CN102370770B - Self-heating traditional Chinese medicine emplastrum for treating asthma - Google Patents
Self-heating traditional Chinese medicine emplastrum for treating asthma Download PDFInfo
- Publication number
- CN102370770B CN102370770B CN 201110313323 CN201110313323A CN102370770B CN 102370770 B CN102370770 B CN 102370770B CN 201110313323 CN201110313323 CN 201110313323 CN 201110313323 A CN201110313323 A CN 201110313323A CN 102370770 B CN102370770 B CN 102370770B
- Authority
- CN
- China
- Prior art keywords
- self
- heating
- chinese medicine
- bag
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 78
- 238000010438 heat treatment Methods 0.000 title claims abstract description 69
- 208000006673 asthma Diseases 0.000 title claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 69
- 239000011505 plaster Substances 0.000 claims abstract description 43
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000007789 sealing Methods 0.000 claims abstract description 18
- 239000000758 substrate Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 8
- 238000006479 redox reaction Methods 0.000 claims abstract description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 54
- 239000000843 powder Substances 0.000 claims description 45
- 239000005995 Aluminium silicate Substances 0.000 claims description 44
- 235000012211 aluminium silicate Nutrition 0.000 claims description 44
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 44
- 210000000582 semen Anatomy 0.000 claims description 42
- 241001643642 Viticis Species 0.000 claims description 31
- 239000004615 ingredient Substances 0.000 claims description 31
- 239000002674 ointment Substances 0.000 claims description 31
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 27
- 239000011780 sodium chloride Substances 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 23
- 238000001035 drying Methods 0.000 claims description 16
- 238000013022 venting Methods 0.000 claims description 16
- 239000012467 final product Substances 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 6
- 230000001464 adherent effect Effects 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 92
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 239000008186 active pharmaceutical agent Substances 0.000 abstract 2
- 241000675108 Citrus tangerina Species 0.000 abstract 1
- 241000801118 Lepidium Species 0.000 abstract 1
- 241001673966 Magnolia officinalis Species 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 235000004347 Perilla Nutrition 0.000 abstract 1
- 244000124853 Perilla frutescens Species 0.000 abstract 1
- 244000063464 Vitex agnus-castus Species 0.000 abstract 1
- 235000009347 chasteberry Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 81
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 78
- 238000002156 mixing Methods 0.000 description 77
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 57
- 239000000203 mixture Substances 0.000 description 47
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 38
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 34
- 239000004745 nonwoven fabric Substances 0.000 description 26
- 230000008961 swelling Effects 0.000 description 26
- 238000012856 packing Methods 0.000 description 25
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 23
- 239000001509 sodium citrate Substances 0.000 description 19
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 19
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 18
- 229920002125 Sokalan® Polymers 0.000 description 18
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 18
- 229960001631 carbomer Drugs 0.000 description 18
- 239000001768 carboxy methyl cellulose Substances 0.000 description 18
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 18
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 18
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 17
- 229920000609 methyl cellulose Polymers 0.000 description 17
- 239000001923 methylcellulose Substances 0.000 description 17
- 239000011787 zinc oxide Substances 0.000 description 17
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
- 239000000741 silica gel Substances 0.000 description 16
- 229910002027 silica gel Inorganic materials 0.000 description 16
- 108010010803 Gelatin Proteins 0.000 description 14
- 238000009472 formulation Methods 0.000 description 14
- 239000008273 gelatin Substances 0.000 description 14
- 229920000159 gelatin Polymers 0.000 description 14
- 235000019322 gelatine Nutrition 0.000 description 14
- 235000011852 gelatine desserts Nutrition 0.000 description 14
- -1 polyethylene Polymers 0.000 description 14
- 239000004698 Polyethylene Substances 0.000 description 13
- 239000002202 Polyethylene glycol Substances 0.000 description 13
- 239000004372 Polyvinyl alcohol Substances 0.000 description 13
- 229920000573 polyethylene Polymers 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- 229920002451 polyvinyl alcohol Polymers 0.000 description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 13
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 13
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 13
- 239000000853 adhesive Substances 0.000 description 12
- 230000001070 adhesive effect Effects 0.000 description 12
- 239000011159 matrix material Substances 0.000 description 12
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 10
- 206010011224 Cough Diseases 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 206010062717 Increased upper airway secretion Diseases 0.000 description 8
- 208000026435 phlegm Diseases 0.000 description 8
- 229920000298 Cellophane Polymers 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 210000003734 kidney Anatomy 0.000 description 7
- 230000000873 masking effect Effects 0.000 description 7
- 208000037656 Respiratory Sounds Diseases 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 208000000059 Dyspnea Diseases 0.000 description 5
- 206010013975 Dyspnoeas Diseases 0.000 description 5
- 206010047924 Wheezing Diseases 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 4
- 230000007812 deficiency Effects 0.000 description 4
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 3
- 239000003431 cross linking reagent Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000009325 pulmonary function Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- 206010037660 Pyrexia Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 230000003187 abdominal effect Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 230000001709 ictal effect Effects 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- KRTSDMXIXPKRQR-AATRIKPKSA-N monocrotophos Chemical compound CNC(=O)\C=C(/C)OP(=O)(OC)OC KRTSDMXIXPKRQR-AATRIKPKSA-N 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 238000001935 peptisation Methods 0.000 description 2
- 208000010540 rapid respiration Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 206010007522 Cardiac asthma Diseases 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 206010013700 Drug hypersensitivity Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010031123 Orthopnoea Diseases 0.000 description 1
- 208000004327 Paroxysmal Dyspnea Diseases 0.000 description 1
- 240000007509 Phytolacca dioica Species 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 208000035286 Spontaneous Remission Diseases 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000037883 airway inflammation Diseases 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 201000004827 cardiac tuberculosis Diseases 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 201000005311 drug allergy Diseases 0.000 description 1
- 208000017574 dry cough Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 210000000222 eosinocyte Anatomy 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000010579 first pass effect Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000013521 mastic Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000012144 orthopnea Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 206010037833 rales Diseases 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 208000013220 shortness of breath Diseases 0.000 description 1
- 230000008326 skin blood flow Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 208000008203 tachypnea Diseases 0.000 description 1
- 206010043089 tachypnoea Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Abstract
The invention relates to a traditional Chinese medicine compound preparation, in particular to a self-heating traditional Chinese medicine emplastrum for treating asthma. The self-heating traditional Chinese medicine emplastrum comprises a sealing bag, and a plaster and a self-heating bag which are vertically bonded together and packed in the sealing bag, wherein the self-heating bag comprises an air-permeable bag and a chemical heating material which is based on redox reaction of iron and packed in the air-permeable bag; and the plaster comprises a back lining layer, a medicine storage layer and an anti-adhesion layer. The self-heating traditional Chinese medicine emplastrum for treating asthma is characterized in that the medicine storage layer comprises a pharmaceutically acceptable substrate and effective components of active pharmaceutical ingredients equivalent to 40wt% of the substrate, wherein the effective components of the active pharmaceutical ingredients comprise the following raw materials in percentage by weight: 1.5-3% of vitex oil, 10-35% of tangerine peel water extract, 5-25% of magnolia bark water extract, 10-30% of pepperweed seed water extract, 10-40% of perilla fruit water extract and 10-30% of mulberry bark.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Asthma is by the various kinds of cell chronic airway inflammation that participates in of mastocyte, eosinophilic granulocyte and T lymphocyte particularly; This kind inflammation can cause repeatedly symptoms such as the panting of outbreak, tachypnea, uncomfortable in chest and cough in the susceptible person, how to take place at night or morning; This type of symptom is often limited with extensive and changeable exhalation flow rate, but natural remission or alleviate through treatment partly; This kind symptom also increases multiple stimulating factor reactivity with air flue.Traditional medicine is thought: the lung being the dominator of QI, the kidney being the root of QI.When asthma was shown effect, the lung road can not main gas, and suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI, and then QI rising in reverse order is in last, and sends out in dyspnea with rapid respiration.The spleen is the source of growth and development, spleen deficiency generating phlegm, and the stagnation of phlegm air flue so see and breath with cough, is breathed hard.Therefore, asthma is kidney, lung, spleen, the disease of three void.At present, modern medicine does not have the radical cure way to it yet to asthma.Yet motherland's medical science has remarkable advantages aspect the preventing and treating of asthma.Therefore, seeking a kind of asthma method of preventing and treating that can bring into play tcm characteristic is desirability.
Because it is many and complicated to influence the factor of asthma, therefore at various factors and the too many levels of developing, multi-level compound Chinese medicinal preparation are more common in the disclosed patent application of Patent Office of the People's Republic of China, wherein publication number is that the patent application of CN101757483A discloses " a kind of Chinese medicine preparation for the treatment of asthma ", said preparation is with Ramulus Cinnamomi, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Radix Peucedani, Fructus Perillae, process Radix Asteris, Fructus Tritici Levis is the oral formulations that raw material is made, though can be used for treating asthma, but there is first pass effect unavoidably in its a kind of oral formulations.
Summary of the invention
Technical problem to be solved by this invention provides a kind of self-heating Chinese medicine patch unguentum for the treatment of asthma, and this patch is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of self-heating Chinese medicine patch unguentum for the treatment of asthma, this self-heating Chinese medicine patch unguentum is made up of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, wherein said effective ingredient is to be made up of the water extract that Oleum Viticis Negundo 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 10%～35%, Cortex Magnoliae Officinalis 5%～25%, Semen Lepidii (Semen Descurainiae) 10%～30%, Fructus Perillae 10%～40%, Cortex Mori 10%～30%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said active ingredient are preferably added the water extract of following crude drug by Oleum Viticis Negundo 2% by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 20%, Cortex Magnoliae Officinalis 10%, Semen Lepidii (Semen Descurainiae) 23%, Fructus Perillae 25%, Cortex Mori 20%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said water extract can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.Oleum Viticis Negundo is sprayed in the prepared extract powder, mixes thoroughly, namely get described effective ingredient.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions first appendix I rules of preparations of Chinese Pharmacopoeia is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is made up of following raw materials by weight percent: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol and propylene glycol, perhaps is one or both the mixture in glycerol, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, triethanolamine, sodium citrate and the aluminum chloride.
Self-heating Chinese medicine patch unguentum of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in described component one, component two and the component three.
Self-heating Chinese medicine patch unguentum of the present invention, wherein, described backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing sealed external package) of the self-heating bag that Qingdao ADO industry and trade company limited is produced is that the disclosed scheme of application for a patent for invention of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is made up of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%.Preferably formed by following raw material by weight percentage: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and desirable fever time is suitable with 7-11 hour.
Asthma is ictal expiratory dyspnea with wheezing sound.Severe patient can be forced to take seat or be orthopnea, dry cough or cough up a large amount of white foam expectorant, even cyanosis etc. appears.Symptoms of asthma can be shown effect in several minutes, through a few hours to a couple of days, with bronchodilator or spontaneous remission.Patient's majority of early stage or light disease with ictal cough and uncomfortable in chest serve as main performance.Ancient Chinese medicine doctor is thought the lung being the dominator of QI, the kidney being the root of QI.When asthma was shown effect, the lung road can not main gas, and suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI, and then QI rising in reverse order is in last, and sends out in dyspnea with rapid respiration.The spleen is the source of growth and development, spleen deficiency generating phlegm, and the stagnation of phlegm air flue so see and breath with cough, is breathed hard.Therefore, asthma is kidney, lung, spleen, the disease of three void.
Active ingredient of the present invention is made by Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori, Oleum Viticis Negundo, and perillaseed droping gas reduces phlegm in the side, and relieving cough and asthma is principal agent; Cortex Magnoliae Officinalis, the Pericarpium Citri Reticulatae therapeutic method to keep the adverse QI flowing downwards are eliminated the phlegm, and it is real to assist the principal agent treatment to go up, and Cortex Mori, Semen Lepidii (Semen Descurainiae) dispersing lung-QI and dissipating phlegm are relievingd asthma, and are accessory drugs; The Oleum Viticis Negundo coordinating the actions of various ingredients in a prescription is for making.
During use, the sealing bag of self-heating Chinese medicine patch unguentum of the present invention is taken apart, be pasted on asthma person's abdominal part, oxidation reaction just takes place and generates heat in the chemical exothermic material chance oxygen of venting bags, heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate function, and then reach the purpose for the treatment of asthma.
In order to understand the present invention better, the clinical trial with self-heating Chinese medicine patch unguentum treatment asthma of the present invention illustrates its effect below.
Clinical experiment
One, physical data
Those selected is the patient that the 2007-2010 annual income meets the bronchial asthma diagnostic criteria 336 examples, adopts " table of random number " that the patient is divided into two groups at random, and 185 examples are organized in treatment, male 96 examples wherein, women 89 examples; Age 5-81 year, average (52.08 ± 9.47) year; Course of disease 2-37, average (19.32 ± 1.27) year; Acute attack stage concurrent infection person 42 examples.Matched group 181 examples, male 94 examples wherein, women 87 examples; Age 5-82 year, average (47.07 ± 8.32) year; Course of disease 1-35, average (21.32 ± 1.45) year; Acute attack stage concurrent infection person 41 examples.Two groups of case ages, sex, courses of disease are learned by statistics and are handled there was no significant difference (P＞0.05), have comparability.
Two. include standard in
5-58 year meets the diagnosis of doctor trained in Western medicine bronchial asthma, and Chinese medical discrimination is based on the patient of asthenia of pulmonosplenic qi disease.
The Western medicine diagnose standard
The tcm diagnosis standard
Three, exclusion standard:
Can cause tumor in asthma, dyspneic upper respiratory tract and trachea, the bronchus, cardiac asthma, tuberculosis or other organic diseases; Merge cardiovascular, liver, kidney and the serious primary disease of hemopoietic system and psychotic, drug allergy history person is arranged; Not medication in accordance with regulations, merge to use during other similar medicine persons, the treatment because of actute infection adopt antiinflammatory relieving asthma therapist, can't judge curative effect, data not umbra ring curative effect or safety judgement person.
Four, method
Self-heating Chinese medicine patch unguentum group: the self-heating Chinese medicine patch unguentum (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Matched group: use the point application of Guangdong Provincial TCM Hospital medicinal vesiculation cream, select big vertebra, fei shu (two), Tiantu, Danzhong, Dingchuan (two), the annual first day of the first period of the hot season in summer, the second of the three ten-day periods of the hot season, each subsides first day of the last period of the hot season are once taken off after 4 hours, and it is 1 course for the treatment of that continuous treatment is observed 3 years.Treat in back one month and add up curative effect the first day of the last period of the hot season the 3rd year first course for the treatment of.
Five, observation of curative effect
Observation index: before treatment, after treating, measure pulmonary function respectively for two groups; Clinicing symptom observation is the asthma situation round the clock, dyspnea with shortness of breath, cough, cough up phlegm fear of cold aversion to wind, spontaneous perspiration, pulmonary's rale, with reference to " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " that the Ministry of Public Health clinical research guideline of asthma " new Chinese medicine treatment " and the 1995-01-01 of State Administration of Traditional Chinese Medicine implement, work out symptoms of asthma and Chinese medical discrimination standards of grading, by do not have, gently, in, remember 0,1,2,3 fen heavily respectively.
Efficacy assessment standard: with reference to " prevention and control of bronchial asthma guide ", evaluate (1) clinic control according to " the clinical research guideline for the treatment of asthma new Chinese medicine " standard: the symptom of panting and pulmonary's wheezing sound disappear or not enough slight person.(2) produce effects: the symptom of panting and pulmonary's wheezing sound are clearly better, and FEV1 and PEF increment are more than 30%.(3) effective: the symptom of panting and pulmonary's wheezing sound take a favorable turn, FEV1 and PEF increment 10%-30%.(4) invalid: the symptom of panting and pulmonary's wheezing sound do not have improvement or increase the weight of, and FEV1 and PEF increment are less than 10%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.In the group, more all adopt t check between group, two groups of curative effects are relatively analyzed with Ridit.
Six, therapeutic outcome
Two groups of patient's clinical efficacies compare: two groups of clinical efficacies are analyzed through Ridit, and difference does not have significance (P＞0.05).Wherein, light middle severe asthma is respectively 79 examples, 98 examples, 8 examples before the treatment for the treatment of group; Be respectively 168 examples, 15 examples, 2 examples after the treatment.Light before the treatment of control group, in, severe asthma 78 examples, 101 examples, 2 examples respectively; Treatment back is light, in, severe asthma is respectively 163 examples, 17 examples, 1 example.See Table 1.
Table 1 liang group clinical efficacy relatively
Two groups for the treatment of back pulmonary functions change relatively two groups of FEV1 and PEF is significantly increased (all P＜0.05) before the treatment, between two groups for the treatment of backs relatively, therapeutic combination matched group FEV1 no significant difference (P＞0.05).See Table 2.
Pulmonary function variation comparison before and after the table 2 liang group patient treatment (x ± s)
Annotate: with * P＜0.01 relatively before the treatment on the same group, #P＜0.05 relatively between group
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 80g, Cortex Magnoliae Officinalis 40g, Semen Lepidii (Semen Descurainiae) 92g, Fructus Perillae 100g, Cortex Mori 80g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Cortex Mori and decoct with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve namely.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerol mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 6g, Pericarpium Citri Reticulatae 53g, Cortex Magnoliae Officinalis 49g, Semen Lepidii (Semen Descurainiae) 81g, Fructus Perillae 130g, Cortex Mori 81g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 10g, Pericarpium Citri Reticulatae 40g, Cortex Magnoliae Officinalis 38g, Semen Lepidii (Semen Descurainiae) 76g, Fructus Perillae 123g, Cortex Mori 113g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 12g, Pericarpium Citri Reticulatae 113g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 59g, Fructus Perillae 98g, Cortex Mori 98g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 10g, Pericarpium Citri Reticulatae 132g, Cortex Magnoliae Officinalis 76g, Semen Lepidii (Semen Descurainiae) 40g, Fructus Perillae 66g, Cortex Mori 76g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, carbomer and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 108g, Cortex Magnoliae Officinalis 94g, Semen Lepidii (Semen Descurainiae) 94g, Fructus Perillae 40g, Cortex Mori 56g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 7g, Pericarpium Citri Reticulatae 76g, Cortex Magnoliae Officinalis 67g, Semen Lepidii (Semen Descurainiae) 101g, Fructus Perillae 109g, Cortex Mori 40g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Sodium carboxymethyl cellulose, polyvinyl alcohol and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 57g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 88g, Fructus Perillae 139g, Cortex Mori 88g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 133g, Cortex Magnoliae Officinalis 76g, Semen Lepidii (Semen Descurainiae) 76g, Fructus Perillae 67g, Cortex Mori 40g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 40g, Cortex Magnoliae Officinalis 38g, Semen Lepidii (Semen Descurainiae) 114g, Fructus Perillae 124g, Cortex Mori 76g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 9g, Pericarpium Citri Reticulatae 63g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 58g, Fructus Perillae 154g, Cortex Mori 96g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 11g, Pericarpium Citri Reticulatae 90g, Cortex Magnoliae Officinalis 40g, Semen Lepidii (Semen Descurainiae) 40g, Fructus Perillae 99g, Cortex Mori 120g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Claims (4)
1. self-heating Chinese medicine patch unguentum for the treatment of asthma, this self-heating Chinese medicine patch unguentum is made up of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, wherein said effective ingredient is to be made up of the water extract that Oleum Viticis Negundo 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 10%～35%, Cortex Magnoliae Officinalis 5%～25%, Semen Lepidii (Semen Descurainiae) 10%～30%, Fructus Perillae 10%～40%, Cortex Mori 10%～30%.
2. a kind of self-heating Chinese medicine patch unguentum for the treatment of asthma according to claim 1 is characterized in that, described effective ingredient is the water extract that is added following crude drug by the percentage by weight of crude drug by Oleum Viticis Negundo 2%: Pericarpium Citri Reticulatae 20%, Cortex Magnoliae Officinalis 10%, Semen Lepidii (Semen Descurainiae) 23%, Fructus Perillae 25%, Cortex Mori 20%.
3. a kind of self-heating Chinese medicine patch unguentum for the treatment of asthma according to claim 1 and 2, it is characterized in that described water extract is prepared by following method: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.
4. a kind of self-heating Chinese medicine patch unguentum for the treatment of asthma according to claim 1 and 2, it is characterized in that described chemical exothermic material is made up of following raw materials by weight percent: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110313323 CN102370770B (en) | 2011-10-16 | 2011-10-16 | Self-heating traditional Chinese medicine emplastrum for treating asthma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110313323 CN102370770B (en) | 2011-10-16 | 2011-10-16 | Self-heating traditional Chinese medicine emplastrum for treating asthma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102370770A CN102370770A (en) | 2012-03-14 |
| CN102370770B true CN102370770B (en) | 2013-08-14 |
Family
ID=45790354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110313323 Active CN102370770B (en) | 2011-10-16 | 2011-10-16 | Self-heating traditional Chinese medicine emplastrum for treating asthma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102370770B (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| US6453648B1 (en) * | 1999-07-06 | 2002-09-24 | Zars, Inc. | Method for manufacturing a heat generating apparatus |
| CN1833689A (en) * | 2006-01-12 | 2006-09-20 | 北京阜康仁生物制药科技有限公司 | Asthma stop preparation and novel prepn. |
-
2011
- 2011-10-16 CN CN 201110313323 patent/CN102370770B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN102370770A (en) | 2012-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102370730B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for treating osteoarthritis | |
| CN102370740B (en) | Self-heating Chinese medicinal adhesive plaster for treating prostatitis | |
| CN102416140B (en) | Self-heating type Chinese medicinal emplastrum for treating proliferation of mammary gland | |
| CN102366501B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving sleep quality | |
| CN102370795B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for treating primary dysmenorrhea | |
| CN102370770B (en) | Self-heating traditional Chinese medicine emplastrum for treating asthma | |
| CN102370762B (en) | Self-heating Chinese medicinal adhesive plaster for improving constipation | |
| CN102366495B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for lowering lipid and losing weight | |
| CN101829272B (en) | Traditional Chinese medicine composition for treating diabetes mellitus and preparation method thereof | |
| CN102366471B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for warming deficiency of kidney | |
| CN102370723B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving chest bi | |
| CN102366451B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving stroke sequelae | |
| CN102366462B (en) | Self-heating traditional Chinese medicine plaster for improving sub-health | |
| CN102366446B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for improving pelvic inflammation | |
| CN102366463B (en) | Self-heating traditional Chinese medicinal emplastrum for treating chronic gastritis | |
| CN101804119B (en) | Traditional Chinese medicine preparation for treating thrombocytopenia and preparation method thereof | |
| CN102370809B (en) | Self-heated traditional Chinese medicine (TCM) emplastrum for preventing and curing hypertension | |
| CN100376259C (en) | Externally-applied chinese medicinal preparation for treating nervus and intestinal diseases | |
| CN102366441B (en) | Self-heating Chinese medicinal emplastrum for cold prevention | |
| CN102366439B (en) | Self-heated traditional Chinese medicine emplastrum for treating chronic simple rhinitis | |
| CN102579804A (en) | Chinese medicine for treating stenocardia | |
| CN106728828A (en) | A kind of Chinese medicine preparation and its preparation technology for treating coronary heart disease | |
| CN102370769B (en) | Self-heated emplastrum for dispelling bromhidrosis | |
| CN1168285A (en) | Preparation of Astragalus medicine capsule | |
| CN104758860A (en) | Traditional Chinese medicine composition for treating combined allergic rhinitis and asthma syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211101 Address after: 510000 room 161, first floor, No. 364, middle Industrial Avenue, Haizhu District, Guangzhou, Guangdong Patentee after: Shennong (Guangzhou) traditional Chinese Medicine Technology Co.,Ltd. Address before: 510665 No. 30, Xinzhuang 2nd Road, Yonghe street, Luogang District, Guangzhou, Guangdong Patentee before: Guangdong Yangmei Medicine Investment Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221130 Address after: 510000 Room 101, building 1, 265 Chigang West Road, Haizhu District, Guangzhou City, Guangdong Province Patentee after: GUANGZHOU NEW-DESIGN BIOTECHNOLOGY CO.,LTD. Address before: 510000 room 161, first floor, No. 364, middle Industrial Avenue, Haizhu District, Guangzhou, Guangdong Patentee before: Shennong (Guangzhou) traditional Chinese Medicine Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right |