CN102008419B - Skin-cleaning moisturizer - Google Patents
Skin-cleaning moisturizer Download PDFInfo
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- CN102008419B CN102008419B CN2010105838479A CN201010583847A CN102008419B CN 102008419 B CN102008419 B CN 102008419B CN 2010105838479 A CN2010105838479 A CN 2010105838479A CN 201010583847 A CN201010583847 A CN 201010583847A CN 102008419 B CN102008419 B CN 102008419B
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Abstract
The invention discloses a cleaning skin moisturizer which is prepared from the following raw materials in percentage by weight: 10-20% of glycerin, 1-3% of glycerin, 2-7% of cocoanut diethanol amide (CDEA), 10-30% of ethanol, 0.2-0.4% of peppermint oil, a proper amount of essence, and the balance deionized water. By using the cleaning skin moisturizer provided by the invention, the odour is pleasant, and the skin is refreshing and smooth. The test result proves that the cleaning skin moisturizer has stronger bacteriostatic efficacy, non skin acute absorption toxicity for damaged or complete skin of the rat; and the cleaning skin moisturizer is easy to take, is in no need of washing after being used, has good cleaning effect, and long cleaning effect time. The cleaning skin moisturizer canbe suitable for field operators, officers and men in militaries under special environments, and seriously injured personnel in hospitals.
Description
Technical field
The invention belongs to the bath article field, relate in particular to a kind of cleaning skin care liquid.
Background technology
Epidemic prevention team is the backbone of army epidemic prevention work, has very important effect to carrying out flat wartime hygienic epidemic prevention work.Wartime, march or operation under various unfavorable conditions, the chance that disease and popular infectious disease take place increases, thereby weakens combat effectiveness of the troops, even influences the enforcement of campaign, fight.Therefore, wartime hygienic epidemic prevention ensures and just seems even more important.The theoretical research that health and epidemic prevention ensures is all discussed from army's health support angle, inquires into from the angle of epidemic prevention seldom specially.We accomplish that People's Armed Police deals with contingencies and the research and the personnel reduction influence factor theoretical research basis in army's " non-war " uses of force of on sick and wounded pests occurrence rule of disaster assistance and characteristics on; Find that army's skin infection in wartime property disease is still the main pathogenic factors that influences the officers and men of army; Characteristics are under the situation of rescue such as natural disasters such as earthquake, big flood, the integumentary system disease account for 37% of total number of the infected.
Health ministry has proposed very high requirement to the basic nursing quality in the various big hospital, and centering, severely injured patient person will improve basic nursing, for example requires the regular bathing to patient, and this is a basic nursing problem that operation easier is bigger.
In addition, field work or tourism, or outlying mountain area or arid area lack the water source, and bathing also becomes a great problem.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art; Providing a kind of is easy to carry about with one; Can play the effect that skin protection is kept a public place clean, with after need not water flushing, be applicable to the cleaning skin care liquid that noneffectives's in field work personnel, the officers and men of army under special environment, the hospital skin is kept a public place clean and nursed.
Technical scheme of the present invention is summarized as follows:
A kind of cleaning skin care liquid, process by following raw material by mass percentage:
Glycerin 10%-20%, sodium chloride 1%-3%, coconut oil diethanol amide 2%-7%, ethanol 10%-30%, Oleum menthae 0.2%-0.4%, essence is an amount of, the deionized water surplus.
Preferably said glycerin is 15%, and sodium chloride is 2%, and coconut oil diethanol amide is 5%, and ethanol is 20%, and Oleum menthae is 0.3%.
Advantage of the present invention: cleaning skin care liquid of the present invention is pleasant with the back abnormal smells from the patient, and skin is salubrious, smooth, and result of the test shows that cleaning skin care liquid fungistatic effect of the present invention is stronger, and, intact skin damaged to rat all do not have the acute absorption toxicity of skin; , damaged skin complete and matched group to rat relatively, reluctantly visible erythema, but water breakthrough is swollen, the reaction scoring is 1, stimulus intensity＜2.99 belong to slightly and stimulating.Satisfy behind the 48h and gradually recover normal; Rat skin is not produced sensitization.Show that cleaning skin care liquid of the present invention is used for prevention and treatment eczema, dermatitis, pruritus are comparison safety.
In addition, the present invention is light to be easy to carry about with one, and after using the present invention to clear up skin care liquid, need not the water flushing, and skin is kept a public place clean effective, and the time is long.Cleaning skin care liquid of the present invention goes in field work personnel, the officers and men of army under special environment, the hospital, severely injured patient person's skin cleaning and nursing.
Description of drawings
Fig. 1 compares with back different time skin removed percentage of bacteria for the cleaning skin care liquid.
Carried out the skin removed bacteria test relatively at the cleaning skin care liquid that uses embodiment 1 with back 1 hour, 2 hours, 3 hours, 4 hours respectively, the result shows that the degerming rate is respectively 40.02%, 48.32%, 92.15%, 92.89%.
Fig. 2 compares with back different time preventing and treating skin diseases total effective rate for the cleaning skin care liquid.
The crowd that will try out is divided into three groups, respectively after with the cleaning skin care liquid of embodiment 11 day, 3 days, 7 days, 15 day time preventing and treating skin diseases total effective rate relatively, the result show one group be respectively 36.20%, 47.61%, 51.30%, 62.11.05%; Two groups are respectively 37.20%, 50.26%, 55.76%, 63.43%; Three groups are respectively 55.23%, 75.69%, 81.02%, 81.59%.
The specific embodiment
Below in conjunction with specific embodiment the present invention is further described.
A kind of cleaning skin care liquid, process by following raw material by mass percentage:
Glycerin 15%, sodium chloride 2%, coconut oil diethanol amide 5%, ethanol 20%, Oleum menthae 0.3%, essence is an amount of, adds deionized water to 100%.
A kind of cleaning skin care liquid, process by following raw material by mass percentage:
Glycerin 10%, sodium chloride 2%, coconut oil diethanol amide 7%, ethanol 10%, Oleum menthae 0.3%, essence is an amount of, adds deionized water to 100%.
A kind of cleaning skin care liquid, process by following raw material by mass percentage:
Glycerin 20%, sodium chloride 3%, coconut oil diethanol amide 2%, ethanol 20%, Oleum menthae 0.4%, essence is an amount of, adds deionized water to 100%.
Glycerin 15%, sodium chloride 1%, coconut oil diethanol amide 5%, ethanol 30%, Oleum menthae 0.2%, essence is an amount of, adds deionized water to 100%.
Embodiment 5
A kind of method for preparing of clearing up skin care liquid
After the raw material of each embodiment took by weighing in proportion, mix homogeneously was promptly processed a kind of cleaning skin care liquid.
A kind of cleaning skin care liquid can vacuum comprise into bagged product, can also textile towel be soaked into it, under relative gnotobasis, uses packer to carry out vacuum packaging and gets final product.
Experimental example 1:
Cleaning skin care liquid skin toxicology test
1. experiment material
1.1 experimental liquid
The cleaning skin care liquid adopts the embodiment of the invention 1 feedstock production.Blank liquid: 75% (v/v) ethanol water.Positive sensitizer: 2,4 one dinitrochlorobenzene, use 75% alcoholic solution, be made into 1% sensitization concentration and 0.1% and excite concentration.
1.2SD rat
Body weight 200g～300g purchases in Jun Keyuan hygienic conditions institute animal housing, and animal adapts to 3～5 day time before the test in the experimental animal room environment, selects conventional feed for use, and drinking-water does not limit.
2. experimental technique and result
2.1 acute toxicity test
Get 50 of satisfactory healthy SD rats, 24h before test, with the depilation of spinal column both sides, back, area is 3.5cm
2, behind the depilation 24h, satisfactory rat is pressed body weight, sex random packet, 10 every group.One group is that blank group, all the other four groups are test group, is respectively intact skin high dose group, damaged skin high dose group, intact skin low dose group, damaged skin low dose group.The damaged skin group is drawn " # " space, the degree of being with the oozing of blood with the sterilization syringe needle.
Test the same day; With the cleaning skin care liquid 4.0ml/ of embodiment 1 only, 1.0ml/ only, only each once is applied to the depilation district to 70% alcoholic solution 10ml/ the upper and lower respectively noon; With oilpaper, topped, the immobilization with adhesive tape of gauze, with warm water flush away residue, remove and to be tried behind the thing 1,24,48,72h to seven day behind the 24h; Observe and write down the variation of body weight, skin and hair, eye and the mucosa of animal every day, breathing, central nervous system, extremity activity etc. and other poisoning manifestations.If meet dead animal should in time perform an autopsy on sb with meat with observing, when the visible pathological changes of naked eyes. should carry out histopathologic examination.
The result: the cleaning skin care liquid does not all have the acute absorption toxicity of skin to damaged with completion skin.
2.2 skin irritation test
Get 10 of healthy rats, with its spinal column both sides, back depilation, area is 3.5cm
2, behind the depilation 24h.After observation 24h is non-stimulated, be the administration district, respectively the present invention cleared up skin care liquid liquid 1ml and evenly spread upon the depilation district that the right side is the check plot with the left side.Smear with equivalent 70% alcoholic solution, topped with the two-layer gauze of one deck oilpaper, use immobilization with adhesive tape.Once a day, continuous seven days. behind the last administration 24h, tried thing, observe to remove and to be tried behind the thing 1,24,48,72h smears the position and have or not erythema, situation such as edema, and recovery situation and time with warm water cleaning.
Other gets 10 of healthy rats, and depilating method is the same, in taking off the district, draws " # " word with No. 16 sterilization syringe needles behind the depilation 24h, does not hinder corium to hinder epidermis, and slight oozing of blood is arranged, and observes 24h.With the left side is the administration district. will clear up skin care liquid 1ml respectively and be evenly coated in the damaged skin district, the right side is that smear with equivalent 70% alcoholic solution the check plot, and is topped with the two-layer gauze of one deck oilpaper, uses immobilization with adhesive tape.Once a day, continuous seven days, behind the last administration 24h, tried thing with warm water cleaning, observe to remove and to be tried behind the thing 1,24h, 48h, 72h smear the position and have or not erythema, situation such as edema, and recovery situation and time.Every healthy rat result presses " study of tcm new drug guide " skin irritation test reaction standards of grading scoring of Ministry of Public Health bureau of drug policy & administration issue, and calculates mean scores and carry out the stimulus intensity evaluation.Experimental result is seen table 1.
The average response value that table 1 cleaning skin care liquid stimulates rat skin
2.3 skin anaphylactic test
Get 30 of healthy rats, with its spinal column both sides, back depilation, every lateral area is 2.5cm
2, after observation 24h is non-stimulated, be divided into three groups at random by body weight, 10 every group.Give embodiment 1 cleaning skin care liquid for first group, give blank liquid for second group, give positive sensitizer (2,4 one dinitrochlorobenzene group) for the 3rd group.
Sensitization contact: will clear up skin care liquid 0.25ml and evenly be applied to rats with left depilation district, and continue 6h, the 7th day in kind repeats once with fortnight, and blank group and positive sensitization group operational approach are the same.
Excite sensitization: fortnight after the last administration, will clear up skin care liquid 0.25ml and be applied to depilation district, right side.Warm water cleaning is tried thing behind the 6h, observe at once, then in 24,48,72h observes the quick response situation of skin skin once more.Blank group and positive sensitization group (2,4 one dinitrochlorobenzene group) method is the same.
The result: after positive thing 2,4 one dinitrochlorobenzene groups, animal skin receive examination district self-excitation administration 6h, significantly slight erythema, no edema are arranged, the sensitization rate is 100%.Rat skin receives self-excitation administration 6～72h in examination district erythema not occur and edema forms for administration group (giving embodiments of the invention 1 cleaning skin care liquid group), with blank group indifference.
The cleaning skin care liquid of embodiment 2, embodiment 3 and embodiment 4 is carried out acute toxicity test, skin irritation test and skin anaphylactic test respectively, obtain the result similar with embodiment 1.
3. conclusion
Experimental result shows. the cleaning skin care liquid is damaged to rat, intact skin does not all have the acute absorption toxicity of skin; , damaged skin complete and matched group to rat relatively, reluctantly visible erythema, but water breakthrough is swollen, the reaction scoring is 1, stimulus intensity＜2.99 belong to slightly and stimulating.Satisfy behind the 48h and gradually recover normal; Rat skin is not produced sensitization.Show that military cleaning skin care liquid is used for prevention and treatment eczema, dermatitis, pruritus are comparison safety.
Experimental example 2
Crowd's result of use of cleaning skin care liquid is observed
1. object and method
1.1 military training and field training personnel (result of use of the healthy population of perspiring is in a large number observed)
Object: certain army defends 40 altogether of the diligent students who drills, 19.56 years old mean age, 27 of male, 13 of women to be trained for the participation of main soldier and late June.All there is not dermatosis.
Test method: object of study is all after perspiring largely; Operating procedure according to packing; Earlier carry out skin wiping with towel; Wipe away clean back and add clean water 100ml-500ml erasing whole body with one of the cleaning skin care liquid of embodiments of the invention 1-embodiment 4 20ml, emphasis is used for jaw cervical region, oxter and groin place, and the wiping whole body just can effectively be removed the dirt on the skin and needn't wash by water.
1.2 serious symptom sickbed patients
Object: select 100 of serious symptom sickbed patients at Chinese people armed police's hospital attached to a medical college, wherein the man is 56, and 44 of women comprise 45～50 years old 20,50～65 years old 36,44 of 65 years old and above patients.Be divided into 2 groups at random, every group of each 50 people.Experimental group uses embodiment 1 cleaning skin care liquid wiping on the basis of routine care, matched group only adopts routine care.
Method for using: earlier with the cotton towel wiping skin that is soaked with the cleaning skin care liquid, emphasis wiping jaw cervical region, oxter, groin place, reuse skin-care towel or clear water wiping whole body.Require each wiping morning and afternoon every day once.The time of following up a case by regular visits to is 1 month.
Sense organ investigation: the back situation is used in the form investigation with questionnaire, skin situation easy to use, clean that index comprises, with after comfort, have or not excitement and conscious abnormal smells from the patient.
2. result
2.1 effect observation
100% soldier thinks easy to use after using.
90.00% soldier uses aftersensation skin salubrious, smooth, and 10.00% sensation skin is salubrious and smoothness is general.
95.00% soldier uses the aftersensation abnormal smells from the patient pleasant, and 5.00% soldier uses the aftersensation abnormal smells from the patient general.
100% soldier uses aftersensation non-stimulated to skin.
100% soldier uses the back to investigate with 7 days the time in the 1st day, does not all have edema, erythema and the allergic phenomena at wiping position.
92.00% serious symptom sickbed patients uses aftersensation skin salubrious, smooth, and 8.00% sensation skin is salubrious and smoothness is general.
90.00% serious symptom sickbed patients uses the aftersensation abnormal smells from the patient pleasant, and 10.00% uses the aftersensation abnormal smells from the patient general.
98% serious symptom sickbed patients uses aftersensation non-stimulated to skin, and 2% serious symptom sickbed patients sensation has slight stimulation with the back to skin.
2.2 clinical observation
After following up a case by regular visits to 1 month, the skin infection incidence rate of experimental group serious symptom sickbed patients is lower than matched group, and difference has statistical significance (table 3).
Table 3 is the incidence rate (%) of serious symptom sickbed patients skin infection after January comparison on the same group not
Conclusion
Cleaning skin care liquid of the present invention, its pH is similar with skin, and dirt-removing power is strong, and escherichia coli, staphylococcus aureus and Candida albicans etc. are all had stronger inhibition and killing action.To the skin nonirritant, have no side effect.Even have dermatosis and minor cut or wound also not to influence use.Adapt to and be used for the field work personnel; Winter xeroderma, personnel such as skin pruritus use; In, the serious symptom sickbed patients uses.Cleaning skin care liquid of the present invention goes in field work personnel, the officers and men of army under special environment, the hospital, severely injured patient person's skin cleaning and nursing, and military affairs and social benefit are obvious.
Claims (2)
1. clear up skin care liquid for one kind, it is characterized in that processing by following raw material by mass percentage:
Glycerin 10%-20%, sodium chloride 1%-3%, coconut oil diethanol amide 2%-7%, ethanol 10%-30%, Oleum menthae 0.2%-0.4%, essence is an amount of, the deionized water surplus.
2. a kind of cleaning skin care liquid according to claim 1 is characterized in that said glycerin is 15%, and sodium chloride is 2%, and coconut oil diethanol amide is 5%, and ethanol is 20%, and Oleum menthae is 0.3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105838479A CN102008419B (en) | 2010-12-10 | 2010-12-10 | Skin-cleaning moisturizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105838479A CN102008419B (en) | 2010-12-10 | 2010-12-10 | Skin-cleaning moisturizer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102008419A CN102008419A (en) | 2011-04-13 |
| CN102008419B true CN102008419B (en) | 2012-05-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105838479A Expired - Fee Related CN102008419B (en) | 2010-12-10 | 2010-12-10 | Skin-cleaning moisturizer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1096945A (en) * | 1993-06-30 | 1995-01-04 | 李谦德 | Natural cold-type yellow (clear) liquor for washing hair or skin manufacture method |
| CZ20012617A3 (en) * | 1999-01-20 | 2002-07-17 | The Procter & Gamble Company | Detergent composition for hand washing of dishes |
| BR0012289A (en) * | 1999-05-26 | 2002-03-26 | Procter & Gamble | Detergent compositions comprising polymeric enhancers of foam volume and duration of foams and methods of washing with foams |
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