CN101959404A - 单磷酸腺苷活化蛋白激酶调节剂 - Google Patents
单磷酸腺苷活化蛋白激酶调节剂 Download PDFInfo
- Publication number
- CN101959404A CN101959404A CN2009801075500A CN200980107550A CN101959404A CN 101959404 A CN101959404 A CN 101959404A CN 2009801075500 A CN2009801075500 A CN 2009801075500A CN 200980107550 A CN200980107550 A CN 200980107550A CN 101959404 A CN101959404 A CN 101959404A
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- substituted
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- aryl
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- 0 *C(CO)=C(c(cc1)ccc1Br)Cl Chemical compound *C(CO)=C(c(cc1)ccc1Br)Cl 0.000 description 4
- OHYDWXHZVXBOOQ-VURMDHGXSA-N C/C(/CO)=C/c(cc1)ccc1Br Chemical compound C/C(/CO)=C/c(cc1)ccc1Br OHYDWXHZVXBOOQ-VURMDHGXSA-N 0.000 description 1
- BZPVPJFNVSPQSD-XKBMDUCPSA-N C[C@H](C(C(C1O)C#N)O)c2c1c(-c(cc1)ccc1-c1ccccc1O)n[o]2 Chemical compound C[C@H](C(C(C1O)C#N)O)c2c1c(-c(cc1)ccc1-c1ccccc1O)n[o]2 BZPVPJFNVSPQSD-XKBMDUCPSA-N 0.000 description 1
- ZRYZBQLXDKPBDU-UHFFFAOYSA-N O=Cc(cc1)ccc1Br Chemical compound O=Cc(cc1)ccc1Br ZRYZBQLXDKPBDU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
Description
化合物编号 | 半数有效量 |
1 | II |
2 | III |
3 | III |
4 | II |
5 | III |
6 | I |
7 | III |
8 | III |
9 | II |
Claims (20)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2600108P | 2008-02-04 | 2008-02-04 | |
US61/026,001 | 2008-02-04 | ||
US5120008P | 2008-05-07 | 2008-05-07 | |
US61/051,200 | 2008-05-07 | ||
PCT/US2009/033077 WO2009100130A1 (en) | 2008-02-04 | 2009-02-04 | Ampk modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101959404A true CN101959404A (zh) | 2011-01-26 |
CN101959404B CN101959404B (zh) | 2015-12-02 |
Family
ID=40952443
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200980107550.0A Expired - Fee Related CN101959404B (zh) | 2008-02-04 | 2009-02-04 | 单磷酸腺苷活化蛋白激酶调节剂 |
Country Status (16)
Country | Link |
---|---|
US (3) | US8273744B2 (zh) |
EP (1) | EP2240016A4 (zh) |
JP (2) | JP5525456B2 (zh) |
KR (1) | KR20100115789A (zh) |
CN (1) | CN101959404B (zh) |
AU (1) | AU2009212462B2 (zh) |
BR (1) | BRPI0905952A2 (zh) |
CA (1) | CA2714181C (zh) |
EA (1) | EA019309B1 (zh) |
IL (1) | IL207234A (zh) |
MX (1) | MX2010008376A (zh) |
MY (1) | MY158994A (zh) |
NZ (1) | NZ587165A (zh) |
UA (1) | UA106037C2 (zh) |
WO (1) | WO2009100130A1 (zh) |
ZA (1) | ZA201005600B (zh) |
Cited By (9)
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---|---|---|---|---|
CN103476258A (zh) * | 2011-02-25 | 2013-12-25 | 默沙东公司 | 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物 |
CN103517896A (zh) * | 2011-03-07 | 2014-01-15 | 葛兰素史密斯克莱有限责任公司 | 喹啉酮衍生物 |
TWI449702B (zh) * | 2012-07-11 | 2014-08-21 | Merck Sharp & Dohme | 作為抗糖尿病劑之新穎環氮雜苯并咪唑衍生物 |
CN104045625A (zh) * | 2013-03-15 | 2014-09-17 | 辉瑞大药厂 | 活化ampk 的吲哚类和吲唑类化合物 |
CN104245688A (zh) * | 2012-04-10 | 2014-12-24 | 辉瑞大药厂 | 活化ampk的吲哚和吲唑类化合物 |
CN104774172A (zh) * | 2015-04-08 | 2015-07-15 | 河南师范大学 | 一种3-氰基吲哚类化合物的合成方法 |
CN107556309A (zh) * | 2017-09-11 | 2018-01-09 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
CN112342216A (zh) * | 2020-11-13 | 2021-02-09 | 中国人民解放军军事科学院军事医学研究院 | 用于提高CHO细胞的表达效率的CRISPR-Cas13d***以及重组CHO细胞 |
CN112739352A (zh) * | 2018-08-06 | 2021-04-30 | 斯凯拉克生物科技有限责任公司 | 活化amp-活化的蛋白激酶的化合物及其用途 |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2007041641A1 (en) * | 2005-10-03 | 2007-04-12 | University Of Tennessee Research Foundation | Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species |
TWI468162B (zh) | 2005-12-13 | 2015-01-11 | 英塞特公司 | 作為傑納斯激酶(JANUS KINASE)抑制劑之經雜芳基取代之吡咯并〔2,3-b〕吡啶及吡咯并〔2,3-b〕嘧啶 |
SG10201509887UA (en) | 2007-06-13 | 2016-01-28 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
US8273744B2 (en) * | 2008-02-04 | 2012-09-25 | Mercury Therapeutics, Inc. | AMPK modulators |
CN101998853B (zh) | 2008-04-11 | 2015-02-11 | 默克专利有限公司 | 作为amp-活化的蛋白激酶(ampk)激活剂的噻吩并吡啶酮衍生物 |
MX2011003239A (es) | 2008-09-26 | 2011-04-28 | Merck Sharp & Dohme | Nuevos derivados de bencimidazol ciclicos utiles como agentes anti-diabeticos. |
CA2741125A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051176A1 (en) | 2008-10-29 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
WO2010051206A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
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WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
GB0915892D0 (en) * | 2009-09-10 | 2009-10-14 | Smithkline Beecham Corp | Compounds |
WO2011032320A1 (en) * | 2009-09-21 | 2011-03-24 | F. Hoffmann-La Roche Ag | Novel alkene oxindole derivatives |
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US8895596B2 (en) | 2010-02-25 | 2014-11-25 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
MX347851B (es) | 2010-03-10 | 2017-05-16 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
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WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
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CA2939833A1 (en) | 2014-02-27 | 2015-09-03 | Nusirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
JP6579550B2 (ja) * | 2014-08-27 | 2019-09-25 | 塩野義製薬株式会社 | Ampk活性化作用を有するアザインドール誘導体 |
WO2016068099A1 (ja) | 2014-10-28 | 2016-05-06 | 塩野義製薬株式会社 | Ampk活性化作用を有する複素環誘導体 |
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CN112739352A (zh) * | 2018-08-06 | 2021-04-30 | 斯凯拉克生物科技有限责任公司 | 活化amp-活化的蛋白激酶的化合物及其用途 |
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CN112342216A (zh) * | 2020-11-13 | 2021-02-09 | 中国人民解放军军事科学院军事医学研究院 | 用于提高CHO细胞的表达效率的CRISPR-Cas13d***以及重组CHO细胞 |
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EA019309B1 (ru) | 2014-02-28 |
JP2011511008A (ja) | 2011-04-07 |
IL207234A (en) | 2016-06-30 |
EP2240016A4 (en) | 2011-11-16 |
US8980895B2 (en) | 2015-03-17 |
EP2240016A1 (en) | 2010-10-20 |
AU2009212462A1 (en) | 2009-08-13 |
JP2014028828A (ja) | 2014-02-13 |
CN101959404B (zh) | 2015-12-02 |
WO2009100130A1 (en) | 2009-08-13 |
US8273744B2 (en) | 2012-09-25 |
US20120302576A1 (en) | 2012-11-29 |
US20100009992A1 (en) | 2010-01-14 |
IL207234A0 (en) | 2010-12-30 |
JP5525456B2 (ja) | 2014-06-18 |
BRPI0905952A2 (pt) | 2015-06-30 |
UA106037C2 (uk) | 2014-07-25 |
CA2714181C (en) | 2013-12-24 |
US20150266892A1 (en) | 2015-09-24 |
AU2009212462B2 (en) | 2012-09-13 |
ZA201005600B (en) | 2016-09-28 |
MX2010008376A (es) | 2011-02-22 |
MY158994A (en) | 2016-11-30 |
EA201001257A1 (ru) | 2011-04-29 |
NZ587165A (en) | 2012-03-30 |
CA2714181A1 (en) | 2009-08-13 |
KR20100115789A (ko) | 2010-10-28 |
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