CN102370770A - Self-heating traditional Chinese medicine emplastrum for treating asthma - Google Patents
Self-heating traditional Chinese medicine emplastrum for treating asthma Download PDFInfo
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- CN102370770A CN102370770A CN2011103133232A CN201110313323A CN102370770A CN 102370770 A CN102370770 A CN 102370770A CN 2011103133232 A CN2011103133232 A CN 2011103133232A CN 201110313323 A CN201110313323 A CN 201110313323A CN 102370770 A CN102370770 A CN 102370770A
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine compound preparation, in particular to a self-heating traditional Chinese medicine emplastrum for treating asthma. The self-heating traditional Chinese medicine emplastrum comprises a sealing bag, and a plaster and a self-heating bag which are vertically bonded together and packed in the sealing bag, wherein the self-heating bag comprises an air-permeable bag and a chemical heating material which is based on redox reaction of iron and packed in the air-permeable bag; and the plaster comprises a back lining layer, a medicine storage layer and an anti-adhesion layer. The self-heating traditional Chinese medicine emplastrum for treating asthma is characterized in that the medicine storage layer comprises a pharmaceutically acceptable substrate and effective components of active pharmaceutical ingredients equivalent to 40wt% of the substrate, wherein the effective components of the active pharmaceutical ingredients comprise the following raw materials in percentage by weight: 1.5-3% of vitex oil, 10-35% of tangerine peel water extract, 5-25% of magnolia bark water extract, 10-30% of pepperweed seed water extract, 10-40% of perilla fruit water extract and 10-30% of mulberry bark.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Asthma is by various kinds of cell mastocyte, eosinophilic granulocyte and the T lymphocyte chronic airway inflammation of participating in particularly; This kind inflammation can cause repeatedly symptoms such as the panting of outbreak, tachypnea, uncomfortable in chest and cough in the susceptible person, how to take place at night or morning; This type of symptom is often limited with extensive and changeable exhalation flow rate, but partly natural remission or warp treatment alleviation; This kind symptom also increases multiple stimulating factor reactivity with air flue.Traditional medicine is thought: the lung being the dominator of QI, the kidney being the root of QI.When asthma was shown effect, the lung road can not main gas, and suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI, and then the QI rising in reverse order is in last, and sends out in dyspnea with rapid respiration.The spleen is the source of growth and development, spleen deficiency generating phlegm, and the stagnation of phlegm air flue so see and breath with cough, is breathed hard.Therefore, asthma is kidney, lung, spleen, the disease of three void.At present, modern medicine does not have the radical cure way to it to asthma yet.Yet motherland's medical science has remarkable advantages aspect the preventing and treating of asthma.Therefore, seeking a kind of asthma method of preventing and treating that can bring into play tcm characteristic is desirability.
Because it is many and complicated to influence the factor of asthma; Therefore to various factors and the too many levels of developing, multi-level compound Chinese medicinal preparation are more common in the disclosed patent application of Patent Office of the People's Republic of China; Wherein publication number is that the patent application of CN101757483A discloses " a kind of Chinese medicine preparation of treating asthma "; Said preparation is with Ramulus Cinnamomi, Radix Glycyrrhizae, Cortex Magnoliae Officinalis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Radix Peucedani, Fructus Perillae, process Radix Asteris, Fructus Tritici Levis is the oral formulations that raw material is processed; Though can be used for treating asthma, there is first pass effect unavoidably in its a kind of oral formulations.
Summary of the invention
Technical problem to be solved by this invention provides a kind of self-heating Chinese medicine patch unguentum of treating asthma, and this patch is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is described below:
A kind of self-heating Chinese medicine patch unguentum of treating asthma; This self-heating Chinese medicine patch unguentum is made up of sealing bag and bag plaster that is bonded together up and down and self-heating bag within it; Wherein, said self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Said plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Said medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%; Wherein said effective ingredient is to be made up of the water extract that Oleum Viticis Negundo 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 10%～35%; Cortex Magnoliae Officinalis 5%～25%; Semen Lepidii (Semen Descurainiae) 10%～30%, Fructus Perillae 10%～40%, Cortex Mori 10%～30%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said active ingredient are preferably added the water extract of following crude drug by Oleum Viticis Negundo 2% by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 20%, Cortex Magnoliae Officinalis 10%, Semen Lepidii (Semen Descurainiae) 23%, Fructus Perillae 25%, Cortex Mori 20%.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said water extract can adopt this area water extracting method commonly used to prepare; The method that the inventor recommends is described below: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori by proportioning; Add 6-10 times of water gaging earlier, decocted 1.5-3 hour, filter; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate drying becomes extract powder to get final product.Oleum Viticis Negundo is sprayed in the prepared extract powder, mixes thoroughly, promptly get said effective ingredient.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said substrate can be the substrate of conventional patch; As; 2005 editions first appendix I rules of preparations of Chinese Pharmacopoeia is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommended is made up of following raw materials by weight percent: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerin and propylene glycol, perhaps is one or both the mixture in glycerin, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, triethanolamine, sodium citrate and the aluminum chloride.
Self-heating Chinese medicine patch unguentum of the present invention, the desirable method for preparing of wherein said medicine storing layer is: said effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, abundant swelling, component one; To in component one, be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the said component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in said component one, component two and the component three.
Self-heating Chinese medicine patch unguentum of the present invention, wherein, said backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is processed by non-woven fabrics; Described sealing bag is processed by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is promptly got said plaster.
Self-heating Chinese medicine patch unguentum of the present invention; Wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat; Usually form by reduced iron powder, water and catalyst; The inner packing (promptly removing sealed external package) of the self-heating bag of producing like, Qingdao ADO industry and trade company limited is that the scheme that application for a patent for invention disclosed of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is made up of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%.Preferably form: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15% by following raw material by weight percentage.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and ideal fever time is suitable with 7-11 hour.
Asthma is ictal expiratory dyspnea with wheezing sound.Severe patient can be compelled to take seat or be orthopnea, dry cough or cough up a large amount of white foam expectorant, even cyanosis etc. appears.SOA can show effect in several minutes, through several hours to a couple of days, with bronchodilator or spontaneous remission.Patient's majority of early stage or light disease with ictal cough and uncomfortable in chest serve as main performance.Ancient Chinese medicine doctor is thought the lung being the dominator of QI, the kidney being the root of QI.When asthma was shown effect, the lung road can not main gas, and suffering from a deficiency of the kidney can not improving inspiration by invigorating kidney-QI, and then the QI rising in reverse order is in last, and sends out in dyspnea with rapid respiration.The spleen is the source of growth and development, spleen deficiency generating phlegm, and the stagnation of phlegm air flue so see and breath with cough, is breathed hard.Therefore, asthma is kidney, lung, spleen, the disease of three void.
Active ingredient of the present invention is processed by Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori, Oleum Viticis Negundo, and perillaseed droping gas reduces phlegm in the side, and relieving cough and asthma is principal agent; Cortex Magnoliae Officinalis, the Pericarpium Citri Reticulatae therapeutic method to keep the adverse QI flowing downwards are eliminated the phlegm, and it is real to assist the principal agent treatment to go up, and Cortex Mori, Semen Lepidii (Semen Descurainiae) dispersing lung-QI and dissipating phlegm are relievingd asthma, and are accessory drugs; The Oleum Viticis Negundo coordinating the actions of various ingredients in a prescription is for making.
During use, the sealing bag of self-heating Chinese medicine patch unguentum of the present invention is taken apart, be pasted on asthma person's abdominal part; Oxidation reaction just takes place and generates heat in the chemical exothermic material chance oxygen of venting bags; Heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body; Regulate function, and then reach the purpose of treatment asthma.
In order to understand the present invention better, with the clinical trial of self-heating Chinese medicine patch unguentum treatment asthma of the present invention its effect is described below.
Clinical experiment
One, physical data
Those selected is the patient that the 2007-2010 annual income meets the bronchial asthma diagnostic criteria 336 examples, adopts " table of random number " that the patient is divided into two groups at random, and 185 examples are organized in treatment, wherein male 96 examples, women 89 examples; Age 5-81 year, average (52.08 ± 9.47) year; Course of disease 2-37, average (19.32 ± 1.27) year; Acute attack stage concurrent infection person 42 examples.Matched group 181 examples, wherein male 94 examples, women 87 examples; Age 5-82 year, average (47.07 ± 8.32) year; Course of disease 1-35, average (21.32 ± 1.45) year; Acute attack stage concurrent infection person 41 examples.Two groups of case ages, sex, the course of disease have comparability through statistical procedures there was no significant difference (P＞0.05).
Two. include standard in
5-58 year meets the diagnosis of doctor trained in Western medicine bronchial asthma, and Chinese medical discrimination is master's patient with asthenia of pulmonosplenic qi disease.
The Western medicine diagnose standard
The tcm diagnosis standard
Three, exclusion standard:
Can cause tumor in asthma, dyspneic upper respiratory tract and trachea, the bronchus, cardiac asthma, tuberculosis or other organic diseases; Merge cardiovascular, liver, kidney and serious primary disease of hemopoietic system and psychotic, drug allergy history person is arranged; By the regulation medication, merge to use during other similar medicine persons, the treatment because of actute infection adopt antiinflammatory relieving asthma therapist, can't judge curative effect, data not umbra ring curative effect or safety judgement person.
Four, method
Self-heating Chinese medicine patch unguentum group: the self-heating Chinese medicine patch unguentum (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Matched group: use the point application of Guangdong Provincial TCM Hospital medicinal vesiculation cream, select big vertebra, fei shu (two), Tiantu, Danzhong, Dingchuan (two), the annual first day of the first period of the hot season in summer, the second of the three ten-day periods of the hot season, each subsides first day of the last period of the hot season are once taken off after 4 hours, and it is 1 course of treatment that continuous treatment is observed 3 years.Treat in back one month and add up curative effect the first day of the last period of the hot season the 3rd year first course of treatment.
Five, observation of curative effect
Observation index: before treatment, after treating, measure pulmonary function respectively for two groups; Clinicing symptom observation is the asthma situation round the clock, dyspnea with shortness of breath, cough; Cough up phlegm fear of cold aversion to wind, spontaneous perspiration; Pulmonary's hello sound; With reference to the Ministry of Public Health clinical research guideline of asthma " new Chinese medicine treatment " and " traditional Chinese medical science disease diagnosis criterion of therapeutical effect " that the 1995-01-01 of State Administration of Traditional Chinese Medicine implements, work out SOA and Chinese medical discrimination standards of grading, by do not have, gently, in, remember 0,1,2,3 fen heavily respectively.
Efficacy assessment standard: with reference to " prevention and control of bronchial asthma guide ", evaluate (1) clinic control according to " the clinical research guideline of treatment asthma new Chinese medicine " standard: the symptom of panting and pulmonary's wheezing sound disappear or not enough slight person.(2) produce effects: the symptom of panting and pulmonary's wheezing sound are clearly better, and FEV1 and PEF increment are more than 30%.(3) effective: the symptom of panting and pulmonary's wheezing sound take a favorable turn, FEV1 and PEF increment 10%-30%.(4) invalid: the symptom of panting and pulmonary's wheezing sound do not have improvement or increase the weight of, and FEV1 and PEF increment are less than 10%.
Statistical procedures:
Total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, and measurement data is with mean ± standard deviation (x ± s) expression.In the group, more all adopt t check between group, two groups of curative effects are relatively analyzed with Ridit.
Six, therapeutic outcome
Two groups of patient's clinical efficacies compare: two groups of clinical efficacies are analyzed through Ridit, and difference does not have significance (P＞0.05).Wherein, light middle severe asthma is respectively 79 examples, 98 examples, 8 examples before the treatment of treatment group; Be respectively 168 examples, 15 examples, 2 examples after the treatment.Light before the treatment of control group, in, severe asthma 78 examples, 101 examples, 2 examples respectively; Treatment back is light, in, severe asthma is respectively 163 examples, 17 examples, 1 example.See table 1.
Table 1 liang group clinical efficacy relatively
Two groups of treatment back pulmonary functions change relatively two groups of FEV1 and PEF has obvious increase (all P＜0.05) before the treatment, between two groups of treatment backs relatively, therapeutic combination matched group FEV1 no significant difference (P＞0.05).See table 2.
Pulmonary function variation comparison before and after the table 2 liang group patient treatment (x ± s)
Annotate: with * P＜0.01 relatively before the treatment on the same group, #P＜0.05 relatively between group
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 80g, Cortex Magnoliae Officinalis 40g, Semen Lepidii (Semen Descurainiae) 92g, Fructus Perillae 100g, Cortex Mori 80g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerin 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae and Cortex Mori decocte with water secondary, add 6 times of water gagings for the first time, add 6 times of water gagings for the second time; Each 1.5 hours, merge the secondary decocting liquid, filter; Filtrating is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey); 80 ℃ of dryings are ground into fine powder, and sieving promptly gets.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerin mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 6g, Pericarpium Citri Reticulatae 53g, Cortex Magnoliae Officinalis 49g, Semen Lepidii (Semen Descurainiae) 81g, Fructus Perillae 130g, Cortex Mori 81g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerin 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerin, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 10g, Pericarpium Citri Reticulatae 40g, Cortex Magnoliae Officinalis 38g, Semen Lepidii (Semen Descurainiae) 76g, Fructus Perillae 123g, Cortex Mori 113g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g; Polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerin 156g, propylene glycol 156g; Micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 12g, Pericarpium Citri Reticulatae 113g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 59g, Fructus Perillae 98g, Cortex Mori 98g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g; Glycerin 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g; Zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 10g, Pericarpium Citri Reticulatae 132g, Cortex Magnoliae Officinalis 76g, Semen Lepidii (Semen Descurainiae) 40g, Fructus Perillae 66g, Cortex Mori 76g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerin 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, carbomer and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 108g, Cortex Magnoliae Officinalis 94g, Semen Lepidii (Semen Descurainiae) 94g, Fructus Perillae 40g, Cortex Mori 56g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerin 246g; Propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g; Sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 7g, Pericarpium Citri Reticulatae 76g, Cortex Magnoliae Officinalis 67g, Semen Lepidii (Semen Descurainiae) 101g, Fructus Perillae 109g, Cortex Mori 40g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerin 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Sodium carboxymethyl cellulose, polyvinyl alcohol and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 57g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 88g, Fructus Perillae 139g, Cortex Mori 88g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g; Pressure sensitive adhesive 108g, carbomer 30g, glycerin 224g, propylene glycol 224g, butanediol 38g; Zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 133g, Cortex Magnoliae Officinalis 76g, Semen Lepidii (Semen Descurainiae) 76g, Fructus Perillae 67g, Cortex Mori 40g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerin 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerin and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, mixing, component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 8g, Pericarpium Citri Reticulatae 40g, Cortex Magnoliae Officinalis 38g, Semen Lepidii (Semen Descurainiae) 114g, Fructus Perillae 124g, Cortex Mori 76g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerin 258g; Propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g; Micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerin and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 9g, Pericarpium Citri Reticulatae 63g, Cortex Magnoliae Officinalis 20g, Semen Lepidii (Semen Descurainiae) 58g, Fructus Perillae 154g, Cortex Mori 96g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerin 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Oleum Viticis Negundo 11g, Pericarpium Citri Reticulatae 90g, Cortex Magnoliae Officinalis 40g, Semen Lepidii (Semen Descurainiae) 40g, Fructus Perillae 99g, Cortex Mori 120g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerin 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Oleum Viticis Negundo is sprayed in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerin and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, processes suitable 10cm * 10cm, promptly gets.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Method for preparing: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, promptly gets in the venting bags of the 10cm * 10cm that processed by non-woven fabrics of packing into.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, promptly gets in the sealing bag of being processed by polyethylene film of packing at last.
Claims (6)
1. self-heating Chinese medicine patch unguentum of treating asthma; This self-heating Chinese medicine patch unguentum is made up of sealing bag and bag plaster that is bonded together up and down and self-heating bag within it; Wherein, said self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Said plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Said medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%; Wherein said effective ingredient is to be made up of the water extract that Oleum Viticis Negundo 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Pericarpium Citri Reticulatae 10%～35%; Cortex Magnoliae Officinalis 5%～25%; Semen Lepidii (Semen Descurainiae) 10%～30%, Fructus Perillae 10%～40%, Cortex Mori 10%～30%.
2. a kind of self-heating Chinese medicine patch unguentum of treating asthma according to claim 1; It is characterized in that; Described active ingredient is the water extract that is added following crude drug by the percentage by weight of crude drug by Oleum Viticis Negundo 2%: Pericarpium Citri Reticulatae 20%, Cortex Magnoliae Officinalis 10%, Semen Lepidii (Semen Descurainiae) 23%; Fructus Perillae 25%, Cortex Mori 20%.
3. a kind of self-heating Chinese medicine patch unguentum of treating asthma according to claim 1 and 2; It is characterized in that described water extract is prepared by following method: get Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Cortex Mori by proportioning, add 6-10 times of water gaging earlier; Decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrating twice, concentrate drying becomes extract powder to get final product.
4. a kind of self-heating Chinese medicine patch unguentum of treating asthma according to claim 1 and 2; It is characterized in that; Described substrate is made up of following raw materials by weight percent: sticker 6.1%-26.5%, wetting agent 20%-80%, filler 0.5%-1.5%; Cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerin and propylene glycol, perhaps is one or both the mixture in glycerin, propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or more in citric acid, sodium citrate and the aluminum chloride.
5. a kind of self-heating Chinese medicine patch unguentum of treating asthma according to claim 4 is characterized in that described medicine storing layer is prepared by following method: said effective ingredient is soluble in water, add described wetting agent mixing, and get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, abundant swelling, component one; To in component one, be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the said component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the described substrate of claim 4 in said component one, component two and the component three.
6. a kind of self-heating Chinese medicine patch unguentum of treating asthma according to claim 1 and 2; It is characterized in that the following raw materials by weight percent of described chemical exothermic material is formed: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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Citations (3)
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|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| WO2001001900A1 (en) * | 1999-07-06 | 2001-01-11 | University Of Utah Research Foundation | Method for manufacturing a heat generating apparatus |
| CN1833689A (en) * | 2006-01-12 | 2006-09-20 | 北京阜康仁生物制药科技有限公司 | Asthma stop preparation and novel prepn. |
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2011
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| WO2001001900A1 (en) * | 1999-07-06 | 2001-01-11 | University Of Utah Research Foundation | Method for manufacturing a heat generating apparatus |
| CN1833689A (en) * | 2006-01-12 | 2006-09-20 | 北京阜康仁生物制药科技有限公司 | Asthma stop preparation and novel prepn. |
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| Title |
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| 马红: "扶正益肺巴布膏的药学研究", 《北京中医药大学硕士研究生毕业论文》 * |
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