CN102370740B - Self-heating Chinese medicinal adhesive plaster for treating prostatitis - Google Patents
Self-heating Chinese medicinal adhesive plaster for treating prostatitis Download PDFInfo
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Abstract
The invention relates to a compound Chinese medicinal preparation, in particular to a self-heating Chinese medicinal adhesive plaster for treating prostatitis. The self-heating Chinese medicinal adhesive plaster consists of a sealing bag, and plaster and a self-heating bag which are wrapped in the sealing bag and are adhered vertically, wherein the self-heating bag consists of a permeable bag and a chemical heating material which is wrapped in the permeable bag for iron oxidation-reduction reaction; the plaster consists of a back lining layer, a medicament storage layer and an anti-adhesion layer; the self-heating Chinese medicinal adhesive plaster is characterized in that: the medicament storage layer consists of a pharmaceutically acceptable substrate and active ingredients of the raw material medicaments which are equivalently 40 percent of the weight of the substrate; the active ingredients consist of 1.5-3 percent of borneol and water extracts of the following raw material medicaments in weight percentage of the raw material medicaments: 10-30 percent of rhubarb, 10-30 percent of seed of cowherb, 20-40 percent of herba lycopi, 10-25 percent of peach kernel and 10-25 percent of root of three-nerved spicebush. The self-heating Chinese medicinal adhesive plaster has the advantages of quick response, good transdermal absorption and clear curative effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Prostate is maximum among a genital orgnas,male attached gonad.The prostatic fluid that it is secreted is the important component part of seminal fluid.Other internal organs of prostate and health are the same, also can be sick, and modal is chronic prostatitis.Clinical discovery, 25%～50% male suffered the puzzlement of this disease.At present, prostatitis can be divided into non-specific bacterial prostatitis, special prostatitis, congestion of prostate and the prostatodynia that property bacterial prostatitis, specific prostatitis (being caused by gonococcus, tulase, fungus, parasite etc.), nonspecific granulomatous prostatitis, other pathogen (as virus, mycoplasma, chlamydia etc.) cause, modern medicine does not also have the better prevention way to it.Yet motherland's medical science has remarkable advantages aspect the preventing and treating of chronic prostatitis.Because prostatitic incidence rate is very high, this just requires must be popular to its means of prevention and method, to satisfy numerous prostatitis crowd demand.Therefore, seek a kind of can bring into play tcm characteristic again the popular prostatitis method of preventing and treating be desirability.
Summary of the invention
Technical problem to be solved by this invention provides a kind of prostatitic self-heating Chinese medicine patch unguentum for the treatment of, and this emplastrum is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind ofly treat prostatitic self-heating Chinese medicine patch unguentum, this self-heating Chinese medicine patch unguentum is made up of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, and wherein said effective ingredient is to be made up of the water extract that Borneolum Syntheticum 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 10%-30%, Semen Vaccariae 10%-30%, Herba Lycopi 20%-40%, Semen Persicae 10%-25%, Radix Linderae 10%-25%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said active ingredient preferably are made up of the water extract that Borneolum Syntheticum 2% adds following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 20%, Semen Vaccariae 20%, Herba Lycopi 30%, Semen Persicae 15%, the Radix Linderae 13%.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said water extract can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get by proportioning and close Radix Et Rhizoma Rhei, Semen Vaccariae, Herba Lycopi, Semen Persicae, the Radix Linderae, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.Borneolum Syntheticum is added in the prepared extract powder, mix thoroughly, namely get described effective ingredient.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions first appendix I rules of preparations of Chinese Pharmacopoeia is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is made up of following raw materials by weight percent: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol (glycerol) and propylene glycol, perhaps is one or both the mixture in glycerol (glycerol), propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or three in citric acid, sodium citrate and the aluminum chloride.
Self-heating Chinese medicine patch unguentum of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling is transferred PH to 8, gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in described component one, component two and the component three.
Self-heating Chinese medicine patch unguentum of the present invention, wherein, described backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating Chinese medicine patch unguentum of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing sealed external package) of the self-heating bag that Qingdao ADO industry and trade company limited is produced is that the disclosed scheme of application for a patent for invention of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is made up of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%; Preferably formed by following raw material by weight percentage: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and desirable fever time is suitable with 7-11 hour.
Prostatitis can be included the category of motherland's medical science " smart turbid ", " stranguria caused by overstrain ", " excessive in vain " basically in.Its main diseases is because having: the scorchingly hot heresy of (1) diseases caused by exogenous pathogenic factor, and be reluctant to leave and do not go, or sexual behavior is unclean, damp and hot staying in smart chamber, essence is turbid to be obscured, smart in its position.(2) the phase hyperactivity of fire is contained, and is willing to or bears essence and do not let out that the kidney fire stagnation is and diffusing unsuccessful because of institute, and refining of offing normal is nebulousurine.(3) chamber is excessive, exhausting its essence, smart chamber inanition, damp and hot seizing the opportunity attacked into smart chamber, smart by force, can not Jing Zang.Active ingredient of the present invention is made up of Radix Et Rhizoma Rhei, Semen Vaccariae, Herba Lycopi, Semen Persicae, the Radix Linderae, Borneolum Syntheticum etc., and its monarch drug is Semen Persicae, Semen Vaccariae and the Radix Linderae, and it is smart to have the YIN nourishing benefit, blood circulation promoting and blood stasis dispelling, the detumescence of stimulating the menstrual flow, the capable water of soothing liver-QI, the merit of heat clearing and damp drying; Ministerial drug is Radix Et Rhizoma Rhei and Herba Lycopi, the energy clearing away heat and cooling blood; Messenger drug is Borneolum Syntheticum, and the energy waking up the patient from unconsciousness by clearing away heat has the merit of priming.The mutual reinforcement between of full side's Six-element, Xiang Zuo reach the prostatitic effect for the treatment of.
During use, the sealing bag of self-heating Chinese medicine patch unguentum of the present invention is taken apart, the person's that is pasted on the prostatitis abdominal part, oxidation reaction just takes place and generates heat in the chemical exothermic material chance oxygen of venting bags, heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate function, and then reach the prostatitic purpose for the treatment of.
In order to understand the present invention better, treat prostatitic clinical trial with self-heating Chinese medicine patch unguentum of the present invention below its effect is described.
Clinical experiment
One, physical data
All cases are the volunteer that prostatosis is arranged, male's 60 examples, age 40-76 year.Be divided into self-heating Chinese medicine patch unguentum group and blank group at random, every group of number is 30 examples.2 groups of data are learned processing by statistics, treat preceding two groups of patients' sex, age, symptom integral there are no significant difference (P＞0.05), have comparability.
Two. include standard in
Meet symptom yardstick scoring 〉=4 minutes in the chronic prostatitis diagnostic criteria " CP of NIH (NIH) symptom score " or EP-WBC 〉=10/HP, and do not accept any associated treatment person in nearly 2 weeks and can include this observation in.There is the infull person of serious liver, kidney disease and data all not include observation in.
Three, method
Self-heating Chinese medicine patch unguentum group: the self-heating Chinese medicine patch unguentum (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Blank group: not containing effective composition is that blank substrate subsides (specification is 10cm*10cm) are affixed on abdominal part, once a day, and each 6h, continuous 1 week.
Four, observation of curative effect
The clinical symptoms standards of grading: this canonical reference " the clinical research guideline of new Chinese medicine treatment chronic prostatitis (non-specific) " table 6.3 is formulated, it is following chronic prostatitis (non-specific) symptom scalar quantization table, by the symptom shown in the symptom hurdle in the table, be divided into nothing, light, neutralization weighs 4 grades, wherein, do not have meter 0 minute, gently counted 1 fen, fell into a trap restatement 3 minutes 2 fens.Evaluation time is respectively before the treatment beginning and after the treatment end.
Chronic prostatitis (non-specific) symptom scalar quantization table
Efficacy assessment standard: this canonical reference " the clinical research guideline of new Chinese medicine treatment chronic prostatitis (non-specific) " is formulated, produce effects reduces 〉=60% for the clinical symptoms integration, prostate tenderness and quality all have clear improvement, and EPS checks the continuous preceding minimizing 〉=60% for the treatment of of numeration of leukocyte more than 2 times; Effective is that the clinical symptoms integration reduces 〉=30%, and prostate tenderness and quality all have improvement, and EPs checks the continuous preceding minimizing 〉=30% for the treatment of of numeration of leukocyte more than 2 times; Invalidly is that the clinical symptoms integration reduces＜30% or no change, prostate tenderness and quality all do not have improvement, and EPS check continuous more than 2 times numeration of leukocyte reduce＜30% or no change before the treatment.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's clinical efficacies relatively adopt X
2Check.
Result of the test
The clinical symptoms integration relatively sees Table 1 before and after self-heating Chinese medicine patch unguentum group and the blank group.Curative effect relatively sees Table 2.As known from Table 2, self-heating Chinese medicine patch unguentum group: produce effects 18 examples, effective 6 examples, invalid 6 examples, total effective rate is 80%, blank group: produce effects 0 example, effective 6 examples, invalid 24 examples, total effective rate is 20%.Self-heating Chinese medicine patch unguentum group effect is organized apparently higher than blank.N in table 1～table 3 represents number.
(x ± s divides) compared in the clinical symptoms scoring before and after table 1 a liang group sticked
| Group | n | Before sticking | After sticking |
| Self-heating Chinese medicine patch unguentum group | 30 | 30.90±14.82 | 19.27±11.99ab |
| Blank group | 30 | 31.67±14.91 | 27.90±11.90 |
With stick preceding comparison: Pa＜0.05, with matched group relatively: Pb＜0.05
Table 2 liang group curative effect relatively
Table 3 self-heating Chinese medicine patch unguentum group and blank group cardinal symptom sign are improved relatively
Stick preceding comparison: Pa＜0.05 with this group, bathe the foot back relatively with the blank group: Pb＜0.05
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 80g, Semen Vaccariae 80g, Herba Lycopi 120g, Semen Persicae 60g, Radix Linderae 52g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: Radix Et Rhizoma Rhei, Semen Vaccariae, Herba Lycopi, Semen Persicae and the Radix Linderae are decocted with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve namely.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerol mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Radix Et Rhizoma Rhei 51g, Semen Vaccariae 68g, Herba Lycopi 119g, Semen Persicae 84g, Radix Linderae 72g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 11g, Radix Et Rhizoma Rhei 40g, Semen Vaccariae 57g, Herba Lycopi 115g, Semen Persicae 81g, Radix Linderae 96g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 12g, Radix Et Rhizoma Rhei 98g, Semen Vaccariae 40g, Herba Lycopi 98g, Semen Persicae 69g, Radix Linderae 83g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 10g, Radix Et Rhizoma Rhei 108g, Semen Vaccariae 90g, Herba Lycopi 80g, Semen Persicae 49g, Radix Linderae 63g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Carbomer, sodium carboxymethyl cellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 85g, Semen Vaccariae 101g, Herba Lycopi 119g, Semen Persicae 40g, Radix Linderae 47g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 7g, Radix Et Rhizoma Rhei 67g, Semen Vaccariae 83g, Herba Lycopi 132g, Semen Persicae 71g, Radix Linderae 40g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Polyvinyl alcohol, sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 7g, Radix Et Rhizoma Rhei 107g, Semen Vaccariae 89g, Herba Lycopi 107g, Semen Persicae 49g, Radix Linderae 41g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 6g, Radix Et Rhizoma Rhei 53g, Semen Vaccariae 106g, Herba Lycopi 124g, Semen Persicae 62g, Radix Linderae 49g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 8g, Radix Et Rhizoma Rhei 40g, Semen Vaccariae 56g, Herba Lycopi 150g, Semen Persicae 80g, Radix Linderae 66g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 9g, Radix Et Rhizoma Rhei 60g, Semen Vaccariae 46g, Herba Lycopi 100g, Semen Persicae 100g, Radix Linderae 85g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: Borneolum Syntheticum 11g, Radix Et Rhizoma Rhei 80g, Semen Vaccariae 60g, Herba Lycopi 94g, Semen Persicae 55g, Radix Linderae 100g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: Borneolum Syntheticum is added in the prepared water extract, and mixing gets the Chinese medical concrete powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, namely.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, it is even to add the sodium chloride solution remix, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into namely.
3, the preparation of self-heating Chinese medicine patch unguentum finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last namely.
Claims (4)
1. treat prostatitic self-heating Chinese medicine patch unguentum for one kind, this self-heating Chinese medicine patch unguentum is made up of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is made up of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is made up of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is made up of acceptable substrate pharmaceutically and the raw material the effective elements of the medicine that is equivalent to substrate weight 40%, and wherein said effective ingredient is to be made up of the water extract that Borneolum Syntheticum 1.5%-3% adds following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 10%-30%, Semen Vaccariae 10%-30%, Herba Lycopi 20%-40%, Semen Persicae 10%-25%, Radix Linderae 10%-25%.
2. a kind of prostatitic self-heating Chinese medicine patch unguentum for the treatment of according to claim 1, it is characterized in that described effective ingredient is to be made up of the water extract that Borneolum Syntheticum 2% adds following crude drug by the percentage by weight of crude drug: Radix Et Rhizoma Rhei 20%, Semen Vaccariae 20%, Herba Lycopi 30%, Semen Persicae 15%, the Radix Linderae 13%.
3. a kind of prostatitic self-heating Chinese medicine patch unguentum for the treatment of according to claim 1 and 2, it is characterized in that, described water extract is prepared by following method: get Radix Et Rhizoma Rhei, Semen Vaccariae, Herba Lycopi, Semen Persicae, the Radix Linderae by proportioning, add 6-10 times of water gaging earlier, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.
4. a kind of prostatitic self-heating Chinese medicine patch unguentum for the treatment of according to claim 1 and 2, it is characterized in that described chemical exothermic material is made up of following raw materials by weight percent: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110313324.7A CN102370740B (en) | 2011-10-16 | 2011-10-16 | Self-heating Chinese medicinal adhesive plaster for treating prostatitis |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110313324.7A CN102370740B (en) | 2011-10-16 | 2011-10-16 | Self-heating Chinese medicinal adhesive plaster for treating prostatitis |
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| Publication Number | Publication Date |
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| CN102370740A CN102370740A (en) | 2012-03-14 |
| CN102370740B true CN102370740B (en) | 2013-08-14 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102813571A (en) * | 2012-05-04 | 2012-12-12 | 王可剑 | Device for curing prostatosis by traditional Chinese medicine heat conduction |
| CN104107228A (en) * | 2014-08-01 | 2014-10-22 | 王国森 | External application traditional Chinese medicinal patch for treating prostate disease |
| CN108126080A (en) * | 2018-02-09 | 2018-06-08 | 贵州苗康医药科技有限公司 | A kind of prostate patch and preparation method thereof |
| CN112915072A (en) * | 2021-03-31 | 2021-06-08 | 重庆彭铿生物科技有限公司 | Plaster for hyperosteogeny |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1191294A (en) * | 1998-03-19 | 1998-08-26 | 李连生 | Heat-generating agent and its use |
| US6453648B1 (en) * | 1999-07-06 | 2002-09-24 | Zars, Inc. | Method for manufacturing a heat generating apparatus |
| CN1709295A (en) * | 2005-06-03 | 2005-12-21 | 贵阳云岩西创药物科技开发有限公司 | Medicinal formulation for treating prostatitis, and its preparing method and quality control method |
| CN101829259B (en) * | 2010-05-17 | 2011-10-05 | 广东养美医药投资有限公司 | Footbath effervescent tablet for improving prostatitis |
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