CN102161752A - 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 - Google Patents
肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 Download PDFInfo
- Publication number
- CN102161752A CN102161752A CN201110059090.8A CN201110059090A CN102161752A CN 102161752 A CN102161752 A CN 102161752A CN 201110059090 A CN201110059090 A CN 201110059090A CN 102161752 A CN102161752 A CN 102161752A
- Authority
- CN
- China
- Prior art keywords
- lactic acid
- creatinine
- reactor
- synthetic
- polylactic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims abstract description 64
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 229920000747 poly(lactic acid) Polymers 0.000 title claims abstract description 46
- 235000014655 lactic acid Nutrition 0.000 title claims abstract description 32
- 239000004310 lactic acid Substances 0.000 title claims abstract description 32
- 238000000034 method Methods 0.000 title claims abstract description 30
- 229940109239 creatinine Drugs 0.000 title claims abstract description 27
- 239000004626 polylactic acid Substances 0.000 title claims abstract description 20
- 238000006068 polycondensation reaction Methods 0.000 title claims abstract description 11
- 239000003054 catalyst Substances 0.000 title abstract description 11
- 230000002194 synthesizing effect Effects 0.000 title abstract description 8
- -1 guanidine compound Chemical class 0.000 claims abstract description 61
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000178 monomer Substances 0.000 claims abstract description 9
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 8
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000003814 drug Substances 0.000 claims abstract description 8
- 239000007864 aqueous solution Substances 0.000 claims abstract description 5
- 238000013270 controlled release Methods 0.000 claims abstract description 5
- 239000004475 Arginine Substances 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 238000009833 condensation Methods 0.000 claims abstract description 3
- 230000005494 condensation Effects 0.000 claims abstract description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 32
- 238000006243 chemical reaction Methods 0.000 claims description 30
- 229910052786 argon Inorganic materials 0.000 claims description 16
- 230000015572 biosynthetic process Effects 0.000 claims description 9
- 238000003786 synthesis reaction Methods 0.000 claims description 9
- 238000006297 dehydration reaction Methods 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 8
- 238000010792 warming Methods 0.000 claims description 8
- 238000006555 catalytic reaction Methods 0.000 claims description 6
- 238000003672 processing method Methods 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 4
- 230000004060 metabolic process Effects 0.000 claims description 4
- 238000012643 polycondensation polymerization Methods 0.000 claims description 4
- 239000002131 composite material Substances 0.000 claims description 2
- 230000006837 decompression Effects 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 239000002184 metal Substances 0.000 abstract description 9
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 239000002028 Biomass Substances 0.000 abstract description 5
- 238000006116 polymerization reaction Methods 0.000 abstract description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract description 2
- 238000009826 distribution Methods 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000000969 carrier Substances 0.000 abstract 1
- 230000007541 cellular toxicity Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000012974 tin catalyst Substances 0.000 abstract 1
- 231100000701 toxic element Toxicity 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 12
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 12
- 239000007787 solid Substances 0.000 description 12
- 239000000126 substance Substances 0.000 description 12
- 231100000252 nontoxic Toxicity 0.000 description 7
- 230000003000 nontoxic effect Effects 0.000 description 7
- 230000003292 diminished effect Effects 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 5
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 5
- 235000011150 stannous chloride Nutrition 0.000 description 5
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 5
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- KSBAEPSJVUENNK-UHFFFAOYSA-L tin(ii) 2-ethylhexanoate Chemical compound [Sn+2].CCCCC(CC)C([O-])=O.CCCCC(CC)C([O-])=O KSBAEPSJVUENNK-UHFFFAOYSA-L 0.000 description 3
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- 230000003592 biomimetic effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- HQAOHWHHJQFYHU-UHFFFAOYSA-N 1-pyren-1-ylbutan-1-ol Chemical class C1=C2C(C(O)CCC)=CC=C(C=C3)C2=C2C3=CC=CC2=C1 HQAOHWHHJQFYHU-UHFFFAOYSA-N 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Natural products P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000003519 biomedical and dental material Substances 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000006471 dimerization reaction Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- BPMFZUMJYQTVII-UHFFFAOYSA-N guanidinoacetic acid Chemical compound NC(=N)NCC(O)=O BPMFZUMJYQTVII-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 239000012434 nucleophilic reagent Substances 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/78—Preparation processes
- C08G63/82—Preparation processes characterised by the catalyst used
- C08G63/823—Preparation processes characterised by the catalyst used for the preparation of polylactones or polylactides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Polyesters Or Polycarbonates (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (3)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110059090.8A CN102161752B (zh) | 2011-03-14 | 2011-03-14 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
PCT/CN2011/081723 WO2012122807A1 (zh) | 2011-03-14 | 2011-11-03 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
JP2013504112A JP5458216B2 (ja) | 2011-03-14 | 2011-11-03 | クレアチニンを触媒とする乳酸からの重縮合による医療用生分解性ポリ乳酸の製造方法 |
US13/511,311 US8846853B2 (en) | 2011-03-14 | 2011-11-03 | Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110059090.8A CN102161752B (zh) | 2011-03-14 | 2011-03-14 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102161752A true CN102161752A (zh) | 2011-08-24 |
CN102161752B CN102161752B (zh) | 2013-02-27 |
Family
ID=44463233
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110059090.8A Active CN102161752B (zh) | 2011-03-14 | 2011-03-14 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8846853B2 (zh) |
JP (1) | JP5458216B2 (zh) |
CN (1) | CN102161752B (zh) |
WO (1) | WO2012122807A1 (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102504214A (zh) * | 2011-11-11 | 2012-06-20 | 南京大学 | 一种仿生有机胍盐催化合成聚乳酸-乙醇酸的工艺方法 |
CN102675607A (zh) * | 2012-05-22 | 2012-09-19 | 南京大学 | 乳酸自催化熔融缩聚—肌酐催化固相缩聚联用法合成高分子量聚乳酸 |
WO2012122807A1 (zh) * | 2011-03-14 | 2012-09-20 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
CN102702487A (zh) * | 2012-07-02 | 2012-10-03 | 南京大学 | 肌酐催化缩聚d-乳酸合成高生物安全性聚d-乳酸的工艺方法 |
CN102702535A (zh) * | 2012-07-02 | 2012-10-03 | 南京大学 | 肌酐催化合成聚乳酸—聚乙二醇嵌段共聚物的工艺方法 |
WO2013000226A1 (zh) * | 2011-06-30 | 2013-01-03 | 南京大学 | 仿生氯化肌酐胍合成及催化缩聚法合成高分子量聚乳酸 |
GB2496227A (en) * | 2011-11-03 | 2013-05-08 | Nanjing University | Process for synthesizing medical biodegradable polylactic acid by creatinine catalysed lactic acid condensation |
CN103193759A (zh) * | 2013-04-24 | 2013-07-10 | 南京大学 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
CN104119518A (zh) * | 2014-07-22 | 2014-10-29 | 南京大学 | 生物有机胍盐催化法合成聚(丁二酸丁二醇酯-共-己二酸丁二醇酯)的方法 |
WO2016090878A1 (zh) * | 2014-12-12 | 2016-06-16 | 南京大学 | 高性能高分子量聚l-乳酸合成工艺 |
CN113582965A (zh) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备高纯度丙交酯的方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104725616B (zh) * | 2015-04-13 | 2017-01-11 | 南京大学 | 有机胍催化熔融-固相缩聚合成聚(己二酸-共-对苯二甲酸丁二醇酯) |
CN104725615B (zh) * | 2015-04-13 | 2016-08-03 | 南京大学 | 生物有机胍催化法合成聚丁二酸丁二醇酯的工艺方法 |
CN112266469A (zh) * | 2020-10-30 | 2021-01-26 | 河南龙都天仁生物材料有限公司 | 一种超高分子量聚乳酸的合成工艺 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1556128A (zh) * | 2004-01-08 | 2004-12-22 | 南开大学 | 生物质有机胍化物催化合成医用生物降解材料的工艺方法 |
CN101367921A (zh) * | 2008-10-06 | 2009-02-18 | 中国人民解放军第二军医大学 | 一种丙交酯开环合成聚乳酸的方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH0678425B2 (ja) * | 1984-07-06 | 1994-10-05 | 和光純薬工業株式会社 | 重合体の新規製造法 |
JP3168263B2 (ja) * | 1984-07-06 | 2001-05-21 | 和光純薬工業株式会社 | 新規重合体及びこれを用いた医薬 |
EP2374895A4 (en) * | 2008-12-26 | 2013-03-06 | Toray Industries | PROCESS FOR THE PREPARATION OF MILKY ACID AND METHOD FOR THE PRODUCTION OF POLYMILIC ACID |
US8367796B2 (en) * | 2009-07-01 | 2013-02-05 | International Business Machines Corporation | Catalytic polymerization of polymers containing electrophilic linkages using nucleophilic reagents |
CN102161752B (zh) * | 2011-03-14 | 2013-02-27 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
-
2011
- 2011-03-14 CN CN201110059090.8A patent/CN102161752B/zh active Active
- 2011-11-03 JP JP2013504112A patent/JP5458216B2/ja not_active Expired - Fee Related
- 2011-11-03 WO PCT/CN2011/081723 patent/WO2012122807A1/zh active Application Filing
- 2011-11-03 US US13/511,311 patent/US8846853B2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1556128A (zh) * | 2004-01-08 | 2004-12-22 | 南开大学 | 生物质有机胍化物催化合成医用生物降解材料的工艺方法 |
CN101367921A (zh) * | 2008-10-06 | 2009-02-18 | 中国人民解放军第二军医大学 | 一种丙交酯开环合成聚乳酸的方法 |
Non-Patent Citations (2)
Title |
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《功能材料》 20041231 李弘 生物降解聚合物合成研究进展 第35卷, 2 * |
《高分子学报》 20080731 李弘张赛晖焦志峰等 肌酐乳酸胍催化L-丙交酯活性开环聚合反应研究 , 第7期 2 * |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012122807A1 (zh) * | 2011-03-14 | 2012-09-20 | 南京大学 | 肌酐催化乳酸缩聚合成医用生物降解性聚乳酸的工艺方法 |
WO2013000226A1 (zh) * | 2011-06-30 | 2013-01-03 | 南京大学 | 仿生氯化肌酐胍合成及催化缩聚法合成高分子量聚乳酸 |
US9062006B2 (en) | 2011-06-30 | 2015-06-23 | Nanjing University | High molecular weight polylactic acid synthesized via polycondensation catalyzed by bionic creatinine guanidinium chloride |
GB2496227B (en) * | 2011-11-03 | 2015-11-04 | Nanjing University | Polycondensation of lactic acid for medical biodegradable polylactic acid catalyzed by creatinine |
GB2496227A (en) * | 2011-11-03 | 2013-05-08 | Nanjing University | Process for synthesizing medical biodegradable polylactic acid by creatinine catalysed lactic acid condensation |
CN102504214B (zh) * | 2011-11-11 | 2013-12-11 | 南京大学 | 一种仿生有机胍盐催化合成聚乳酸-乙醇酸的工艺方法 |
CN102504214A (zh) * | 2011-11-11 | 2012-06-20 | 南京大学 | 一种仿生有机胍盐催化合成聚乳酸-乙醇酸的工艺方法 |
CN102675607A (zh) * | 2012-05-22 | 2012-09-19 | 南京大学 | 乳酸自催化熔融缩聚—肌酐催化固相缩聚联用法合成高分子量聚乳酸 |
CN102702535A (zh) * | 2012-07-02 | 2012-10-03 | 南京大学 | 肌酐催化合成聚乳酸—聚乙二醇嵌段共聚物的工艺方法 |
CN102702487A (zh) * | 2012-07-02 | 2012-10-03 | 南京大学 | 肌酐催化缩聚d-乳酸合成高生物安全性聚d-乳酸的工艺方法 |
CN103193759A (zh) * | 2013-04-24 | 2013-07-10 | 南京大学 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
WO2014173047A1 (zh) * | 2013-04-24 | 2014-10-30 | 南京大学 | 生物质有机胍催化法合成光学纯l-/d-丙交酯的工艺方法 |
US9630942B2 (en) | 2013-04-24 | 2017-04-25 | Nanjing University | Technological method for synthesis of optically pure L-/D-lactide catalyzed by biogenic guanidine |
CN104119518A (zh) * | 2014-07-22 | 2014-10-29 | 南京大学 | 生物有机胍盐催化法合成聚(丁二酸丁二醇酯-共-己二酸丁二醇酯)的方法 |
CN104119518B (zh) * | 2014-07-22 | 2016-01-20 | 南京大学 | 生物有机胍盐催化法合成聚(丁二酸丁二醇酯-共-己二酸丁二醇酯)的方法 |
WO2016090878A1 (zh) * | 2014-12-12 | 2016-06-16 | 南京大学 | 高性能高分子量聚l-乳酸合成工艺 |
CN113582965A (zh) * | 2021-08-23 | 2021-11-02 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备高纯度丙交酯的方法 |
CN113582965B (zh) * | 2021-08-23 | 2022-04-26 | 扬州惠通科技股份有限公司 | 一种基于有机胍配合物催化裂解制备丙交酯的方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2013515164A (ja) | 2013-05-02 |
US20130116400A1 (en) | 2013-05-09 |
JP5458216B2 (ja) | 2014-04-02 |
WO2012122807A1 (zh) | 2012-09-20 |
US8846853B2 (en) | 2014-09-30 |
CN102161752B (zh) | 2013-02-27 |
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