CN102038927A - Pharmaceutical composition for preventing and treating climacteric metancholia and other diseases - Google Patents
Pharmaceutical composition for preventing and treating climacteric metancholia and other diseases Download PDFInfo
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Abstract
The invention provides a pharmaceutical composition for preventing and treating climacteric metancholia and other diseases, relating to the field of medical technology, and particularly providing a new application of a pharmaceutical composition which is called as Qi-replenishing sharp and bright decoction and is composed of ginseng or codonopsis pilosula, astragalus membranaceus, cimicifugae foetidae, root of kudzuvine, simpleleaf shrub chastetree fruit, radix paeoniae alba, cortex phellodendri and liquorice in the preparation of a drug or food for preventing and treating climacteric metancholia, senile chronic vaginitis, senile chronic urethritis or cystitis, and senile chronic prostate hypertrophy as a main raw material. In addition, the invention further relates to an application of a new pharmaceutical composition which is obtained according to the modification of prescription of the Qi-replenishing sharp and bright decoction or the prescription of the Qi-replenishing sharp and bright decoction in the preparation of a drug or food for preventing and treating the diseases above as a main raw material. The pharmaceutical composition for preventing and treating climacteric metancholia and other diseases provided by the invention has the advantages that the raw materials of the pharmaceutical composition can be mixed after crushing to powder independently or crushed to powder after mixing, the edible preparation can be prepared directly, the raw materials can be mixed after extracting independently or extracted after mixing, and the pharmaceutical composition is prepared into all the normally used pharmaceutical dosage forms such as pills, powders, capsules, tablets, medicinal granules, oral liquids and the like together with pharmaceutically acceptable accessories.
Description
Technical field
The present invention relates to medical technical field, relating to the pharmaceutical composition of being made up of Radix Ginseng or Radix Codonopsis, the Radix Astragali, Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae that is called yiqi clever soup is primary raw material, is used to prepare prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, the medicine of senile chronic prostate hyperplasia or the new purposes of food.Simultaneously, the present invention also relates to the plus-minus side of yiqi clever soup or instructing the new pharmaceutical composition that forms down with the yiqi clever soup principles of formulating prescriptions is primary raw material, is used to the purposes for preparing the prevention and treat the medicine or the food of above-mentioned illness.
Background technology
Yiqi clever soup has benefiting qi and raising yang, yin fluid astringing pathogenic fire purging effect, is deafness and tinnitus, auditory dysesthesia and the cataractous prescription of the old deficiency of QI in middle-JIAO of control.The yiqi clever ball is the Chinese patent medicine of the accurate word of traditional Chinese medicines, is one of its preparation.The objective of the invention is to enlarge the scope of application of yiqi clever soup in medical domain, be used to prevent and treat the new purposes of the medicine or the food of climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia.
Yiqi clever soup comes from " Dong Yuan examination efficacious prescriptions eye door ", Rhizoma Cimicifugae (7 money half), Radix Puerariae (3 money) and Fructus Viticis (1 money half) by the suffering flavor, the Radix Astragali of sugariness, Radix Ginseng (each 1 money 2 minutes half) and Radix Glycyrrhizae Preparata (5 minutes), assistant is with the Radix Paeoniae of tart flavour and the Cortex Phellodendri of bitterness (each 1 money), and totally 8 flavor medicines are formed.Function is mainly replenishing QI to invigorate the spleen and yang invigorating, and assistant is with tonifying YIN yin fluid astringing and clearing away heat-fire.Wherein the Radix Astragali of sugariness medicine, Radix Ginseng and Radix Glycyrrhizae Preparata be with replenishing QI to invigorate the spleen, and the Rhizoma Cimicifugae of acrid, Radix Puerariae and Fructus Viticis to be rising the spleen sun, assistant with the Radix Paeoniae Alba of tart flavour with the Cortex Phellodendri of tonifying YIN yin fluid astringing and bitterness with clearing away heat-fire.Cure mainly " eating and drinking without temperance, the forced labour body, the taste deficiency, cataract tinnitus, or blurred vision is dark for many years, look thing can not ", and cloud " spirit of clothes order is for a long time crossed doubly, vigour bootstrap, the light body of body is strong, and is clear-headed and clear-sighted ".
Report is not the same in the different in ancient times documents of weight portion of 8 kinds of crude drug of composition yiqi clever soup.In conjunction with modern clinical application experience and experimental studies results, this pharmaceutical composition can be formed by following weight portion: Radix Ginseng or Radix Codonopsis 1-20 weight portion, Radix Astragali 2-30 weight portion, Rhizoma Cimicifugae 1-20 weight portion, Radix Puerariae 2-30 weight portion, Fructus Viticis 1-20 weight portion, Radix Paeoniae Alba 1-20 weight portion, Cortex Phellodendri 1-20 weight portion, Radix Glycyrrhizae 0.1-10 weight portion.
Female dimacteric syndrome is before and after menopause, flushed face occurs, or Hong hot side is red, and then sweating, tired mind, irritated irritability, have a dizzy spell, tinnitus cardiopalmus, insomnia forgetfulness, sore waist and aching in the waist and the back, feverish sensation in the palms and soles, or with as symptoms relevant with menopause such as menoxenias, the traditional Chinese medical science is called " all diseases before and after the menopause ", and western medicine is also referred to as perimenopausal syndrome.Western medicine thinks that it lowly is the principal element that primary disease takes place that hypo-ovaria causes sex hormone level.In addition, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia, these and age growth, the relevant illness of physical function decline, also with body in sex hormone level closely related.To the prevention and the treatment of these illness, controversies in hormone replacement in the elderly has certain curative effect, but because of side effect is bigger, can not finely satisfy clinical needs at present.Under this situation, the native chemical composition that is called phytoestrogen with weak estrogen action of plant origin receives very big concern.Phytoestrogen can play certain estrogen-like effects when estrogen level is not enough in vivo, and plays antagonism when estrogen level is too high in vivo, shows as two-ways regulation, does not find significant side effects, has good safety.Phytoestrogen can substitute the control that estrogen is used for above-mentioned illness to a certain extent.Nearest studies show that Radix Puerariae, Rhizoma Cimicifugae etc. contain the phytoestrogen composition, and its extract has separately begun to be applied to the control of above-mentioned illness.Yiqi clever soup of the present invention not only includes Radix Puerariae, Rhizoma Cimicifugae, also contains the cooperation of other six kinds of medicines, have benefiting qi and raising yang, yin fluid astringing pathogenic fire purging effect, belong to traditional Chinese medical science classical prescription, for the above-mentioned illness of control, can expect has better therapeutic than single medicine or time side.
The traditional Chinese medical science think that the etiology and pathogenesis of above-mentioned illness mainly blames in kidney, also dirty relevant with the heart, liver, spleen etc., according to its clinical symptoms, mainly be divided into syndrome of deficiency of kidney yin, syndrome of deficiency of kidney-YANG, all deficiency syndrome of kidney yin sun, pattern of syndrome such as asthenia of both the spleen and kidney, heart kidney two void, deficiency of both the heart and spleen, deficiency of heart-yin, deficiency of YIN liver-yang hyperactivity are still arranged in addition, use different legislation and prescription for different pattern of syndrome.Yiqi clever soup not only can be used for the card of insufficiency of the spleen or deficiency of QI in middle-JIAO, and can be used in other each pattern of syndrome, reason is climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia, and it is empty that these illness relevant with the decline of age growth, physical function all exist insufficiency of primordial QI or vigour to lose.Unit's aerial root is former in kidney, by the life of congenital kidney essense instituteization, and relies on the taste vital essence nourishing day after tomorrow.Lose empty illness for insufficiency of primordial QI or vigour, we are according to Li Gao described " vital qi has another name called vigour, is the vital essence of first body lifes, and non-gastric qi can not be grown ", thereby adopt the tonification taste day after tomorrow and reach the method for substantial vigour.The used yiqi clever soup of the present invention has the benefiting qi and raising yang function, not only can be by strengthening the spleen and stomach tonification vigour, simultaneously, " fire is the thief of vigour mutually ", its yin fluid astringing pathogenic fire purging function can also be removed " fire mutually ", prevents the dark consumption of vigour, reduces the loss of vigour.
The present invention also expects the plus-minus side of yiqi clever soup or serves as to instruct the Chinese medicine preparation of the new pharmaceutical composition that forms with the principles of formulating prescriptions of the benefiting qi and raising yang of yiqi clever soup, yin fluid astringing pathogenic fire purging, also can be used for the control of above-mentioned illness.
Summary of the invention
The present invention is with the constituent of yiqi clever soup: Radix Ginseng or Radix Codonopsis, the Radix Astragali, Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae are primary raw material, are used to prepare prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, the medicine of senile chronic prostate hyperplasia or the purposes of food.Simultaneously, the present invention relates to the plus-minus side of yiqi clever soup or instructing the new pharmaceutical composition that forms down with the yiqi clever soup principles of formulating prescriptions is the Chinese medicine preparation of primary raw material, is used to prevent and treat the new purposes of the medicine or the food of climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia.
Eight kinds of crude drug of yiqi clever soup can be formed by following weight portion: Radix Ginseng or Radix Codonopsis 1-20 weight portion, Radix Astragali 2-30 weight portion, Rhizoma Cimicifugae 1-20 weight portion, Radix Puerariae 2-30 weight portion, Fructus Viticis 1-20 weight portion, Radix Paeoniae Alba 1-20 weight portion, Cortex Phellodendri 1-20 weight portion, Radix Glycyrrhizae 0.1-10 weight portion.Wherein the Radix Astragali of sugariness medicine, Radix Ginseng and Radix Glycyrrhizae Preparata be with replenishing QI to invigorate the spleen, and the Rhizoma Cimicifugae of acrid, Radix Puerariae and Fructus Viticis to be rising the spleen sun, assistant with the Radix Paeoniae Alba of tart flavour with the Cortex Phellodendri of tonifying YIN yin fluid astringing and bitterness with clearing away heat-fire.
According to the principles of formulating prescriptions of yiqi clever soup are analyzed, can be divided into replenishing QI to invigorate the spleen, yang invigorating, tonifying YIN yin fluid astringing and clearing away heat-fire four classes to its employed medicine, so the plus-minus side of the yiqi clever soup that under these principles of formulating prescriptions instruct, forms or new pharmaceutical composition, also can be used for preparing prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, the medicine of senile chronic prostate hyperplasia or the purposes of food, it is characterized in that:
Qi-benefiting and spleen-strengthening drug derives from following a kind and arrives several crude drug: Radix Ginseng, Radix Codonopsis, Radix Panacis Quinquefolii, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Fructus Jujubae, Radix Glycyrrhizae, each crude drug weight ratio can be the 0.1-30 weight portion.
Shengyang medicine derives from following a kind of crude drug to several: Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae, Rhizoma Ligustici, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, each crude drug weight ratio can be the 1-30 weight portion.
Tonifying YIN yin fluid astringing medicine derives from following a kind of crude drug to several: the Radix Paeoniae Alba, Radix Paeoniae Rubra, Colla Corii Asini, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Carapax Trionycis, Carapax et Plastrum Testudinis, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori, Fructus Lycii, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Herba Dendrobii, Radix Asparagi, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), each crude drug weight ratio can be the 1-30 weight portion.
Heat clearing and fire purging medicine derives from following a kind of crude drug to several: Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Trichosanthis, Radix Scrophulariae, the Rhizoma Anemarrhenae, Herba Lophatheri, each crude drug weight ratio can be the 1-30 weight portion.
Each crude drug of forming yiqi clever soup, and the plus-minus side of yiqi clever soup or the principles of formulating prescriptions of pressing yiqi clever soup instruct the new pharmaceutical composition that forms down, mix after can being ground into powder separately, or be ground into powder again after mixing, directly be processed into the preparation that to take; Also can mix through crude drug being extracted the back separately, or each crude drug mixed earlier, extract again, be prepared into any common drug dosage form with acceptable accessories then, as pill, powder, capsule, tablet, electuary, oral liquid etc.
Following embodiment and effect experiment example can make the new purposes of yiqi clever soup of the present invention be achieved and confirm, should not regard the following example and experimental example as limitation of the present invention again simultaneously.
Embodiment 1
Preparation method (Chinese medicine ministry standard book page number: Z4-164 standard numbering: with Chinese medicine ministry standard yiqi clever ball WS3-B-0820-91) as reference preparation yiqi clever decoction pulvis.That is: Radix Codonopsis 100g, Radix Astragali 100g, Rhizoma Cimicifugae 60g, Radix Puerariae 60g, Cortex Phellodendri (stir-fry) 20g, Radix Paeoniae Alba 20g, Fructus Viticis 30g, Radix Glycyrrhizae (processing) 10g, more than eight flavors, be ground into fine powder, sieve, mixing promptly gets the yiqi clever decoction pulvis.Oral, a 6-18g 1-3 time on the one, is used for prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia.
Embodiment 2
Get each crude drug: Radix Ginseng 60g, Radix Astragali 120g, Rhizoma Cimicifugae 60g, Radix Puerariae 120g, Fructus Vitics Simplicifoliae 30g, Cortex Phellodendri 20g, Radix Paeoniae Alba 60g, Radix Glycyrrhizae 10g, more than eight flavors mix, be soaked in 5-10 and doubly extract solvent, reflux, extract, one obtains extracting solution to repeatedly.Extract solvent and can be the 0-95% ethanol water, preferred 30-95% ethanol, preferred 8 times are extracted solvent during reflux, extract,, reflux each 2 hours 3 times.Decompression and solvent recovery, crushed after being dried becomes fine powder, promptly gets the powder of our concentrate or extract.The powder of gained concentrate or extract is mixed with the capsular adjuvant commonly used of making, incapsulate and make capsule.Oral dose is converted according to the concentrated ratio of crude drug.Final concentrated ratio to crude drug is 10 times, crude drug calculates by take 6-18g at every turn, then once should take the weight that concentrates the back medicine is 0.6-1.8g, 2-6 the capsule of can packing into, 1-3 time on the one, be used for prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia.
Embodiment 3
Get each crude drug: Radix Ginseng 60g, Radix Astragali 100g, Rhizoma Cimicifugae 60g, Radix Puerariae 100g, Fructus Vitics Simplicifoliae 30g, Cortex Phellodendri 20g, Radix Paeoniae Alba 60g, Radix Glycyrrhizae 10g, it is soaked in 5-10 doubly extracts solvent respectively, reflux, extract, one gets extracting solution to repeatedly.Extract solvent and can be the 0-95% ethanol water, preferred 30-95% ethanol, preferred 8 times are extracted solvent during reflux, extract,, reflux each 2 hours 3 times.Decompression and solvent recovery, the concentrate of each medicine or extract crushed after being dried are mixed, and add tablet adjuvant commonly used, and tabletting promptly gets tablet, also can make different dosage forms such as pill, unguentum, mixture routinely.After making tablet, it is 10 times that crude drug final concentrated ratio, and crude drug calculates by take 6-18g at every turn, and the amount that then once should take the tablet after concentrating is 0.6-1.8g, 1-3 time on the one.Be used for prevention and treatment climacteric syndrome, senile chronic vaginitis, senile chronic urethritis or cystitis, senile chronic prostate hyperplasia.
Experimental example 1. yiqi clever soup are to the effect of oestrogen deficiencies Mouse Uterus
1. material and method
1.1 medicine
Radix Ginseng 90g, Radix Astragali 150g, Rhizoma Cimicifugae 90g, Radix Puerariae 150g, Fructus Vitics Simplicifoliae 45g, Radix Paeoniae Alba 45g, Cortex Phellodendri 15g, Radix Glycyrrhizae 10g, more than after eight flavors mix, be soaked in 8 times of 70% ethanol water, each 2 hours, extract 3 times.Behind the decompression recycling ethanol, 95 ℃ of heating concentrate, and make the yiqi clever decoction formulation that contains 1.5g/ml, and 4 ℃ of cold preservations are standby.
1.2 animal model and pharmaceutical intervention
32 of the female kunming mices in 8 weeks are divided into 4 groups at random: sham operated rats, model group, yiqi clever soup group and estrogen group, 8 every group.Every mouse cage of independently being raised in 24cmx15cmx15cm.In the 12/12h light and shade cycle, ambient temperature is (22 ± 1) ℃.Under 1% pentobarbital sodium anesthesia and sterile working, except that sham operated rats not spay implement the sham-operation, other each organize and all excise the mice bilateral ovaries, make the mouse model of estrogen deficiency.Postoperative, sham operated rats and model group are given and normal saline, and each 0.5ml irritates stomach, every day secondary.Yiqi clever soup group is given and the each 0.5ml of the yiqi clever soup that contains 1.5g/ml irritates stomach, every day secondary.The estrogen group is given with the each 0.5ml of diethylstilbestrol suspension and is irritated stomach, secondary every day (0.02 microgram/sky).Mice is allowed to freely ingest and drinks water.After 4 weeks of experiment beginning, mice anaesthetized down heart extracting blood cause death die after, the taking-up uterus is used for quality analysis.
1.3 uterus weight analysis
Take out the uterus, inhale with filter paper and go in the cavity of uterus and surface liquid, claim weight in wet base, measure uterus weight, the comparable group differences with ten thousand/balance.
1.4 date processing
All data are expressed as mean+/-standard error (means ± SEM).(one-wayanalysis of variance ANOVA) judges that it has there was no significant difference by one factor analysis of variance.The level of significant difference is decided to be p≤0.05.
2 results
Model group Mouse Uterus quality significantly descends after the oophorectomize.Diethylstilbestrol has suppressed the decline of uterus quality fully.Yiqi clever soup group has certain inhibitory action to the decline of uterus quality, its difference significance.
3. conclusion
Yiqi clever soup has certain inhibitory action to Mouse Uterus atrophy and degeneration variation, illustrate that yiqi clever soup has certain estrogen activity, can effectively prevent and treat climacteric syndrome, senile chronic vaginitis, urethritis and cystitis, also can be applicable to the prevention of male's chronic prostate hyperplasia and the treatment of one of controversies in hormone replacement in the elderly indication.
Experimental example 2: yiqi clever soup is used for the treatment of the clinical observation of climacteric syndrome
Climacteric syndrome is the commonly encountered diseases before and after the postmenopausal women, clinically mainly show as menoxenia or menopause, hectic fever sweating, irritated irritability, uncomfortable in chest, cardiopalmus, dizziness and dim eyesight, tinnitus, insomnia, dreaminess, all diseases such as cry and laugh by turns, without any apparent reason, general the most common with the women of 45～one's mid-50s, have a strong impact on patient's physically and mentally healthy and life.The clinical observation result that is used for the treatment of climacteric syndrome with yiqi clever soup is as follows.
1 data and method
1.1 the diagnostic criteria patient all according to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " regulation of State Administration of Traditional Chinese Medicine's promulgation, meets the diagnostic criteria of menopausal syndrome.
1.2 physical data is originally organized 30 routine patients, the age between 45～55 years old, menopause 11 examples, menoxenia 19 examples in conjunction with medical history and clinical symptoms, are got rid of organic diseases such as heart disease, tuberculosis, hyperthyroidism through electrocardiogram, X line etc. inspection.
1.3 Therapeutic Method side selects yiqi clever soup: Radix Codonopsis 9g, Radix Astragali 12g, Rhizoma Cimicifugae 9g, Radix Puerariae 15g, Fructus Viticis 6g, Radix Paeoniae Alba 15g, Cortex Phellodendri 6g, Radix Glycyrrhizae 3g.Be decocted in water for oral dose, 1 dose of every day, divide 3 times decoction being taken warmly.Take medicine minimum 6 doses, maximum 21 doses, most 10～14 doses.
2 therapeutic outcomes
2.1 " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " of 1994 issues of criterion of therapeutical effect reference year State Administration of Traditional Chinese Medicine is to the criterion of therapeutical effect of all disease one diseases before and after the menopause.Clinical cure: scorching sweating, transference cures such as irritated irritability; Take a turn for the better: clinical all diseases alleviate; Do not heal: clinical symptoms does not have improvement.
13 examples 2.2 therapeutic outcome is fully recovered account for 43.3%; 12 examples that take a turn for the better account for 40%; 5 examples more account for 16.6%; Total effective rate 83.3%.
3 conclusions
Observe by above-mentioned clinical experiment, find that the yiqi clever soup with benefiting qi and raising yang, tonifying YIN pathogenic fire purging effect has tangible curative effect aspect the treatment climacteric syndrome.
Claims (9)
1. the pharmaceutical composition of yiqi clever soup is main constitutive material, is used to prepare prevention and the medicine of treatment climacteric syndrome or the new purposes of food.
2. the pharmaceutical composition of yiqi clever soup is main constitutive material, is used to prepare prevention and treatment senile chronic vaginitis, senile chronic urethritis or the medicine of cystitis or the new purposes of food.
3. the pharmaceutical composition of yiqi clever soup is main constitutive material, is used to prepare prevention and the medicine of treatment senile chronic prostate hyperplasia or the new purposes of food.
4. yiqi clever Tonga side of subtracting or the new pharmaceutical composition that forms by yiqi clever soup combination principle, preparation is used to prevent and treats as the medicine of illness as described in the claim 1-3 or the purposes of food, it is characterized in that said composition is that primary raw material is formed by replenishing QI to invigorate the spleen, yang invigorating, tonifying YIN yin fluid astringing and clearing away heat-fire four class crude drug.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that qi-benefiting and spleen-strengthening drug in the said composition derive from following a kind to several crude drug: Radix Ginseng, Radix Codonopsis, Radix Panacis Quinquefolii, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Fructus Jujubae, Radix Glycyrrhizae, each crude drug weight ratio can be the 0.1-30 weight portion.
6. pharmaceutical composition as claimed in claim 4, it is characterized in that Shengyang medicine in the said composition derive from following a kind to several crude drug: Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae, Rhizoma Ligustici, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, each crude drug weight ratio can be the 1-30 weight portion.
7. pharmaceutical composition as claimed in claim 4, it is characterized in that tonifying YIN yin fluid astringing medicine in the said composition derive from following a kind to several crude drug: the Radix Paeoniae Alba, Radix Paeoniae Rubra, Colla Corii Asini, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Carapax Trionycis, Carapax et Plastrum Testudinis, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori, Fructus Lycii, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Herba Dendrobii, Radix Asparagi, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), each crude drug weight ratio can be the 1-30 weight portion.
8. pharmaceutical composition as claimed in claim 4, it is characterized in that heat clearing and fire purging medicine in the said composition derive from following a kind to several crude drug: Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Trichosanthis, Radix Scrophulariae, the Rhizoma Anemarrhenae, Gypsum Fibrosum, Herba Lophatheri, each crude drug weight ratio can be the 1-30 weight portion.
9. be main constitutive material as pharmaceutical composition as described in the claim 4-8,, be used to prepare prevention and the treatment medicine of illness or the purposes of food shown in claim 1-3 by method of pharmacy and the conventional preparation process of knowing.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743596A (en) * | 2012-06-17 | 2012-10-24 | 黄俊花 | Preparation method of Chinese medicine irrigation solution for treating kidney-yin deficiency type senile vaginitis |
| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
| CN102935144A (en) * | 2012-11-21 | 2013-02-20 | 云南植萃堂保健品有限公司 | Drug for treating climacteric syndrome and preparation process of drug |
| CN103239632A (en) * | 2013-03-24 | 2013-08-14 | 隋玉玲 | Chinese medicine preparation for treating chronic periodontitis |
| CN106420963A (en) * | 2016-09-27 | 2017-02-22 | 张舸 | Medicinal and edible active rooting preparation (tablet) and preparation method thereof |
-
2009
- 2009-10-10 CN CN2009102058487A patent/CN102038927A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102743596A (en) * | 2012-06-17 | 2012-10-24 | 黄俊花 | Preparation method of Chinese medicine irrigation solution for treating kidney-yin deficiency type senile vaginitis |
| CN102872425A (en) * | 2012-10-26 | 2013-01-16 | 谢春红 | Chinese medicinal decoction for treating climacteric syndrome |
| CN102935144A (en) * | 2012-11-21 | 2013-02-20 | 云南植萃堂保健品有限公司 | Drug for treating climacteric syndrome and preparation process of drug |
| CN103239632A (en) * | 2013-03-24 | 2013-08-14 | 隋玉玲 | Chinese medicine preparation for treating chronic periodontitis |
| CN106420963A (en) * | 2016-09-27 | 2017-02-22 | 张舸 | Medicinal and edible active rooting preparation (tablet) and preparation method thereof |
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Application publication date: 20110504 |