CN102008421A - Skin refreshing agent - Google Patents
Skin refreshing agent Download PDFInfo
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- CN102008421A CN102008421A CN 201010585205 CN201010585205A CN102008421A CN 102008421 A CN102008421 A CN 102008421A CN 201010585205 CN201010585205 CN 201010585205 CN 201010585205 A CN201010585205 A CN 201010585205A CN 102008421 A CN102008421 A CN 102008421A
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Abstract
The invention discloses a skin refreshing agent, which is prepared from the following raw materials in percentage by mass: 1 to 4 percent of menthol, 30 to 50 percent of dichlorodifluoromethane, 20 to 60 percent of dichlorotetrafluoroethylene, 0.2 to 0.5 percent of peppermint oil, a proper amount of essence and the balance of deionized water. The skin refreshing agent is comfortable in smell, refreshes skin and has the effect of refreshing and restoring consciousness. The skin refreshing agent is portable, local or whole skin can be coated with only 20ml of the skin refreshing agent, the skin is not needed to be washed with water after the skin refreshing agent is used, and the effect of normally refreshing the skin can be achieved.
Description
Technical field
The present invention relates to the salubrious agent of a kind of skin.
Background technology
Army in training when the field training or at disaster assistance, officers and men and be subjected to the pollution of perspiration, and the discomfort of dedicate one's life to body skin, the salubrious agent of skin that we send out name has solved this problem, and has carried out pre-on probation in the part officers and men.Effect shows: certain army defends 50 altogether of the diligent students who drills, 19.56 years old mean age, 37 of male, 13 of women to be trained for the participation of main soldier and late June.Test is not to all there being dermatosis.Test method: object of study is all after perspiring largely, operating procedure according to packing, earlier carry out skin wiping with towel, wipe away clean back and add clean water 100ml-500ml erasing whole body with the salubrious agent of concentrated skin, emphasis is used for jaw cervical region, oxter and groin place, the salubrious agent wiping of reuse skin whole body.Observational technique: use the back situation with the investigation of the form of questionnaire, skin situation easy to use, clean that index comprises, with back comfort, have or not excitement and conscious abnormal smells from the patient.
Therefore, the salubrious agent of military skin be a be suitable for army training and field work personnel use the salubrious product of skin, in the time of can be to army's operation at high temperature and the skin desuperheat under the special environment reach the effect of affixing one's name in the prevention.
Summary of the invention
The objective of the invention is to overcome deficiency of the prior art, provide a kind of skin salubrious agent.
Technical scheme of the present invention is summarized as follows:
The salubrious agent of a kind of skin, make by following raw material by mass percentage:
Menthol 1%-4%, dichlorodifluoromethane 30%-50%, dichloro-tetrafluoro ethylene 20%-60%, Oleum menthae 0.2%-0.5%, essence is an amount of, the deionized water surplus.
Preferably described menthol is 2%, and dichlorodifluoromethane is 40%, and dichloro-tetrafluoro ethylene is 49.5%, and Oleum menthae is 0.3%.
Advantage of the present invention: the salubrious agent of skin of the present invention is pleasant with the back abnormal smells from the patient, and skin is very salubrious, have refresh oneself, the effect of refreshment.
In addition, the present invention is light to be easy to carry about with one, and after using the salubrious agent of skin of the present invention, only needs the 20ml just can wiping part or whole skin, certainly with after also can need not water and wash, just can reach the salubrious effect of usual skin.
Description of drawings
Fig. 1 for the salubrious agent of skin with back different time skin feel nice and cool, refresh oneself, the comparison of refreshment effect percentage ratio.
Carried out the skin removed bacteria test relatively in 10 minutes, 30 minutes, 1 hour, 2 hours respectively after using the salubrious agent of embodiment 1 skin, the result shows that the degerming rate is respectively 35.00%, 45.31%, 87.63%, 89.56%.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
The salubrious agent of a kind of skin, make by following raw material by mass percentage:
Menthol 2%, dichlorodifluoromethane 40%, dichloro-tetrafluoro ethylene 49.5%, Oleum menthae 0.3%, essence is an amount of, adds deionization to 100%.
Embodiment 2
The salubrious agent of a kind of skin, make by following raw material by mass percentage:
Menthol 1%, dichlorodifluoromethane 30%, dichloro-tetrafluoro ethylene 60%, Oleum menthae 0.2%, essence is an amount of, adds deionization to 100%.
Embodiment 3
The salubrious agent of a kind of skin, make by following raw material by mass percentage:
Menthol 2%, dichlorodifluoromethane 50%, dichloro-tetrafluoro ethylene 20%, Oleum menthae 0.3%, essence is an amount of, adds deionization to 100%.
Embodiment 4
The salubrious agent of a kind of skin, make by following raw material by mass percentage:
Menthol 4%, dichlorodifluoromethane 40%, dichloro-tetrafluoro ethylene 40%, Oleum menthae 0.5%, essence is an amount of, adds deionization to 100%.
Embodiment 5
The preparation method of the salubrious agent of a kind of skin
After the raw material of each embodiment took by weighing in proportion, mix homogeneously was promptly made the salubrious agent of skin.
The salubrious agent of skin can vacuum comprise into bagged product, can also textile towel be soaked into it, uses packer to carry out vacuum packaging under relative gnotobasis and gets final product.
Experimental example 1:
The salubrious agent skin toxicology test of skin
1. experiment material
1.1 experimental liquid
The embodiment of the invention 1 feedstock production is adopted in the salubrious agent of skin.Blank liquid: 75% (v/v) ethanol water.Positive sensitizer: 2,4 one dinitrochlorobenzene, use 75% alcoholic solution, be made into 1% sensitization concentration and 0.1% and excite concentration.
1.2SD rat
Body weight 200g～300g purchases in Jun Keyuan hygienic conditions institute animal housing, and animal adapts to 3～5 day time before the test in the experimental animal room environment, selects conventional feed for use, and drinking-water does not limit.
2. experimental technique and result
2.1 acute toxicity test
Get 50 of satisfactory healthy SD rats, 24h before test, with the depilation of spinal column both sides, back, area is 3.5cm
2, behind the depilation 24h, satisfactory rat is pressed body weight, sex random packet, 10 every group.One group is that blank group, all the other four groups are test group, is respectively intact skin high dose group, damaged skin high dose group, intact skin low dose group, damaged skin low dose group.The damaged skin group is drawn " # " space, the degree of being with the oozing of blood with the sterilization syringe needle.
Test the same day, with the salubrious agent stock solution of skin 4.0ml/ only, 1.0ml/ only, only each once is applied to the depilation district to 70% alcoholic solution 10ml/ the upper and lower respectively noon, with oilpaper, topped, the immobilization with adhesive tape of gauze, use warm water flush away residue behind the 24h, removal is tried behind the thing 1,24,48,72h to seven day, observe and write down the variation of body weight, skin and hair, eye and the mucosa of animal every day, breathing, central nervous system, extremity activity etc. and other poisoning manifestations.Dead animal should in time perform an autopsy on sb and meat is followed observation if meet, when the visible pathological changes of naked eyes. should carry out histopathologic examination.
The result: the salubrious agent of skin is to damaged and finish skin and all do not have the acute absorption toxicity of skin.
2.2 skin irritation test
Get 10 of healthy rats, with its spinal column both sides, back depilation, area is 3.5cm
2, behind the depilation 24h.After observation 24h is non-stimulated, be the administration district with the left side, respectively the salubrious agent stock solution of skin of the present invention 1ml evenly spread upon the depilation district, the right side is the check plot.Smear with equivalent 70% alcoholic solution, topped with the two-layer gauze of one deck oilpaper, use immobilization with adhesive tape.Once a day, continuous seven days. behind the last administration 24h, tried thing, observe to remove and to be tried behind the thing 1,24,48,72h smears the position and have or not erythema, situations such as edema, and recovery situation and time with warm water cleaning.
Other gets 10 of healthy rats, and depilating method is the same, draws " # " word with No. 16 sterilization syringe needles behind the depilation 24h in taking off the district, does not hinder corium to hinder epidermis, and slight oozing of blood is arranged, and observes 24h.With the left side is the administration district. respectively the salubrious agent stock solution of skin 1ml is evenly coated in the damaged skin district, the right side is that smear with equivalent 70% alcoholic solution the check plot, and is topped with the two-layer gauze of one deck oilpaper, uses immobilization with adhesive tape.Once a day. continuous seven days, behind the last administration 24h, tried thing with warm water cleaning, observe to remove and to be tried behind the thing 1,24h, 48h, 72h smear the position and have or not erythema, situations such as edema, and recovery situation and time.Every healthy rat result is by " study of tcm new drug guide " skin irritation test reaction standards of grading scoring of Ministry of Public Health bureau of drug policy ﹠ administration issue. and calculate mean scores and carry out the stimulus intensity evaluation.Experimental result sees Table 1.
The average response value that the salubrious agent stock solution of table 1 skin stimulates rat skin
2.3 skin anaphylactic test
Get 30 of healthy rats, with its spinal column both sides, back depilation, every lateral area is 2.5cm
2, after observation 24h is non-stimulated, be divided into three groups at random by body weight, 10 every group.Give the salubrious agent stock solution of skin for first group, give blank liquid for second group, give positive sensitizer (2,4 one dinitrochlorobenzene group) for the 3rd group.
Sensitization contact: the salubrious agent stock solution of skin 0.25ml evenly is applied to rats with left depilation district, continues 6h, the 7th day and fortnight in kind repeat once, and blank group and positive sensitization group operational approach are the same.
Excite sensitization: fortnight after the last administration, 0.25ml is applied to depilation district, right side with the salubrious agent stock solution of skin.Warm water cleaning is tried thing behind the 6h, observe at once, then in 24,48,72h observes the quick response situation of skin skin once more.Blank group and positive sensitization group (2,4 one dinitrochlorobenzene group) method is the same.
The result: after positive thing 2,4 one dinitrochlorobenzene groups, animal skin are subjected to examination district self-excitation administration 6h, significantly slight erythema, no edema are arranged, the sensitization rate is 100%.Administration group (giving the salubrious agent group of skin of the present invention) rat skin is subjected to self-excitation administration 6～72h in examination district erythema not occur and edema forms, with blank group indifference.
Test of acute toxicity test, skin irritation and skin anaphylactic test are carried out in the salubrious agent of skin of embodiment 2, embodiment 3 and embodiment 4 respectively, obtain the result similar to embodiment 1.
3. conclusion
Experimental result shows. the salubrious agent of skin does not all have the acute absorption toxicity of skin to rat breakage, intact skin; , damaged skin complete and matched group to rat relatively, reluctantly visible erythema, but water breakthrough is swollen, the reaction scoring is 1, stimulus intensity＜2.99 belong to slightly and stimulating.Satisfy behind the 48h and gradually recover normal; Rat skin is not produced sensitization.Show that the salubrious agent of army's skin is used for that skin is felt nice and cool, refreshed oneself, the refreshment effect is comparison safety.
Experimental example 2
The crowd of the salubrious agent of skin uses the sense organ investigation
1. object and method
1.1 method: select 90 of 18～20 years old Healthy Youth male at random, be divided into 3 groups at random, under identical environment, each group objects respectively water, conventional external fall summer-heat article, this product successively behind wiping forehead, the ear, cervical region, oxter, groin position, each part guarantees wiping 5～10 times, inquires that it is felt nice and cool, refreshes oneself, the effect of cephalocathartic.Function grade is respectively according to nothing, general, good, fine 0,1,2,3 score values that give successively.Its result is as follows:
The salubrious agent of table 1 skin with the nice and cool effect in back relatively
1. 2. 3.: same time point is S-N-K method comparative result between mean on the same group not, P between same numbers＞0.05, P between different digital＜0.05
The salubrious agent of table 2 skin with after refresh oneself effect relatively
1. 2. 3.: same time point is S-N-K method comparative result between mean on the same group not, P between same numbers＞0.05, P between different digital＜0.05
The salubrious agent of table 3 skin with back refreshment effect relatively
1. 2. 3.: same time point is S-N-K method comparative result between mean on the same group not, P between same numbers＞0.05, P between different digital＜0.05
Conclusion
The salubrious agent of skin of the present invention, its pH is similar to skin, to the skin nonirritant, have no side effect.Even have dermatosis and minor cut or wound also not to influence use.
1, indication:
Be specially adapted to the field work personnel, under special environment, example army is in (disaster) big flood rescue action, officers and men are subjected to the restriction of environment and condition in rescue, or due to the operation at high temperature in skin and the body during increase in temperature, the salubrious agent wiping of available military skin health, it reaches nice and cool, refreshes oneself, the effect of refreshment.
Using method:
This product is easy to use, carries out skin wiping with towel or napkin, and emphasis is used for jaw cervical region, oxter and groin place, gives skin smooth and pleasant sense after using this product, is easy to carry simultaneously with its effect easily.
Claims (2)
1. salubrious agent of skin is characterized in that being made by following raw material by mass percentage:
Menthol 1%-4%, dichlorodifluoromethane 30%-50%, dichloro-tetrafluoro ethylene 20%-60%, Oleum menthae 0.2%-0.5%, essence is an amount of, the deionized water surplus.
2. the salubrious agent of a kind of skin according to claim 1 is characterized in that described menthol is 2%, and dichlorodifluoromethane is 40%, and dichloro-tetrafluoro ethylene is 49.5%, and Oleum menthae is 0.3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010585205 CN102008421A (en) | 2010-12-10 | 2010-12-10 | Skin refreshing agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010585205 CN102008421A (en) | 2010-12-10 | 2010-12-10 | Skin refreshing agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102008421A true CN102008421A (en) | 2011-04-13 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010585205 Pending CN102008421A (en) | 2010-12-10 | 2010-12-10 | Skin refreshing agent |
Country Status (1)
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|---|---|
| CN (1) | CN102008421A (en) |
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2010
- 2010-12-10 CN CN 201010585205 patent/CN102008421A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 《洗涤剂概论》 20001031 徐宝财 薄荷油浴用气雾剂 化学工业出版社 , 第1版 1 * |
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Owner name: MEDICAL COLLEGE OF CAPF Free format text: FORMER OWNER: MEDICAL COLLEGE, CHINESE PEOPLE S ARMED POLICE FORCES Effective date: 20111117 |
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Effective date of registration: 20111117 Address after: 300162 Tianjin City Hedong District Forest Road No. 222 Applicant after: Logistics College of Chinese Armed Police Force Address before: 300161 Tianjin City Hedong District Forest Road Medical College of Armed Police Applicant before: Medical College, Chinese People's Armed Police Forces |
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Application publication date: 20110413 |