CN102366501B - Self-heated traditional Chinese medicine (TCM) emplastrum for improving sleep quality - Google Patents
Self-heated traditional Chinese medicine (TCM) emplastrum for improving sleep quality Download PDFInfo
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- CN102366501B CN102366501B CN 201110313259 CN201110313259A CN102366501B CN 102366501 B CN102366501 B CN 102366501B CN 201110313259 CN201110313259 CN 201110313259 CN 201110313259 A CN201110313259 A CN 201110313259A CN 102366501 B CN102366501 B CN 102366501B
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- Medicinal Preparation (AREA)
Abstract
The invention relates to a traditional Chinese medicine (TCM) compound preparation, in particular to a self-heated TCM emplastrum for improving sleep quality. The self-heated TCM emplastrum comprises a sealing bag, a plaster and a self-heated bag, wherein the plaster and the self-heated bag are wrapped in the sealing bag and are bonded together up and down; the self-heated bag comprises an air-permeable bag and chemical heating materials which are wrapped in the air-permeable bag and are used for iron oxidation-reduction reactions; and the plaster comprises a backing layer, a medicine storage layer and an anti-adhesion layer. The emplastrum is characterized in that the medicine storage layer comprises a pharmaceutically acceptable matrix and active ingredients of raw medicines; the active ingredients account for 40% of the matrix by weight and comprise 1.5-3% of rose balm and aqueous extracts of the following raw medicines according to the weight percent of the raw medicines: 20-50% of silktree albizzia bark, 20-50% of tuber fleeceflower stem, 10-30% of cinnamon, 5-20% of Chinese magnoliavine fruit and 5-20% of rhizoma acori graminei. The self-heated TCM emplastrum provided by the invention has the advantages of high effect taking speed, good percutaneous absorption and definite curative effect.
Description
Invention field
The present invention relates to medicinal preparation, be specifically related to a kind of compound Chinese medicinal preparation.
Technical background
Insomnia is often can not obtain ortho sleep as a kind of disease of feature, for a variety of causes causes that difficulty falling asleep, Depth of sleep or frequency too short (the shallow aypnia of sleeping), early awakening and the length of one's sleep are not enough or of poor quality etc., usually be called DIMS (D1MS), motherland's medical science is referred to as " being insomnia ", " insomnia ", " must not crouch ", " unable to close the eyes ".At present, not yet fully clear and definite for the mechanism of insomnia, modern medicine to it also without prevention and treatment method preferably.Yet, motherland's medical science the insomnia prevent and treat aspect have obvious advantage.Because the incidence rate of insomnia is very high, this just requires must be popular to its means of prevention and method, therefore, seek a kind of can bring into play tcm characteristic again the popular insomnia method of preventing and treating be desirability.
Because the factor of impact sleep is many and complicated, therefore the too many levels of developing for various factors, multi-level compound Chinese medicinal preparation is more common in the disclosed patent application of Patent Office of the People's Republic of China, wherein the Patent Application Publication of publication number CN 101837109A " a kind of foot-bath effervescent tablet that improves sleep ", the active ingredient of this foot-bath effervescent tablet is to be comprised of 5%～20% Rhizoma Chuanxiong power and the water extract of following crude drug by the percentage by weight of crude drug: Rhizoma Acori Graminei 10%～30%, Rhizoma Cyperi 5%～20%, Caulis Polygoni Multiflori 5%～20%, Radix Curcumae 5%～20%, Poria 8%～25%, Fructus Schisandrae Chinensis 5%～20%, Radix Bupleuri 4%～15%.Although the disclosed medicine of above-mentioned patent application has the adjusting function, but reach benefiting vital QI and blood, the logical brain network that relaxes, Yin Yang balancing improves the effects such as sleep, still, adopts the mode Transdermal absorption of foot bath, and obvious inapplicable foot has wound the wounded to use.
Summary of the invention
Technical problem to be solved by this invention provides a kind of Self-heating traditional Chinese medicine plaster that improves sleep, and this emplastrum is rapid-action, and Transdermal absorption is effective, determined curative effect.
The technical scheme that the present invention addresses the above problem is as described below:
A kind of Self-heating traditional Chinese medicine plaster that improves sleep, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is by the percentage by weight of the crude drug water extract by rose essence 1.5%-3% and following crude drug: Cortex Albiziae 20%～50%, Caulis Polygoni Multiflori 20%～50%, Cortex Cinnamomi 10%～30%, Fructus Schisandrae Chinensis 5%～20%, Rhizoma Acori Graminei 5%～20%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said active ingredient preferably forms by the percentage by weight of the crude drug water extract by rose essence 2% and following crude drug: Cortex Albiziae 30%, Caulis Polygoni Multiflori 30%, Cortex Cinnamomi 20%, Fructus Schisandrae Chinensis 10%, Rhizoma Acori Graminei 8%.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said water extract can adopt this area water extracting method commonly used to prepare, the method that the inventor recommends is as described below: get Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Schisandrae Chinensis, Cortex Cinnamomi, Rhizoma Acori Graminei by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered.Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.Rose essence is sprayed in the resulting extract powder, mixes thoroughly, namely get described effective ingredient.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said substrate can be the substrate of conventional patch, as, 2005 editions First appendix of Chinese Pharmacopoeia I rules of preparations is about the substrate of cataplasma described in the emplastrum, i.e. sodium polyacrylate, sodium carboxymethyl cellulose, gelatin, glycerol and micropowder silica gel etc.The substrate that the inventor recommends is comprised of the raw material of following percentage by weight: sticker 6.1%-26.5%, and wetting agent 20%-80%, filler 0.5%-1.5%, cross-linking agent 1.9%-6.5%, all the other are water; Wherein, described sticker be in gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, pressure sensitive adhesive and the carbomer more than three kinds or three kinds; Described wetting agent is glycerol (glycerol) and propylene glycol, perhaps is one or both the mixture in glycerol (glycerol), propylene glycol and Polyethylene Glycol and the butanediol; Described filler is one or more in Kaolin, zinc oxide and the micropowder silica gel; Described cross-linking agent is two or three in citric acid, sodium citrate and the aluminum chloride.
Self-heating traditional Chinese medicine plaster of the present invention, the desirable preparation method of wherein said medicine storing layer is: described effective ingredient is soluble in water, add described wetting agent mixing, get mixed liquor; Then, in the described sticker composition any is dissolved in 1/2 mixed liquor, fully swelling is transferred PH to 8, gets component one; To be dissolved in 1/6 mixed liquor by the 1-6 kind sticker composition the used sticker composition in component one, fully swelling gets component two; Described filler is dissolved in 1/6 mixed liquor, adds any sticker composition the used sticker composition in component one and component two, mixing gets component three; Described cross-linking agent is dissolved in 1/6 mixed liquor, and mixing gets component four; After adding component one mixing behind component two and component three mixings, get final product with component four mix homogeneously; Wherein,
When contained sticker composition is carbomer in the described component one, just adds triethanolamine, sodium bicarbonate or sodium hydrogen phosphate and transfer PH to 8;
Used sticker composition weight sum equals the content of sticker in the above-mentioned substrate in described component one, component two and the component three.
Self-heating traditional Chinese medicine plaster of the present invention, wherein, described backing layer is non-woven fabrics commonly used; Adherent layer (isolating membrane on mastic surface) is masking foil or cellophane commonly used; Described venting bags is made by non-woven fabrics; Described sealing bag is made by polyethylene film.
The said medicine bin-storing layer is coated on the backing layer, and drying is added a cover adherent layer and is namely got described plaster.
Self-heating traditional Chinese medicine plaster of the present invention, wherein said chemical exothermic material is a kind of common chance oxygen generation oxidation reaction and the reduced iron powder oxidation exothermic material that generates heat, usually formed by reduced iron powder, water and catalyst, as, the inner packing (namely removing the outer package of sealing) of the self-heating bag that Qingdao ADO industry and trade company limited is produced is that the disclosed scheme of application for a patent for invention of CN1172143A, CN1181482A, CN1191294A or CN1760310A is produced voluntarily by publication number perhaps.The chemical exothermic material that the inventor recommends is comprised of following raw material by weight percentage: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25%, Kaolin 5-30%; Preferably formed by by weight percentage following raw material: reduced iron powder 57%, active carbon 12.5%, 15% sodium chloride solution 10.5%, Kaolin 15%.The consumption of above-mentioned chemical exothermic material and proportioning can be adjusted according to needed heating temp and fever time, and suitable heating temp is advisable with 35-50 ℃, and desirable fever time is suitable with 7-11 hour.
Clinically, insomnia is sleeping to be difficult for, and it is rear easily awake to sleep, and can not sleep after waking up again, sometimes sleeping and sometimes waking, or be insomnia all night and be its syndrome characteristics, and often with lassitude in the daytime, bradykinesia, fatigue and asthenia, very then vexed annoyance has a strong impact on physical and mental health and work, studying and living.Ancient Chinese medicine doctor is thought the etiology and pathogenesis of insomnia take internal injury caused by excess of seven emotions as Etiological, and its internal organs that relate to are nothing more than the heart, spleen, liver, gallbladder, kidney, and its pathogenesis always belongs to battalion to be defended and becomes estranged, imbalance of YIN and YANG be disease, or the deficiency of YIN can not receive sun, or the excess of YANG must not enter the moon.
Active ingredient of the present invention is by Cortex Albiziae, Caulis Polygoni Multiflori, Cortex Cinnamomi, Fructus Schisandrae Chinensis, Rhizoma Acori Graminei and Oleum Rosae Rugosae are made, its monarch drug is Fructus Schisandrae Chinensis, Caulis Polygoni Multiflori, Cortex Albiziae, the merit of tool supplementing QI for promoting the production of body fluid, mind tranquilizing and the heart calming, cure mainly the cardiopalmus of feelings will due to disgruntled, fidgets due to deficiency insomnia, forgetful, stagnation of liver-QI is uncomfortable in chest; Ministerial drug is Cortex Cinnamomi, and auxiliary monarch drug promoting blood circulation to restore menstrual flow, to mend fire supporing yang; Adjuvant drug is Rhizoma Acori Graminei, Oleum Rosae Rugosae, cooperates monarch-minister drug mind tranquilizing and the heart calming, YIN nourishing and the production of body fluid promoting.Full side's Six-element compatibility, combined effect reaches benefiting vital QI and blood, relaxes and lead to brain network, Yin Yang balancing, improves sleep and waits effect.
During use, the sealing bag of Self-heating traditional Chinese medicine plaster of the present invention is taken apart, be pasted on insomniac's abdominal part, oxidation reaction just occurs and generates heat in the chemical exothermic material chance oxygen of venting bags, heat energy makes the unimpeded and quickening of skin blood circulation, further promotes the effective ingredient Transdermal absorption, the holographic echo area of effective stimulus whole body, regulate function, and then reach the purpose of improving sleep.
In order to understand better the present invention, the below illustrates its effect with the clinical trial that Self-heating traditional Chinese medicine plaster of the present invention improves sleep.
Clinical experiment
One, physical data
All cases are the volunteer that insomnia is arranged, male's 32 examples, age 66-76 year, the course of disease 1～15 year; Women's 28 examples, 67～74 years old age; The course of disease 1.5～12 years.Be divided at random Self-heating traditional Chinese medicine plaster group 30 examples (male 16 examples, women 14 examples); Blank group 30 examples (male 16 examples, women 14 examples).Treat front two groups of patients' sex, age, insomnia integration there are no significant difference (P＞0.05), have comparability.
Two, inclusive criteria
Classical symptom with insomnia continues more than one month, the person that meets the Standards of Chinese Medical Syndrome Differentiation.Namely there is the classical symptom of following insomnia " new Chinese medicine guideline of clinical investigations " (1993) that its traditional Chinese medical science diagnostic criteria is promulgated with reference to Ministry of Public Health: difficulty falling asleep, often awakening, sleep and unstable or wake up after can not sleep again; Wake up too early morning, and can not fall asleep night, and daytime is drowsy, does not have enough sleep 5 hours, and history of repeated attack is arranged.
Three, exclusion standard:
Get rid of systemic disease such as pain, heating, cough, operation etc., and external interference factor causer and psychotic and look into EKG, hepatic and renal function when being admitted to hospital, just blood, urine, conventional unusual person.
Four, method
The Self-heating traditional Chinese medicine plaster group: the Self-heating traditional Chinese medicine plaster (specification is 10cm*10cm) of embodiment one is affixed on abdominal part, once a day, each 6h, continuous 1 week.
Blank group: the blank substrate subsides (specification is 10cm*10cm) that do not contain active component are affixed on abdominal part, once a day, and each 6h, continuous 1 week.
Five, observation of curative effect
The symptom scores standard: the sleep quality index (PSQI) of this standard reference Pittsburgh is formulated, respectively at stick the beginning before and stick 1 the week after by through the training the professional, according to 9 problems in the following sleep quality index questionnaire, the sleep quality that each case is nearest 1 month is divided into sleep quality, time for falling asleep, Sleep efficiency, sleep disorder, hypnotic drug and 6 factors of daytime function obstacle and scores respectively, each factor is divided score by 0-3, total points scope 0～18 minute, total points is higher, and sleep quality is poorer.
Sleep quality index questionnaire
According to above-mentioned sleep quality index questionnaire, concrete scoring rule is as described below:
Sleep quality: sleep quality is divided into, better, relatively poor and very poor 4 grades, and wherein good do not wake up night for sleeping fast, and few dream was counted 0 minute; Preferably sleeping very fast, night, idol was waken up, and than dreaminess, counted 1 minute; Relatively poor more easily wake up or easier early awakening night for sleeping difficult, and dreaminess was counted 2 minutes; Very poor is difficulty falling asleep, easily wakes up night or easy early awakening, and many nightmares were counted 3 minutes.
Time for falling asleep:
Calculate first the score of the sleeping time that usually needs, sleeping time "≤15 minutes " meter that usually needs 0 minute, the sleeping time " 16-30 divides " that usually needs counted 1 minute, was " 31-60 " meter 2 minutes when the sleeping time that usually needs, time " 〉=60 minutes " meter that usually needs when falling asleep 3 minutes; Calculate again the score of the rear 30 minutes wakeful situations of going to bed, go to bed and counted 0 minute when wakeful situation was for " nothing " in rear 30 minutes, the rear 30 minutes wakeful situations of going to bed meter 1 minute during for "＜1 week/time ", the rear 30 minutes wakeful situations of going to bed meter 2 minutes during for " 1-2 week/time ", the rear 30 minutes wakeful situations of going to bed meter 3 minutes during for " 〉=3 week/time "; Then, the score of the sleeping time that usually needs is cumulative with the score of the rear 30 minutes wakeful situations of going to bed, if cumulative " 0 " meter 0 minute that is divided into, " 1-2 " meter 1 minute, " 3-4 " meter 2 minutes, " 5-6 " meter 3 minutes.
Sleep efficiency: deduct the time of going to bed with time of getting up first and obtain the upper time of bed, obtain Sleep efficiency percent with multiply by 100% divided by the time on the bed the actual length of one's sleep again, when gained Sleep efficiency percent, greater than 85% time meter 0 minute, meter is 1 minute when equaling 75-84%, meter was 2 minutes when equaling 65-74%, less than 65% time meter 3 minutes.
Sleep disorder: count first in the above-mentioned sleep quality index questionnaire the 5th and ask each score of asking of middle b to j, its scoring rule is, do not count 0 minute at previous month, and a week, on every Mondays to twice 2 minutes, time above meter was 3 minutes on every Wendesdays less than once counting 1 minute; Each score of asking is cumulative with b to j again, if, cumulative meter 0 minute when being divided into " 0 ", cumulative meter 1 minute when being divided into " 1-9 ", cumulative meter 2 minutes when being divided into " 10-18 ", cumulative " 19-27 " meter 3 minutes that are divided into.
Hypnotic drug: in previous month, do not take the situation meter 0 minute that hypnotic helps sleep; Arranged less than once taking the situation meter 1 minute that hypnotic helps sleep one week; Have on every Mondays to taking the situation meter 2 minutes that hypnotic helps sleep for twice; Take the situation meter 3 minutes that hypnotic helps sleep more than having on every Wendesdays time.
Daytime function obstacle: calculate first and feel sleepy situation score, namely, in previous month, drive, after meal or when being engaged in social activity, feel that sleepy situation do not count 0 minute, feel that sleepy one week of situation is less than once counting 1 minute, feel sleepy situation on every Mondays to twice 2 minutes, feel on every Wendesdays time above meter 3 minutes of sleepy situation; Calculate to do things again and feel the score of deficient in energy situation, that is, in previous month, do things and feel deficient in energy situation, do not count 0 minute, meter 1 minute is arranged once in a while, meter 2 minutes are arranged sometimes, meter 3 minutes are often arranged; Then, will feel that sleepy situation score adds up with the score of feeling deficient in energy situation of doing things, if cumulative being divided into, " 0 " meter 0 minute, " 1-2 " meter 1 minute, " 3-4 " meter 2 minutes, " 5-6 " counted 3 minutes.
Efficacy assessment standard: this standard reference " new Chinese medicine guideline of clinical investigations " is formulated, score value * 100% before clinical symptoms integrated value improvement rate=(symptom integral value after symptom integral value before the treatment-treatment)/treatment.
Efficacy assessment standard:
Produce effects: symptom integral value improvement rate 〉=70%;
Effectively: symptom integral value improvement rate 〉=50%;
Invalid: symptom has no obvious improvement or instead sees deterioration, symptom integral value improvement rate＜50%.
Statistical procedures: total data adopts SPSS 13.0 statistics softwares to carry out statistical analysis, measurement data mean ± standard deviation (x ± s) expression.Symptom score more all adopted the t check before and after two groups of experimenters treated, and two groups of experimenter's Clinical efficacy comparisons adopt X
2Check.
Result of the test
The clinical symptoms integral contrast sees Table 1 before and after Self-heating traditional Chinese medicine plaster group and the blank group, and curative effect relatively sees Table 2.As known from Table 2, Self-heating traditional Chinese medicine plaster: produce effects 18 examples, effective 9 examples, invalid 3 examples, total effective rate is 90%, blank group: produce effects 0 example, effective 9 examples, invalid 21 examples, total effective rate is 30%.The Self-heating traditional Chinese medicine plaster successful is higher than blank group.N in table 1～table 3 represents number.
Symptom scores compared (x ± s divides) before and after table 1 a liang group sticked
| Group | n | Before sticking | After sticking |
| The Self-heating traditional Chinese medicine plaster group | 30 | 13.90±5.81 | 8.38±4.48 ab |
| Blank group | 30 | 14.26±5.70 | 12.48±4.51 |
With stick front comparison: Pa＜0.05, with matched group relatively: Pb＜0.05
Table 2 liang group curative effect relatively
Table 3 Self-heating traditional Chinese medicine plaster group and blank group cardinal symptom sign are improved relatively
Stick front comparison: Pa＜0.05 with this group, stick rear comparison: Pb＜0.05 with the blank group
The specific embodiment
Embodiment one
1, the preparation of plaster:
Crude drug prescription: rose essence 8g, Cortex Albiziae 120g, Caulis Polygoni Multiflori 120g, Cortex Cinnamomi 80g, Fructus Schisandrae Chinensis 40g, Rhizoma Acori Graminei 32g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, polyvinyl alcohol 8g, pressure sensitive adhesive 88g, carbomer 24g, glycerol 250g, propylene glycol 250g, Kaolin 5g, zinc oxide 5g, citric acid 9g, sodium citrate 33g, water 285g.
The preparation of water extract: Cortex Albiziae, Caulis Polygoni Multiflori, Cortex Cinnamomi, Fructus Schisandrae Chinensis and Rhizoma Acori Graminei are decocted with water secondary, add for the first time 6 times of water gagings, add for the second time 6 times of water gagings, each 1.5 hours, merge the secondary decocting liquid, filter, filtrate is concentrated into the thick paste that relative density is 1.28-1.32 (60 ℃ of survey), 80 ℃ of dryings are ground into fine powder, sieve and get final product.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, and adding propylene glycol, glycerol mixing get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Gelatin, sodium carboxymethyl cellulose, polyvinyl alcohol are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid and sodium citrate are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment two
1, the preparation of plaster:
Crude drug prescription: rose essence 6g, Cortex Albiziae 88g, Caulis Polygoni Multiflori 111g, Cortex Cinnamomi 80g, Fructus Schisandrae Chinensis 63g, Rhizoma Acori Graminei 52g.
Matrix formulations: gelatin 37g, sodium carboxymethyl cellulose 14g, polyvinyl alcohol 10g, glycerol 307g, propylene glycol 306g, Polyethylene Glycol 50g, butanediol 50g, zinc oxide 6g, micropowder silica gel 6g, sodium citrate 29g, aluminum chloride 8g, water 177g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add propylene glycol, glycerol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose is dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add gelatin, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 537g, active carbon 146g, 15% sodium chloride solution 146g, Kaolin 171g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment three
1, the preparation of plaster:
Crude drug prescription: rose essence 10g, Cortex Albiziae 80g, Caulis Polygoni Multiflori 102g, Cortex Cinnamomi 74g, Fructus Schisandrae Chinensis 60g, Rhizoma Acori Graminei 74g.
Matrix formulations: gelatin 40g, sodium carboxymethyl cellulose 17g, methylcellulose 17g, sodium polyacrylate 11g, polyvinyl alcohol 11g, polyvinylpyrrolidone 11g, pressure sensitive adhesive 125g, carbomer 33g, glycerol 156g, propylene glycol 156g, micropowder silica gel 8g, citric acid 15g, sodium citrate 27g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Gelatin, sodium carboxymethyl cellulose, methylcellulose, sodium polyacrylate, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add carbomer, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 432g, active carbon 227g, 15% sodium chloride solution 182g, Kaolin 159g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment four
1, the preparation of plaster:
Crude drug prescription: rose essence 11g, Cortex Albiziae 152g, Caulis Polygoni Multiflori 80g, Cortex Cinnamomi 54g, Fructus Schisandrae Chinensis 45g, Rhizoma Acori Graminei 58g.
Matrix formulations: gelatin 32g, sodium carboxymethyl cellulose 13g, methylcellulose 12g, sodium polyacrylate 8g, pressure sensitive adhesive 91g, glycerol 266g, propylene glycol 267g, Polyethylene Glycol 44g, butanediol 44g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 4g, sodium citrate 10g, aluminum chloride 9g, water 190g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose, methylcellulose and sodium polyacrylate are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 602g, active carbon 172g, 15% sodium chloride solution 129g, Kaolin 97g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment five
1, the preparation of plaster:
Crude drug prescription: rose essence 8g, Cortex Albiziae 155g, Caulis Polygoni Multiflori 131g, Cortex Cinnamomi 40g, Fructus Schisandrae Chinensis 27g, Rhizoma Acori Graminei 39g.
Matrix formulations: gelatin 31g, sodium carboxymethyl cellulose 12g, pressure sensitive adhesive 86g, polyvinylpyrrolidone 8g, carbomer 23g, glycerol 256, propylene glycol 256, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, aluminum chloride 13g, citric acid 10g, water 214g,
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol, Polyethylene Glycol and butanediol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Carbomer, sodium carboxymethyl cellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin is dissolved in 1/6 above-mentioned mixed liquor, adds polyvinylpyrrolidone, mixing gets component three; Aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 422g, active carbon 133g, 15% sodium chloride solution 178g, Kaolin 267g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment six
1, the preparation of plaster:
Crude drug prescription: rose essence 7g, Cortex Albiziae 126g, Caulis Polygoni Multiflori 147g, Cortex Cinnamomi 74g, Fructus Schisandrae Chinensis 20g, Rhizoma Acori Graminei 26g.
Matrix formulations: gelatin 24g, sodium carboxymethyl cellulose 9g, methylcellulose 9g, pressure sensitive adhesive 68g, glycerol 246g, propylene glycol 246g, Polyethylene Glycol 42g, Kaolin 5g, zinc oxide 5g, micropowder silica gel 5g, sodium citrate 32g, aluminum chloride 11g, citric acid 11g, water 285g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol, propylene glycol and Polyethylene Glycol mixing and get mixed liquor; Gelatin is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin, zinc oxide and micropowder silica gel are dissolved in 1/6 above-mentioned mixed liquor, add pressure sensitive adhesive, mixing gets component three; Sodium citrate, aluminum chloride and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 589g, active carbon 85g, 15% sodium chloride solution 126g, Kaolin 200g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment seven
1, the preparation of plaster:
Crude drug prescription: rose essence 6g, Cortex Albiziae 106g, Caulis Polygoni Multiflori 128g, Cortex Cinnamomi 91g, Fructus Schisandrae Chinensis 49g, Rhizoma Acori Graminei 20g.
Matrix formulations: carbomer 27g, sodium carboxymethyl cellulose 14g, methylcellulose 13g, pressure sensitive adhesive 100g, polyvinyl alcohol 9g, glycerol 197g, propylene glycol 197g, micropowder silica gel 5g, citric acid 18g, sodium citrate 35g, aluminum chloride 12g, water 373g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with triethanolamine, gets component one; Polyvinyl alcohol, sodium carboxymethyl cellulose and methylcellulose are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel is dissolved in 1/6 above-mentioned mixed liquor, adds pressure sensitive adhesive, mixing gets component three; Citric acid, sodium citrate, aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 532g, active carbon 128g, 15% sodium chloride solution 85g, Kaolin 255g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment eight
1, the preparation of plaster:
Crude drug prescription: rose essence 6g, Cortex Albiziae 101g, Caulis Polygoni Multiflori 123g, Cortex Cinnamomi 87g, Fructus Schisandrae Chinensis 47g, Rhizoma Acori Graminei 36g.
Matrix formulations: sodium carboxymethyl cellulose 15g, methylcellulose 15g, sodium polyacrylate 10g, polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 108g, carbomer 30g, glycerol 224g, propylene glycol 224g, butanediol 38g, zinc oxide 6g, citric acid 16g, aluminum chloride 15g, water 279g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Sodium carboxymethyl cellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Methylcellulose, sodium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; The zinc oxide peptization in 1/6 above-mentioned mixed liquor, is added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 494g, active carbon 180g, 15% sodium chloride solution 224g, Kaolin 102g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment nine
1, the preparation of plaster:
Crude drug prescription: rose essence 6g, Cortex Albiziae 88g, Caulis Polygoni Multiflori 158g, Cortex Cinnamomi 80g, Fructus Schisandrae Chinensis 40g, Rhizoma Acori Graminei 28g.
Matrix formulations: polyvinyl alcohol 10g, polyvinylpyrrolidone 10g, pressure sensitive adhesive 109g, carbomer 30g, glycerol 255g, propylene glycol 255g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 5g, citric acid 11g, aluminum chloride 12g, water 212g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Polyvinyl alcohol is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Kaolin and zinc oxide peptization in 1/6 above-mentioned mixed liquor, are added carbomer, and mixing gets component three; Citric acid and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 444g, active carbon 162g, 15% sodium chloride solution 202g, Kaolin 192g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment ten
1, the preparation of plaster:
Crude drug prescription: rose essence 7g, Cortex Albiziae 80g, Caulis Polygoni Multiflori 100g, Cortex Cinnamomi 109g, Fructus Schisandrae Chinensis 59g, Rhizoma Acori Graminei 45g.
Matrix formulations: methylcellulose 16g, sodium polyacrylate 15g, pressure sensitive adhesive 110g, polyvinylpyrrolidone 10g, glycerol 258g, propylene glycol 258g, Polyethylene Glycol 43g, butanediol 43g, Kaolin 5g, zinc oxide 4g, micropowder silica gel 5g, sodium citrate 35g, aluminum chloride 15g, water 183g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add Polyethylene Glycol, butanediol, glycerol and propylene glycol mixing and get mixed liquor; Methylcellulose is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling gets component one; Sodium polyacrylate and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel, Kaolin and zinc oxide are dissolved in 1/6 above-mentioned mixed liquor, add polyvinylpyrrolidone, mixing gets component three; Sodium citrate and aluminum chloride are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 490g, active carbon 118g, 15% sodium chloride solution 157g, Kaolin 235g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 11
1, the preparation of plaster:
Crude drug prescription: rose essence 9g, Cortex Albiziae 109g, Caulis Polygoni Multiflori 80g, Cortex Cinnamomi 59g, Fructus Schisandrae Chinensis 79g, Rhizoma Acori Graminei 64g.
Matrix formulations: carbomer 31g, pressure sensitive adhesive 89g, methylcellulose 12g, sodium polyacrylate 8g, glycerol 257g, propylene glycol 257g, butanediol 43g, Kaolin 7g, micropowder silica gel 6g, citric acid 10g, sodium citrate 36g, water 244g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium hydrogen phosphate, gets component one; Methylcellulose and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Micropowder silica gel and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add sodium polyacrylate, mixing gets component three; Sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover masking foil, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 544g, active carbon 155g, 15% sodium chloride solution 116g, Kaolin 185g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Embodiment 12
1, the preparation of plaster:
Crude drug prescription: rose essence 11g, Cortex Albiziae 134g, Caulis Polygoni Multiflori 105g, Cortex Cinnamomi 40g, Fructus Schisandrae Chinensis 34g, Rhizoma Acori Graminei 76g.
Matrix formulations: methylcellulose 13g, polyvinylpyrrolidone 9g, pressure sensitive adhesive 97g, carbomer 27g, glycerol 207g, propylene glycol 207g, butanediol 35g, Kaolin 6g, zinc oxide 6g, citric acid 10g, sodium citrate 38g, aluminum chloride 10g, water 335g.
The preparation of water extract: identical with embodiment one.
The preparation of effective ingredient: rose essence is sprayed in the prepared water extract, and mixing gets traditional Chinese medicinal extract powder and gets final product.
The preparation plaster: prepared effective ingredient is soluble in water, add butanediol, glycerol and propylene glycol mixing and get mixed liquor; Carbomer is dissolved in 1/2 above-mentioned mixed liquor, and fully swelling is transferred PH to 8 with sodium bicarbonate, gets component one; Polyvinylpyrrolidone and pressure sensitive adhesive are dissolved in 1/6 above-mentioned mixed liquor, and fully swelling gets component two; Zinc oxide and Kaolin are dissolved in 1/6 above-mentioned mixed liquor, add methylcellulose, mixing gets component three; Aluminum chloride, sodium citrate and citric acid are dissolved in 1/6 above-mentioned mixed liquor, and mixing gets component four; With adding behind component two and component three mixings behind component one mixing and component four mix homogeneously, to coat on the non-woven fabrics, drying is added a cover cellophane, makes suitable 10cm * 10cm, and get final product.
2, self-heating bag preparation:
Raw material: reduced iron powder 500g, active carbon 200g, 15% sodium chloride solution 160g, Kaolin 140g.
Preparation method: with reduced iron powder, active carbon and Kaolin mix homogeneously, add sodium chloride solution and remix evenly, in the venting bags of the 10cm * 10cm that made by non-woven fabrics of packing into and get final product.
3, the preparation of Self-heating traditional Chinese medicine plaster finished product
The another side of the plaster backing layer that step 1 is made is bonded in the one side of the self-heating bag that step 2 makes with adhesive of medical, in the sealing bag of being made by polyethylene film of packing at last and get final product.
Claims (4)
1. Self-heating traditional Chinese medicine plaster that improves sleep, this Self-heating traditional Chinese medicine plaster is comprised of sealing bag and the bag plaster that is bonded together up and down and self-heating bag within it, wherein, described self-heating bag is comprised of the chemical exothermic material of venting bags and bag ferrum redox reaction within it; Described plaster is comprised of backing layer, medicine storing layer and adherent layer, it is characterized in that,
Described medicine storing layer is comprised of acceptable substrate pharmaceutically and the effective ingredient that is equivalent to the crude drug of substrate weight 40%, wherein said effective ingredient is by the percentage by weight of the crude drug water extract by rose essence 1.5%-3% and following crude drug: Cortex Albiziae 20%～50%, Caulis Polygoni Multiflori 20%～50%, Cortex Cinnamomi 10%～30%, Fructus Schisandrae Chinensis 5%～20%, Rhizoma Acori Graminei 5%～20%.
2. a kind of Self-heating traditional Chinese medicine plaster that improves sleep according to claim 1, it is characterized in that, described active ingredient is to form by the percentage by weight of the crude drug water extract by rose essence 2% and following crude drug: Cortex Albiziae 30%, Caulis Polygoni Multiflori 30%, Cortex Cinnamomi 20%, Fructus Schisandrae Chinensis 10%, Rhizoma Acori Graminei 8%.
3. a kind of Self-heating traditional Chinese medicine plaster that improves sleep according to claim 1 and 2, it is characterized in that, described water extract is prepared by following methods: get Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Schisandrae Chinensis, Cortex Cinnamomi, Rhizoma Acori Graminei by proportioning, add first 6-10 times of water gaging, decocted 1.5-3 hour, and filtered; Filtering residue adds 6-10 times of water gaging again, decocts 1.5-3 hour, filters; Merge filtrate twice, concentrate drying becomes extract powder to get final product.
4. a kind of Self-heating traditional Chinese medicine plaster that improves sleep according to claim 1 and 2, it is characterized in that the raw material of the following percentage by weight of described chemical exothermic material forms: reduced iron powder 40-70%, active carbon 5-25%, concentration are 15% sodium chloride solution 5-25% and Kaolin 5-30%.
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| CN104398703A (en) * | 2014-12-19 | 2015-03-11 | 青岛百瑞吉生物工程有限公司 | Traditional Chinese medicine preparation for treating insomnia as well as preparation method and application thereof |
| CN106890252A (en) * | 2017-04-13 | 2017-06-27 | 平阳微体日用品有限公司 | A kind of preparation method beneficial to sleeping warm patch |
| CN108703899B (en) * | 2018-08-31 | 2021-02-02 | 圣菲之美（湖北）生物科技有限公司 | Skin-care massage essential oil |
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