation: Fructus Cannabis contains the significant quantities of fat oil meal and is prone to agglomerating, sticking screen cloth when broken, so the Fructus Cannabis of getting fire, the Radix Astragali and the Rhizoma Atractylodis Macrocephalae are with " flushing method " pulverizing; The Radix Aucklandiae contains volatile oil, extracts with volatile oil extractor, and volatile oil is volatile and meet light, thermally labile, but behind beta-cyclodextrin inclusion compound, is beneficial to preservation, steady quality.

Dosage form design is that 3 layers of branch dissolve concentrated pill: outer molten earlier, it is clear and rich to work hard, and increases liquid and sails a boat; The middle level is continued molten, air making-up and spleen enlivening, and ascending the clear and descending the turbid promotes gastrointestinal peristalsis, dissolves after 3 layers, rush down down at logical mansion, by dirty toxin expelling.

Instructions of taking: 5 o'clock every afternoons are (medicine) being taken before meal 10～20 balls before the meal, and eliminating cold for resuscitation water send down, through about 15 hours, to morning next day, can soft stool of unimpeded discharge be good.Also to cooperate in addition regularly take medicine, the custom of defecation, polydipsia boiled water, polyphagia vegetable on time.

The side separates: insufficiency of the spleen, gastrointestinal peristalsis is unable, Rhizoma Atractylodis Macrocephalae sweetness and bitterness and temperature, big tonifying the spleen and stomach, sweet can the spleen invigorating invigorating the spleen and replenishing QI, bitterly can remove in the stomach damp and hotly, taste are good for and are consolidated, so be monarch; Spleen is the mansion of vigour, Radix Astragali tonifying Qi and lifting yang, hemopoietic, hidroschesis Gu Wei, and gastrointestinal promotes strong; Radix Codonopsis strongly invigorating primordial QI, principal drug assistance air making-up and spleen enlivening power doubly, so be minister; Rhizoma Atractylodis Macrocephalae resolving and invigoration therapies being applied simultaneously; The Semen Raphani (parched) sending down the abnormal ascending QI removes and expands; The Radix Aucklandiae, Rhizoma Cyperi regulating the flow of QI to alleviate depression are capable to stagnate; Semen Cassiae enrich blood tonifying YIN, heat clearing away softening the hard mass; Fructus Cannabis YIN nourishing tonify deficiency loosening bowel to relieve constipation, invigorate blood circulation in the logical mansion of Radix Et Rhizoma Rhei, and Semen Pruni is moisturized, laxation; The Radix Rehmanniae, Radix Ophiopogonis and Radix Scrophulariae heat clearing away YIN nourishing change intestinal because of the dry symptom of heat; Full side plays altogether that spleen invigorating is actuated, the merit of loosening bowel to relieve constipation, dissolving blood stasis and detoxication.

Modern pharmacology shows: Herba Cistanches can strengthen enterokinesia, and the effect that promotes defecation is arranged; Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae have the effect of excited gastrointestinal motility, and Fructus Cannabis increases the liquid institute's fatty acids of sailing a boat can stimulate juice to increase, and reduces moisture absorption, increases osmotic pressure in the enteric cavity, promotes enterokinesia.Radix Et Rhizoma Rhei has the stimulation intestinal wall, improves intestinal and shrinks, and the intestinal secretion thing is increased, and causes the effect that intestinal contents is easy to discharge, and is applicable to various constipation.

The specific embodiment:

A kind of Chinese herbal medicine pill of treating constipation, pharmaceutical formulation of the present invention is: the Rhizoma Atractylodis Macrocephalae 30 restrains, Semen Cassiae 20 restrains, the Radix Astragali 20 restrains, Herba Cistanches 20 restrains, Radix Codonopsis 15 restrains, Semen Raphani (parched) 15 restrains, Rhizoma Cyperi 15 restrains, Fructus Cannabis 15 restrains, the Radix Aucklandiae 10 restrains, Radix Et Rhizoma Rhei 10 restrains, Semen Pruni 12 restrains, the Radix Rehmanniae 12 restrains, restrain Radix Ophiopogonis 9 and Radix Scrophulariae 9 restrains.Its method for making is: Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae that get in the said medicine (1) are pulverized with " flushing method ", and it is subsequent use to cross 100 mesh sieves; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, and it is subsequent use to cross 100 mesh sieves; Radix Et Rhizoma Rhei powder is broken into fine powder, and it is subsequent use to cross 100 mesh sieves; The Radix Aucklandiae adds an amount of immersion of water 1 hour, extracts volatile oil with volatile oil extractor, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, and is subsequent use; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and the decocte with water of Radix Aucklandiae medicinal residues 2 times merge 2 times fried liquid, and be concentrated into-decocting liquid: crude drug is 1: 1 mixture, and is subsequent use; (2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer; In oven dry below 40 ℃; The Benexate Hydrochloride of reuse Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae and part decocting liquid flooding ball middle level; In oven dry below 40 ℃, the general ball of reuse Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and surplus water decocting liquid is outer, is drying to obtain at 50 ℃.

The case checking:

With these side's treatment constipation 78 examples, medication 5th was a course of treatment, produce effects 3 examples.Medication cured person 70 examples on the 5th～15.Wherein, 1 the course of treatment healing person's 49 examples; 2 the course of treatment healing person's 28 examples; 3 the course of treatment healing person's 1 example, total effective rate 100%, prognosis is followed up a case by regular visits to and do not see recurrence half a year.

Model case is introduced:

1, certain man, 56 years old, because of the cerebral infarction hospitalization, difficult defecation appearred in clinotherapy all day, did not have just meaning on the 3rd～5, for a long time difficult defecation then.Give each 20 balls of constipation ball therewith, morning on the secondth occurs just meaning every day 2 times, adhere to later on that once a day each 20 balls are defecated 2 days 1 time, very rule is followed up a case by regular visits to after 3 months and is not had recurrence.

2, Wang, the woman, 42 years old, suspicious, vexed because of sensitivity, worry too much, insomnia, outpatient service is taken in institute with schizophrenia, gives and risperidone treatment, and it is more dried stool to occur, difficult defecation, the every day 1 time of taking this medicine, each 20 balls, the back stool is once a day.

3, Deng, the man, 68 years old, suffered from habitual constipation 6 years, the informal dress phenolphthalein tablet, poor effect changed the glycerin external afterwards, useful the pill in back, free movement of the bowels, rule, blood pressure stabilization.Follow up a case by regular visits to and do not have recurrence in 1 year.

4, Lee, 67 years old, because of slow in action behind hypertension, the cerebral infarction, insomnia, fidgety being admitted to hospital; Constipation is serious, and about 3～5 days stool once, and are very stiff; Do not have positive effect through polyphagia vegetable, fruit, glycerin is often used in 3 also not effects of oral phenolphthalein tablets; Use this Chinese medicine pill instead, the rule of defecating after 3 days, 1～3 day is once.

5, Jin, the man, 28 years old, because of heavy drinking repeatedly causes bifilar head necrosis, to give and hip replacement, constipation appears in postoperative, gives orally with this Chinese herbal medicine pill, and stool is consolidated after 10 days and is not had repeatedly after the drug withdrawal once a day.

Claims

1. Chinese herbal medicine pill of treating constipation; It is characterized in that: pharmaceutical formulation of the present invention is that the Rhizoma Atractylodis Macrocephalae 30 restrains, Semen Cassiae 20 restrains, the Radix Astragali 20 restrains, Herba Cistanches 20 restrains, Radix Codonopsis 15 restrains, Semen Raphani (parched) 15 restrains, Rhizoma Cyperi 15 restrains, Fructus Cannabis 15 restrains, the Radix Aucklandiae 10 restrains, Radix Et Rhizoma Rhei 10 restrains, Semen Pruni 12 restrains, the Radix Rehmanniae 12 restrains, restrain Radix Ophiopogonis 9 and Radix Scrophulariae 9 restrains.

2. a kind of Chinese herbal medicine pill of treating constipation according to claim 1 is characterized in that: Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae and the Radix Scrophulariae that get in the said medicine (1) are pulverized with " flushing method ", and it is subsequent use to cross 100 mesh sieves; Herba Cistanches, Radix Codonopsis powder are broken into fine powder, and it is subsequent use to cross 100 mesh sieves; Radix Et Rhizoma Rhei powder is broken into fine powder, and it is subsequent use to cross 100 mesh sieves; The Radix Aucklandiae adds an amount of immersion of water 1 hour, extracts volatile oil with volatile oil extractor, adopts saturated solution to prepare volatile oil beta cyclodextrin inclusion complex, and is subsequent use; Rhizoma Cyperi, Semen Cassiae, Semen Raphani (parched), Radix Ophiopogonis and the decocte with water of Radix Aucklandiae medicinal residues 2 times merge 2 times fried liquid, and be concentrated into-decocting liquid: crude drug is 1: 1 mixture, and is subsequent use; (2) get the Radix Et Rhizoma Rhei powder pulverized in (1) step and the molding of part decocting liquid, general ball internal layer; In oven dry below 40 ℃; The Benexate Hydrochloride of reuse Herba Cistanches, Radix Codonopsis powder, volatile oil of Radix Aucklandiae and part decocting liquid flooding ball middle level; In oven dry below 40 ℃, the general ball of reuse Fructus Cannabis, Semen Pruni, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, the Radix Rehmanniae, Radix Scrophulariae powder and surplus water decocting liquid is outer, is drying to obtain at 50 ℃.