CN101918385A - 二甲氧基多西紫杉醇的结晶形式及其制备方法 - Google Patents
二甲氧基多西紫杉醇的结晶形式及其制备方法 Download PDFInfo
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- CN101918385A CN101918385A CN2009801023898A CN200980102389A CN101918385A CN 101918385 A CN101918385 A CN 101918385A CN 2009801023898 A CN2009801023898 A CN 2009801023898A CN 200980102389 A CN200980102389 A CN 200980102389A CN 101918385 A CN101918385 A CN 101918385A
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- hydroxyl
- dimethoxy
- benzoyloxy
- tert
- oxo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (22)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800243 | 2008-01-17 | ||
FR0800243A FR2926551A1 (fr) | 2008-01-17 | 2008-01-17 | Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation |
PCT/FR2009/000042 WO2009115655A2 (fr) | 2008-01-17 | 2009-01-15 | Formes cristallines du dimethoxy docetaxel et leurs procedes de preparation |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410258534.4A Division CN104130221A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
CN201410257561.XA Division CN104130220A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN101918385A true CN101918385A (zh) | 2010-12-15 |
CN101918385B CN101918385B (zh) | 2014-07-02 |
Family
ID=39712334
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410257561.XA Pending CN104130220A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
CN200980102389.8A Expired - Fee Related CN101918385B (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
CN201410258534.4A Pending CN104130221A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410257561.XA Pending CN104130220A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410258534.4A Pending CN104130221A (zh) | 2008-01-17 | 2009-01-15 | 二甲氧基多西紫杉醇的结晶形式及其制备方法 |
Country Status (42)
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102503913A (zh) * | 2011-10-20 | 2012-06-20 | 江苏红豆杉生物科技有限公司 | 直接用于x射线单晶衍射分析的二甲氧基紫杉烷类化合物单晶晶体的制备方法 |
CN102675257A (zh) * | 2012-05-10 | 2012-09-19 | 上海金和生物技术有限公司 | 一种卡巴他赛晶体及其制备方法 |
CN102746258A (zh) * | 2012-07-25 | 2012-10-24 | 重庆泰濠制药有限公司 | 卡巴他赛的结晶形式及其制备方法 |
CN102898406A (zh) * | 2012-11-02 | 2013-01-30 | 上海金和生物技术有限公司 | 一种卡巴他赛晶体及其制备方法 |
CN103058960A (zh) * | 2012-12-12 | 2013-04-24 | 江苏奥赛康药业股份有限公司 | 卡巴他赛多晶型形式及其制备方法 |
WO2013111157A1 (en) * | 2012-01-03 | 2013-08-01 | Shilpa Medicare Limited | Process for preparing amorphous cabazitaxel |
CN103450119A (zh) * | 2013-09-24 | 2013-12-18 | 天津炜捷制药有限公司 | 一种卡巴他赛晶型w及其制备方法 |
CN103601704A (zh) * | 2013-11-22 | 2014-02-26 | 赵军旭 | 无定形卡巴他赛的制备 |
CN103664836A (zh) * | 2012-09-20 | 2014-03-26 | 齐鲁制药有限公司 | 7β,10β-二甲氧基多西紫杉醇氘代丙酮合物的晶型A及其制备方法 |
CN103764637A (zh) * | 2011-04-12 | 2014-04-30 | 普拉斯化学品有限公司 | 卡巴他赛的固态形式及其制备方法 |
CN103910697A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛乙酸合物及其结晶 |
CN103910698A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛丙酮合物及其结晶 |
CN103910696A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛异丙醚合物及其结晶 |
CN104011035A (zh) * | 2011-11-28 | 2014-08-27 | 费森尤斯卡比肿瘤学有限公司 | 卡巴他赛的晶型和用于制备其的方法 |
CN104039771A (zh) * | 2011-09-26 | 2014-09-10 | Kabi费森尤斯肿瘤学有限公司 | 包括c(7)-oh和c(13)-oh甲硅烷基化或仅c(7)-oh甲硅烷基化的用于制备卡巴他赛的方法 |
CN104220431A (zh) * | 2012-03-08 | 2014-12-17 | 伊瓦克斯国际有限责任公司 | 卡巴他赛的固态形式及其制备方法 |
CN105849093A (zh) * | 2013-10-23 | 2016-08-10 | 因德纳有限公司 | 卡巴他赛无水结晶形式、其制备方法和药用组合物 |
CN104945453B (zh) * | 2014-03-28 | 2018-06-26 | 江苏天士力帝益药业有限公司 | 吡唑衍生物的多晶型物 |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY164086A (en) | 2009-10-29 | 2017-11-30 | Aventis Pharma Sa | Novel antitumoral use of cabazitaxel |
TWI526437B (zh) * | 2011-09-09 | 2016-03-21 | 台灣神隆股份有限公司 | 卡巴他賽之結晶型 |
WO2013065070A1 (en) | 2011-11-01 | 2013-05-10 | Fresenius Kabi Encology Ltd. | Amorphous form of cabazitaxel and process for its preparation |
JP6025861B2 (ja) | 2011-12-13 | 2016-11-16 | アベンティス・ファーマ・ソシエテ・アノニム | カバジタキセルの結晶形およびこれを調製するための方法 |
WO2014022237A1 (en) | 2012-07-31 | 2014-02-06 | Yung Shin Pharm. Ind. Co., Ltd. | Amorphous cabazitaxel |
EP2884963B1 (en) | 2012-08-15 | 2017-12-27 | Yung Shin Pharm. Ind. Co. Ltd. | Stable pharmaceutical formulation of cabazitaxel |
EP2743264A1 (en) | 2012-12-13 | 2014-06-18 | INDENA S.p.A. | New crystalline form of cabazitaxel, process for the preparation and pharmaceutical compositions thereof |
KR101429543B1 (ko) * | 2012-12-13 | 2014-08-14 | 주식회사 삼양바이오팜 | 카바지탁셀의 신규 결정형 및 그 제조방법 |
AU2013368947B2 (en) * | 2012-12-31 | 2016-11-24 | Shilpa Medicare Limited | Process for preparing amorphous Cabazitaxel |
WO2014115168A2 (en) * | 2013-01-23 | 2014-07-31 | Leiutis Pharmaceuticals Private Limited | Novel solvate forms of cabazitaxel and process for preparation thereof |
WO2014128728A2 (en) * | 2013-02-25 | 2014-08-28 | Laurus Labs Private Limited | Solid forms of cabazitaxel and processes for preparation thereof |
EP2815749A1 (en) | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
WO2015000165A1 (zh) * | 2013-07-04 | 2015-01-08 | 北京新天宇科技开发有限公司 | 二甲氧基多西紫杉醇一丙酮化物的稳定转化物及其结晶形式、以及它们的制备方法 |
EP2865674A1 (en) | 2013-10-23 | 2015-04-29 | INDENA S.p.A. | Crystalline solvate forms of Cabazitaxel |
US10188626B2 (en) | 2015-11-03 | 2019-01-29 | Cipla Limited | Stabilized cabazitaxel formulations |
WO2020249507A1 (en) | 2019-06-11 | 2020-12-17 | Indena S.P.A. | Anhydrous crystalline form of cabazitaxel, a process for its preparation and pharmaceutical compositions containing it |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2163837C (en) * | 1994-12-13 | 1999-07-20 | Robert K. Perrone | Crystalline paclitaxel hydrates |
US5847170A (en) * | 1995-03-27 | 1998-12-08 | Rhone-Poulenc Rorer, S.A. | Taxoids, their preparation and pharmaceutical compositions containing them |
MA23823A1 (fr) * | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
FR2745814B1 (fr) * | 1996-03-06 | 1998-04-03 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2771092B1 (fr) * | 1997-11-18 | 1999-12-17 | Rhone Poulenc Rorer Sa | Procede de preparation de derives de la classe des taxoides |
US6346543B1 (en) * | 1998-08-17 | 2002-02-12 | Aventis Pharma S.A. | Use of a taxoid to treat abnormal cell proliferation in the brain |
AU2002365883A1 (en) * | 2001-11-30 | 2003-06-17 | Bristol-Myers Squibb Company | Paclitaxel solvates |
FR2859996B1 (fr) * | 2003-09-19 | 2006-02-03 | Aventis Pharma Sa | Solvat acetonique du dimethoxy docetaxel et son procede de preparation |
US20070142457A1 (en) * | 2005-10-12 | 2007-06-21 | Alessandro Pontiroli | Crystalline forms of docetaxel and processes for their preparation |
TWI394765B (zh) * | 2008-12-12 | 2013-05-01 | Ind Tech Res Inst | 難燃水性聚胺基甲酸酯分散液 |
MY164086A (en) | 2009-10-29 | 2017-11-30 | Aventis Pharma Sa | Novel antitumoral use of cabazitaxel |
TWI526437B (zh) | 2011-09-09 | 2016-03-21 | 台灣神隆股份有限公司 | 卡巴他賽之結晶型 |
EP2785701B1 (en) | 2011-11-28 | 2019-01-02 | Fresenius Kabi Oncology Limited | Crystalline form of carbazitaxel and process for preparation thereof |
JP6025861B2 (ja) | 2011-12-13 | 2016-11-16 | アベンティス・ファーマ・ソシエテ・アノニム | カバジタキセルの結晶形およびこれを調製するための方法 |
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2008
- 2008-01-17 FR FR0800243A patent/FR2926551A1/fr not_active Withdrawn
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2009
- 2009-01-15 KR KR1020107015939A patent/KR20100103614A/ko not_active Application Discontinuation
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- 2009-01-15 CA CA2712373A patent/CA2712373C/fr not_active Expired - Fee Related
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Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103764637A (zh) * | 2011-04-12 | 2014-04-30 | 普拉斯化学品有限公司 | 卡巴他赛的固态形式及其制备方法 |
CN104039771B (zh) * | 2011-09-26 | 2017-10-27 | Kabi费森尤斯肿瘤学有限公司 | 包括c(7)‑oh和c(13)‑oh甲硅烷基化或仅c(7)‑oh甲硅烷基化的用于制备卡巴他赛的方法 |
CN104039771A (zh) * | 2011-09-26 | 2014-09-10 | Kabi费森尤斯肿瘤学有限公司 | 包括c(7)-oh和c(13)-oh甲硅烷基化或仅c(7)-oh甲硅烷基化的用于制备卡巴他赛的方法 |
CN102503913B (zh) * | 2011-10-20 | 2014-03-26 | 江苏红豆杉生物科技股份有限公司 | 直接用于x射线单晶衍射分析的二甲氧基紫杉烷类化合物单晶晶体的制备方法 |
CN102503913A (zh) * | 2011-10-20 | 2012-06-20 | 江苏红豆杉生物科技有限公司 | 直接用于x射线单晶衍射分析的二甲氧基紫杉烷类化合物单晶晶体的制备方法 |
CN104011035A (zh) * | 2011-11-28 | 2014-08-27 | 费森尤斯卡比肿瘤学有限公司 | 卡巴他赛的晶型和用于制备其的方法 |
WO2013111157A1 (en) * | 2012-01-03 | 2013-08-01 | Shilpa Medicare Limited | Process for preparing amorphous cabazitaxel |
CN104220431A (zh) * | 2012-03-08 | 2014-12-17 | 伊瓦克斯国际有限责任公司 | 卡巴他赛的固态形式及其制备方法 |
CN102675257B (zh) * | 2012-05-10 | 2014-07-02 | 上海金和生物技术有限公司 | 一种卡巴他赛晶体及其制备方法 |
CN102675257A (zh) * | 2012-05-10 | 2012-09-19 | 上海金和生物技术有限公司 | 一种卡巴他赛晶体及其制备方法 |
CN102746258A (zh) * | 2012-07-25 | 2012-10-24 | 重庆泰濠制药有限公司 | 卡巴他赛的结晶形式及其制备方法 |
WO2014015760A1 (zh) * | 2012-07-25 | 2014-01-30 | 重庆泰濠制药有限公司 | 卡巴他赛的结晶形式及其制备方法 |
US9353076B2 (en) | 2012-07-25 | 2016-05-31 | Chongqing Taihao Pharmaceutical Co., Ltd. | Crystal form of cabazitaxel and preparation method thereof |
CN103664836A (zh) * | 2012-09-20 | 2014-03-26 | 齐鲁制药有限公司 | 7β,10β-二甲氧基多西紫杉醇氘代丙酮合物的晶型A及其制备方法 |
CN103664836B (zh) * | 2012-09-20 | 2016-04-20 | 齐鲁制药有限公司 | 7β,10β-二甲氧基多西紫杉醇氘代丙酮合物的晶型A及其制备方法 |
CN102898406A (zh) * | 2012-11-02 | 2013-01-30 | 上海金和生物技术有限公司 | 一种卡巴他赛晶体及其制备方法 |
CN103058960A (zh) * | 2012-12-12 | 2013-04-24 | 江苏奥赛康药业股份有限公司 | 卡巴他赛多晶型形式及其制备方法 |
CN103910696A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛异丙醚合物及其结晶 |
CN103910698A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛丙酮合物及其结晶 |
CN103910697A (zh) * | 2012-12-30 | 2014-07-09 | 上海医药工业研究院 | 卡巴他赛乙酸合物及其结晶 |
CN103910697B (zh) * | 2012-12-30 | 2016-08-03 | 上海医药工业研究院 | 卡巴他赛乙酸合物及其结晶 |
CN103450119B (zh) * | 2013-09-24 | 2015-06-17 | 天津炜捷制药有限公司 | 一种卡巴他赛晶型w及其制备方法 |
CN103450119A (zh) * | 2013-09-24 | 2013-12-18 | 天津炜捷制药有限公司 | 一种卡巴他赛晶型w及其制备方法 |
CN105849093A (zh) * | 2013-10-23 | 2016-08-10 | 因德纳有限公司 | 卡巴他赛无水结晶形式、其制备方法和药用组合物 |
CN103601704A (zh) * | 2013-11-22 | 2014-02-26 | 赵军旭 | 无定形卡巴他赛的制备 |
CN104945453B (zh) * | 2014-03-28 | 2018-06-26 | 江苏天士力帝益药业有限公司 | 吡唑衍生物的多晶型物 |
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