CN102008418B - Skin cleaning solution - Google Patents
Skin cleaning solution Download PDFInfo
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- CN102008418B CN102008418B CN2010105833846A CN201010583384A CN102008418B CN 102008418 B CN102008418 B CN 102008418B CN 2010105833846 A CN2010105833846 A CN 2010105833846A CN 201010583384 A CN201010583384 A CN 201010583384A CN 102008418 B CN102008418 B CN 102008418B
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Abstract
The invention discloses a skin cleaning solution. The skin cleaning solution is prepared by the following raw materials by mass percent: 5-20% of sodium laureth sulphate, 2-7% of glycerine, 2-7% of lauryl dimethyl benzyl amine bromide, 1-3% of sodium chloride, 2-7% of coconut diethanol amide and 0.2-0.4% of peppermint oil, and the balance of deionized water. The skin cleaning solution disclosed in the invention has pleasant smell after use, skin is fresh, cool and smooth after the skin cleaning solution is used, test result shows that the skin cleaning solution disclosed in the invention has strong bacteriostasis effect and has no skin acute absorption toxicity on injured and complete skins of rats; the skin cleaning solution is light and is easy to carry; and after the skin cleaning solution disclosed in the invention is used, systemic skin can be cleaned by only 250ml of water, thus water is saved. The skin cleaning solution disclosed in the invention can be applicable to skin cleaning of field operating personnel, officers and soldiers in special environment and seriously ill personnel in a hospital.
Description
Technical field
The present invention relates to a kind of clean skin liquid.
Background technology
Epidemic prevention team is the backbone of army epidemic prevention work, has very important effect to carrying out flat wartime hygienic epidemic prevention work.Wartime, march or operation under various unfavorable conditions, the chance that disease and popular infectious disease take place increases, thereby weakens combat effectiveness of the troops, even influences the enforcement of campaign, fight.Therefore, wartime hygienic epidemic prevention ensures and just seems even more important.The theoretical research that health and epidemic prevention ensures is all discussed from army's health support angle, inquires into from the angle of epidemic prevention seldom specially.We accomplish that People's Armed Police deals with contingencies and the research and the personnel reduction influence factor theoretical research basis in army's " non-war " uses of force of on sick and wounded pests occurrence rule of disaster assistance and characteristics on; Find that army's skin infection property disease is still the principal element that influences the officers and men of army fighting capacity; Characteristics are under the situation of rescue such as natural disasters such as earthquake, big flood, skin infection property disease account for 37% of total number of the infected.
Health ministry proposes very high requirement to the basic nursing quality in the various big hospital, in, to improve basic nursing among the severely injured patient person, for example require patient is wanted regular bathing, this is a basic nursing problem that operation easier is bigger.
In addition, field work or tourism, or outlying mountain area or arid area lack the water source, and bathing also becomes a great problem.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide a kind of and be easy to carry about with one, only need a spot of water just can clean whole skin, thereby reach the clean skin liquid of the effect of having a bath usually.
Technical scheme of the present invention is summarized as follows:
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 5%-20%, glycerin 2%-7%, dodecyl dimethyl benzyl amine bromide 2%-7%, sodium chloride 1%-3%, coconut oil diethanol amide 2%-7%, Oleum menthae 0.2%-0.4%, deionized water surplus.
Preferably said lauryl alcohol sodium sulfate is 10%; Said glycerin is 5%; Said dodecyl dimethyl benzyl amine bromide is 5%; Said sodium chloride is 2%; Said coconut oil diethanol amide is 5%, and said Oleum menthae is 0.3%.
Advantage of the present invention: clean skin liquid of the present invention is pleasant with the back abnormal smells from the patient, and salubrious, smooth with back skin, result of the test shows that clean skin liquid fungistatic effect of the present invention is stronger, and, intact skin damaged to rat all do not have the acute absorption toxicity of skin; , damaged skin complete and matched group to rat relatively, reluctantly visible erythema, but water breakthrough is swollen, the reaction scoring is 1, stimulus intensity＜2.99 belong to slightly and stimulating.Satisfy behind the 48h and gradually recover normal; Rat skin is not produced sensitization.Show that clean skin liquid of the present invention is used for prevention and treatment eczema, dermatitis, pruritus are comparison safety.
In addition, the present invention is light to be easy to carry about with one, and after using the clean skin liquid of the present invention, only needs the water (about half bottle of mineral water) of 250ml just can clean the skin of whole body, certainly with after also can need not water and wash, just can reach the effect of having a bath usually, using water wisely.Clean skin liquid of the present invention goes in field work personnel, the officers and men of army under special environment, the hospital, severely injured patient person's skin cleaning and nursing.
Description of drawings
Fig. 1 shows: for clean skin liquid compares with back different time skin removed percentage of bacteria.
Carried out the skin removed bacteria test relatively at clean skin liquid with back 10 minutes, 30 minutes, 1 hour, 2 hours respectively, the result shows that the degerming rate is respectively 35%, 45.31%, 87.63%, 89.56%.
Fig. 2 shows: for clean skin liquid compares with back different time preventing and treating skin diseases total effective rate.
The crowd that will try out is divided into three groups, is comparing with back 1 day, 3 days, 7 days, 15 day time preventing and treating skin diseases total effective rate respectively, and the result shows that one group is respectively 29.98%, 42.10%, 49.40%, 50.05%; Two groups are respectively 39.00%, 48.70%, 50.30%, 53.10%; Three groups are respectively 41.25%, 56.20%, 61.12%, 63.10%.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
Embodiment 1
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 10%, glycerin 5%, dodecyl dimethyl benzyl amine bromide 5%, sodium chloride 2%, coconut oil diethanol amide 5%, Oleum menthae 0.3%, essence is an amount of, add deionized water to 100%.
Embodiment 2
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 5%, glycerin 7%, dodecyl dimethyl benzyl amine bromide 5%, sodium chloride 1%, coconut oil diethanol amide 7%, Oleum menthae 0.2%, essence is an amount of, add deionized water to 100%.
Embodiment 3
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 10%, glycerin 2%, dodecyl dimethyl benzyl amine bromide 7%, sodium chloride 2%, coconut oil diethanol amide 2%, Oleum menthae 0.4%, essence is an amount of, add deionized water to 100%.
Embodiment 4
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 20%, glycerin 5%, dodecyl dimethyl benzyl amine bromide 2%, sodium chloride 3%, coconut oil diethanol amide 5%, Oleum menthae 0.2%, essence is an amount of, add deionized water to 100%.
Embodiment 5
A kind of clean skin liquid, process by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 15%, glycerin 5%, dodecyl dimethyl benzyl amine bromide 2%, sodium chloride 2%, coconut oil diethanol amide 4%, Oleum menthae 0.15%, essence is an amount of, add deionized water to 100%.
Embodiment 6
The method for preparing of clean skin liquid
After the raw material of each embodiment took by weighing in proportion, mix homogeneously was promptly processed clean skin liquid.
Clean skin liquid can vacuum comprise into bagged product, can also textile towel be soaked into it, under relative gnotobasis, uses packer to carry out vacuum packaging and gets final product.
Experimental example 1:
Clean skin liquid skin toxicology test
1. experiment material
1.1 experimental liquid
Clean skin liquid adopts the embodiment of the invention 1 feedstock production.Blank liquid: 75% (v/v) ethanol water.Positive sensitizer: 2,4 one dinitrochlorobenzene, use 75% alcoholic solution, be made into 1% sensitization concentration and 0.1% and excite concentration.
1.2SD rat
Body weight 200g～300g purchases in Jun Keyuan hygienic conditions institute animal housing, and animal adapts to 3～5 day time before the test in the experimental animal room environment, selects conventional feed for use, and drinking-water does not limit.
2. experimental technique and result
2.1 acute toxicity test
Get 50 of satisfactory healthy SD rats, 24h before test, with the depilation of spinal column both sides, back, area is 3.5cm
2, behind the depilation 24h, satisfactory rat is pressed body weight, sex random packet, 10 every group.One group is that blank group, all the other four groups are test group, is respectively intact skin high dose group, damaged skin high dose group, intact skin low dose group, damaged skin low dose group.The damaged skin group is drawn " # " space, the degree of being with the oozing of blood with the sterilization syringe needle.
Test the same day; With the clean skin liquid 4.0ml/ of embodiment 1 only, 1.0ml/ only, only each once is applied to the depilation district to 70% alcoholic solution 10ml/ the upper and lower respectively noon; With oilpaper, topped, the immobilization with adhesive tape of gauze, with warm water flush away residue, remove and to be tried behind the thing 1,24,48,72h to seven day behind the 24h; Observe and write down the variation of body weight, skin and hair, eye and the mucosa of animal every day, breathing, central nervous system, extremity activity etc. and other poisoning manifestations.If meet dead animal should in time perform an autopsy on sb with meat with observing, when the visible pathological changes of naked eyes. should carry out histopathologic examination.
The result: clean skin liquid does not all have the acute absorption toxicity of skin to damaged with completion skin.
2.2 skin irritation test
Get 10 of healthy rats, with its spinal column both sides, back depilation, area is 3.5cm
2, behind the depilation 24h.After observation 24h is non-stimulated, be the administration district with the left side, the clean skin liquid 1ml with the embodiment of the invention 1 evenly spreads upon the depilation district respectively, and the right side is the check plot.Smear with equivalent 70% alcoholic solution, topped with the two-layer gauze of one deck oilpaper, use immobilization with adhesive tape.Once a day, continuous seven days. behind the last administration 24h, tried thing, observe to remove and to be tried behind the thing 1,24,48,72h smears the position and have or not erythema, situation such as edema, and recovery situation and time with warm water cleaning.
Other gets 10 of healthy rats, and depilating method is the same, in taking off the district, draws " # " word with No. 16 sterilization syringe needles behind the depilation 24h, does not hinder corium to hinder epidermis, and slight oozing of blood is arranged, and observes 24h.With the left side is the administration district. the clean skin liquid 1ml with embodiment 1 is evenly coated in the damaged skin district respectively, and the right side is that smear with equivalent 70% alcoholic solution the check plot, and is topped with the two-layer gauze of one deck oilpaper, uses immobilization with adhesive tape.Once a day. continuous seven days, behind the last administration 24h, tried thing with warm water cleaning, observe to remove and to be tried behind the thing 1,24h, 48h, 72h smear the position and have or not erythema, situation such as edema, and recovery situation and time.Every healthy rat result is by " study of tcm new drug guide " skin irritation test reaction standards of grading scoring of Ministry of Public Health bureau of drug policy & administration issue. and calculate mean scores and carry out the stimulus intensity evaluation.Experimental result is seen table 1.
The average response value that the clean skin liquid stock solution of table 1 embodiment 1 stimulates rat skin
2.3 skin anaphylactic test
Get 30 of healthy rats, with its spinal column both sides, back depilation, every lateral area is 2.5cm
2, after observation 24h is non-stimulated, be divided into three groups at random by body weight, 10 every group.First group of clean skin liquid of giving embodiment 1 is given blank liquid for second group, gives positive sensitizer (2,4 one dinitrochlorobenzene group) for the 3rd group.
Sensitization contact: clean skin liquid stock solution 0.25ml evenly is applied to rats with left depilation district, continues 6h, the 7th day in kind repeats once with fortnight, and blank group and positive sensitization group operational approach are the same.
Excite sensitization: fortnight after the last administration is applied to depilation district, right side with clean skin liquid 0.25ml.Warm water cleaning is tried thing behind the 6h, observe at once, then in 24,48,72h observes the quick response situation of skin skin once more.Blank group and positive sensitization group (2,4 one dinitrochlorobenzene group) method is the same.
The result: after positive thing 2,4 one dinitrochlorobenzene groups, animal skin receive examination district self-excitation administration 6h, significantly slight erythema, no edema are arranged, the sensitization rate is 100%.Administration group (giving the clean skin liquid group of the embodiment of the invention 1) rat skin receives self-excitation administration 6～72h in examination district erythema not occur and edema forms, with blank group indifference.
The clean skin liquid of embodiment 2, embodiment 3 and embodiment 4 is carried out acute toxicity test, skin irritation test and skin anaphylactic test respectively, obtain the result similar with embodiment 1.
3. conclusion
Experimental result shows. the clean skin liquid of embodiment 1-embodiment 4 is damaged to rat, intact skin does not all have the acute absorption toxicity of skin; , damaged skin complete and matched group to rat relatively, reluctantly visible erythema, but water breakthrough is swollen, the reaction scoring is 1, stimulus intensity＜2.99 belong to slightly and stimulating.Satisfy behind the 48h and gradually recover normal; Rat skin is not produced sensitization.Show that clean skin liquid of the present invention is used for prevention and treatment eczema, dermatitis, pruritus are comparison safety.
Experimental example 2
Crowd's result of use of clean skin liquid is observed
1. object and method
1.1 military training and field training personnel (result of use of the healthy population of perspiring is in a large number observed)
Object: certain army defends 40 altogether of the diligent students who drills, 19.21 years old mean age, 22 of male, 18 of women to be trained for the participation of main soldier and late June.Test is not to all there being dermatosis.
Test method: object of study is all after perspiring largely; Operating procedure according to packing; Earlier carry out skin wiping with towel; Wipe away clean back and add clean water 100ml-500ml dilution back erasing whole body with one of the clean skin liquid of embodiments of the invention 1-embodiment 4 20ml, emphasis is used for jaw cervical region, oxter and groin place, and the wiping whole body just can effectively be removed the dirt on the skin and needn't wash by water.
Observational technique: use the back situation with the investigation of the form of questionnaire, skin situation easy to use, clean that index comprises, with back comfort, have or not excitement and conscious abnormal smells from the patient.
1.2 serious symptom sickbed patients
Object: select 120 of serious symptom sickbed patients at Chinese people armed police's hospital attached to a medical college, wherein the man is 81, and 39 of women comprise 45～50 years old 28,50～65 years old 52,40 of 65 years old and above patients.Be divided into 2 groups at random, every group of each 60 people.Experimental group is further divided into four groups, and each 15 people of every group use the clean skin liquid of the clean skin liquid wiping of embodiment 1-embodiment 4 respectively on the basis of routine care, and matched group only adopts routine care.
The test method for using: earlier with the cotton towel wiping skin that is soaked with clean skin liquid, emphasis wiping jaw cervical region, oxter, groin place and the decubital ulcer place is arranged, reuse skin-care towel or clear water wiping whole body.Require each wiping morning and afternoon every day once.The time of following up a case by regular visits to of experimental group and matched group is 1 month.
Sense organ investigation: the back situation is used in the form investigation with questionnaire, skin situation easy to use, clean that index comprises, with after comfort, have or not excitement and conscious abnormal smells from the patient.
2. result
2.1 sensory effects is observed
100% soldier thinks easy to use after using.
92.50% soldier uses aftersensation skin salubrious, smooth, and 7.50% sensation skin is salubrious and smoothness is general.
90.00% soldier uses the aftersensation abnormal smells from the patient pleasant, and 10.00% soldier uses the aftersensation abnormal smells from the patient general.
100% soldier uses aftersensation non-stimulated to skin.
100% soldier uses the back to investigate with 7 days the time in the 1st day, does not all have edema, erythema and the allergic phenomena at wiping position.
92.00% serious symptom sickbed patients uses aftersensation skin salubrious, smooth, and 8.00% sensation skin is salubrious and smoothness is general.
80.00% serious symptom sickbed patients uses the aftersensation abnormal smells from the patient pleasant, and 20.00% uses the aftersensation abnormal smells from the patient general.
90% serious symptom sickbed patients uses aftersensation non-stimulated to skin, and 10% serious symptom sickbed patients sensation has slight stimulation with the back to skin.
2.2 clinical observation
After following up a case by regular visits to 1 month, the skin infection incidence rate of experimental group (the difference not statistically significant between each group) serious symptom sickbed patients is lower than matched group, and difference has statistical significance (table 3).
Table 3 is the incidence rate (%) of serious symptom sickbed patients skin infection after January comparison on the same group not
Conclusion
Clean skin liquid of the present invention, its pH is similar with skin, and dirt-removing power is strong, and escherichia coli, staphylococcus aureus and Candida albicans etc. are all had stronger inhibition and killing action.To the skin nonirritant, have no side effect.Even have dermatosis and minor cut or wound also not to influence use.
Be specially adapted to the field work personnel, under special environment, routine army is in (disaster) big flood rescue action; Officers and men receive the restriction of environment and condition in rescue; Adding soaking into and polluting of rainwater and sewage, during unconditional bathing, the clean health of available military skin-cleaning liquid; It reaches the purpose of clean skin, thereby plays the dermopathic effect of prevention.
Can use at ordinary times; Winter xeroderma, personnel such as skin pruritus use; In, the serious symptom sickbed patients uses; Being fit to the water-deficient area personnel simultaneously uses.
Method for using:
These article are easy to use; Earlier carry out skin wiping with towel; Wipe away clean back with clean skin liquid 20ml (adding clean water 100ml-500ml) erasing whole body; Emphasis is used for jaw cervical region, oxter and groin place, its diluent wiping whole body just can effectively remove on the skin dirt and needn't water flushing, give skin smooth and pleasant sense after using these article.Be easy to carry simultaneously with its effect easily.
Claims (1)
1. clean skin liquid is characterized in that being processed by following raw material by mass percentage:
Lauryl alcohol sodium sulfate 10%, glycerin 5%, dodecyl dimethyl benzyl ammonium bromide 5%, sodium chloride 2%, coconut oil diethanol amide 5%, Oleum menthae 0.3%, deionized water surplus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105833846A CN102008418B (en) | 2010-12-10 | 2010-12-10 | Skin cleaning solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105833846A CN102008418B (en) | 2010-12-10 | 2010-12-10 | Skin cleaning solution |
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| Publication Number | Publication Date |
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| CN102008418A CN102008418A (en) | 2011-04-13 |
| CN102008418B true CN102008418B (en) | 2012-01-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105833846A Expired - Fee Related CN102008418B (en) | 2010-12-10 | 2010-12-10 | Skin cleaning solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106214554A (en) * | 2016-08-24 | 2016-12-14 | 秦艳红 | A kind of clean skin liquid |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096945A (en) * | 1993-06-30 | 1995-01-04 | 李谦德 | Natural cold-type yellow (clear) liquor for washing hair or skin manufacture method |
| CN1602840A (en) * | 2003-09-29 | 2005-04-06 | 浙江工业大学 | Shower lotion |
| CN101132834A (en) * | 2005-03-04 | 2008-02-27 | 宝洁公司 | Rinse-off or wipe-off skin cleansing compositions |
| CN101332160A (en) * | 2007-06-25 | 2008-12-31 | 陈丽妹 | Ice cool shower cream |
-
2010
- 2010-12-10 CN CN2010105833846A patent/CN102008418B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096945A (en) * | 1993-06-30 | 1995-01-04 | 李谦德 | Natural cold-type yellow (clear) liquor for washing hair or skin manufacture method |
| CN1602840A (en) * | 2003-09-29 | 2005-04-06 | 浙江工业大学 | Shower lotion |
| CN101132834A (en) * | 2005-03-04 | 2008-02-27 | 宝洁公司 | Rinse-off or wipe-off skin cleansing compositions |
| CN101332160A (en) * | 2007-06-25 | 2008-12-31 | 陈丽妹 | Ice cool shower cream |
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| CN102008418A (en) | 2011-04-13 |
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